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公开(公告)号：US20130303544A1
公开(公告)日：2013-11-14
申请号：US13977149
申请日：2011-12-21
Applicant: Hongxia Ding , Kun Meng , Jin Li
Inventor： Hongxia Ding , Kun Meng , Jin Li
IPC: C07D311/28 , C07D417/04 , C07D405/04 , C07D407/04
CPC classification number: C07D311/28 , C07D311/30 , C07D311/54 , C07D311/60 , C07D311/76 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04
Abstract: The present invention provides a kind of benzopyrone compounds having a structure of formula (I) and the pharmaceutically acceptable salts or prodrugs thereof, and the pharmaceutical compositions containing such compounds, which can be used to regulate the novel estrogen receptor ER-a36, and prevent and/or treat the related diseases mediated by the ER-a36 receptor, such as cancers, etc.
Abstract translation: 本发明提供一种具有式（I）结构的苯并吡喃酮化合物及其药学上可接受的盐或前药，以及含有这些化合物的药物组合物，其可用于调节新型雌激素受体ER-a36，并防止 和/或治疗由ER-a36受体介导的相关疾病，例如癌症等。
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2.发明授权公开(公告)号：US08252835B2
公开(公告)日：2012-08-28
申请号：US11877575
申请日：2007-10-23
CPC classification number: A61K31/352
Abstract: Provided herein in certain embodiments are compounds, pharmaceutical compositions and methods for modulating the functions of estrogen receptor alpha 36, for preventing and/or treating diseases related to estrogen receptor alpha 36, for preventing and/or treating respiratory diseases such as asthma, for inducing cell death and/or inhibiting cell proliferation and for preventing and/or treating diseases involving abnormal cell proliferation such as cancers.
Abstract translation: 在某些实施方案中提供的化合物，药物组合物和调节雌激素受体α36功能的方法，用于预防和/或治疗与雌激素受体α36相关的疾病，用于预防和/或治疗呼吸系统疾病如哮喘，用于诱导 细胞死亡和/或抑制细胞增殖并预防和/或治疗涉及异常细胞增殖的疾病如癌症。
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3.发明申请公开(公告)号：US20110311517A1
公开(公告)日：2011-12-22
申请号：US13148669
申请日：2010-02-10
IPC: A61K39/395 , C07K16/46 , C07K17/02 , C12N15/13 , C12N15/63 , C12P21/08 , C12N1/15 , C12N1/19 , C12N5/10 , C12N1/21 , A61K47/48 , C12N5/00 , A61P19/08 , A61P3/06 , A61P9/00 , A61P9/10 , A61P15/00 , A61P25/24 , A61P37/04 , A61P35/00 , A61P29/00 , A61P11/06 , G01N33/566 , C07K16/00
CPC classification number: C07K16/2869 , A61K31/138 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92
Abstract: Provided herein in certain embodiments are antibodies, antibody fragments, pharmaceutical compositions, methods for modulating the functions of estrogen receptor alpha 36, and methods for preventing and/or treating diseases mediated by estrogen receptor alpha 36.
Abstract translation: 本文在某些实施方案中提供了抗体，抗体片段，药物组合物，调节雌激素受体α36功能的方法，以及用于预防和/或治疗由雌激素受体α36介导的疾病的方法。
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Patent Agency Ranking
4.发明申请公开(公告)号：US20080146658A1
公开(公告)日：2008-06-19
申请号：US11877575
申请日：2007-10-23
IPC: A61K31/352 , A61P35/00
CPC classification number: A61K31/352
Abstract: Provided herein in certain embodiments are compounds, pharmaceutical compositions and methods for modulating the functions of estrogen receptor alpha 36, for preventing and/or treating diseases related to estrogen receptor alpha 36, for preventing and/or treating respiratory diseases such as asthma, for inducing cell death and/or inhibiting cell proliferation and for preventing and/or treating diseases involving abnormal cell proliferation such as cancers.
Abstract translation: 在某些实施方案中提供的化合物，药物组合物和调节雌激素受体α36功能的方法，用于预防和/或治疗与雌激素受体α36相关的疾病，用于预防和/或治疗呼吸系统疾病如哮喘，用于诱导 细胞死亡和/或抑制细胞增殖并预防和/或治疗涉及异常细胞增殖的疾病如癌症。
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公开(公告)号：US09090583B2
公开(公告)日：2015-07-28
申请号：US13977149
申请日：2011-12-21
Applicant: Hongxia Ding , Kun Meng , Jin Li
Inventor： Hongxia Ding , Kun Meng , Jin Li
IPC: C07D311/28 , C07D417/04 , C07D405/04 , C07D407/04 , C07D311/30 , C07D311/54 , C07D311/60 , C07D311/76 , C07D409/04 , C07D413/04
CPC classification number: C07D311/28 , C07D311/30 , C07D311/54 , C07D311/60 , C07D311/76 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04
Abstract: The present invention provides a kind of benzopyrone compounds having a structure of formula (I) and the pharmaceutically acceptable salts or prodrugs thereof, and the pharmaceutical compositions containing such compounds, which can be used to regulate the novel estrogen receptor ER-a36, and prevent and/or treat the related diseases mediated by the ER-a36 receptor, such as cancers, etc.
Abstract translation: 本发明提供一种具有式（I）结构的苯并吡喃酮化合物及其药学上可接受的盐或前药，以及含有这些化合物的药物组合物，其可用于调节新型雌激素受体ER-a36，并防止 和/或治疗由ER-a36受体介导的相关疾病，例如癌症等。
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6.发明申请公开(公告)号：US20100016352A1
公开(公告)日：2010-01-21
申请号：US12558392
申请日：2009-09-11
IPC: A61K31/47 , A61K31/353 , A61P35/00
CPC classification number: A61K31/35
Abstract: Provided herein in certain embodiments are compounds, pharmaceutical compositions and methods for modulating the functions of estrogen receptor alpha 36, for preventing and/or treating diseases mediated by estrogen receptor alpha 36, for preventing and/or treating osteoporosis, for inducing cell death and/or inhibiting cell proliferation and for preventing and/or treating diseases involving abnormal cell proliferation such as cancers.
Abstract translation: 本文在某些实施方案中提供化合物，药物组合物和调节雌激素受体α36功能的方法，用于预防和/或治疗由雌激素受体α36介导的疾病，用于预防和/或治疗骨质疏松症，用于诱导细胞死亡和/ 或抑制细胞增殖并预防和/或治疗涉及异常细胞增殖的疾病如癌症。
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公开(公告)号：US08455620B2
公开(公告)日：2013-06-04
申请号：US12298948
申请日：2006-04-30
Applicant: Bin Yao , Huiying Luo , Huoqing Huang , Yaru Wang , Tiezheng Yuan , Xiuyun Shi , Yingguo Bai , Kun Meng , Peilong Yang
Inventor： Bin Yao , Huiying Luo , Huoqing Huang , Yaru Wang , Tiezheng Yuan , Xiuyun Shi , Yingguo Bai , Kun Meng , Peilong Yang
IPC: C07K14/195
CPC classification number: C07K14/195 , A23K20/189 , A23K50/00 , C12N9/16 , Y10S530/825
Abstract: The present invention relates to a novel phytase enzyme, a novel isolated nucleic acid molecule coding the enzyme, and a novel Yersinia intermedia having phytase activity. Particularly, the present invention relates to the phytase having (a) Theoretical molecular weight 45.5 kDa, (b) high specific activity 3960±248 U/mg, (c) high stability at high temperature and wide pH, (d) optimal pH of 4.0-5.0, (e) optimal temperature of 50-60° C., (f) high resistance to pepsin and trypsin. The phytase is very suitable to be used in feed of monogastrics as feed additive. The present invention also relates to a recombinant vector comprising said nucleic acid molecule, a recombinant host cell (e.g., Pichia pastoris) harboring said recombinant vector, and a method for producing phytase using the recombinant host cell. The present invention further provides a feed additive comprising said phytase and/or host cells expressing a phytase as effective ingredient. In addition, the present invention provides a novel method for isolating phytase from a target organism.
Abstract translation: 本发明涉及一种新的植酸酶，一种编码该酶的新的分离的核酸分子，以及具有植酸酶活性的新颖的中间叶耶尔森菌。 特别地，本发明涉及具有（a）理论分子量45.5kDa，（b）高比活性3960±248U / mg的植酸酶，（c）在高温和宽pH下的高稳定性，（d）最佳pH 4.0-5.0，（e）50-60℃的最佳温度，（f）对胃蛋白酶和胰蛋白酶的高抗性。 植酸酶非常适合用作饲料添加剂的单胃饲料。 本发明还涉及包含所述核酸分子的重组载体，携带所述重组载体的重组宿主细胞（例如巴斯德毕赤酵母），以及使用重组宿主细胞产生肌醇六磷酸酶的方法。 本发明还提供一种饲料添加剂，其包含表达植酸酶作为有效成分的所述植酸酶和/或宿主细胞。 此外，本发明提供了从目标生物体中分离植酸酶的新方法。
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公开(公告)号：US20100092613A1
公开(公告)日：2010-04-15
申请号：US12298948
申请日：2006-04-30
Applicant: Bin Yao , Huiying Luo , Huoqing Huang , Yaru Wang , Tiezheng Yuan , Xiuyun Shi , Yingguo Bai , Kun Meng , Peilong Yang
Inventor： Bin Yao , Huiying Luo , Huoqing Huang , Yaru Wang , Tiezheng Yuan , Xiuyun Shi , Yingguo Bai , Kun Meng , Peilong Yang
CPC classification number: C07K14/195 , A23K20/189 , A23K50/00 , C12N9/16 , Y10S530/825
Abstract: The present invention relates to a novel phytase enzyme, a novel isolated nucleic acid molecule coding the enzyme, and a novel Yersinia intermedia having phytase activity. Particularly, the present invention relates to the phytase having (a) Theoretical molecular weight 45.5 kDa, (b) high specific activity 3960±248 U/mg, (c) high stability at high temperature and wide pH, (d) optimal pH of 4.0-5.0, (e) optimal temperature of 50-60° C., (f) high resistance to pepsin and trypsin. The phytase is very suitable to be used in feed of monogastrics as feed additive. The present invention also relates to a recombinant vector comprising said nucleic acid molecule, a recombinant host cell (e.g., Pichia pastoris) harboring said recombinant vector, and a method for producing phytase using the recombinant host cell. The present invention further provides a feed additive comprising said phytase and/or host cells expressing a phytase as effective ingredient. In addition, the present invention provides a novel method for isolating phytase from a target organism.
Abstract translation: 本发明涉及一种新的植酸酶，一种编码该酶的新的分离的核酸分子，以及具有植酸酶活性的新颖的中间叶耶尔森菌。 特别地，本发明涉及具有（a）理论分子量45.5kDa，（b）高比活性3960±248U / mg的植酸酶，（c）在高温和宽pH下的高稳定性，（d）最佳pH 4.0-5.0，（e）50-60℃的最佳温度，（f）对胃蛋白酶和胰蛋白酶的高抗性。 植酸酶非常适合用作饲料添加剂的单胃饲料。 本发明还涉及包含所述核酸分子的重组载体，携带所述重组载体的重组宿主细胞（例如巴斯德毕赤酵母），以及使用重组宿主细胞产生肌醇六磷酸酶的方法。 本发明还提供一种饲料添加剂，其包含表达植酸酶作为有效成分的所述植酸酶和/或宿主细胞。 此外，本发明提供了从目标生物体中分离植酸酶的新方法。
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