公开(公告)号：US20210371827A1

公开(公告)日：2021-12-02

申请号：US16963278

申请日：2018-11-13

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Yong JON ,  Min Suk CHOI ,  Sung Gap IM ,  Daeyoup LEE ,  Seung Jung YU ,  Yoon Jung CHOI

IPC: C12N5/095 ,  C12N5/00 ,  A61K35/13

Abstract: The present invention relates to a method or kit for producing cancer stem cell spheroids, and a method of screening of drugs for treating cancer cell resistance using the prepared cancer stem cell spheroid, and it can conveniently produce cancer stem cell spheroids, and the prepared cancer stem cell spheroids can be effectively utilized for screening drugs for treating cancer cell resistance.

公开(公告)号：US20220170110A1

公开(公告)日：2022-06-02

申请号：US17601332

申请日：2019-11-19

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Daeyoup LEE ,  Taemook KIM ,  Sungwook HAN

IPC: C12Q1/6886

Abstract: The present invention relates to a cancer diagnostic marker screened using assay for transposase-accessible chromatin using sequencing (ATAC sequencing), and the use thereof. The open chromatin structural variation marker according to the present invention is useful as a cancer diagnostic marker because it can confirm the structural variation of chromatin with high accuracy. In addition, the open chromatin structural variation marker may be used as a new cancer diagnostic marker when detecting chromatin structural variation using a composition for detecting the marker.