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    Antifungal 4-substituted 5,6-dihydro-4H-pyrrolo [1,2-a][1,4]benzodiazepines
    5.
    发明授权
    Antifungal 4-substituted 5,6-dihydro-4H-pyrrolo [1,2-a][1,4]benzodiazepines 有权
    抗真菌4-取代的5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并二氮杂卓

    公开(公告)号：US07820650B2

    公开(公告)日：2010-10-26

    申请号：US11680700

    申请日：2007-03-01

    Applicant: Terence Gilkerson ,  Roger John Nash ,  Jozef Frans Elisabetha Van Gestel ,  Lieven Meerpoel

    Inventor： Terence Gilkerson ,  Roger John Nash ,  Jozef Frans Elisabetha Van Gestel ,  Lieven Meerpoel

    IPC: A61P31/10 ,  A61K31/55 ,  C07D487/04

    CPC classification number: C07D487/04 ,  A61K31/55 ,  A61K31/551

    Abstract: The present invention concerns compounds for use as a medicine having the formula the N-oxide forms, the salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 represents hydrogen, C1-6alkyl, C1-4alkylthio, C1-4alkyloxy, or halo; R2 represents hydrogen or C1-6alkyl; R3 represents phenyl substituted with halo, cyano, C1-4alkyloxy, C1-4alkylthio, C1-6alkyl, haloC1-6alkyl; 2-thienyl; or 3-thienyl, R4 represents hydrogen; or R2 and R4 form an extra bond, which are active against dermatophytes, and their preparation; it further relates to compositions comprising them, as well as their use as a medicine.

    Abstract translation: 本发明涉及用作具有N-氧化物形式的药物的化合物，其盐，季胺和立体化学异构形式，其中R 1表示氢，C 1-6烷基，C 1-4烷硫基，C 1-4烷氧基或卤素 ; R 2表示氢或C 1-6烷基; R 3表示被卤素，氰基，C 1-4烷氧基，C 1-4烷硫基，C 1-6烷基，卤代C 1-6烷基取代的苯基; 2-噻吩基; 或3-噻吩基，R 4表示氢; 或R2和R4形成额外的键，其对皮肤癣菌有活性，并且它们的制备; 它还涉及包含它们的组合物以及它们作为药物的用途。

    Fibre Optic Sensor Package
    6.
    发明申请
    Fibre Optic Sensor Package 有权
    光纤传感器封装

    公开(公告)号：US20090087136A1

    公开(公告)日：2009-04-02

    申请号：US12293172

    申请日：2007-03-29

    Applicant: Philip John Nash ,  David John Hill

    Inventor： Philip John Nash ,  David John Hill

    IPC: G02B6/00 ,  G02B6/42

    CPC classification number: G01H9/004 ,  G01D5/35383 ,  G01V1/16 ,  G01V1/184 ,  G01V1/186

    Abstract: A fibre-optic sensor package (10) comprises a serial array of fibre-optic sensing coils (14, 16, 18, 20, 22) each of which is comprised in a respective fibre-optic sensor. Four (14, 16, 18, 22) of the coils are housed in a protective casing (24). One of the coils (22) is comprised in a fibre-optic electromagnetic field sensor. The other coils are comprised in respective fibre-optic geophones and/or hydrophones. A single package of the invention allows detection of both seismic and electromagnetic signals. An array of packages of the invention provides detection of both seismic and electromagnetic signal at a series of positions over a long distance or wide area, thus avoiding the need for two conventional arrays. A packages of the invention, and an array of such packages, require little or no electrical power input.

    Abstract translation: 光纤传感器封装（10）包括光纤传感线圈（14,16,18,20,22）的串联阵列，每个光纤传感线圈包括在相应的光纤传感器中。 四个（14,16,18,22）的线圈被容纳在保护壳体（24）中。 其中一个线圈（22）包含在光纤电磁场传感器中。 其他线圈包括在相应的光纤地震检波器和/或水听器中。 本发明的单个包装允许检测地震和电磁信号。 本发明的封装阵列提供在长距离或广泛区域上的一系列位置处的地震和电磁信号的检测，从而避免了对两个常规阵列的需要。 本发明的封装和这种封装的阵列需要很少或没有电力输入。

    Systems and methods for profiled and focused searching of litigation information
    7.
    发明申请
    Systems and methods for profiled and focused searching of litigation information 审中-公开
    对诉讼信息进行分析和集中搜索的系统和方法

    公开(公告)号：US20090083328A1

    公开(公告)日：2009-03-26

    申请号：US12010777

    申请日：2008-01-30

    Applicant: Michele Vivona ,  Donald G. Peterson ,  Jeffrey Pfeifer ,  Kevin Stehr ,  David Dilenschneider ,  John Nash ,  William Hagy ,  Duane Wald ,  Ryan Sanders ,  Travis J. Olson

    Inventor： Michele Vivona ,  Donald G. Peterson ,  Jeffrey Pfeifer ,  Kevin Stehr ,  David Dilenschneider ,  John Nash ,  William Hagy ,  Duane Wald ,  Ryan Sanders ,  Travis J. Olson

    IPC: G06F17/30

    CPC classification number: G06Q10/10 ,  G06F16/338 ,  G06Q50/18

    Abstract: Systems and methods for profiled and focused searching of litigation information allow a user to access specific legal information for use during litigation. The user can connect to a web site and access particular information from multiple sources based on the litigation task the user wishes to accomplish One litigation task is to create a litigation profile for a target, such as a particular litigant, attorney, judge, court, or firm. In this way, the user can perform focused and task-based searching to receive information about particular filings in particular locations, made by particular entities without knowing which sources contain certain pieces of the litigation information. For example, the user can receive all documents relating to summary judgment for patent infringement filed by a particular attorney in a particular court without specifying the source of information. In one aspect, the user can also access the source(s) upon receiving the results.

    Abstract translation: 用于分析和集中搜索诉讼信息的系统和方法允许用户访问特定的法律信息以供诉讼期间使用。 用户可以根据用户希望完成的诉讼任务，连接到网站并访问多个来源的特定信息。一个诉讼任务是为目标创建诉讼简档，例如特定诉讼人，律师，法官，法庭， 或公司。 以这种方式，用户可以执行重点突出和基于任务的搜索来接收关于特定地点的特定文件的信息，由特定实体制作，而不知道哪些源包含某些诉讼信息。 例如，用户可以接收与特定律师在特定法院提交的专利侵权的简易判断有关的所有文件，而不指定信息来源。 在一个方面，用户还可以在接收到结果时访问源。

    System, method and program product for recovering from a failure
    9.
    发明授权
    System, method and program product for recovering from a failure 有权
    用于从故障中恢复的系统，方法和程序产品

    公开(公告)号：US07395455B2

    公开(公告)日：2008-07-01

    申请号：US11082043

    申请日：2005-03-16

    Applicant: Richard John Nash ,  Gary Paul Noble

    Inventor： Richard John Nash ,  Gary Paul Noble

    IPC: G06F11/00

    CPC classification number: G06F11/3055 ,  G06F11/0793

    Abstract: System, method and computer program product for recovering from a failure of a computing device. Start up of a first component of the device is monitored and a determination is made whether the first component has started successfully. If so, a second, higher level component of the device is started. Operational data received from the second component is monitored. If the operational data falls outside of an operational boundary, an action is performed on the second component to enable the second component to operate within a preferred operational boundary. If the first component does not start up successfully, a determination is made if start up of the first component is critical to operation of the second component. If so, a corrective action is performed relative to the first component and afterwards, an attempt is made to start up the second component.

    Abstract translation: 用于从计算设备的故障中恢复的系统，方法和计算机程序产品。 监视设备的第一个组件的启动，并确定第一个组件是否已成功启动。 如果是这样，则开始第二个较高级别的设备组件。 监视从第二个组件接收的操作数据。 如果操作数据落在操作边界之外，则对第二组件执行动作以使第二组件能够在优选的操作边界内操作。 如果第一个组件没有成功启动，则确定启动第一个组件对于第二个组件的运行至关重要。 如果是这样，则相对于第一组件执行校正动作，然后尝试启动第二组件。

    THROMBECTOMY AND SOFT DEBRIS REMOVAL DEVICE
    10.
    发明申请
    THROMBECTOMY AND SOFT DEBRIS REMOVAL DEVICE 有权
    镜像和软件去除设备

    公开(公告)号：US20080097499A1

    公开(公告)日：2008-04-24

    申请号：US11871908

    申请日：2007-10-12

    Applicant: John Nash ,  Greg Walters ,  Dennis Sauro ,  Mark Eberharot ,  William Fisher ,  Douglas Evans

    Inventor： John Nash ,  Greg Walters ,  Dennis Sauro ,  Mark Eberharot ,  William Fisher ,  Douglas Evans

    IPC: A61B17/22

    CPC classification number: A61B17/320758 ,  A61B17/320783 ,  A61B2017/00685 ,  A61B2017/320733 ,  A61B2017/320741 ,  A61B2017/320766 ,  A61B2217/005

    Abstract: A device suitable for removing material from a living being is provided, featuring at least an aspiration pump, powered by a motor. The aspiration pump and any optional infusate pump preferably feature a helical pumping mechanism, and operate at a high rate of rotation, thereby ensuring adequate pumping performance and flexibility. The helical pumping mechanism may be a helical coiled wire about a central core tube. The helical coil wire, whether together with, or independent of, the core tube, may be rotated to cause a pumping action. Additionally, a narrow crossing profile is maintained, ensuring that the device may reach more tortuous regions of the vasculature. In one embodiment, the system comprises a wire-guided mono-rail catheter with a working head mounted on a flexible portion of the catheter that can laterally displace away from the guide wire to facilitate thrombus removal. The working head may be operated to separate and move away from the guide wire to come within a closer proximity of the obstructive material to more effectively remove it from the vessel.

    Abstract translation: 提供一种适用于从活体中去除材料的装置，其特征在于至少一个由马达驱动的抽吸泵。 抽吸泵和任何可选的输注泵优选地具有螺旋泵送机构，并且以高转速进行操作，从而确保了足够的泵送性能和灵活性。 螺旋泵送机构可以是围绕中心芯管的螺旋卷绕的线。 螺旋线圈线，无论是与芯管一起，还是独立于芯管，可以旋转以引起泵送动作。 另外，保持狭窄的横截面，确保装置可能达到脉管系统的更曲折的区域。 在一个实施例中，系统包括导线单轨导管，其具有安装在导管的柔性部分上的工作头，所述工作头能横向移位远离引导线以促进血栓移除。 工作头可以被操作以分离并远离引导线进入更靠近阻塞物质的位置，以更有效地将其从容器中移出。

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