公开(公告)号：US4802913A

公开(公告)日：1989-02-07

申请号：US893272

申请日：1986-08-05

申请人： John Clough ,  Christopher R. A. Godfrey

发明人： John Clough ,  Christopher R. A. Godfrey

IPC分类号： C07C253/00 ,  A01N37/34 ,  A01N37/36 ,  A01N37/38 ,  A01N37/42 ,  A01N37/44 ,  A01N37/46 ,  A01N37/48 ,  A01N39/00 ,  A01N39/02 ,  A01N43/40 ,  C07C67/00 ,  C07C69/618 ,  C07C69/734 ,  C07C229/30 ,  C07C229/44 ,  C07C233/15 ,  C07C233/25 ,  C07C233/43 ,  C07C233/54 ,  C07C235/42 ,  C07C237/30 ,  C07C255/54 ,  C07C255/57 ,  C07C313/00 ,  C07C323/54 ,  C07C323/62 ,  C07C323/63 ,  C07C325/00 ,  C07D207/323 ,  C07D213/30 ,  C07D213/64 ,  C07D307/38 ,  C07D307/54 ,  C07D333/14 ,  C07D333/24 ,  C07D333/54 ,  A01N37/10

CPC分类号： C07C321/00 ,  A01N37/36 ,  A01N37/44 ,  A01N39/00 ,  A01N39/02 ,  A01N43/40 ,  C07C323/00

摘要： Compounds of formula (I): ##STR1## and stereoisomers thereof, wherein V is an oxygen or a sulphur atom; X and Y, which may be the same or different, are hydrogen or halogen atoms, or optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkynyl, haloalkyl, alkoxy, haloalkoxy, optionally substituted aryloxy, optionally substituted arylalkoxy, optionally substituted acyloxy, optionally substituted amino, acylamino, nitro, nitrile, --CO.sub.2 R.sup.3, --CONR.sup.4 R.sup.5, or --COR.sup.6 groups; or the groups X and Y, when they are in adjacent positions on the phenyl ring, may join to form a fused ring, either aromatic or aliphatic, optionally containing one or more heteroatoms; and Z is optionally substituted methylene, optionally substituted amino, oxygen or sulphur and when Z is a substituted methylene group, the substituent may join the 2-position of the phenyl ring to form a non-aromatic fused ring; R.sup.1 and R.sup.2 are alkyl groups containing from one to four carbon atoms, optionally substituted with one or more halogen atoms; and R.sup.3, R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, are hydrogen atoms or optionally substituted alkyl, cycloalkyl, alkenyl, alkynyl, optionally substituted aryl, optionally substituted aralkyl, or cycloalkylalkyl groups; and metal complexes thereof.

摘要翻译： 式（I）化合物：其中V是氧或硫原子; X和Y可以相同或不同，是氢或卤素原子，或任选取代的烷基，任选取代的烯基，任选取代的芳基，任选取代的杂芳基，任选取代的炔基，卤代烷基，烷氧基，卤代烷氧基，任选取代的芳氧基， 取代的芳基烷氧基，任选取代的酰氧基，任选取代的氨基，酰氨基，硝基，腈，-CO 2 R 3，-CONR 4 R 5或-COR 6基团; 或基团X和Y当它们在苯环上的相邻位置时，可以连接形成任选含有一个或多个杂原子的芳族或脂族稠合的稠环; Z是任选取代的亚甲基，任选取代的氨基，氧或硫，当Z是取代的亚甲基时，取代基可以连接苯环的2-位，形成非芳香稠环; R1和R2是含有1-4个碳原子的烷基，任选地被一个或多个卤素原子取代; 可以相同或不同的R 3，R 4，R 5和R 6是氢原子或任选取代的烷基，环烷基，烯基，炔基，任选取代的芳基，任选取代的芳烷基或环烷基烷基; 及其金属络合物。

公开(公告)号：US20110144654A1

公开(公告)日：2011-06-16

申请号：US13031310

申请日：2011-02-21

申请人： Thomas L. Isaacs ,  Hayden Beatty ,  John Clough

发明人： Thomas L. Isaacs ,  Hayden Beatty ,  John Clough

IPC分类号： A61F9/007

CPC分类号： A61M37/0069 ,  A61F2/1616 ,  A61F2/167 ,  A61F2/1678 ,  A61F2/1691

摘要： A shipping system for a medical device, such as implantable lens for an eye, is provided that may be reconfigured from a shipping mode into an injection mode without manually handling the contained lens or other device. Upon manufacture, a lens may be placed within the system assembly in the shipping configuration. While in the shipping configuration, the lens is kept in its desired shape and within a selected environment. Upon arrival at the destination, the user may attach a nozzle assembly for injecting the device into a body. The process of changing from the shipping to the injection mode deforms the device into a shape suitable for injection. A new assembly for a medical device utilizing the shipping systems is also disclosed. The insertion assembly includes a body for containing the medical device, a plunger casing, a finger-engaging flange, and a resilient ring member all of which are formed as a single piece assembly. Additionally a nozzle assembly may be integrally formed with the insertion assembly or formed as a separate body that is attachable to the insertion assembly.

摘要翻译： 提供用于医疗装置的运输系统，例如用于眼睛的可植入透镜，其可以从运送模式重新配置为注射模式，而不手动处理容纳的透镜或其它装置。 在制造时，透镜可以在运输配置中放置在系统组件内。 在装运配置中，透镜保持在其所需的形状和选定的环境中。 在到达目的地时，用户可以附接用于将装置注射到体内的喷嘴组件。 从运输到喷射模式的变化使设备变形成适合注射的形状。 还公开了一种用于使用运输系统的医疗装置的新组件。 插入组件包括用于容纳医疗装置的主体，柱塞壳体，指接合凸缘和弹性环构件，所有弹性环构件都形成为单件组件。 另外，喷嘴组件可以与插入组件一体地形成或形成为可附接到插入组件的单独主体。

公开(公告)号：US20060279697A1

公开(公告)日：2006-12-14

申请号：US11452134

申请日：2006-06-13

申请人： John Clough ,  Edwin Sarver ,  Donald Sanders

发明人： John Clough ,  Edwin Sarver ,  Donald Sanders

IPC分类号： G02C7/02

CPC分类号： A61F2/1613 ,  A61B3/0025 ,  A61F2/16

摘要： An intraocular lens, with equal conic surfaces, is intended to replace the crystalline lens in the posterior chamber of a patient's eye, in particular after a cataract extraction. The lens provides optical power to focus objects onto a patient's retina. In addition the lens surfaces are shaped to reduce optical aberrations at the retina and are tolerant to lens tilt and decentration within the eye. The lens is designed to have zero longitudinal ray aberrations at a specific ray height.

摘要翻译： 具有相同圆锥曲面的眼内透镜旨在取代患者眼睛的后室中的晶状体，特别是在白内障摘除后。 透镜提供光焦度以将物体聚焦到患者的视网膜上。 此外，镜片表面被成形为减少视网膜处的光学像差，并且能够容忍眼睛内的镜片倾斜和偏心。 透镜被设计为在特定射线高度处具有零纵向射线像差。

公开(公告)号：US4496242A

公开(公告)日：1985-01-29

申请号：US333261

申请日：1981-12-22

申请人： John Clough ,  Henry H. Hollidge

发明人： John Clough ,  Henry H. Hollidge

IPC分类号： G01M11/02 ,  G01N21/01

CPC分类号： G01M11/0221

摘要： A device for positioning the curved surface of a lens beneath a radiuscope provides a variable distance between the lens surface and a pivot point for the lens to thereby accommodate lenses having different curvature radii. The device includes a pair of X- and Y-axis slides for providing adjustment of the lens in a horizontal plane. A first Z-axis slide connected to the X- and Y-axis slides enables the height of the lens relative to the radiuscope to be varied. A second Z-axis slide is pivotably attached to the first Z-axis slide. The lens to be examined is accommodated in a lens holder that is attached to the second Z-axis slide. Movement of the second slide along its translational axis varies the distance between the lens and the pivot point for the slide. Once this distance is set to a value equal to the radius of curvature of the lens being examined, the second slide can be rotated about its pivot point to enable the entire surface of the lens to be examined under the radiuscope without the need to refocus the scope upon repositioning of the lens.

摘要翻译： 用于将透镜的弯曲表面定位在辐射计之下的装置提供透镜表面和用于透镜的枢转点之间的可变距离，从而容纳具有不同曲率半径的透镜。 该装置包括一对X轴和Y轴滑块，用于在水平面中提供透镜的调节。 连接到X轴和Y轴滑块的第一个Z轴滑块可以使透镜相对于放射线的高度变化。 第二Z轴滑块可枢转地附接到第一Z轴滑块。 要检查的镜片容纳在附接到第二Z轴滑块的透镜保持器中。 第二滑块沿着其平移轴线的运动改变了透镜和滑块的枢转点之间的距离。 一旦该距离被设定为等于所检查的透镜的曲率半径的值，则第二滑动件可以围绕其枢转点旋转，以使透镜的整个表面能够被检查，而不需要重新聚焦 范围重新定位镜头。

公开(公告)号：US20100036385A1

公开(公告)日：2010-02-11

申请号：US12554345

申请日：2009-09-04

申请人： Thomas L. Isaacs ,  Hayden Beatty ,  William B. Wright ,  John Clough

发明人： Thomas L. Isaacs ,  Hayden Beatty ,  William B. Wright ,  John Clough

IPC分类号： A61F9/007

CPC分类号： A61F2/1664 ,  A61F2/1616 ,  A61F2/1691 ,  A61M37/0069

摘要： A shipping system for a medical device, such as implantable lens for an eye, is provided that may be reconfigured from a shipping mode into an injection mode without manually handling the contained lens or other device. Upon manufacture, a lens may be placed within the system assembly in the shipping configuration. While in the shipping configuration, the lens is kept in its desired shape and within a selected environment. Upon arrival at the destination, the user may attach fittings for injection of the device into a body. The process of changing from the shipping to the injection mode deforms the device into a shape suitable for injection. A new assembly for insertion of a medical device utilizing the shipping systems is also disclosed.

摘要翻译： 提供用于医疗装置的运输系统，例如用于眼睛的可植入透镜，其可以从运送模式重新配置为注射模式，而不手动处理容纳的透镜或其它装置。 在制造时，透镜可以在运输配置中放置在系统组件内。 在装运配置中，透镜保持在其所需的形状和选定的环境中。 在到达目的地时，用户可以将用于将装置注射的配件附接到体内。 从运输到喷射模式的变化使设备变形成适合注射的形状。 还公开了一种用于插入使用运输系统的医疗装置的新组件。

公开(公告)号：US09149619B2

公开(公告)日：2015-10-06

申请号：US13031310

申请日：2011-02-21

申请人： Thomas L. Isaacs ,  Hayden Beatty ,  John Clough

发明人： Thomas L. Isaacs ,  Hayden Beatty ,  John Clough

IPC分类号： A61F2/16 ,  A61M37/00

CPC分类号： A61M37/0069 ,  A61F2/1616 ,  A61F2/167 ,  A61F2/1678 ,  A61F2/1691

摘要： A shipping system for a medical device, such as implantable lens for an eye, is provided that may be reconfigured from a shipping mode into an injection mode without manually handling the contained lens or other device. Upon manufacture, a lens may be placed within the system assembly in the shipping configuration. Upon arrival at the destination, the user may attach a nozzle assembly for injecting the device into a body. A new assembly for a medical device utilizing the shipping systems is also disclosed. The insertion assembly includes a body for containing the medical device, a plunger casing, a finger-engaging flange, and a resilient ring member all of which are formed as a single piece assembly. Additionally a nozzle assembly may be integrally formed with the insertion assembly or formed as a separate body that is attachable to the insertion assembly.

摘要翻译： 提供用于医疗装置的运输系统，例如用于眼睛的可植入透镜，其可以从运送模式重新配置为注射模式，而不手动处理容纳的透镜或其它装置。 在制造时，透镜可以在运输配置中放置在系统组件内。 在到达目的地时，用户可以附接用于将装置注射到体内的喷嘴组件。 还公开了一种用于使用运输系统的医疗装置的新组件。 插入组件包括用于容纳医疗装置的主体，柱塞壳体，指接合凸缘和弹性环构件，所有弹性环构件都形成为单件组件。 另外，喷嘴组件可以与插入组件一体地形成或形成为可附接到插入组件的单独主体。

公开(公告)号：US08518110B2

公开(公告)日：2013-08-27

申请号：US12554345

申请日：2009-09-04

申请人： Thomas L. Isaacs ,  Hayden Beatty ,  William B. Wright ,  John Clough

发明人： Thomas L. Isaacs ,  Hayden Beatty ,  William B. Wright ,  John Clough

IPC分类号： A61F2/16 ,  A61F9/00

CPC分类号： A61F2/1664 ,  A61F2/1616 ,  A61F2/1691 ,  A61M37/0069

摘要： A shipping system for a medical device, such as implantable lens for an eye, is provided that may be reconfigured from a shipping mode into an injection mode without manually handling the contained lens or other device. Upon manufacture, a lens may be placed within the system assembly in the shipping configuration. While in the shipping configuration, the lens is kept in its desired shape and within a selected environment. Upon arrival at the destination, the user may attach fittings for injection of the device into a body. The process of changing from the shipping to the injection mode deforms the device into a shape suitable for injection. A new assembly for insertion of a medical device utilizing the shipping systems is also disclosed.

摘要翻译： 提供用于医疗装置的运送系统，例如用于眼睛的可植入透镜，其可以从运送模式重新配置为注射模式，而不手动处理容纳的透镜或其它装置。 在制造时，透镜可以在运输配置中放置在系统组件内。 在装运配置中，透镜保持在其所需的形状和选定的环境中。 在到达目的地时，用户可以将用于将装置注射的配件附接到体内。 从运输到喷射模式的变化使设备变形成适合注射的形状。 还公开了一种用于插入使用运输系统的医疗装置的新组件。

公开(公告)号：US20060206206A1

公开(公告)日：2006-09-14

申请号：US11384998

申请日：2006-03-20

申请人： Gholam Peyman ,  Edwin Sarver ,  John Clough ,  Hayden Beatty

发明人： Gholam Peyman ,  Edwin Sarver ,  John Clough ,  Hayden Beatty

IPC分类号： A61F2/16

CPC分类号： A61F2/1648 ,  A61F2/1651 ,  A61F2250/0053 ,  A61F2250/0065

摘要： The present invention relates to an intraocular lens, including a first lens having a first portion configured to alter light rays passing therethrough in a first manner and form a first image in an eye and a second portion adjacent said first portion. A second lens is coupled to the first lens and a third lens coupled to at least one of the first lens and the second lens. The second lens, third lens and second portion are configured in series such that the lenses from a telescope that alters light rays in a second manner and forms a second image in the eye.

摘要翻译： 眼内透镜技术领域本发明涉及一种眼内透镜，其包括具有第一部分的第一透镜，第一部分被配置为以第一方式改变穿过其中的光线并且在眼睛中形成第一图像和与所述第一部分相邻的第二部分。 第二透镜耦合到第一透镜和耦合到第一透镜和第二透镜中的至少一个透镜的第三透镜。 第二透镜，第三透镜​​和第二部分被串联配置，使得来自望远镜的透镜以第二种方式改变光线并在眼睛中形成第二图像。

公开(公告)号：US20140128971A1

公开(公告)日：2014-05-08

申请号：US13671900

申请日：2012-11-08

申请人： John Clough

发明人： John Clough

IPC分类号： A61F2/16

CPC分类号： A61F2/1618 ,  A61F2/16 ,  A61F2/1613 ,  A61F2/164 ,  A61F2/1648 ,  A61F2002/1689 ,  A61F2250/0053

摘要： A multifocal intraocular lens has an anterior lens surface which includes a first optic of a first radius and a second optic of a different radius. The posterior surface of the lens include an aspheric surface.

摘要翻译： 多焦点人工晶状体具有前透镜表面，其包括第一半径的第一光学元件和不同半径的第二光学元件。 透镜的后表面包括非球面。

公开(公告)号：US07350918B2

公开(公告)日：2008-04-01

申请号：US11452134

申请日：2006-06-13

申请人： John Clough ,  Edwin J. Sarver ,  Donald R. Sanders

发明人： John Clough ,  Edwin J. Sarver ,  Donald R. Sanders

IPC分类号： G02C7/02

CPC分类号： A61F2/1613 ,  A61B3/0025 ,  A61F2/16

摘要： An intraocular lens, with equal conic surfaces, is intended to replace the crystalline lens in the posterior chamber of a patient's eye, in particular after a cataract extraction. The lens provides optical power to focus objects onto a patient's retina. In addition the lens surfaces are shaped to reduce optical aberrations at the retina and are tolerant to lens tilt and decentration within the eye. The lens is designed to have zero longitudinal ray aberrations at a specific ray height.

摘要翻译： 具有相同圆锥曲面的眼内透镜旨在取代患者眼睛的后室中的晶状体，特别是在白内障摘除后。 透镜提供光焦度以将物体聚焦到患者的视网膜上。 此外，镜片表面被成形为减少视网膜处的光学像差，并且能够容忍眼睛内的镜片倾斜和偏心。 透镜被设计为在特定射线高度处具有零纵向射线像差。