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    IODOARENE DERIVATIVE, METHOD FOR MANUFACTURING OPTICALLY ACTIVE SPIROLACTONE COMPOUND BY USING THE SAME, AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE CYCLOADDUCT
    1.
    发明申请
    IODOARENE DERIVATIVE, METHOD FOR MANUFACTURING OPTICALLY ACTIVE SPIROLACTONE COMPOUND BY USING THE SAME, AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE CYCLOADDUCT 有权
    异恶唑衍生物，使用它们制造光学活性螺旋体化合物的方法和制造光学活性环糊精的方法

    公开(公告)号：US20130338364A1

    公开(公告)日：2013-12-19

    申请号：US14002574

    申请日：2012-03-06

    申请人： Kazuaki Ishihara ,  Muhammet Uyanik ,  Takeshi Yasui

    发明人： Kazuaki Ishihara ,  Muhammet Uyanik ,  Takeshi Yasui

    IPC分类号： B01J31/02 ,  C07D491/107 ,  C07D307/94

    CPC分类号： B01J31/0209 ,  C07C217/20 ,  C07C233/69 ,  C07C233/70 ,  C07C235/48 ,  C07C271/16 ,  C07C311/17 ,  C07D307/94 ,  C07D317/72 ,  C07D491/107

    摘要： An optically active spirolactone compound is highly enantioselectively produced by using an iodoarene derivative which can be synthesized easily and which is not racemized easily. A hypervalent iodine compound precursor (iodoarene derivative) which was able to be designed flexibly was synthesized from 2,6-dihydroxyiodoarene by using 1,2-aminoalcohol as a chiral source in short steps, a hypervalent iodine compound was prepared in a reaction system (in situ) by using a catalyst quantity of the resulting precursor in the presence of a stoichiometric quantity of m-CPBA, and a spirolactonization reaction of 3-(1-hydroxy-2-naphthyl)propionic acid was induced. As a result, a corresponding spirolactone compound was obtained at a high enantiomeric excess.

    摘要翻译： 通过使用可以容易地合成并且不容易外消旋化的碘代芳烃衍生物，高度对映选择性地制备光学活性的己内酯化合物。 通过使用1,2-氨基醇作为手性来源，通过短时间步骤，可以从2,6-二羟基碘代芳烃合成出能够灵活设计的高价碘化合物前体（碘代芳烃衍生物），在反应体系中制备了高价碘化合物 通过在化学计量的m-CPBA的存在下使用所得前体的催化剂量，并引发3-（1-羟基-2-萘基）丙酸的反式己内酯化反应。 结果，以高对映体过量获得相应的己内酯化合物。

    METHOD FOR MANUFACTURING ESTER
    4.
    发明申请
    METHOD FOR MANUFACTURING ESTER 有权
    制造方法

    公开(公告)号：US20130217898A1

    公开(公告)日：2013-08-22

    申请号：US13881544

    申请日：2011-10-11

    申请人： Kazuaki Ishihara ,  Muhammet Uyanik

    发明人： Kazuaki Ishihara ,  Muhammet Uyanik

    IPC分类号： C07D313/04 ,  C07D307/83 ,  C07D307/935 ,  C07D307/33 ,  C07D309/30

    CPC分类号： C07D313/04 ,  C07B33/00 ,  C07C37/56 ,  C07C67/42 ,  C07D307/33 ,  C07D307/77 ,  C07D307/79 ,  C07D307/83 ,  C07D307/88 ,  C07D307/935 ,  C07D309/30 ,  C07D323/04 ,  C07C69/24 ,  C07C39/28

    摘要： The present invention relates to a method for manufacturing an ester from a ketone or an aldehyde, which is a reactive substrate, by a Baeyer-Villiger oxidation reaction using hydrogen peroxide, and in this method, as a catalyst, M(BAr4)n, which is a metal borate, is used (M represents an alkali metal or an alkaline earth metal; Ar represents an aryl; and n is the same number as the valence of M). For example, when cyclohexanone was used as the reactive substrate, and Sr[B(3,5-CF3C6H3)4]2 was used as the catalyst, ε-caprolactone was obtained at an isolated yield of 82%.

    摘要翻译： 本发明涉及通过使用过氧化氢的Baeyer-Villiger氧化反应从作为反应性底物的酮或醛制造酯的方法，在该方法中，作为催化剂M（BAr4）n， 使用金属硼酸盐（M表示碱金属或碱土金属; Ar表示芳基; n表示与M的化合价相同的数）。 例如，当使用环己酮作为反应性底物，并且使用Sr [B（3,5-CF 3 C 6 H 3）4] 2作为催化剂时，以82％的分离收率得到ε-己内酯。

    Process for preparation of carbonyl compound and pro-oxidant for preparation of carbonyl compound
    7.
    发明授权
    Process for preparation of carbonyl compound and pro-oxidant for preparation of carbonyl compound 有权
    用于制备羰基化合物的方法和用于制备羰基化合物的促氧化剂

    公开(公告)号：US08394995B2

    公开(公告)日：2013-03-12

    申请号：US12441194

    申请日：2008-08-29

    申请人： Kazuaki Ishihara ,  Muhammet Uyanik ,  Yukihiro Isogai ,  Suguru Ohara

    发明人： Kazuaki Ishihara ,  Muhammet Uyanik ,  Yukihiro Isogai ,  Suguru Ohara

    IPC分类号： C07C69/76 ,  C07C45/29 ,  C07C45/30

    CPC分类号： C07C45/29 ,  B01J31/0225 ,  B01J31/0229 ,  B01J31/0231

    摘要： The invention provides a process for the preparation of a carbonyl compound in high efficiency by oxidizing an alcohol. The process for the preparation of a carbonyl compound of the present invention includes a step of oxidizing an alcohol in the presence of a compound of the formula (I) or a derivative or a salt thereof, and an oxidant, wherein R1 and R2 independently represent hydrogen, a halogen, a nitro or acidic group, or an alkyl or alkoxy group, each of which optionally has a substituent, or R1 and R2 combine the two carbon atoms to which they are boned to form an aromatic ring.

    摘要翻译： 本发明提供通过氧化醇高效制备羰基化合物的方法。 本发明的羰基化合物的制备方法包括在式（I）化合物或其衍生物或其盐和氧化剂存在下氧化醇的步骤，其中R 1和R 2独立地表示 氢，卤素，硝基或酸性基团，或烷基或烷氧基，其各自任选具有取代基，或者R 1和R 2结合它们所键合的两个碳原子形成芳环。

    PROCESS FOR PREPARATION OF CARBONYL COMPOUND AND PRO-OXIDANT FOR PREPARATION OF CARBONYL COMPOUND
    8.
    发明申请
    PROCESS FOR PREPARATION OF CARBONYL COMPOUND AND PRO-OXIDANT FOR PREPARATION OF CARBONYL COMPOUND 有权
    制备碳化合物的方法和用于制备碳化合物的预氧化剂

    公开(公告)号：US20100041917A1

    公开(公告)日：2010-02-18

    申请号：US12441194

    申请日：2008-08-29

    申请人： Kazuaki Ishihara ,  Muhammet Uyanik ,  Yukihiro Isogai ,  Suguru Ohara

    发明人： Kazuaki Ishihara ,  Muhammet Uyanik ,  Yukihiro Isogai ,  Suguru Ohara

    IPC分类号： C07C309/00

    CPC分类号： C07C45/29 ,  B01J31/0225 ,  B01J31/0229 ,  B01J31/0231

    摘要： The invention provides a process for the preparation of a carbonyl compound in high efficiency by oxidizing an alcohol. The process for the preparation of a carbonyl compound of the present invention includes a step of oxidizing an alcohol in the presence of a compound of the formula (I) or a derivative or a salt thereof, and an oxidant, wherein R1 and R2 independently represent hydrogen, a halogen, a nitro or acidic group, or an alkyl or alkoxy group, each of which optionally has a substituent, or R1 and R2 combine the two carbon atoms to which they are boned to form an aromatic ring.

    摘要翻译： 本发明提供通过氧化醇高效制备羰基化合物的方法。 本发明的羰基化合物的制备方法包括在式（I）化合物或其衍生物或其盐和氧化剂存在下氧化醇的步骤，其中R 1和R 2独立地表示 氢，卤素，硝基或酸性基团，或烷基或烷氧基，其各自任选具有取代基，或者R 1和R 2结合它们所键合的两个碳原子形成芳环。