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    Microchip unit, and method of conducting biochemical reaction using the microchip unit
    2.
    发明申请
    Microchip unit, and method of conducting biochemical reaction using the microchip unit 审中-公开
    Microchip单元和使用微芯片单元进行生化反应的方法

    公开(公告)号：US20060078931A1

    公开(公告)日：2006-04-13

    申请号：US11245348

    申请日：2005-10-06

    申请人： Kwang-wook Oh ,  Yu-jin Seo ,  Gyeong-sik Ok ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    发明人： Kwang-wook Oh ,  Yu-jin Seo ,  Gyeong-sik Ok ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： B01L3/502715 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2400/065

    摘要： Provided is a microchip unit, including a microchip on which a plurality of micro-channels are formed, a housing disposed below the microchip to fix the microchip; and at least two injecting and sealing elements having through-holes corresponding to inlets of the microchip. The injecting and sealing elements are vertically fixed on the top of the housing and slide in a horizontal direction from a first location to a second location and vice versa. The through-holes are aligned with inlets of the microchip so that a reaction solution can be injected through the through-holes when the injecting and sealing elements are placed at the first location. The inlets of the microchip are sealed by elastic members formed on bottom surfaces of the injecting and sealing elements when the injecting and sealing elements are placed at the second location.

    摘要翻译： 提供一种微芯片单元，其包括形成有多个微通道的微芯片，设置在微芯片下面以固定微芯片的壳体; 以及至少两个具有对应于微芯片的入口的通孔的注入和密封元件。 注射和密封元件垂直地固定在壳体的顶部上，并且在从第一位置到第二位置的水平方向上滑动，反之亦然。 通孔与微芯片的入口对准，使得当注射和密封元件放置在第一位置时，反应溶液可以通过通孔注入。 当注射和密封元件放置在第二位置时，微芯片的入口由形成在注射和密封元件的底表面上的弹性构件密封。

    Real-time PCR monitoring apparatus and method
    3.
    发明授权
    Real-time PCR monitoring apparatus and method 有权
    实时PCR监测装置及方法

    公开(公告)号：US07767439B2

    公开(公告)日：2010-08-03

    申请号：US10890350

    申请日：2004-07-13

    申请人： Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    发明人： Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    IPC分类号： C12M1/34 ,  C12M3/00 ,  C12Q1/68 ,  G01N21/25

    CPC分类号： G01N21/645 ,  B01L3/50851 ,  B01L7/52 ,  B01L2300/0627 ,  B01L2300/18 ,  G01N21/0332

    摘要： A real time polymerase chain reaction (“PCR”) monitoring apparatus includes, a microchip-type PCR tube that has a PCR solution-containing PCR chamber, a micro-heater, a detection unit detecting a PCR product signal based on the PCR solution, a plurality of modules, each of which includes the abovementioned elements in addition to a cooling fan and a control unit controlling the micro-heater and the cooling fan to adjust the temperature of the PCR chamber, a base instrument that comprises a power supply unit connected to the modules and a data communication unit connected to the control unit of each of the modules, and a display unit displaying data from the data communication unit, wherein the control unit of each of the modules independently controls at least one of both the detection unit and the temperature of the PCR chamber of the PCR tube in each of the modules.

    摘要翻译： 实时聚合酶链式反应（“PCR”）监测装置包括：具有含PCR溶液的PCR室的微芯片型PCR管，微加热器，基于PCR溶液检测PCR产物信号的检测单元， 多个模块，每个模块除了冷却风扇之外还包括上述元件，以及控制单元，其控制微加热器和冷却风扇来调节PCR室的温度;基础仪器，包括连接的电源单元 连接到每个模块的控制单元的数据通信单元和从数据通信单元显示数据的显示单元，其中每个模块的控制单元独立地控制检测单元中的至少一个 以及每个模块中PCR管的PCR室的温度。

    Polymerase chain reaction module, and multiple polymerase chain reaction system including the module
    4.
    发明授权
    Polymerase chain reaction module, and multiple polymerase chain reaction system including the module 有权
    聚合酶链反应模块，以及多个聚合酶链反应系统，包括该模块

    公开(公告)号：US07754452B2

    公开(公告)日：2010-07-13

    申请号：US11377793

    申请日：2006-03-16

    申请人： Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chin-sung Park ,  Yu-jin Seo

    发明人： Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chin-sung Park ,  Yu-jin Seo

    IPC分类号： C12P19/34 ,  C12M1/36 ,  G01N15/06

    CPC分类号： B01L7/52 ,  B01L3/5027 ,  B01L9/52 ,  B01L2300/0822 ,  B01L2300/1827 ,  B01L2300/1844 ,  C12Q1/686

    摘要： Provided are a polymerase chain reaction (PCR) module and a PCR system including the same. The PCR module includes: a detachable PCR chip including a PCR chamber unit in which a PCR solution is accommodated; a heater unit for heating the PCR solution in the PCR chip with a preset temperature; a detecting unit for detecting a PCR signal of the PCR solution; a PCR chip installation unit for mounting/detaching the PCR chip using a one-touch method, in which the heater unit is adhered to the PCR chip with a predetermined pressure when mounting the PCR chip and the heater unit is separated from the PCR chip when detaching the PCR chip; and a housing covering at least the heater unit and the detecting unit so that they are not exposed to the outside.

    摘要翻译： 提供了聚合酶链反应（PCR）模块和包括其的PCR系统。 所述PCR模块包括：可拆卸PCR芯片，其包括其中容纳PCR溶液的PCR室单元; 用于以预设温度加热PCR芯片中的PCR溶液的加热器单元; 用于检测PCR溶液的PCR信号的检测单元; 用于使用一触式方法安装/分离PCR芯片的PCR芯片安装单元，其中当将PCR芯片和加热器单元安装在PCR芯片上时，将加热器单元以预定的压力粘附到PCR芯片上，与PCR芯片分离， 分离PCR芯片; 以及至少覆盖加热器单元和检测单元的壳体，使得它们不暴露于外部。

    Real-time PCR monitoring apparatus and method
    8.
    发明申请
    Real-time PCR monitoring apparatus and method 有权
    实时PCR监测装置及方法

    公开(公告)号：US20050130183A1

    公开(公告)日：2005-06-16

    申请号：US10890350

    申请日：2004-07-13

    申请人： Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    发明人： Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    IPC分类号： C12Q1/68 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  G01N21/03 ,  G01N21/64 ,  C12M1/34

    CPC分类号： G01N21/645 ,  B01L3/50851 ,  B01L7/52 ,  B01L2300/0627 ,  B01L2300/18 ,  G01N21/0332

    摘要： Provided are a real-time PCR monitoring apparatus and method. The real-time PCR monitoring apparatus includes a microchip-type PCR tube that has a PCR solution-containing PCR chamber, a micro-heater that applies heat to the PCR chamber of the PCR tube, a detection unit that detects a PCR product signal based on the amount of a PCR product of the PCR solution, a plurality of modules, each of which includes a cooling fan for lowering the inside air temperature and a control unit for adjusting the temperature of the PCR chamber of the PCR tube by controlling the micro-heater and the cooling fan, and receives the PCR tube, the micro-heater, and the detection unit, a base instrument that includes a power supply unit electrically connected to the modules for power supply and a data communication unit electrically connected to the modules for data communication with the control unit of each of the modules, and a display unit that displays data received from the data communication unit, wherein the control unit of each of the modules independently controls at least one of both the detection unit and the temperature of the PCR chamber of the PCR tube received in each of the modules. Therefore, co-amplification of different samples at different temperature conditions can be carried out and monitored in real time.

    摘要翻译： 提供了一种实时PCR监测装置和方法。 实时PCR监视装置包括具有含PCR溶液的PCR室的微芯片型PCR管，向PCR管的PCR室照射热的微加热器，检测基于PCR产物信号的检测单元 关于PCR溶液的PCR产物的量，多个模块，每个模块包括用于降低内部空气温度的冷却风扇和用于通过控制微管来调节PCR管的PCR室的温度的控制单元 加热器和冷却风扇，并且接收PCR管，微加热器和检测单元，基本仪器包括电连接到用于电源的模块的电源单元和与模块电连接的数据通信单元 用于与每个模块的控制单元的数据通信，以及显示单元，显示从数据通信单元接收的数据，其中每个模块的控制单元独立地控制 在每个模块中接收PCR管的PCR室的检测单元和温度中的至少一个。 因此，不同温度条件下不同样品的共扩增可以进行实时监测。

    Fluid mixing device using cross channels
    9.
    发明授权
    Fluid mixing device using cross channels 有权
    流体混合装置使用交叉通道

    公开(公告)号：US07736050B2

    公开(公告)日：2010-06-15

    申请号：US11433594

    申请日：2006-05-12

    申请人： Chin-sung Park ,  Joon-ho Kim ,  Kak Namkoong ,  Kwang-wook Oh

    发明人： Chin-sung Park ,  Joon-ho Kim ,  Kak Namkoong ,  Kwang-wook Oh

    IPC分类号： B01F5/00

    CPC分类号： B01F13/1013 ,  B01F5/0475 ,  B01F5/0478 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01F13/1019 ,  B01F15/0203 ,  B01F15/0404 ,  B01F2015/0221 ,  G01N1/38

    摘要： Provided is a fluid mixing device which produces a series of solutions with a concentration gradient. The fluid mixing device includes: a plurality of first channels disposed parallel to each other on a layer, and into which an equal amount of diluent flows from its upstream; a plurality of second channels formed perpendicular to the first channels on an adjacent layer to the layer on which the first channels are formed, and into which an equal amount of sample solution flows from its upstream; and via holes formed at at least one intersection between each of the first channel and a plurality of second channels so that a predetermined amount of sample solution flows from the second channels into corresponding first channels, wherein a series of solutions with different concentrations is produced in the first channels depending on the amount of sample solution that flows into the first channels through the via holes. Thus, a series of solutions with different concentrations is output from the first channels.

    摘要翻译： 提供了一种流体混合装置，其产生具有浓度梯度的一系列溶液。 流体混合装置包括：在层上彼此平行设置的多个第一通道，等量的稀释剂从其上游流入其中; 多个第二通道，其垂直于与形成有第一通道的层相邻的第一通道形成，并且等量的样品溶液从其上游流入其中; 以及形成在每个第一通道和多个第二通道之间的至少一个相交处的通孔，使得预定量的样品溶液从第二通道流入相应的第一通道，其中一系列具有不同浓度的溶液在 第一通道取决于通过通孔流入第一通道的样品溶液的量。 因此，从第一通道输出一系列具有不同浓度的溶液。

    Fluid mixing device using cross channels
    10.
    发明申请
    Fluid mixing device using cross channels 有权
    流体混合装置使用交叉通道

    公开(公告)号：US20060262642A1

    公开(公告)日：2006-11-23

    申请号：US11433594

    申请日：2006-05-12

    申请人： Chin-sung Park ,  Joon-ho Kim ,  Kak Namkoong ,  Kwang-wook Oh

    发明人： Chin-sung Park ,  Joon-ho Kim ,  Kak Namkoong ,  Kwang-wook Oh

    IPC分类号： B01F5/06

    CPC分类号： B01F13/1013 ,  B01F5/0475 ,  B01F5/0478 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01F13/1019 ,  B01F15/0203 ,  B01F15/0404 ,  B01F2015/0221 ,  G01N1/38

    摘要： Provided is a fluid mixing device which produces a series of solutions with a concentration gradient. The fluid mixing device includes: a plurality of first channels disposed parallel to each other on a layer, and into which an equal amount of diluent flows from its upstream; a plurality of second channels formed perpendicular to the first channels on an adjacent layer to the layer on which the first channels are formed, and into which an equal amount of sample solution flows from its upstream; and via holes formed at at least one intersection between each of the first channel and a plurality of second channels so that a predetermined amount of sample solution flows from the second channels into corresponding first channels, wherein a series of solutions with different concentrations is produced in the first channels depending on the amount of sample solution that flows into the first channels through the via holes. Thus, a series of solutions with different concentrations is output from the first channels.

    摘要翻译： 提供了一种流体混合装置，其产生具有浓度梯度的一系列溶液。 流体混合装置包括：在层上彼此平行设置的多个第一通道，等量的稀释剂从其上游流入其中; 多个第二通道，其垂直于与形成有第一通道的层相邻的第一通道形成，并且等量的样品溶液从其上游流入其中; 以及形成在每个第一通道和多个第二通道之间的至少一个相交处的通孔，使得预定量的样品溶液从第二通道流入相应的第一通道，其中一系列具有不同浓度的溶液在 第一通道取决于通过通孔流入第一通道的样品溶液的量。 因此，从第一通道输出一系列具有不同浓度的溶液。