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    METHOD AND SYSTEM FOR ANALYSING A BIOLOGICAL SAMPLE
    1.
    发明申请
    METHOD AND SYSTEM FOR ANALYSING A BIOLOGICAL SAMPLE 有权

    公开(公告)号：US20250012813A1

    公开(公告)日：2025-01-09

    申请号：US18762684

    申请日：2024-07-03

    Applicant: Leica Microsystems CMS GmbH

    Inventor： Soeren ALSHEIMER

    IPC: G01N33/68 ,  G01N21/64 ,  G01N33/543

    Abstract: A method for analysing a biological sample with at least one target analyte includes adding to the biological sample at least a first marker and a second marker. The first marker is configured to bind specifically to a first part of the at least one target analyte. The second marker is configured to bind specifically to a second part of the at least one target analyte. The method further includes determining a presence of the target analyte in the biological sample based on detecting the first marker and the second marker in the biological sample.

    MARKER, KIT AND METHOD FOR ANALYSING A BIOLOGICAL SAMPLE
    4.
    发明申请
    MARKER, KIT AND METHOD FOR ANALYSING A BIOLOGICAL SAMPLE 有权

    公开(公告)号：US20250075253A1

    公开(公告)日：2025-03-06

    申请号：US18823713

    申请日：2024-09-04

    Applicant: Leica Microsystems CMS GmbH

    Inventor： Soeren ALSHEIMER

    IPC: C12Q1/6823 ,  C12Q1/37 ,  C12Q1/44

    Abstract: A marker for analysing a biological sample includes an affinity reagent with a backbone and a barcode oligonucleotide attached to the backbone. The backbone is configured to specifically bind to a target analyte. The marker further includes a label comprising a label oligonucleotide and at least one labelling moiety. The label oligonucleotide and the barcode oligonucleotide of the affinity reagent are configured to hybridise to each other. One of the label oligonucleotide and the barcode oligonucleotide is sensitive to a degradation agent. The other one of the label oligonucleotide and the barcode oligonucleotide is resistant to the degradation agent.

    METHOD AND COMPACT MARKER FOR MARKING A BIOLOGICAL SAMPLE
    5.
    发明申请
    METHOD AND COMPACT MARKER FOR MARKING A BIOLOGICAL SAMPLE 有权

    公开(公告)号：US20240393341A1

    公开(公告)日：2024-11-28

    申请号：US18669554

    申请日：2024-05-21

    Applicant: Leica Microsystems CMS GmbH

    Inventor： Soeren ALSHEIMER ,  Yongsheng CHENG

    IPC: G01N33/58 ,  C12Q1/6841

    Abstract: A method for marking a biological sample includes providing a biological sample with at least one first target analyte, introducing into the biological sample at least one first nucleic acid backbone, at least one first label configured to attach to the first nucleic acid backbone, and at least one first affinity reagent specific to the first target analyte and configured to attach to the first nucleic acid backbone, and introducing into the biological sample a first plurality of staple strands. Each staple strand of the first plurality of staple strands is configured to hybridise to pairs of folding binding sites of the first nucleic acid backbone, in order to fold the first nucleic acid backbone and generate a compact optically detectable first marker in the biological sample.

    METHOD FOR ANALYZING A BIOLOGICAL SAMPLE OR A CHEMICAL COMPOUND OR A CHEMICAL ELEMENT
    6.
    发明公开
    METHOD FOR ANALYZING A BIOLOGICAL SAMPLE OR A CHEMICAL COMPOUND OR A CHEMICAL ELEMENT 审中-公开

    公开(公告)号：US20240255497A1

    公开(公告)日：2024-08-01

    申请号：US18561777

    申请日：2021-08-28

    Applicant: LEICA MICROSYSTEMS CMS GMBH

    Inventor： Soeren ALSHEIMER

    IPC: G01N33/542 ,  G01N33/53

    CPC classification number: G01N33/542 ,  G01N33/5302

    Abstract: A method for analyzing a sample is provided. The sample includes a plurality of affinity reagents, at least one of the affinity reagents being attached to an analyte, and a first plurality of combinations of dyes. Each combination of dyes includes at least two dyes having different characteristics for at least one of excitation or emission. Each one of the unique combinations of dyes is attached to an associated affinity reagent of the plurality of affinity reagents according to a first mapping. The method includes directing excitation light at the sample, the excitation light having characteristics for exciting at least one of the at least two dyes having different characteristics, generating at least one first readout from emission light emitted by the excited dyes, and determining, by at least one computer processor, at least one affinity reagent present in the sample based on the at least one first readout.

    METHOD FOR ANALYSING A BIOLOGICAL SAMPLE
    9.
    发明申请
    METHOD FOR ANALYSING A BIOLOGICAL SAMPLE 有权

    公开(公告)号：US20240409982A1

    公开(公告)日：2024-12-12

    申请号：US18733881

    申请日：2024-06-05

    Applicant: Leica Microsystems CMS GmbH

    Inventor： Soeren ALSHEIMER

    IPC: C12Q1/6823 ,  C12N15/115 ,  G01N21/64 ,  G01N33/68

    Abstract: A method for analysing a biological sample includes providing a biological sample with a plurality of target analytes, and introducing a first marker into the biological sample. The first marker includes a first affinity reagent and a first optically detectable label bound to the first affinity reagent. The first affinity reagent is configured to specifically bind to one of the target analytes. The method further includes generating a first optical readout of the biological sample with the first marker, applying the degradation agent to degrade the first affinity reagent, and introducing a second marker into the biological sample. The second marker includes a second affinity reagent and a second optically detectable label bound to the second affinity reagent. The second affinity reagent is configured to specifically bind to one of the target analytes. The method further includes generating a second optical readout of the biological sample with the second marker.

    IMAGING SYSTEM AND METHOD
    10.
    发明申请
    IMAGING SYSTEM AND METHOD 有权

    公开(公告)号：US20240402475A1

    公开(公告)日：2024-12-05

    申请号：US18698024

    申请日：2022-09-30

    Applicant: LEICA MICROSYSTEMS CMS GMBH

    Inventor： Soeren ALSHEIMER ,  Joachim BRADL

    IPC: G02B21/00 ,  G01N15/1434 ,  G02B21/26

    Abstract: An imaging system for imaging a sample includes a sample moving unit configured to move the sample in a sample space along a movement direction. The imaging system further includes at least one detection optic including an optical axis enclosing a first angle with the movement direction within a range of 20° to 70°, the optical axis of the at least one detection optic and the movement direction defining a first plane; and at least one illumination optic including an optical axis that encloses a second angle with the movement direction within a range of 70° to 110°, and that encloses a third angle with the optical axis of the at least one detection optic within a range of 70° to 110°, the optical axis of the at least one illumination optic and the movement direction defining a second plane, the first and second planes intersecting and being different.

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