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1.发明申请Modified Nucleic Acid Binding Cyanine Dyes for the Detection of Reactive Oxygen Species 有权用于检测活性氧物质的改性核酸结合花青染料公开(公告)号：US20150079622A1
公开(公告)日：2015-03-19
申请号：US14384843
申请日：2013-02-26
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Yi-Zhen Hu , Aimei Chen , Hee Chol Kang , Kyle Gee , Bhaskar Mandavilli
IPC: G01N33/52 , C07D417/06
Abstract: Disclosed herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced nucleic acid binding cyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.
Abstract translation: 本文公开了通过常规荧光显微镜，荧光光谱，流式细胞术和/或高含量成像检测活性氧（ROS）的化合物，组合物，方法和试剂盒。 本文公开的化合物是新的还原性核酸结合花青染料，其染料是用于检测ROS的探针，并测定体外和/或体内细胞中的氧化应激。 本文还描述了用于制备用于所公开的组合物，方法和试剂盒的新型还原染料即ROS探针的方法。
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2.发明申请公开(公告)号：US20170108518A1
公开(公告)日：2017-04-20
申请号：US15340134
申请日：2016-11-01
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Yi-Zhen HU , Aimei Chen , Hee Chol Kang , Kyle Gee , Bhaskar Mandavilli
Abstract: Disclosed herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced nucleic acid binding cyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.
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3.发明授权Modified nucleic acid binding cyanine dyes for the detection of reactive oxygen species 有权用于检测活性氧的修饰的核酸结合花青染料公开(公告)号：US09518981B2
公开(公告)日：2016-12-13
申请号：US14384843
申请日：2013-02-26
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Yi-Zhen Hu , Aimei Chen , Hee Chol Kang , Kyle Gee , Bhaskar Mandavilli
IPC: C07D215/00 , G01N33/52 , C09B23/02 , C09B23/04 , C09B23/06 , G01N33/84 , C07D417/06
Abstract: Disclosed herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced nucleic acid binding cyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.
Abstract translation: 本文公开了通过常规荧光显微镜，荧光光谱，流式细胞术和/或高含量成像检测活性氧（ROS）的化合物，组合物，方法和试剂盒。 本文公开的化合物是新的还原性核酸结合花青染料，其染料是用于检测ROS的探针，并测定体外和/或体内细胞中的氧化应激。 本文还描述了用于制备用于所公开的组合物，方法和试剂盒的新型还原染料即ROS探针的方法。
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公开(公告)号：US20180202936A1
公开(公告)日：2018-07-19
申请号：US15923262
申请日：2018-03-16
Applicant: Life Technologies Corporation
Inventor： Hee Chol Kang , Kyle Gee , Bhaskar Mandavilli , Lai-Qiang Ying , Bruce Branchaud
CPC classification number: G01N21/6486 , C09B23/06 , C09B23/08 , C09B23/083 , C09B57/00
Abstract: The present invention is directed to compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced dyes, including Cy-based hydrocyanine dyes and Cy-based deuterocyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.
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