公开(公告)号：US10988798B2

公开(公告)日：2021-04-27

申请号：US16164348

申请日：2018-10-18

Applicant: Life Technologies Corporation

Inventor： Scott C. Benson ,  Cinna Monighetti ,  Sandy M. Koepf

IPC: C12Q1/68 ,  C12Q1/6818 ,  C09B15/00 ,  C12Q1/6851 ,  C12Q1/6844

Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.

公开(公告)号：US20210292818A1

公开(公告)日：2021-09-23

申请号：US17219551

申请日：2021-03-31

Applicant: Life Technologies Corporation

Inventor： Scott C. Benson ,  Cinna Monighetti ,  Sandy M. Koepf

IPC: C12Q1/6818 ,  C09B15/00 ,  C12Q1/6851 ,  C12Q1/6844

Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.

公开(公告)号：US20180127811A1

公开(公告)日：2018-05-10

申请号：US15707157

申请日：2017-09-18

Applicant: Life Technologies Corporation

Inventor： Scott C. Benson ,  Cinna Monighetti ,  Sandy M. Koepf

IPC: C12Q1/6818 ,  C12Q1/6844 ,  C09B15/00 ,  C12Q1/6851

CPC classification number: C12Q1/6844 ,  C09B15/00 ,  C12Q1/6818 ,  C12Q1/6851 ,  C12Q2527/125 ,  C12Q2545/101 ,  C12Q2561/113 ,  C12Q2563/107

Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.

公开(公告)号：US09790544B2

公开(公告)日：2017-10-17

申请号：US15066248

申请日：2016-03-10

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Scott C. Benson ,  Cinna Monighetti ,  Sandy M. Koepf

IPC: C12Q1/68 ,  C12P19/34 ,  C09B15/00

CPC classification number: C12Q1/6818 ,  C09B15/00 ,  C12Q1/6844 ,  C12Q1/6851 ,  C12Q2527/125 ,  C12Q2545/101 ,  C12Q2561/113 ,  C12Q2563/107

Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.

公开(公告)号：US09315859B2

公开(公告)日：2016-04-19

申请号：US14071552

申请日：2013-11-04

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Scott C. Benson ,  Cinna Monighetti ,  Sandy M. Koepf

IPC: C12Q1/68 ,  C12P19/34 ,  C09B15/00 ,  C07H21/02 ,  C07H21/04

CPC classification number: C12Q1/6818 ,  C09B15/00 ,  C12Q1/6844 ,  C12Q1/6851 ,  C12Q2527/125 ,  C12Q2545/101 ,  C12Q2561/113 ,  C12Q2563/107

Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.

Abstract translation: 根据本教导，提供利用至少一种式（I）的参考染料的方法和组合物：在一些实施方案中，一种方法包括测量报道染料和至少一种式（I）的参考染料的检测信号， 。 在一些实施方案中，组合物包含式（1）的参考染料，缓冲液，核苷酸和蛋白质的选择。

公开(公告)号：US20190119732A1

公开(公告)日：2019-04-25

申请号：US16164348

申请日：2018-10-18

Applicant: Life Technologies Corporation

Inventor： Scott C. Benson ,  Cinna Monighetti ,  Sandy M. Koepf

IPC: C12Q1/6818 ,  C12Q1/6844 ,  C09B15/00 ,  C12Q1/6851

Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.

公开(公告)号：US10131936B2

公开(公告)日：2018-11-20

申请号：US15707157

申请日：2017-09-18

Applicant: Life Technologies Corporation

Inventor： Scott C. Benson ,  Cinna Monighetti ,  Sandy M. Koepf

IPC: C12Q1/68 ,  C12Q1/6818 ,  C09B15/00 ,  C12Q1/6851 ,  C12Q1/6844 ,  C12P19/34

Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.

公开(公告)号：US20160258004A1

公开(公告)日：2016-09-08

申请号：US15066248

申请日：2016-03-10

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Scott C. Benson ,  Cinna Monighetti ,  Sandy M. Koepf

IPC: C12Q1/68 ,  C09B15/00

CPC classification number: C12Q1/6818 ,  C09B15/00 ,  C12Q1/6844 ,  C12Q1/6851 ,  C12Q2527/125 ,  C12Q2545/101 ,  C12Q2561/113 ,  C12Q2563/107

Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.

Abstract translation: 根据本教导，提供利用至少一种式（I）的参考染料的方法和组合物：在一些实施方案中，一种方法包括测量报道染料和至少一种式（I）的参考染料的检测信号， 。 在一些实施方案中，组合物包含式（1）的参考染料，缓冲液，核苷酸和蛋白质的选择。

公开(公告)号：US20140134615A1

公开(公告)日：2014-05-15

申请号：US14071552

申请日：2013-11-04

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Scott C. Benson ,  Cinna Monighetti ,  Sandy M. Koepf

IPC: C12Q1/68

CPC classification number: C12Q1/6818 ,  C09B15/00 ,  C12Q1/6844 ,  C12Q1/6851 ,  C12Q2527/125 ,  C12Q2545/101 ,  C12Q2561/113 ,  C12Q2563/107

Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I); In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (I), a buffer, a selection of nucleotides and a protein.

Abstract translation: 根据本教导，提供利用至少一种式（I）的参考染料的方法和组合物; 在一些实施方案中，一种方法包括测量报道染料和至少一种式（I）的参考染料的检测信号。 在一些实施方案中，组合物包含式（I）的参考染料，缓冲液，核苷酸和蛋白质的选择。