公开(公告)号：US5935147A

公开(公告)日：1999-08-10

申请号：US992041

申请日：1997-12-17

Applicant: Kenneth Kensey ,  John Nash ,  Douglas Evans

Inventor： Kenneth Kensey ,  John Nash ,  Douglas Evans

IPC: A61B17/12 ,  A61B17/00 ,  A61B17/03 ,  A61B17/04 ,  A61B19/00 ,  A61F2/06 ,  A61M25/00 ,  A61M37/00 ,  F16G11/04 ,  F16G11/10 ,  A61B17/08

CPC classification number: A61B17/0057 ,  F16G11/108 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00672 ,  A61B2017/00898 ,  A61B2017/0496 ,  A61B2090/032 ,  A61B2090/0811 ,  A61B90/03 ,  A61B90/39 ,  Y10S604/90

Abstract: A system, a closure, and method of use for sealing a percutaneous puncture in a blood vessel. The puncture includes an opening in the vessel wall and a tract leading to the opening. The system includes an introducer sheath and associated positioning device, a hemostatic puncture closure, and a deployment instrument. The positioning device enables the introducer sheath to be positioned at a desired position within the vessel. The deployment instrument includes a tubular carrier storing the closure. The closure comprises a rigid, e.g., radio-opaque, anchor, a compressed collagen plug, and a thin filament connecting the two in a pulley-like arrangement. The instrument and introducer are used to introduce the closure into the puncture, with the anchor located within the artery and with the collagen plug within the puncture tract. A locking member is provided to hold the closure in place at its operative position, whereupon hemostasis occurs rapidly, thereby sealling the puncture.

Abstract translation: 用于密封血管中的经皮穿刺的系统，闭合件和方法。 穿刺包括血管壁中的开口和通向开口的通道。 该系统包括引导器护套和相关联的定位装置，止血穿刺闭合器和展开装置。 定位装置使引导器护套能够定位在容器内的期望位置。 展开仪器包括一个储存封闭件的管状载体。 封闭件包括刚性例如不透射线的锚，压缩的胶原塞，以及以滑轮状布置连接两者的细丝。 仪器和导引器用于将闭合件引入穿刺中，锚固件位于动脉内并且胶原栓塞在穿刺道内。 提供锁定构件以在其操作位置处将闭合件保持在适当位置，从而快速发生止血，从而刺穿穿刺。

公开(公告)号：US06179863B2

公开(公告)日：2001-01-30

申请号：US09294154

申请日：1999-04-19

Applicant: Kenneth Kensey ,  John Nash ,  Douglas Evans

Inventor： Kenneth Kensey ,  John Nash ,  Douglas Evans

IPC: A61B1708

CPC classification number: A61B17/0057 ,  A61B90/03 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00672 ,  A61B2017/00898 ,  A61B2017/0496 ,  A61B2090/032 ,  A61B2090/0811 ,  F16G11/108 ,  Y10S604/90

Abstract: A system, a closure, and method of use for sealing a percutaneous puncture in a blood vessel. The puncture includes an opening in the vessel wall and a tract leading to the opening. The system includes an introducer sheath and associated positioning device, a hemostatic puncture closure, and a deployment instrument. The positioning device enables the introducer sheath to be positioned at a desired position within the vessel. The deployment instrument includes a tubular carrier storing the closure. The closure comprises a rigid, e.g., radio-opaque, anchor, a compressed collagen plug, and a thin filament connecting the two in a pulley-like arrangement. The instrument and introducer are used to introduce the closure into the puncture, with the anchor located within the artery and with the collagen plug within the puncture tract. A locking member is provided to hold the closure in place at its operative position, whereupon hemostasis occurs rapidly, thereby sealing the puncture.

公开(公告)号：US5676689A

公开(公告)日：1997-10-14

申请号：US608428

申请日：1996-02-28

Applicant: Kenneth Kensey ,  John Nash ,  Douglas Evans

Inventor： Kenneth Kensey ,  John Nash ,  Douglas Evans

IPC: A61B17/00 ,  A61B17/04 ,  A61B17/12 ,  A61B19/00 ,  F16G11/04 ,  F16G11/10

CPC classification number: A61B17/0057 ,  F16G11/108 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00672 ,  A61B2017/0496 ,  A61B2090/032 ,  A61B2090/0811 ,  A61B90/03 ,  A61B90/39 ,  Y10S604/90

Abstract: A system for sealing a percutaneous puncture in a blood vessel in a living being and method of use thereof. The system includes a hemostatic closure, a blood vessel locator device for determining the position of the blood vessel via the percutaneous puncture, and a deployment instrument for deploying the closure within the puncture to seal the puncture. The vessel locator includes means for enabling blood from the vessel to flow therethrough so that the position of the vessel can be rapidly determined. Once the vessel has been located the deployment instrument, which includes a tubular carrier storing the closure, is extend into the puncture to deploy the closure. The closure basically comprises a radiopaque rigid anchor for location within the blood vessel, a compressed collagen plug for location within the puncture tract leading to the vessel, and a thin filament connecting the two in a pulley-like arrangement. The deployment instrument also includes a tamper which is used to mechanically deform the plug within the tract. Once the closure is positioned hemostasis occurs rapidly, thereby locking the closure in place.

Abstract translation: 一种用于密封生物体内的血管中的经皮穿刺的系统及其使用方法。 该系统包括止血闭合件，用于通过经皮穿刺确定血管位置的血管定位装置，以及用于在穿刺部内展开封闭物以密封穿刺的展开装置。 容器定位器包括用于使来自血管的血液流过其中的装置，使得能够快速确定容器的位置。 一旦容器已经定位，包括容纳封闭件的管状载体的展开器械延伸到穿刺部分中以展开闭合件。 闭合件基本上包括用于定位在血管内的不透射线的刚性锚固件，用于定位在穿过血管的穿刺道内的压缩胶原塞，以及以滑轮状布置连接两者的细丝。 部署仪器还包括用于将管塞内的插头机械地变形的篡改。 一旦闭合物被定位，止血就快速发生，从而将闭合件锁定就位。

公开(公告)号：US5222974A

公开(公告)日：1993-06-29

申请号：US789704

申请日：1991-11-08

Applicant: Kenneth Kensey ,  John Nash ,  Douglas Evans

Inventor： Kenneth Kensey ,  John Nash ,  Douglas Evans

IPC: A61B17/00 ,  A61B17/04 ,  A61B17/12 ,  A61B19/00 ,  F16G11/04 ,  F16G11/10

CPC classification number: A61B17/0057 ,  F16G11/108 ,  A61B2017/00004 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00898 ,  A61B2017/0496 ,  A61B2090/032 ,  A61B2090/0811 ,  A61B90/03 ,  A61B90/39

Abstract: A system, a closure, and method of sealing a percutaneous puncture in an artery. The system includes a conventional introducer sheath, a hemostatic puncture closure, and an instrument for deploying the closure. The instrument includes a tubular carrier storing the closure. The carrier has a distally located free end to be extended through the puncture and its associated tract. The closure comprises a rigid anchor, a compressed collagen plug, and a thin filament connect the two in a pulley-like arrangement. The carrier is operated to eject the plug through the puncture and to then draw it against the free end of the introducer. The instrument and introducer are then withdrawn together to pull the anchor against the tissue contiguous with the puncture on the inside of the artery. Further withdrawing of the introducer and the instrument draws the plug out of the carrier into the puncture tract, whereupon it moves with respect to the anchor and into engagement with the outside of artery wall contiguous with the puncture to seal the puncture. The carrier also includes a tamper which is used to mechanically deform the plug within the tract. Once positioned the hemostasis occurs rapidly, thereby locking the closure device in place.

Abstract translation: 一种在动脉中密封经皮穿刺的系统，闭合件和方法。 该系统包括常规的引导器护套，止血穿刺闭合件和用于展开封闭件的器械。 仪器包括一个储存封闭件的管状载体。 载体具有远端定位的自由端，以延伸通过穿刺及其相关联的管道。 封闭件包括刚性锚固件，压缩胶原塞和细丝，以滑轮状布置连接两者。 操作载体以通过穿刺将插塞推出，然后将其拉到引导器的自由端。 然后将仪器和引导器一起拉出以将锚固件靠在与动脉内侧上的穿刺邻接的组织上。 进一步取出导引器和仪器将插塞从载体中抽出到穿刺管中，于是其相对于锚移动并与与穿刺相邻的动脉壁的外侧接合以密封穿刺。 载体还包括用于使塞子在管道内机械变形的篡改。 一旦定位，止血快速发生，从而将闭合装置锁定就位。

公开(公告)号：US5707393A

公开(公告)日：1998-01-13

申请号：US604205

申请日：1996-02-21

Applicant: Kenneth Kensey ,  John Nash ,  Douglas Evans

Inventor： Kenneth Kensey ,  John Nash ,  Douglas Evans

IPC: A61B17/12 ,  A61B17/00 ,  A61B17/03 ,  A61B17/04 ,  A61B19/00 ,  A61F2/06 ,  A61M25/00 ,  A61M37/00 ,  F16G11/04 ,  F16G11/10

CPC classification number: A61B17/0057 ,  F16G11/108 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00672 ,  A61B2017/00898 ,  A61B2017/0496 ,  A61B2090/032 ,  A61B2090/0811 ,  A61B90/03 ,  A61B90/39 ,  Y10S604/90

Abstract: A system, a closure, and method of use for sealing a percutaneous puncture in a blood vessel. The puncture includes an opening in the vessel wall and a tract leading to the opening. The system includes an introducer sheath and associated positioning device, a hemostatic puncture closure, and a deployment instrument. The positioning device enables the introducer sheath to be positioned at a desired position within the vessel. The deployment instrument includes a tubular carrier holding the closure. The closure comprises a rigid, e.g., radio-opaque, anchor, a compressed collagen plug, and a thin filament connecting the two in a-pulley-like arrangement. The instrument and introducer are used to introduce the closure into the puncture, with the anchor located within the artery and with the collagen plug within the puncture tract. A locking member is provided to hold the closure in place at its operative position, whereupon hemostasis occurs rapidly, thereby sealing the puncture.

Abstract translation: 用于密封血管中的经皮穿刺的系统，闭合件和方法。 穿刺包括血管壁中的开口和通向开口的通道。 该系统包括引导器护套和相关联的定位装置，止血穿刺闭合器和展开装置。 定位装置使引导器护套能够定位在容器内的期望位置。 展开装置包括保持封闭件的管状载体。 封闭件包括刚性例如不透射线的锚，压缩的胶原塞和连接两个以滑轮状排列的细丝。 仪器和导引器用于将闭合件引入穿刺中，锚固件位于动脉内并且胶原栓塞在穿刺道内。 提供锁定构件以将闭合件保持在其操作位置的适当位置，从而快速发生止血，从而密封穿刺。

公开(公告)号：US5021059A

公开(公告)日：1991-06-04

申请号：US519622

申请日：1990-05-07

Applicant: Kenneth Kensey ,  John Nash ,  Douglas Evans

Inventor： Kenneth Kensey ,  John Nash ,  Douglas Evans

IPC: A61B17/04 ,  A61B17/00 ,  A61B17/12 ,  A61B19/00

CPC classification number: A61B17/0057 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B90/03

Abstract: An instrument, a closure, and method of use for sealing an opening, e.g., a percutaneous incision or puncture, in a living being. The instrument includes a tubular carrier storing the closure. The carrier has a distally located free end to be extended through the opening. The closure comprises an anchoring portion, a sealing portion and a thin filament connected therebetween. The instrument is operated to eject the anchoring portion of the closure through the incision or puncture and to then draw that portion against the free end of the carrier. The instrument is then withdrawn to pull the anchoring portion of the closure against the tissue contiguous with the incision or puncture. Further withdrawing of the instrument draws the sealing portion of the closure out of the carrier, whereupon it moves with respect to the anchoring portion and into engagement with the tissue contiguous with the opening on the opposite side of the anchoring portion to seal it. Signals are produced to indicate proper operation.

Abstract translation: 用于在生活中密封开口（例如经皮切口或穿刺）的仪器，封闭件和方法。 仪器包括一个储存封闭件的管状载体。 载体具有远离位置的自由端，以延伸穿过开口。 封闭件包括锚固部分，密封部分和连接在它们之间的细丝。 该仪器被操作以通过切口或穿刺来弹出封闭件的锚定部分，然后将该部分拉离载体的自由端。 然后取出器械以将闭合件的锚定部分拉向与切口或穿刺相邻的组织。 仪器的进一步退回将盖子的密封部分拉出载体，于是它相对于锚定部分移动并与与锚定部分的相对侧上的开口相邻的组织接合以将其密封。 产生信号以指示正确的操作。

公开(公告)号：US5545178A

公开(公告)日：1996-08-13

申请号：US327262

申请日：1994-10-21

Applicant: Kenneth Kensey ,  John E. Nash ,  Douglas Evans

Inventor： Kenneth Kensey ,  John E. Nash ,  Douglas Evans

IPC: A61B17/00 ,  A61B17/04 ,  A61B17/06 ,  A61B17/12 ,  A61B19/00 ,  A61F2/00

CPC classification number: A61B17/0057 ,  A61B17/0401 ,  A61B17/00234 ,  A61B17/06 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00663 ,  A61B2017/00898 ,  A61B2017/0406 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B90/39 ,  A61F2/0063 ,  A61F2/0077

Abstract: A system and method for sealing a percutaneous puncture extending into internally located tissue, e.g., the peritoneum, of a living being. The system includes a sealing device and a deployment instrument. In one embodiment the sealing device comprises a substantially rigid anchor, a resorbable holding member, a collagen plug, and a resorbable thin filament connecting the anchor, holding member, and plug. The anchor or the plug or both may be formed of a resorbable material having a non-resorbable mesh reinforcement embedded therein. The deployment instrument is operated to place the anchor in the interior of the peritoneum and the plug and the holding member in the puncture tract, with both ends of the filament extending out of the puncture. The extending ends of the filament are formed into a knot, a portion of which extends through the skin contiguous with the puncture, to lock the closure in place. The reinforced mesh of the closure reinforces any scar tissue which forms at the opening. In an alternative embodiment the sealing device comprises only the anchoring member and the filament.

Abstract translation: 用于密封延伸到生物体的内部定位的组织例如腹膜的经皮穿刺的系统和方法。 该系统包括密封装置和展开装置。 在一个实施例中，密封装置包括基本上刚性的锚固件，可再吸收保持构件，胶原塞和连接锚固件，保持构件和塞子的可再吸收的细丝。 锚或插塞或两者可以由其中嵌有不可吸收的网状增强物的可再吸收材料形成。 操作部署仪器将锚固体放置在腹膜内部，将栓塞和保持构件放置在穿刺管中，使丝的两端延伸穿刺。 长丝的延伸端形成结，其一部分延伸穿过与穿刺连续的皮肤，以将封闭物锁定就位。 封口的加强网加强了在开口处形成的任何疤痕组织。 在替代实施例中，密封装置仅包括锚定构件和细丝。

公开(公告)号：US5531759A

公开(公告)日：1996-07-02

申请号：US235825

申请日：1994-04-29

Applicant: Kenneth Kensey ,  John E. Nash ,  Douglas Evans

Inventor： Kenneth Kensey ,  John E. Nash ,  Douglas Evans

IPC: A61B17/00 ,  A61B17/04 ,  A61B17/06 ,  A61B19/00 ,  A61F2/00

CPC classification number: A61B17/0401 ,  A61B17/0057 ,  A61B17/00234 ,  A61B17/06 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00898 ,  A61B2017/0406 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B90/39 ,  A61F2/0063 ,  A61F2/0077

Abstract: A system and method for sealing a percutaneous puncture extending into internally located tissue, e.g., the peritoneum, of a living being. The system includes a reinforcing device and a deployment instrument. The device comprises a substantially rigid anchor, a resorbable holding member, a collagen plug, and a resorbable thin filament connecting the anchor, holding member, and plug in a pulley-like arrangement. The anchor or the plug or both may be formed of a resorbable material having a non-resorbable mesh reinforcement embedded therein. The deployment instrument includes a tubular carrier in which the closure and a tamping member are located. The tamping member is operated to expel the closure so that the anchor is in the interior of the peritoneum and the plug and the holding member are in the puncture tract, with both ends of the filament extending out of the puncture and with the holding member fixedly secured to a portion of the filament adjacent one end. The other end of the filament is then drawn proximally while the tamping is pushed distally to draw the anchor member against the tissue contiguous with the opening. The tamper mechanically deforms the plug within the tract. The extending ends of the filament are formed into a knot, a portion of which extends through the skin contiguous with the puncture, to lock the closure in place. The reinforced mesh of the closure reinforces any scar tissue which forms at the opening.

Abstract translation: 用于密封延伸到生物体的内部定位的组织例如腹膜的经皮穿刺的系统和方法。 该系统包括加强装置和展开装置。 该装置包括基本上刚性的锚固件，可再吸收保持构件，胶原塞和可再吸收的细丝，其将锚固件，保持构件和塞子以滑轮状布置连接。 锚或插塞或两者可以由其中嵌有不可吸收的网状增强物的可再吸收材料形成。 展开仪器包括管状载体，封闭件和捣固构件位于其中。 捣固构件被操作以排出封闭物，使得锚固体位于腹膜内部，并且塞子和保持构件位于穿刺管道中，丝的两端延伸出穿刺部分并且保持构件固定 紧固在一端的细丝的一部分。 然后将丝线的另一端向近侧拉伸，同时向后推动夯实以将锚固构件拉向抵靠与开口相邻的组织。 篡改将机头上的插头机械地变形。 长丝的延伸端形成结，其一部分延伸穿过与穿刺连续的皮肤，以将封闭物锁定就位。 封口的加强网加强了在开口处形成的任何疤痕组织。

公开(公告)号：US5441517A

公开(公告)日：1995-08-15

申请号：US154882

申请日：1993-11-18

Applicant: Kenneth Kensey ,  John E. Nash ,  Douglas Evans

Inventor： Kenneth Kensey ,  John E. Nash ,  Douglas Evans

IPC: A61B17/12 ,  A61B17/00 ,  A61B17/03 ,  A61B17/04 ,  A61B19/00 ,  A61F2/06 ,  A61M25/00 ,  A61M37/00 ,  F16G11/04 ,  F16G11/10

CPC classification number: A61B17/0057 ,  F16G11/108 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00672 ,  A61B2017/00898 ,  A61B2017/0496 ,  A61B2090/032 ,  A61B2090/0811 ,  A61B90/03 ,  A61B90/39 ,  Y10S604/90

Abstract: A system, a closure, and method of use for determining the position of a blood vessel via a percutaneous puncture and for sealing the percutaneous puncture in the blood vessel. The system includes an introducer sheath and associated positioning device, a hemostatic puncture closure, and a deployment instrument. The positioning device enables the introducer sheath to be positioned at a desired position within the vessel. The deployment instrument includes a tubular carrier storing the closure. The carrier has a distally located free end to be extended via an introducer through the puncture and its associated tract. The closure comprises a radiopaque rigid anchor, a compressed collagen plug, and a thin filament connecting the two in a pulley-like arrangement. The carrier ejects the anchor through the introducer and puncture and then draws it against the free end of the introducer. The instrument and introducer are then withdrawn together to pull the anchor against the tissue contiguous with the puncture inside the artery. Further withdrawl draws the plug out of the carrier into the puncture tract, whereupon the plug moves with respect to the anchor into engagement with the outside of artery wall to seal the puncture or incision. A tensioning device limits the force applied to the filament. The carrier also includes a tamper which is used to mechanically deform the plug within the tract. Once positioned hemostasis occurs rapidly, thereby locking the closure in place.

Abstract translation: 一种用于通过经皮穿刺确定血管位置并用于密封血管中经皮穿刺的系统，闭合件和方法。 该系统包括引导器护套和相关联的定位装置，止血穿刺闭合器和展开装置。 定位装置使引导器护套能够定位在容器内的期望位置。 展开仪器包括一个储存封闭件的管状载体。 载体具有远端定位的自由端，通过穿刺器穿过穿刺器及其相关的管道延伸。 闭合件包括不透射线的刚性锚固件，压缩的胶原塞，以及以滑轮状布置连接两者的细丝。 托架通过导引器弹出锚固件并穿刺，然后将其拉到导引器的自由端。 然后将仪器和引导器一起拉出以将锚固件靠在与动脉内的穿刺相邻的组织上。 进一步撤出将塞子从载体中抽出到穿刺管中，于是塞子相对于锚移动，与动脉壁的外侧接合以密封穿刺或切口。 张紧装置限制施加到细丝上的力。 载体还包括用于使塞子在管道内机械变形的篡改。 一旦定位，止血快速发生，从而将闭合件锁定就位。

公开(公告)号：US5282827A

公开(公告)日：1994-02-01

申请号：US846322

申请日：1992-03-05

Applicant: Kenneth Kensey ,  John E. Nash ,  Douglas Evans

Inventor： Kenneth Kensey ,  John E. Nash ,  Douglas Evans

IPC: A61B17/12 ,  A61B17/00 ,  A61B17/03 ,  A61B17/04 ,  A61B19/00 ,  A61F2/06 ,  A61M25/00 ,  A61M37/00 ,  F16G11/04 ,  F16G11/10

CPC classification number: A61B17/0057 ,  F16G11/108 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00672 ,  A61B2017/00898 ,  A61B2017/0496 ,  A61B2090/032 ,  A61B2090/0811 ,  A61B90/03 ,  A61B90/39 ,  Y10S604/90

Abstract: A system, a closure, and method of use for determining the position of a blood vessel via a percutaneous puncture and for sealing the percutaneous puncture in the blood vessel. The system includes an introducer sheath and associated positioning device, a hemostatic puncture closure, and a deployment instrument. The positioning device enables the introducer sheath to be positioned at a desired position within the vessel. The deployment instrument includes a tubular carrier storing the closure. The carrier has a distally located free end to be extended via an introducer through the puncture and its associated tract. The closure comprises a radiopaque rigid anchor, a compressed collagen plug, and a thin filament connecting the two in a pulley-like arrangement. The carrier ejects the anchor through the introducer and puncture and then draws it against the free end of the introducer. The instrument and introducer are then withdrawn together to pull the anchor against the tissue contiguous with the puncture inside the artery. Further withdrawl draws the plug out of the carrier into the puncture tract, whereupon the plug moves with respect to the anchor into engagement with the outside of artery wall to seal the puncture or incision. A tensioning device limits the force applied to the filament. The carrier also includes a tamper which is used to mechanically deform the plug within the tract. Once positioned hemostasis occurs rapidly, thereby locking the closure in place.

Abstract translation: 一种用于通过经皮穿刺确定血管位置并用于密封血管中经皮穿刺的系统，闭合件和方法。 该系统包括引导器护套和相关联的定位装置，止血穿刺闭合器和展开装置。 定位装置使引导器护套能够定位在容器内的期望位置。 展开仪器包括一个储存封闭件的管状载体。 载体具有远端定位的自由端，通过穿刺器穿过穿刺器及其相关的管道延伸。 闭合件包括不透射线的刚性锚固件，压缩的胶原塞，以及以滑轮状布置连接两者的细丝。 托架通过导引器弹出锚固件并穿刺，然后将其拉到导引器的自由端。 然后将仪器和引导器一起拉出以将锚固件靠在与动脉内的穿刺相邻的组织上。 进一步撤出将塞子从载体中抽出到穿刺管中，于是塞子相对于锚移动，与动脉壁的外侧接合以密封穿刺或切口。 张紧装置限制施加到细丝上的力。 载体还包括用于使塞子在管道内机械变形的篡改。 一旦定位，止血快速发生，从而将闭合件锁定就位。