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    Transparent resin composition radiating far infrared rays
    1.
    发明授权
    Transparent resin composition radiating far infrared rays 失效
    透明树脂组合物辐射远红外线

    公开(公告)号：US5234985A

    公开(公告)日：1993-08-10

    申请号：US915944

    申请日：1992-07-17

    申请人： Jung K. Koo ,  Sung K. Kim ,  Byeong S. Kim ,  Dong W. Han

    发明人： Jung K. Koo ,  Sung K. Kim ,  Byeong S. Kim ,  Dong W. Han

    IPC分类号： C08K3/36

    CPC分类号： C08K3/36

    摘要： A far infrared ray radiating transparent resin composition is disclosed. The composition is composed of a transparent resin and a far infrared ray radiating ceramic material. The ceramic material which is added to the resin in the amount of 1-30 weight parts, has an SiO.sub.2 purity of over 96.0%, and an average particle diameter of 0.1-15 .mu.m. The resin composition according to the present invention not only radiates far infrared rays, but also maintains transparency at an acceptable level. Therefore it can be applied to various products where the both transparency and extended freshness of food are required.

    摘要翻译： 公开了一种远红外线辐射透明树脂组合物。 该组合物由透明树脂和远红外线辐射陶瓷材料组成。 以1-30重量份的量添加到树脂中的陶瓷材料的SiO 2纯度高于96.0％，平均粒径为0.1〜15μm。 根据本发明的树脂组合物不仅辐射远红外线，而且将透明度保持在可接受的水平。 因此，它可以应用于需要透明度和延长新鲜度的各种产品。

    Reactive thiophosphate derivatives of thia(dia)zole acetic acid and process for preparing the same
    3.
    发明授权
    Reactive thiophosphate derivatives of thia(dia)zole acetic acid and process for preparing the same 失效
    硫酸（dia）唑乙酸的活性硫代磷酸酯衍生物及其制备方法

    公开(公告)号：US5502200A

    公开(公告)日：1996-03-26

    申请号：US223756

    申请日：1994-04-06

    申请人： Sung K. Kim ,  Jong C. Lim ,  Tae S. Kwon ,  Bong J. Park ,  Woo H. Kim

    发明人： Sung K. Kim ,  Jong C. Lim ,  Tae S. Kwon ,  Bong J. Park ,  Woo H. Kim

    IPC分类号： C07D277/20 ,  C07D277/56 ,  C07D285/08 ,  C07F9/6539 ,  C07F9/02

    CPC分类号： C07F9/6539 ,  C07F9/65397 ,  Y02P20/55

    摘要： The present invention relates to a novel reactive thiophosphate derivative of thia(dia)zole acetic acid which can be very effectively used in the preparation of .beta.-lactam antibiotics, and which is represented by the following general formula (I): ##STR1## in which R.sup.1 represents hydrogen or an amino-protecting group;R.sup.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, or --C(R.sup.a)(R.sup.b)CO.sub.2 R.sup.c, wherein R.sup.a and R.sup.b are identical or different from each other and represent hydrogen or C.sub.1 -C.sub.4 alkyl, or R.sup.a and R.sup.b together with a carbon atom to which they are bound can form a C.sub.3 -C.sub.7 cycloalkyl group and R.sup.c is hydrogen or a carboxy-protecting group;R.sup.3 represents C.sub.1 -C.sub.4 alkyl or phenyl or R.sup.3 together with an oxygen atom and a phosphorus atom to which it is bound can form a 5- or 6-membered heterocyclic ring; andQ represents N or CH, and to a process for preparing the same.

    摘要翻译： 本发明涉及一种可以非常有效地用于制备β-内酰胺抗生素的噻唑（dia）唑乙酸的新型反应性硫代磷酸酯衍生物，其由以下通式（I）表示：或氨基 - 保护组 R 2表示氢，C 1 -C 4烷基或-C（R a）（R b）CO 2 R c，其中R a和R b彼此相同或不同，表示氢或C 1 -C 4烷基，或者R a和R b与碳原子一起 它们被结合可以形成C 3 -C 7环烷基，R c是氢或羧基保护基; R3表示C1-C4烷基或苯基或R3与氧原子一起形成与其结合的磷原子可形成5-或6-元杂环; 并且Q表示N或CH，以及其制备方法。

    Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-dihydro benzopyan-2H-one class having antiaggregatory properties
    6.
    发明授权
    Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-dihydro benzopyan-2H-one class having antiaggregatory properties 失效
    属于6,7-二取代-3,4-二氢苯并吡喃-2H一类的氨基还原酮化合物具有抗聚集性质

    公开(公告)号：US4845121A

    公开(公告)日：1989-07-04

    申请号：US874148

    申请日：1986-06-13

    申请人： Donald T. Witiak ,  Sung K. Kim ,  Dennis R. Feller ,  Karl J. Romstedt

    发明人： Donald T. Witiak ,  Sung K. Kim ,  Dennis R. Feller ,  Karl J. Romstedt

    IPC分类号： C07D311/56

    CPC分类号： C07D311/56

    摘要： The present invention relates to novel benzopyranone aci-reductone compounds of the formula I wherein X and Y are selected from the group comprising H (except that X and Y are not both H, unless otherwise indicated) Cl or other halogen, OH, a straight or branched C.sub.1 -C.sub.6 alkyl or alkoxy group or phenyl or phenyloxy groups, such as, for example a phenyl or a tertiary butyl group. The invention also provides for compounds of the general formula I wherein X, Y=OCH.sub.2 O. ##STR1## The compounds of the invention are useful in the treatment or prevention of thromboembolic disorders.

    摘要翻译： 本发明涉及式I的新型苯并吡喃酮缩合物化合物，其中X和Y选自H（除非另有说明，X和Y不能同时为H）Cl或其它卤素OH，直链 或支链C 1 -C 6烷基或烷氧基或苯基或苯氧基，例如苯基或叔丁基。 本发明还提供通式I的化合物，其中X，Y = OCH 2 O。 本发明的化合物可用于治疗或预防血栓栓塞性疾病。

    Process for preparing cephalosporin compounds from reactive organic acid derivatives
    7.
    发明授权
    Process for preparing cephalosporin compounds from reactive organic acid derivatives 失效
    从反应性有机酸衍生物制备头孢菌素化合物的方法

    公开(公告)号：US5567813A

    公开(公告)日：1996-10-22

    申请号：US258184

    申请日：1994-06-10

    申请人： Sung K. Kim ,  Jong C. Lim ,  Seong N. Kim ,  Hee M. Oh ,  Woo H. Kim

    发明人： Sung K. Kim ,  Jong C. Lim ,  Seong N. Kim ,  Hee M. Oh ,  Woo H. Kim

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/06 ,  C07D501/22 ,  C07D501/56 ,  C07F9/6539

    CPC分类号： C07F9/6539 ,  C07D501/00 ,  Y02P20/55

    摘要： The present invention provides a process for preparing cephem derivatives having the following general formula (I): ##STR1## in which R.sup.1 represents a carboxy group or a protected carboxy group which can form the salt of --COO.sup.- M.sup.+ with an alkali metal ion (M.sup.+) such as sodium, or may represent --COO.sup.- when R.sup.2 has a substituent having positive electric charge such as pyridinium, pyrimidinium or thiazolium,R.sup.2 represents hydrogen, acyloxymethyl, heterocyclic methyl or heterocyclic thiomethyl, each of which can be substituted with appropriate substituents,R.sup.3 represents hydrogen or an amino-protecting group,R.sup.4 represents C.sub.1 -C.sub.4 alkyl or phenyl, or together with the oxygen or phosphorus atom to which it is attached may form a 5- or 6-membered heterocyclic ring, andQ represents N or CH, characterized in that a reactive thiophosphate derivative of thia(dia)zole acetic acid having the following general formula (II): ##STR2## wherein R.sup.3, R.sup.4 and Q are defined as above is acylated with an 7-ACA derivative having the following general formula (III): ##STR3## wherein R.sup.1 and R.sup.2 are defined as above, in the presence of a solvent and a base.

    摘要翻译： 本发明提供了具有以下通式（I）的头孢烯衍生物的制备方法：其中R 1表示羧基或保护的羧基，其可与碱形成-COO-M +的盐 金属离子（M +）如钠，或当R2具有正电荷的取代基如吡啶鎓，嘧啶鎓或噻唑鎓时，可以表示-COO-，R2代表氢，酰氧基甲基，杂环甲基或杂环硫甲基，每个可以被取代 具有适当的取代基，R 3表示氢或氨基保护基，R 4表示C 1 -C 4烷基或苯基，或与其连接的氧或磷原子一起形成5-或6-元杂环，Q 表示N或CH，其特征在于具有以下通式（II）的噻唑（dia）唑乙酸的反应性硫代磷酸酯衍生物：其中R 3，R 4和Q如上定义，其中R 7，R 4和Q如上定义，用7 -AC 具有以下通式（III）的衍生物：其中R 1和R 2如上定义，在溶剂和碱的存在下。

    Process for the preparation of cephalosporin derivatives
    10.
    发明授权
    Process for the preparation of cephalosporin derivatives 失效
    头孢菌素衍生物的制备方法

    公开(公告)号：US4835267A

    公开(公告)日：1989-05-30

    申请号：US1875

    申请日：1987-01-09

    申请人： Moon H. Chang ,  Bong J. Kim ,  Sung K. Kim ,  Woan J. Kim

    发明人： Moon H. Chang ,  Bong J. Kim ,  Sung K. Kim ,  Woan J. Kim

    IPC分类号： C07D501/24 ,  A61K31/545 ,  C07D501/26 ,  C07D501/32 ,  C07D501/36 ,  C07D501/44

    CPC分类号： C07D501/36 ,  C07D501/32

    摘要： The present invention relates to an improved process for producing cephalosporin derivatives of formula (I), the 3-position of which being substituted by acetoxymethyl or tetrazolylthiomethyl and the 7-acyl group of which being substituted by D-mandelic acid derivatives, which comprises simultaneously reacting the compound of formula (III) with the compound of formula (IV) in the presence of a compound of formula (II) and anamine in high yield, ##STR1## wherein, R.sup.1 is hydrogen or ##STR2## R.sup.2 is methyl, ethyl, propyl or phenyl, X is ##STR3##

    摘要翻译： 本发明涉及一种制备式（I）的头孢菌素衍生物的改进方法，其3-位被乙酰氧基甲基或四唑基硫代甲基取代，其7-酰基被D-扁桃酸衍生物取代，其包括同时 在式（II）化合物和胺的存在下，以高产率使式（III）化合物与式（Ⅳ）化合物反应，其中式（Ⅳ）化合物与式 （IV）其中R1是氢或R2是甲基，乙基，丙基或苯基，X是