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    Protease activated cytokines
    1.
    发明授权
    Protease activated cytokines 有权
    蛋白酶活化细胞因子

    公开(公告)号：US08734774B2

    公开(公告)日：2014-05-27

    申请号：US13639006

    申请日：2011-03-31

    申请人： John G. Frelinger ,  John Puskas ,  Baek Kim ,  Mark Sullivan

    发明人： John G. Frelinger ,  John Puskas ,  Baek Kim ,  Mark Sullivan

    IPC分类号： A61K38/19 ,  A61K38/20

    CPC分类号： C07K19/00 ,  A61K38/00 ,  C07K14/55 ,  C07K2319/21 ,  C07K2319/50 ,  C07K2319/70

    摘要： Provided herein are chimeric nucleic acid sequences encoding chimeric polypeptides. Also provided herein are chimeric polypeptides. Further provided herein are methods of treating a subject with or at risk of developing a cancer. The methods comprise selecting a subject with or at risk of developing a cancer, and administering to the subject an effective amount of the chimeric polypeptides provided herein.

    摘要翻译： 本文提供编码嵌合多肽的嵌合核酸序列。 本文还提供嵌合多肽。 本文进一步提供了治疗患有癌症或具有发展癌症风险的受试者的方法。 所述方法包括选择具有或具有发展癌症风险的受试者，并向受试者施用有效量的本文提供的嵌合多肽。

    PROTEASE ACTIVATED CYTOKINES
    2.
    发明申请
    PROTEASE ACTIVATED CYTOKINES 有权
    PROTEASE激活细胞因子

    公开(公告)号：US20130089516A1

    公开(公告)日：2013-04-11

    申请号：US13639006

    申请日：2011-03-31

    申请人： John G. Frelinger ,  John Puskas ,  Baek Kim ,  Mark Sullivan

    发明人： John G. Frelinger ,  John Puskas ,  Baek Kim ,  Mark Sullivan

    IPC分类号： C07K19/00

    CPC分类号： C07K19/00 ,  A61K38/00 ,  C07K14/55 ,  C07K2319/21 ,  C07K2319/50 ,  C07K2319/70

    摘要： Provided herein are chimeric nucleic acid sequences encoding chimeric polypeptides. Also provided herein are chimeric polypeptides. Further provided herein are methods of treating a subject with or at risk of developing a cancer. The methods comprise selecting a subject with or at risk of developing a cancer, and administering to the subject an effective amount of the chimeric polypeptides provided herein.

    摘要翻译： 本文提供编码嵌合多肽的嵌合核酸序列。 本文还提供嵌合多肽。 本文进一步提供了治疗患有癌症或具有发展癌症风险的受试者的方法。 所述方法包括选择具有或具有发展癌症风险的受试者，并向受试者施用有效量的本文提供的嵌合多肽。

    Rocker arm assembly with an anti-inversion feature
    3.
    发明授权
    Rocker arm assembly with an anti-inversion feature 有权
    摇臂组件具有防反转功能

    公开(公告)号：US08534249B2

    公开(公告)日：2013-09-17

    申请号：US13230520

    申请日：2011-09-12

    申请人： Mark Sullivan ,  Jesse Myers ,  Richard Baker ,  William Carter

    发明人： Mark Sullivan ,  Jesse Myers ,  Richard Baker ,  William Carter

    IPC分类号： F01L1/183 ,  F01L1/185

    CPC分类号： F01L1/181 ,  F01L1/182 ,  F01L2103/00

    摘要： The rocker arm assembly has an anti-inversion part that prevents a support pin from inverting, ensuring proper orientation of the support pin, on which a rocker arm is rotatably mounted, is maintained. The anti-inversion part can be a washer, a plate, a plug, or a sleeve. The washer, which has a flat face and a curved face, is intended for use with a cylindrical support pin which matches the curved face of the washer. The plate can include various combinations of tabs, flanges, and/or protrusions that extend in different directions. The plug can resemble any desirable shape, and is removed prior to final assembly. The sleeve can be hollow and is removable.

    摘要翻译： 摇臂组件具有防反转部分，其防止支撑销反转，确保保持摇臂的可旋转地安装的支撑销的正确定向。 防反转部分可以是垫圈，板，插头或套筒。 具有平坦表面和弯曲表面的垫圈旨在用于与垫圈的曲面匹配的圆柱形支撑销。 板可以包括在不同方向上延伸的突片，凸缘和/或突起的各种组合。 塞子可以类似于任何期望的形状，并且在最终组装之前被移除。 套筒可以是中空的并且是可移动的。

    MOBILE WIRELESS DEVICE WITH AN EMBEDDED MEDIA PLAYER
    6.
    发明申请
    MOBILE WIRELESS DEVICE WITH AN EMBEDDED MEDIA PLAYER 审中-公开
    具有嵌入式媒体播放器的移动无线设备

    公开(公告)号：US20110105182A1

    公开(公告)日：2011-05-05

    申请号：US12988338

    申请日：2009-04-20

    申请人： Philip Sant ,  Michael Lamb ,  Mark Sullivan ,  Stephen Pocock ,  Lucien Rawden

    发明人： Philip Sant ,  Michael Lamb ,  Mark Sullivan ,  Stephen Pocock ,  Lucien Rawden

    IPC分类号： H04W88/02

    CPC分类号： G06F16/4387 ,  G06F16/437 ,  G06F16/447

    摘要： A mobile wireless device includes an embedded media player; the functionality of the media player has been extended by integrating a third party application with the media player, the third party application supporting an unlimited music subscription service. Hence, the invention is based on the insight that a third party application that can provide access to an unlimited music subscription service, such as the MusicStation media player, can be integrated with an embedded media player in a mobile wireless device. The device then behaves as though the functionality of the media player has been extended, but without the extensive engineering effort needed to re-write the embedded media payer so that it can itself provide access to the unlimited music subscription service.

    摘要翻译： 移动无线设备包括嵌入式媒体播放器; 通过将第三方应用与媒体播放器集成，支持无限音乐订阅服务的第三方应用来扩展媒体播放器的功能。 因此，本发明基于以下认识：可以提供对无限音乐订阅服务（例如MusicStation媒体播放器）的访问的第三方应用可以与移动无线设备中的嵌入式媒体播放器集成。 然后，该设备的行为就好像扩展了媒体播放器的功能，但是没有需要大量的工程努力来重新编写嵌入式媒体付款人，使得它本身可以提供对无限音乐订阅服务的访问。

    DIRECT COMBINATION OF FIBER OPTIC LIGHT BEAMS
    7.
    发明申请
    DIRECT COMBINATION OF FIBER OPTIC LIGHT BEAMS 有权
    光纤光束的直接组合

    公开(公告)号：US20050270542A1

    公开(公告)日：2005-12-08

    申请号：US09933606

    申请日：2001-08-20

    申请人： Mark Sullivan ,  Carol Courville ,  Paul Zorabedian ,  Kerry Bagwell ,  David Kittell

    发明人： Mark Sullivan ,  Carol Courville ,  Paul Zorabedian ,  Kerry Bagwell ,  David Kittell

    IPC分类号： G01B9/02 ,  G02B26/08 ,  G02B27/28 ,  G02F2/02

    CPC分类号： G01B9/02007 ,  G01B9/02003 ,  G01B2290/45 ,  G01B2290/70

    摘要： A manipulator for a fiber optic cable assembly (FOCA) provides microradian accuracy in control of the direction of a beam emanating from the FOCA. Such manipulators can control FOCAs to control the incidence angles of beams at a beam combiner in a beam-combining unit. Accordingly, fewer additional optical elements are required for control of input paths in the beam-combining unit. The manipulator and the beam-combining unit are accurate enough for use in an interferometer that combines beams with different frequencies and polarizations. One such interferometer includes a Zeeman split laser providing a heterodyne beam. A beam splitter separates frequency components of the beams, and AOMs increase the frequency separation between the separated beams. The separated beams can be sent via optical fibers to the beam-combining unit, which combines the beams for use in interferometer optics.

    摘要翻译： 用于光纤电缆组件（FOCA）的操纵器提供微控制精度来控制从FOCA发射的光束的方向。 这样的操纵器可以控制FOCA来控制波束组合单元中的波束组合器处的波束的入射角。 因此，需要更少的附加光学元件来控制光束组合单元中的输入路径。 操纵器和光束组合单元足够准确地用于组合具有不同频率和偏振的光束的干涉仪。 一种这样的干涉仪包括提供外差光束的塞曼分割激光器。 分束器分离光束的频率分量，并且AOM增加分离的光束之间的频率间隔。 分离的光束可以通过光纤发送到光束组合单元，其组合用于干涉仪光学元件的光束。

    System and method for fast acquisition position reporting using communication satellite range measurement
    8.
    发明申请
    System and method for fast acquisition position reporting using communication satellite range measurement 有权
    使用通信卫星测距的快速采集位置报告的系统和方法

    公开(公告)号：US20050171695A1

    公开(公告)日：2005-08-04

    申请号：US11030983

    申请日：2005-01-10

    申请人： Mark Sullivan ,  James Kifeather

    发明人： Mark Sullivan ,  James Kifeather

    IPC分类号： G01S5/00 ,  G01S5/14 ,  G01S19/48 ,  G01C21/26

    CPC分类号： G01S19/09 ,  G01S5/0036 ,  G01S5/14 ,  G01S19/256 ,  G01S19/40

    摘要： A geographic tracking system with minimal power and size required at the mobile terminal collects observation data at the mobile terminal, forwards the data to a processor, which calculates the position. The mobile terminal needs only to gather a few milliseconds of observation data, and to relay this observation data to the processor. The range from the satellite (or other airborne transponder) to the terminal is determined using the known positions of an interrogating transmitter and a satellite, and a known terminal delay between the received signal and the transmission of the return signal, and the round trip time. An arc of locations is determined by computing an intersection of a sphere centered at the satellite having a radius given by the calculated range with a model of the Earth's surface. The candidate points are considered and refined using code phase measurements from a set of GPS satellites. The candidate point having the lowest residuals or expected to measured code phases is chosen as the location of the mobile terminal. The measurements can be refined to account for various sources of error including measurement bias, relative motion and timing errors.

    摘要翻译： 移动终端所需的功率和尺寸最小的地理跟踪系统在移动终端收集观测数据，将数据转发到计算位置的处理器。 移动终端仅需要收集几毫秒的观测数据，并将该观测数据中继到处理器。 使用询问发射机和卫星的已知位置以及接收信号与返回信号的发送之间的已知终端延迟以及往返时间来确定从卫星（或其他机载应答器）到终端的范围 。 通过计算以具有由计算范围给出的半径的卫星为中心的球体与地球表面的模型的交点来确定位置弧。 使用一组GPS卫星的码相位测量来考虑和改进候选点。 选择具有最低残差或预期测量码相位的候选点作为移动终端的位置。 可以对测量结果进行细化以解决各种误差源，包括测量偏差，相对运动和定时误差。