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    PARTICLES COMPRISING BILIRUBIN DERIVATIVE AND METAL
    4.
    发明申请
    PARTICLES COMPRISING BILIRUBIN DERIVATIVE AND METAL 审中-公开

    公开(公告)号：US20200230261A1

    公开(公告)日：2020-07-23

    申请号：US16343043

    申请日：2018-05-14

    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

    Inventor： Sang Yong JON ,  Dong Yun LEE ,  Yong Hyun LEE ,  Do Hyun YOO ,  Won Sik JUNG

    IPC: A61K49/10 ,  G01N33/72 ,  A61K33/243 ,  A61K33/26 ,  A61K33/242 ,  A61K47/22

    Abstract: The present invention provides hydrophilic bilirubin derivative particles containing a metal, a use thereof, and a preparation method therefor. The bilirubin derivative particles of the present invention form coordinate bonds with various metals, and thus can be used in MR diagnosis, CT diagnosis, photo-acoustic diagnosis, PET diagnosis, or optical diagnosis. The bilirubin derivative particles of the present invention can release an anticancer drug encapsulated therein to the outside by the combination with a platinum-based anticancer drug and the degradation by a stimulation of light/reactive oxygen species, and exhibit anti-inflammatory and anticancer activities, and thus the bilirubin derivative particles of the present invention have a concept of theranostics in which the bilirubin derivative particles can be for therapeutic uses as well as diagnostic uses.

    SMALL LIPID NANOPARTICLES, AND CANCER VACCINE INCLUDING SAME
    5.
    发明申请
    SMALL LIPID NANOPARTICLES, AND CANCER VACCINE INCLUDING SAME 有权

    公开(公告)号：US20220409708A1

    公开(公告)日：2022-12-29

    申请号：US17773658

    申请日：2019-11-01

    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

    Inventor： Sang Yong JON ,  Yu Jin KIM ,  Suk Mo KANG

    IPC: A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  A61K39/39

    Abstract: The present invention relates to small lipid nanoparticles, a small lipid nanoparticle (SLNP)-based nanovaccine platform including same, and a combination treatment regimen with an immune checkpoint inhibitor. Lipid nanoparticies according to the present invention can easily deliver antigens and anionic drugs into cells, and exhibit strong anti-tumor effects when loaded with tumor-associated antigens. Particularly, a cancer vaccine kit according to the present invention including lipid nanoparticles according to the present invention as a first vaccine composition and lipid nanoparticles and an immune checkpoint inhibitor as a second vaccine composition can be used to effectively suppress tumor regrowth and recurrence triggered by the occurrence of immunosuppression against a cancer nanovaccine.

    BILIRUBIN NANOPARTICLE, USE THEREOF, AND PREPARATION METHOD THEREFOR
    6.
    发明申请
    BILIRUBIN NANOPARTICLE, USE THEREOF, AND PREPARATION METHOD THEREFOR 审中-公开
    BILIRUBIN NANOPARTICLE，及其制备方法

    公开(公告)号：US20170028076A1

    公开(公告)日：2017-02-02

    申请号：US15104040

    申请日：2014-12-26

    Applicant: Korea Advanced Institute of Science and Technology

    Inventor： Sang Yong JON ,  Yong Hyun LEE

    IPC: A61K47/48 ,  A61K31/704

    CPC classification number: A61K47/48215 ,  A61K31/704 ,  A61K47/60 ,  A61K47/6935 ,  B82Y5/00

    Abstract: The present invention provides a bilirubin nanoparticle formed by the self-assembly of bilirubin and a composite comprising a hydrophilic polymer, a use thereof, and a preparation method therefor. The bilirubin nanoparticle according to the present invention can release a drug enclosed therein to the outside by being collapsed by light or active oxygen stimulation. The bilirubin nanoparticle according to the present invention exhibits antioxidant, antiangiogenic, anticancer, and anti-inflammatory activities.

    Abstract translation: 本发明提供了通过胆红素的自组装形成的胆红素纳米颗粒和包含亲水性聚合物的复合物，其用途及其制备方法。 根据本发明的胆红素纳米颗粒可以通过光或活性氧刺激而将其中封闭的药物释放到外部。 根据本发明的胆红素纳米颗粒显示出抗氧化剂，抗血管生成，抗癌和抗炎活性。

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