-
1.发明授权Synthesis of glycerolipid carbamates and dicarbamates and their use as an antitumor compounds 失效甘油脂氨基甲酸酯和二氨基甲酸酯的合成及其作为抗肿瘤化合物的用途公开(公告)号：US08153615B2
公开(公告)日：2012-04-10
申请号：US11917025
申请日：2006-06-12
Applicant: Robert Bittman , Hoe-Sup Byun , Gilbert Arthur
Inventor： Robert Bittman , Hoe-Sup Byun , Gilbert Arthur
IPC: A01N57/26 , A61K31/685 , A01N43/04 , A61K31/70
CPC classification number: C07F9/4006
Abstract: The syntheses and in vitro antitumor properties of carbamate-containing, dicarbamate-containing, and ureido-containing phospholipid compounds that have an ether linkage at the C-1 position of a glycerol backbone, a carbamate, dicarbamate, or ureido moiety at the C-2 position of the glycerol backbone, and a phosphocholine, phosphonocholine, or glycoside moiety at the C-3 position of the glycerol backbone are described. The synthesis and antiproliferative activity of ether lipids with a naphthol moiety at the C-1 position are also described. These compounds were shown to be potent inhibitors of cancer cell growth. These compounds are useful for killing cancer cells and treating cancer.
Abstract translation: 含有氨基甲酸酯，含二氨基甲酸酯和含脲基的磷脂化合物的合成和体外抗肿瘤性质，其在C-末端的甘油骨架，氨基甲酸酯，二氨基甲酸酯或脲基部分的C-1位具有醚键， 描述了甘油主链的2位，甘油骨架的C-3位上的磷酸胆碱，膦酰胆碱或糖苷部分。 还描述了在C-1位置具有萘酚部分的醚脂质的合成和抗增殖活性。 这些化合物被证明是癌细胞生长的有效抑制剂。 这些化合物可用于杀死癌细胞和治疗癌症。
-
2.发明授权Enanitomers of unsaturated alkyllysophosphonocholines and use as anti-neoplastics 失效不饱和烷基亚磷酰胆碱的光学活性物质，用作抗肿瘤剂公开(公告)号：US07323601B2
公开(公告)日：2008-01-29
申请号：US10468766
申请日：2002-02-21
Applicant: Robert Bittman , Gilbert Arthur , Hoe-Sup Byun
Inventor： Robert Bittman , Gilbert Arthur , Hoe-Sup Byun
CPC classification number: C07F9/4015 , C07F9/4075
Abstract: Unsaturated alkyllysophosphonocholines compounds of formula (I) or (II): or pharmaceutically-acceptable salts, prodrugs or isomers thereof. The compounds of the invention have anti-neoplastic activity, and accordingly have utility in treating cancer and related diseases. The invention also provides enantiomers of these compounds, as well as synthetic methods for producing an enantiomer, substantially free of the other enantiomer. Also disclosed are pharmaceutical compositions, as well methods for treating cancer with the pharmaceutical compositions.
Abstract translation: 不饱和的式（I）或（II）的烷基亚磷酰胆碱化合物：或其药学上可接受的盐，前药或异构体。 本发明的化合物具有抗肿瘤活性，因此具有治疗癌症和相关疾病的效用。 本发明还提供这些化合物的对映异构体，以及用于制备基本上不含其它对映异构体的对映异构体的合成方法。 还公开了药物组合物以及用药物组合物治疗癌症的方法。
-
3.发明申请Enanitomers of unsaturated alkyllysophosphonocholines and use as anti-neoplastics 失效不饱和烷基亚磷酰胆碱的光学活性物质，用作抗肿瘤剂公开(公告)号：US20050014971A1
公开(公告)日：2005-01-20
申请号：US10468766
申请日：2002-02-21
Applicant: Robert Bittman , Gilbert Arthur , Hoe-Sup Byun
Inventor： Robert Bittman , Gilbert Arthur , Hoe-Sup Byun
CPC classification number: C07F9/4015 , C07F9/4075
Abstract: Unsaturated alkyllysophosphonocholines compounds of formula (I) or (II): or pharmaceutically-acceptable salts, prodrugs or isomers thereof. The compounds of the invention have anti-neoplastic activity, and accordingly have utility in treating cancer and related diseases. The invention also provides enantiomers of these compounds, as well as synthetic methods for producing an enantiomer, substantially free of the other enantiomer. Also disclosed are pharmaceutical compositions, as well methods for treating cancer with the pharmaceutical compositions.
Abstract translation: 不饱和的式（I）或（II）的烷基亚磷酰胆碱化合物：或其药学上可接受的盐，前药或异构体。 本发明的化合物具有抗肿瘤活性，因此具有治疗癌症和相关疾病的效用。 本发明还提供这些化合物的对映异构体，以及用于制备基本上不含其它对映异构体的对映异构体的合成方法。 还公开了药物组合物以及用药物组合物治疗癌症的方法。
-
4.发明申请Synthesis of Glycerolipid Carbamates and Dicarbamates and Their Use as an Antitumor Compounds 失效甘油脂质体和碳酸氢铵的合成及其作为抗肿瘤化合物的应用公开(公告)号：US20090042811A1
公开(公告)日：2009-02-12
申请号：US11917025
申请日：2006-06-12
Applicant: Robert Bittman , Hoe-Sup Byun , Gilbert Arthur
Inventor： Robert Bittman , Hoe-Sup Byun , Gilbert Arthur
IPC: A61K31/7008 , C07C271/06 , C07H3/02 , C07H15/02 , A61P35/00 , A61K31/27 , A61K31/70
CPC classification number: C07F9/4006
Abstract: The syntheses and in vitro antitumor properties of carbamate-containing, dicarbamate-containing, and ureido-containing phospholipid compounds that have an ether linkage at the C-1 position of a glycerol backbone, a carbamate, dicarbamate, or ureido moiety at the C-2 position of the glycerol backbone, and a phosphocholine, phosphonocholine, or glycoside moiety at the C-3 position of the glycerol backbone are described. The synthesis and antiproliferative activity of ether lipids with a naphthol moiety at the C-1 position are also described. These compounds were shown to be potent inhibitors of cancer cell growth. These compounds are useful for killing cancer cells and treating cancer.
Abstract translation: 含有氨基甲酸酯，含二氨基甲酸酯和含脲基的磷脂化合物的合成和体外抗肿瘤性质，其在C-末端的甘油骨架，氨基甲酸酯，二氨基甲酸酯或脲基部分的C-1位具有醚键， 描述了甘油主链的2位，甘油骨架的C-3位上的磷酸胆碱，膦酰胆碱或糖苷部分。 还描述了在C-1位置具有萘酚部分的醚脂质的合成和抗增殖活性。 这些化合物被证明是癌细胞生长的有效抑制剂。 这些化合物可用于杀死癌细胞和治疗癌症。
-
-
-
Search Results
4
records
(took 0.011 seconds)
