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    Free cholesterol analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the side chain and method of preparation and use thereof
    3.
    发明授权
    Free cholesterol analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the side chain and method of preparation and use thereof 有权
    侧链中含有二溴二苯并（BODIPY）荧光团的游离胆固醇类似物及其制备方法及其用途

    公开(公告)号：US08030482B2

    公开(公告)日：2011-10-04

    申请号：US12013120

    申请日：2008-01-11

    申请人： Robert Bittman ,  Zaiguo Li

    发明人： Robert Bittman ,  Zaiguo Li

    IPC分类号： C07J43/00

    CPC分类号： C07J43/00

    摘要： The present invention relates to free cholesterol analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the side chain and methods of preparation. The compounds of the present invention can be used in fluorescence spectroscopy and fluorescence microscopy to visualize the exchange, distribution, and trafficking of free cholesterol between living cells and to monitor the movement of free cholesterol between ordered and disordered lipid domains in membranes.

    摘要翻译： 本发明涉及在侧链中带有二溴二溴（BODIPY）荧光团的游离胆固醇类似物及其制备方法。 本发明的化合物可用于荧光光谱和荧光显微镜观察活细胞之间游离胆固醇的交换，分布和运输，并监测膜中有序和无序脂质结构域之间游离胆固醇的运动。

    Non-natural sphingolipid analogs and uses thereof
    4.
    发明授权
    Non-natural sphingolipid analogs and uses thereof 有权
    非天然鞘脂类似物及其用途

    公开(公告)号：US08263576B2

    公开(公告)日：2012-09-11

    申请号：US11839024

    申请日：2007-08-15

    申请人： Richard E. Pagano ,  Robert Bittman ,  David L. Marks ,  Hirohito Kita ,  Ramandeep S. Takhter

    发明人： Richard E. Pagano ,  Robert Bittman ,  David L. Marks ,  Hirohito Kita ,  Ramandeep S. Takhter

    IPC分类号： A61K31/715

    CPC分类号： C07F9/65324 ,  C07F9/106 ,  C07H15/04 ,  C07H23/00 ,  G01N33/5023 ,  G01N33/5076

    摘要： This disclosure provides a composition useful for inhibiting caveolar endocytosis, plasma membrane microdomain formation, virus binding and infection, transmembrane signaling, and integrin function in cells. The composition is composed of non-natural analogs of sphingolipids, and may have applications in the treatment or amelioration of diseases associated with caveolar endocytosis, plasma membrane microdomain formation, transmembrane signaling, and integrin function. Methods for making and using the described composition are also provided.

    摘要翻译： 本公开提供了可用于抑制细胞内的卵泡内吞作用，质膜微区形成，病毒结合和感染，跨膜信号转导和整联蛋白功能的组合物。 该组合物由鞘脂的非天然类似物组成，并且可用于治疗或改善与脑膜内吞作用，质膜微区形成，跨膜信号转导和整合素功能相关的疾病。 还提供了制备和使用所述组合物的方法。

    Modified ether glyceroglycolipids
    5.
    发明授权
    Modified ether glyceroglycolipids 失效
    改性醚甘油糖脂

    公开(公告)号：US06573246B1

    公开(公告)日：2003-06-03

    申请号：US09644470

    申请日：2000-08-23

    申请人： Robert Bittman ,  Ravi K. Erukulla ,  Andrew C. Peters ,  Eric G. Mayhew

    发明人： Robert Bittman ,  Ravi K. Erukulla ,  Andrew C. Peters ,  Eric G. Mayhew

    IPC分类号： A61K3170

    CPC分类号： C07H15/04

    摘要： This invention provides lipids having: 1) a glycerol backbone; 2) a hydrocarbon chain, preferably saturated and containing 16 or 18 carbon atoms, attached to C-1 of the backbone by an ether linkage, 3) a methyl group attached to C-2 of the backbone, preferably by an ether linkage; and, 4) a sugar attached to C-3 of the glycerol backbone in either the alpha or beta anomeric configuration, the sugar being altered by modification of, or substitution for, one or more of its hydroxyl groups. Also provided herein are ether-lipid-containing compositions, as well as methods of administering such compositions to animals, for example, those afflicted with cancers, as well as various other diseases and disorders.

    摘要翻译： 本发明提供脂质，其具有：1）甘油骨架; 2）优选饱和并含有16或18个碳原子的烃链，其通过醚键连接到主链的C-1上，3）连接于主链C-2上的甲基，优选通过醚键; 和4）以α或β端基构型连接在甘油骨架的C-3上的糖，通过其一个或多个羟基的修饰或取代来改变糖。 本文还提供了含醚 - 脂质的组合物，以及将这些组合物施用于动物，例如患有癌症的那些以及各种其它疾病和病症的方法。

    Boron dipyrromethene difluoro (BODIPY) conjugates
    6.
    发明授权
    Boron dipyrromethene difluoro (BODIPY) conjugates 有权
    硼二吡咯亚甲基二氟（BODIPY）缀合物

    公开(公告)号：US08277775B2

    公开(公告)日：2012-10-02

    申请号：US12673799

    申请日：2008-08-15

    申请人： Robert Bittman ,  Zaiguo Li

    发明人： Robert Bittman ,  Zaiguo Li

    IPC分类号： A61B5/055 ,  A61K31/41 ,  A61K31/69 ,  A61K51/00 ,  C07D249/00 ,  C07F5/04

    CPC分类号： G01N33/533 ,  C07F5/022 ,  C07F9/6561

    摘要： The present invention relates to FTY720 analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the alkyl side chain and methods of preparation. The compounds of the present invention can be used in fluorescence spectroscopy and fluorescence microscopy and in chromatography using fluorescence detection.

    摘要翻译： 本发明涉及在烷基侧链中带有二溴二溴（BODIPY）荧光团的FTY720类似物及其制备方法。 本发明的化合物可用于荧光光谱和荧光显微镜和使用荧光检测的色谱中。

    Boron Dipyrromethene Difluoro (Bodipy) Conjugates
    7.
    发明申请
    Boron Dipyrromethene Difluoro (Bodipy) Conjugates 有权
    硼二吡咯亚甲基二氟（Bodipy）缀合物

    公开(公告)号：US20110082300A1

    公开(公告)日：2011-04-07

    申请号：US12673799

    申请日：2008-08-15

    申请人： Robert Bittman ,  Zaiguo Li

    发明人： Robert Bittman ,  Zaiguo Li

    IPC分类号： C07F5/02

    CPC分类号： G01N33/533 ,  C07F5/022 ,  C07F9/6561

    摘要： The present invention relates to FTY720 analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the alkyl side chain and methods of preparation. The compounds of the present invention can be used in fluorescence spectroscopy and fluorescence microscopy and in chromatography using fluorescence detection.

    摘要翻译： 本发明涉及在烷基侧链中带有二溴二溴（BODIPY）荧光团的FTY720类似物及其制备方法。 本发明的化合物可用于荧光光谱和荧光显微镜和使用荧光检测的色谱中。

    Synthesis of Glycerolipid Carbamates and Dicarbamates and Their Use as an Antitumor Compounds
    8.
    发明申请
    Synthesis of Glycerolipid Carbamates and Dicarbamates and Their Use as an Antitumor Compounds 失效
    甘油脂质体和碳酸氢铵的合成及其作为抗肿瘤化合物的应用

    公开(公告)号：US20090042811A1

    公开(公告)日：2009-02-12

    申请号：US11917025

    申请日：2006-06-12

    申请人： Robert Bittman ,  Hoe-Sup Byun ,  Gilbert Arthur

    发明人： Robert Bittman ,  Hoe-Sup Byun ,  Gilbert Arthur

    IPC分类号： A61K31/7008 ,  C07C271/06 ,  C07H3/02 ,  C07H15/02 ,  A61P35/00 ,  A61K31/27 ,  A61K31/70

    CPC分类号： C07F9/4006

    摘要： The syntheses and in vitro antitumor properties of carbamate-containing, dicarbamate-containing, and ureido-containing phospholipid compounds that have an ether linkage at the C-1 position of a glycerol backbone, a carbamate, dicarbamate, or ureido moiety at the C-2 position of the glycerol backbone, and a phosphocholine, phosphonocholine, or glycoside moiety at the C-3 position of the glycerol backbone are described. The synthesis and antiproliferative activity of ether lipids with a naphthol moiety at the C-1 position are also described. These compounds were shown to be potent inhibitors of cancer cell growth. These compounds are useful for killing cancer cells and treating cancer.

    摘要翻译： 含有氨基甲酸酯，含二氨基甲酸酯和含脲基的磷脂化合物的合成和体外抗肿瘤性质，其在C-末端的甘油骨架，氨基甲酸酯，二氨基甲酸酯或脲基部分的C-1位具有醚键， 描述了甘油主链的2位，甘油骨架的C-3位上的磷酸胆碱，膦酰胆碱或糖苷部分。 还描述了在C-1位置具有萘酚部分的醚脂质的合成和抗增殖活性。 这些化合物被证明是癌细胞生长的有效抑制剂。 这些化合物可用于杀死癌细胞和治疗癌症。

    Antimycobacterial compounds and method of using same
    9.
    发明授权
    Antimycobacterial compounds and method of using same 失效
    抗分解细菌化合物及其使用方法

    公开(公告)号：US5837732A

    公开(公告)日：1998-11-17

    申请号：US766273

    申请日：1996-12-13

    申请人： James Sacchettini ,  John Blanchard ,  William R. Jacobs ,  Robert Bittman

    发明人： James Sacchettini ,  John Blanchard ,  William R. Jacobs ,  Robert Bittman

    IPC分类号： C07C57/18 ,  C12N9/02 ,  C30B7/00 ,  A61K31/20

    CPC分类号： C07C57/18 ,  C12N9/001 ,  C30B29/58 ,  C30B7/00 ,  Y10S514/924

    摘要： The present invention provides a compound having the structure: ##STR1## wherein R is a branched or unbranched C1-C30 alkyl, alkenyl or alkynl; or a branched or unbranched C1-C30 alkyl, alkenyl or alkynl substituted with S, O, N, P, SO.sub.2, F, Cl, Br, or I, wherein S, O, N, P, or SO.sub.2 replaces at least one --CH.sub.2 --, and F, Cl, Br, or I replaces at least one H. The present invention also provides a pharmaceutical composition comprising the compound above, as well as a method for treating a mycobacterial disease or infection in a subject in need of such treatment by administering to the subject an effective amount of the compound above.

    摘要翻译： 本发明提供具有以下结构的化合物：其中R是支链或非支链C 1 -C 30烷基，烯基或炔烃; 或被S，O，N，P，SO 2，F，Cl，Br或I取代的支链或非支链C 1 -C 30烷基，链烯基或炔烃，其中S，O，N，P或SO 2取代至少一个 - CH 2 - 和F，Cl，Br或I取代至少一个H.本发明还提供了包含上述化合物的药物组合物，以及用于治疗需要这样的受试者的分枝杆菌病或感染的方法 通过向受试者施用有效量的上述化合物进行治疗。

    Synthesis of glycerolipid carbamates and dicarbamates and their use as an antitumor compounds
    10.
    发明授权
    Synthesis of glycerolipid carbamates and dicarbamates and their use as an antitumor compounds 失效
    甘油脂氨基甲酸酯和二氨基甲酸酯的合成及其作为抗肿瘤化合物的用途

    公开(公告)号：US08153615B2

    公开(公告)日：2012-04-10

    申请号：US11917025

    申请日：2006-06-12

    申请人： Robert Bittman ,  Hoe-Sup Byun ,  Gilbert Arthur

    发明人： Robert Bittman ,  Hoe-Sup Byun ,  Gilbert Arthur

    IPC分类号： A01N57/26 ,  A61K31/685 ,  A01N43/04 ,  A61K31/70

    CPC分类号： C07F9/4006

    摘要： The syntheses and in vitro antitumor properties of carbamate-containing, dicarbamate-containing, and ureido-containing phospholipid compounds that have an ether linkage at the C-1 position of a glycerol backbone, a carbamate, dicarbamate, or ureido moiety at the C-2 position of the glycerol backbone, and a phosphocholine, phosphonocholine, or glycoside moiety at the C-3 position of the glycerol backbone are described. The synthesis and antiproliferative activity of ether lipids with a naphthol moiety at the C-1 position are also described. These compounds were shown to be potent inhibitors of cancer cell growth. These compounds are useful for killing cancer cells and treating cancer.

    摘要翻译： 含有氨基甲酸酯，含二氨基甲酸酯和含脲基的磷脂化合物的合成和体外抗肿瘤性质，其在C-末端的甘油骨架，氨基甲酸酯，二氨基甲酸酯或脲基部分的C-1位具有醚键， 描述了甘油主链的2位，甘油骨架的C-3位上的磷酸胆碱，膦酰胆碱或糖苷部分。 还描述了在C-1位置具有萘酚部分的醚脂质的合成和抗增殖活性。 这些化合物被证明是癌细胞生长的有效抑制剂。 这些化合物可用于杀死癌细胞和治疗癌症。