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1.发明公开公开(公告)号：US20240245699A1
公开(公告)日：2024-07-25
申请号：US18591522
申请日：2024-02-29
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , A61K9/20 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14
CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14
摘要： Compounds of formula (I):
wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description.
Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.-
2.发明申请公开(公告)号：US20200253993A1
公开(公告)日：2020-08-13
申请号：US16757052
申请日：2018-10-24
发明人： Jérôme-Benoît STARCK , Didier DURAND , I-Jen CHEN , Arnaud LE TIRAN , Jean-Claude ORTUNO , Miklós NYERGES , Melinda LIGETI , Imre FEJES
IPC分类号： A61K31/675 , A61K45/06 , C07F9/6533 , C07D498/18 , C07D498/22 , A61K31/5377 , A61K31/4748 , A61P35/02
摘要： Compound of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, X, Y and G are as defined in the description, and their use in the manufacture of medicaments.
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3.发明申请公开(公告)号：US20210290631A1
公开(公告)日：2021-09-23
申请号：US17341751
申请日：2021-06-08
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , A61K45/06 , A61K31/4725 , A61K31/5377 , A61K9/20 , C07D401/14 , C07D405/14 , C07D401/10 , C07D471/04 , C07D491/10 , C07D498/04 , A61K31/496 , A61K31/506 , C07D491/107 , C07D498/14
摘要： wherein A1, A2, R3, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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4.发明申请公开(公告)号：US20200261464A1
公开(公告)日：2020-08-20
申请号：US16865855
申请日：2020-05-04
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , lmre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , C07D498/14 , C07D491/107 , A61K31/506 , A61K31/496 , C07D498/04 , C07D491/10 , C07D471/04 , C07D401/10 , C07D405/14 , C07D401/14 , A61K9/20 , A61K31/5377 , A61K31/4725 , A61K45/06
摘要： Compounds of formula (1): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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5.发明申请公开(公告)号：US20150031673A1
公开(公告)日：2015-01-29
申请号：US14336311
申请日：2014-07-21
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , Janos TATAI , Miklos NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： C07D491/107 , A61K31/4725 , A61K31/496 , C07D401/10 , A61K45/06 , C07D405/14 , A61K31/506 , C07D471/04 , C07D498/14 , A61K31/5383 , C07D401/14 , A61K31/5377
CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14 , A61K2300/00
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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公开(公告)号：US20230097678A1
公开(公告)日：2023-03-30
申请号：US17904514
申请日：2021-02-26
发明人： Csaba WÉBER , Klaus SEEDORF , Didier DURAND , Márió GYURIS , Árpád KISS , Zoltán MADARÁSZ , Mark MOLNÁR , Miklós NYERGES , Monika RUDASOVÁ , Attila SÁPI , Sylvie BERGER , Valérie DUVIVIER , Virginie MARTINY , Isabelle THERET , Cédric VINSON
IPC分类号： A61K31/547 , C07D515/18 , A61K9/20 , A61P1/16 , A61P3/10
摘要： A compound of formula (I): wherein Z, Y1, Y2, R1 to R7 are as defined in the description, its optical isomers, and addition salts thereof with a pharmaceutically acceptable base.
Medicaments.-
7.发明申请PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开吡咯化合物，其制备方法及含有它们的药物组合物公开(公告)号：US20150313907A1
公开(公告)日：2015-11-05
申请号：US14797532
申请日：2015-07-13
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , lmre FEJES , Janos TATAI , Miklos NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5377 , A61K31/4725 , A61K45/06
CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14 , A61K2300/00
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
摘要翻译： 式（I）化合物：其中A1，A2，Ra，Rb，Rc，Rd，R3，R4，R5和T如说明书中所定义。 含有该物质的药物可用于治疗涉及细胞凋亡缺陷的病症，如癌症，自身免疫疾病和免疫系统疾病。
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