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公开(公告)号：US10087280B2
公开(公告)日：2018-10-02
申请号：US15491650
申请日：2015-08-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kyle Gee , Xin Wang , Hee Chol Kang , Aimei Chen , Yexin Wu , Yi-Zhen Hu , Robert Aggeler , Quentin Low
IPC: C08G61/12 , C07F7/08 , C08L65/00 , G01N33/533 , G01N33/58 , H01L51/00 , C09K11/06 , G01N33/545
Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.
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2.发明申请METHODS AND COMPOSITIONS FOR ENZYME-MEDIATED SITE-SPECIFIC RADIOLABELING OF GLYCOPROTEINS 审中-公开酶促介导位点特异性放射性糖蛋白的方法和组合物公开(公告)号：US20150246146A1
公开(公告)日：2015-09-03
申请号：US14425114
申请日：2013-10-25
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Brian Agnew , Robert Aggeler , Hee Chol Kang , Aimei Chen , Kyle Gee
CPC classification number: A61K51/10 , C07K14/435 , C07K16/18 , C12P21/005 , C12P21/06 , G01N33/534 , G01N33/582 , G01N33/6854
Abstract: Provided herein are methods, compositions and kits for use in the site-specific labeling of glycoproteins comprising a combination of enzyme-mediated incorporation of modified sugars comprising a chemical handle and cycloaddition chemistry with a labeling molecule comprising a reactive group, a metal ion chelator, and/or a fluorophore.
Abstract translation: 本文提供了用于糖蛋白的位点特异性标记的方法，组合物和试剂盒，其包括酶介导的包含化学处理和环加成化学的修饰的糖的组合与包含反应性基团的标记分子，金属离子螯合剂， 和/或荧光团。
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公开(公告)号：US11865191B2
公开(公告)日：2024-01-09
申请号：US16882271
申请日：2020-05-22
Applicant: Life Technologies Corporation , Pierce Biotechnology, Inc.
Inventor： Surbhi Desai , Marie Christine Nlend , Kyle Gee , Matthew Baker , Robert Aggeler , Scott Sweeney , Aleksey Rukavishnikov , Shih-Jung Huang
CPC classification number: A61K49/0015 , A61K47/10 , A61K47/18 , A61K49/0058 , G01N33/533 , G01N33/582 , G01N33/68
Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
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公开(公告)号：US12071487B2
公开(公告)日：2024-08-27
申请号：US16306610
申请日：2017-06-16
Applicant: Life Technologies Corporation
Inventor： Brian Agnew , Robert Aggeler
IPC: G01N33/68 , A61K9/00 , A61K47/60 , A61K47/68 , A61K47/69 , C07K16/46 , C12N9/24 , C12N15/113 , C12P21/00
CPC classification number: C07K16/468 , A61K9/0021 , A61K47/60 , A61K47/6879 , A61K47/6881 , A61K47/6913 , C12N9/2402 , C12N15/113 , C12P21/005 , C12Y302/01018 , C12Y302/01023 , C12Y302/01096 , G01N33/6854 , C07K2317/10 , C07K2317/31 , C07K2317/41 , C07K2317/52 , C07K2317/54 , C07K2317/622 , C07K2319/30 , C12N2310/14 , C12N2310/3513
Abstract: Methods are provided for making bispecific antibodies and antibody conjugates comprising site-specifically cross-linking two or more antibodies, antibody fragments or Fc-fusion proteins. Also provided are compositions and uses for the bispecific antibodies and antibody conjugates. The bispecific antibodies may be used to treat a disease or condition. Also provided are methods for site-specifically conjugating a liposome, an mRNA or an siRNA to an antibody, and uses of the antibody-conjugated liposome, mRNA or siRNA.
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公开(公告)号：US11857643B2
公开(公告)日：2024-01-02
申请号：US16816015
申请日：2020-03-11
Applicant: Life Technologies Corporation , Pierce Biotechnology, Inc.
Inventor： Surbhi Desai , Marie Christine Nlend , Kyle Gee , Matthew Baker , Robert Aggeler , Scott Sweeney , Aleksey Rukavishnikov , Shih-Jung Huang
CPC classification number: A61K49/0015 , A61K47/10 , A61K47/18 , A61K49/0058 , G01N33/533 , G01N33/582 , G01N33/68
Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
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Patent Agency Ranking
公开(公告)号：US11193057B2
公开(公告)日：2021-12-07
申请号：US16324730
申请日：2017-08-24
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Adam York , Eric Welch , Kyle Gee , Xin Wang , Robert Aggeler , Yi-Zhen Hu
Abstract: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.
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公开(公告)号：US20240392041A1
公开(公告)日：2024-11-28
申请号：US18772605
申请日：2024-07-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Brian Agnew , Robert Aggeler , Rolando Brawer
IPC: C07K16/46 , A61K9/00 , A61K47/60 , A61K47/68 , A61K47/69 , C12N9/24 , C12N15/113 , C12P21/00 , G01N33/68
Abstract: Methods are provided for making bispecific antibodies and antibody conjugates comprising site-specifically cross-linking two or more antibodies, antibody fragments or Fc-fusion proteins. Also provided are compositions and uses for the bispecific antibodies and antibody conjugates. The bispecific antibodies may be used to treat a disease or condition. Also provided are methods for site-specifically conjugating a liposome, an mRNA or an siRNA to an antibody, and uses of the antibody-conjugated liposome, mRNA or siRNA.
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公开(公告)号：US20240042062A1
公开(公告)日：2024-02-08
申请号：US18380388
申请日：2023-10-16
Applicant: Life Technologies Corporation , Pierce Biotechnology, Inc.
Inventor： Surbhi Desai , Marie Christine Nlend , Kyle Gee , Matthew Baker , Robert Aggeler , Scott Sweeney , Aleksey Rukavishnikov , Shih-Jung Huang
CPC classification number: A61K49/0015 , G01N33/582 , A61K47/10 , A61K47/18 , A61K49/0058 , G01N33/533 , G01N33/68
Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
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公开(公告)号：US10570250B2
公开(公告)日：2020-02-25
申请号：US16107818
申请日：2018-08-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kyle Gee , Xin Wang , Hee Chol Kang , Aimei Chen , Yexin Wu , Yi-Zhen Hu , Robert Aggeler , Quentin Low
IPC: C08G61/12 , H01L51/00 , C07F7/08 , C08L65/00 , G01N33/533 , G01N33/58 , C09K11/06 , G01N33/545
Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.
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公开(公告)号：US20180355098A1
公开(公告)日：2018-12-13
申请号：US16107818
申请日：2018-08-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kyle Gee , Xin Wang , Hee Chol Kang , Aimei Chen , Yexin Wu , Yi-Zhen Hu , Robert Aggeler , Quentin Low
IPC: C08G61/12 , H01L51/00 , G01N33/545 , C09K11/06 , G01N33/58 , G01N33/533 , C08L65/00 , C07F7/08
CPC classification number: C08G61/123 , C07F7/0816 , C07F7/083 , C08G2261/122 , C08G2261/124 , C08G2261/1424 , C08G2261/145 , C08G2261/1644 , C08G2261/1646 , C08G2261/3142 , C08G2261/3244 , C08G2261/334 , C08G2261/344 , C08G2261/411 , C08G2261/522 , C08G2261/5222 , C08G2261/72 , C08G2261/94 , C08L65/00 , C09K11/06 , C09K2211/1416 , C09K2211/1491 , G01N33/533 , G01N33/545 , G01N33/582 , H01L51/0039 , H01L51/0043 , H01L51/0094
Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.
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