公开(公告)号：US20210371827A1

公开(公告)日：2021-12-02

申请号：US16963278

申请日：2018-11-13

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Yong JON ,  Min Suk CHOI ,  Sung Gap IM ,  Daeyoup LEE ,  Seung Jung YU ,  Yoon Jung CHOI

IPC: C12N5/095 ,  C12N5/00 ,  A61K35/13

Abstract: The present invention relates to a method or kit for producing cancer stem cell spheroids, and a method of screening of drugs for treating cancer cell resistance using the prepared cancer stem cell spheroid, and it can conveniently produce cancer stem cell spheroids, and the prepared cancer stem cell spheroids can be effectively utilized for screening drugs for treating cancer cell resistance.

公开(公告)号：US20170130195A1

公开(公告)日：2017-05-11

申请号：US15318134

申请日：2014-08-01

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sung Gap IM ,  Hak Rae LEE ,  Sang Yong JON ,  Min Suk CHOI

IPC: C12N5/00 ,  C08F30/08 ,  C09D143/04 ,  C12N5/095

CPC classification number: C12N5/0068 ,  C08F30/08 ,  C09D143/04 ,  C12M25/02 ,  C12N5/0062 ,  C12N5/0695 ,  C12N2533/30

Abstract: The present invention provides a cell culture substrate comprising a polymer formed of a cyclosiloxane compound and a manufacturing method therefor, and a method for preparing a cell spheroid type of cell aggregate or induced pluripotent stem cells using the cell culture substrate. The cell spheroid type of cell aggregate can be easily formed by culturing cells on the cell culture substrate of the present invention, and further, the cell culture substrate can be utilized as a cell culture platform for preparing the induced pluripotent stem cells.