公开(公告)号：US11213557B2

公开(公告)日：2022-01-04

申请号：US17019900

申请日：2020-09-14

Applicant: Jiangnan University

Inventor： Gang Wang ,  Wei Chen ,  Qian Chen ,  Jianxin Zhao ,  Hao Zhang

IPC: A61K35/747 ,  A61K35/00 ,  A23L29/00 ,  C12R1/25

Abstract: The disclosure herein discloses L. plantarum CCFM1019, fermented foods thereof, and application thereof in preparation of a medicine for promoting excretion of plasticizers and metabolites thereof from the body. The L. plantarum CCFM1019 not only is significantly better than the intestinal resident bacteria E. coli and E. faecalis in terms of the effect of promoting the excretion of DEHP and MEHP, but also is better than the commercial strain L. rhamnosus LGG. Therefore, the L. plantarum CCFM1019 of the disclosure can be used as an effective means to prevent and alleviate body damage caused by DEHP and MEHP, and has no toxic side effects of drugs. L. plantarum CCFM1019 can be used to prepare pharmaceutical compositions and fermented foods for alleviating and preventing the toxicity of DEHP and metabolites thereof, and has a very broad application prospect.

公开(公告)号：US11191728B2

公开(公告)日：2021-12-07

申请号：US16928186

申请日：2020-07-14

Applicant: JIANGNAN UNIVERSITY

Inventor： Caihua Ni ,  Zhenle Tian ,  Gang Wang ,  Liping Zhang ,  Ren Liu

IPC: A61K31/704 ,  A61K9/19 ,  C08G63/06 ,  C08J3/14 ,  C08J3/075

Abstract: A method of preparing degradable and environment responsive composite microgels, belonging to polymer material synthesis and biomaterial technology fields. Firstly, a copolymer of L-malic acid and 6-hydroxyhexanoate is prepared; then, N,N,N′,N′-tetramethyl cystamine is prepared. The copolymer and N,N,N′,N′-tetramethyl cystamine are mixed in an organic solvent to form a mixed solution which is added into excess distilled water to produce composite microgels. The microgels have advantages of mild preparing conditions, fast reaction speed without catalysts, no impurity remained, and controllable degradation rate. The microgels can load anticancer drug doxorubicin hydrochloride, showing environment responsive controlled release due to introduction of carboxyl groups and disulfide bonds.

公开(公告)号：US09649347B2

公开(公告)日：2017-05-16

申请号：US14980606

申请日：2015-12-28

Applicant: Jiangnan University

Inventor： Wei Chen ,  Fengwei Tian ,  Wenli Huang ,  Jianxin Zhao ,  Hao Zhang ,  Gang Wang ,  Qiuxiang Zhang ,  Xiaoming Liu ,  Daming Fan ,  Feifei Chi

IPC: A01N63/02 ,  A61K35/747 ,  C12R1/225 ,  A23C9/123 ,  C12N1/20 ,  A23L33/135

CPC classification number: A61K35/747 ,  A23C9/1234 ,  A23L33/135 ,  A23Y2220/73 ,  C12N1/20 ,  C12R1/225

Abstract: An anti-oxidative Lactobacillus rhamnosus CCFM1107 can relieve chronic alcoholic liver injury, and L. rhamnosus CCFM1107 can be used in preparing dairy products as starter culture. The dairy products of this invention include milk, milk powder, milk capsules or fermented milk containing L. rhamnosus CCFM1107. It has strong abilities of anti-oxidation, scavenging diphenyl picrylhydrazyl (DPPH) radical and hydroxyl radical, inhibiting lipid peroxidation, tolerating cholate, chlorine sodium and pH, and can improve liver function and antioxidative index, lower serum endotoxin level and regulate intestinal flora distribution, thus effectively relieving alcoholic liver injury of mice.

公开(公告)号：US20140363501A1

公开(公告)日：2014-12-11

申请号：US14117833

申请日：2012-07-19

Applicant: Jiangnan University

Inventor： Wei Chen ,  Fengwei Tian ,  Wenli Huang ,  Jianxi n Zhao ,  Hao Zhang ,  Gang Wang ,  Qiuxiang Zhang ,  Xiaoming Liu ,  Daming Fan ,  Feifei Chi

IPC: A61K35/74 ,  A23C9/123 ,  A61K9/48 ,  C12N1/20 ,  C12R1/225 ,  A61K47/46

CPC classification number: A61K35/747 ,  A23C9/1232 ,  A23C9/1234 ,  A23C9/18 ,  A23Y2220/15 ,  A23Y2220/73 ,  A23Y2240/75 ,  A61K9/48 ,  A61K47/46 ,  A61K2035/11 ,  C12N1/20 ,  C12R1/225

Abstract: An anti-oxidative Lactobacillus rhamnosus CCFM1107 can relieve chronic alcoholic liver injury, and L. rhamnosus CCFM1107 can be used in preparing dairy products as starter culture. The dairy products of this invention include milk, milk powder, milk capsules or fermented milk containing L. rhamnosus CCFM1107. It has strong abilities of anti-oxidation, scavenging diphenyl picrylhydrazyl (DPPH) radical and hydroxyl radical, inhibiting lipid peroxidation, tolerating cholate, chlorine sodium and pH, and can improve liver function and antioxidative index, lower serum endotoxin level and regulate intestinal flora distribution, thus effectively relieving alcoholic liver injury of mice.

Abstract translation: 抗氧化型鼠李糖乳杆菌CCFM1107可缓解慢性酒精性肝损伤，鼠李糖杆菌CCFM1107可用于制备乳制品作为起始培养物。 本发明的乳制品包括牛奶，奶粉，​​乳胶囊或含有鼠李糖乳杆菌CCFM1107的发酵乳。 抗氧化能力强，二苯基苦基肼基（DPPH）自由基和羟基自由基清除，抑制脂质过氧化，耐胆汁酸，氯钠和pH值高，能改善肝功能和抗氧化指标，降低血清内毒素水平，调节肠道菌群分布 ，从而有效缓解小鼠的酒精性肝损伤。

公开(公告)号：US11564956B2

公开(公告)日：2023-01-31

申请号：US16771224

申请日：2018-07-19

Applicant: Jiangnan University

Inventor： Wei Chen ,  Gang Wang ,  Eryin Wang ,  Jianxin Zhao ,  Hao Zhang

IPC: A61K35/747 ,  C12R1/25 ,  A23L33/135 ,  A23L33/00 ,  A61P1/14 ,  C12N1/20 ,  A23C9/123 ,  A61K9/00 ,  A23L11/50 ,  A23L11/65

Abstract: The present invention relates to the technical field of microbes, in particular to a Lactobacillus plantarum which can significantly inhibit the occurrence of colorectal cancer, and its use thereof. The Lactobacillus plantarum strain CCFM164 has a deposit number CGMCC No. 14520, which has a good tolerance to gastric acid and bile salts, significantly alleviate the level of colorectal inflammation in colorectal cancer model mice, and can reduce the number of tumors in the colon and rectum of the model mice by regulating the Notch1, Notch2 signaling pathway and the expression of VEGFR2 molecule in colorectal tissue. In addition, the Lactobacillus plantarum CCFM164 can also improve the intestinal flora population and short-chain fatty acid levels in the intestine. The Lactobacillus plantarum CCFM164 is used to prepare a fermented food for the inhibition of the occurrence of colorectal cancer with wild applications.

公开(公告)号：US20140369981A1

公开(公告)日：2014-12-18

申请号：US14118867

申请日：2012-07-18

Applicant: Jiangnan University

Inventor： Fengwei Tian ,  Wei Chen ,  Qixiao Zhai ,  Hao Zhang ,  Jianxin Zhao ,  Gang Wang ,  Yuanda Song ,  Qiuxiang Zhang ,  Xiaoming Liu ,  Min Guo ,  Daming Fan

IPC: A61K35/74 ,  A23L1/30

CPC classification number: A61K35/747 ,  A23C9/1234 ,  A23C11/106 ,  A23C13/16 ,  A23C19/032 ,  A23L2/382 ,  A23L19/00 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/67 ,  C12N1/20 ,  C12R1/25

Abstract: The Lactobacillus plantarum CCFM8661 is tolerant to acid and lead ions in vitro which can tolerate lead ions solution with the initial concentration of 150 mg/L, and has a strong capability of binding lead ions, which can reduce the lead level in mice blood, liver, kidney and stomach, significantly improve antioxidant indicators and alleviate pathological symptoms of lead exposed mice.

Abstract translation: 植物乳杆菌CCFM8661在体外耐受酸和铅离子，可以耐受初始浓度为150 mg / L的铅离子溶液，并具有较强的结合铅离子的能力，可以降低小鼠血液，肝脏的铅水平 ，肾，胃，显着改善抗氧化指标，减轻铅暴露小鼠的病理症状。

公开(公告)号：US11492588B2

公开(公告)日：2022-11-08

申请号：US17019985

申请日：2020-09-14

Applicant: Jiangnan University

Inventor： Gang Wang ,  Wei Chen ,  Qian Chen ,  Jianxin Zhao ,  Hao Zhang

IPC: A61K35/747 ,  A61K39/09 ,  A61K35/00 ,  A23C9/123 ,  A23L33/135 ,  C12N1/20

Abstract: The disclosure discloses Lactococcus lactis subsp. lactis CCFM1018 and application thereof in preparation of food and medicine for excreting a plasticizer, and belongs to the technical field of microorganisms. The Lactococcus lactis subsp. lactis CCFM1018 not only is significantly better than the intestinal resident bacteria Escherichia coli and Enterococcus faecalis in terms of the effect of promoting the excretion of DEHP and MEHP, but also is better than the commercial strain Lactobacillus rhamnosus LGG. Therefore, the Lactococcus lactis subsp. lactis CCFM1018 of the disclosure can be used as an effective means to prevent and alleviate body damage caused by DEHP and MEHP, and does not have toxic or side effects of drugs. Lactococcus lactis subsp. lactis CCFM1018 can be used to prepare pharmaceutical compositions and fermented food for alleviating and preventing the toxicity of DEHP and metabolites thereof, and has a very broad application prospect.

公开(公告)号：US11160839B2

公开(公告)日：2021-11-02

申请号：US17019867

申请日：2020-09-14

Applicant: Jiangnan University

Inventor： Gang Wang ,  Wei Chen ,  Xing Jin ,  Jianxin Zhao ,  Hao Zhang

IPC: A61K35/744 ,  A61P31/04 ,  A61K9/00 ,  A61K47/02 ,  A61K47/36 ,  A61K47/38

Abstract: The disclosure discloses P. pentosaceus CCFM1012, fermented food thereof and application thereof to preparation of a C. jejuni infection antagonism medicine. The P. pentosaceus CCFM1012 of the disclosure can remarkably reduce a colonization rate of in-vivo C. jejuni of mice infected with C. jejuni and transcriptional activity of virulence genes flaA, cadF, cdtB, cdtC and dnaJ of the C. jejuni, can effectively relieve physiological damage caused by infection of the C. jejuni, can also be used for preparing dairy products, bean products and fruit and vegetable fruits for preventing infection of the C. jejuni and an additive that can be added to a poultry and livestock feed for reducing infection and carrying of the C. jejuni in poultry and livestock, and has quite broad application prospects.

公开(公告)号：US11623968B2

公开(公告)日：2023-04-11

申请号：US16954734

申请日：2019-11-26

Applicant: JIANGNAN UNIVERSITY

Inventor： Liping Zhang ,  Caihua Ni ,  Ren Liu ,  Gang Wang

IPC: C08B37/00 ,  A61K9/107 ,  A61K9/14 ,  A61K31/723 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: A method for making xanthan gum copolymer nanomicelles comprising: 1) degrading xanthan gum in aqueous solution to obtain degraded xanthan gum; 2) preparing xanthan gum bromide from the degraded xanthan gum; 3) preparing xanthan gum copolymer from the xanthan gum bromide and 4) making the gum copolymer nanomicelles from the xanthan gum copolymer. The xanthan gum copolymer nanomicelles have good morphological regularity, good biocompatibility and stable performance as an anticancer drug carriers.

公开(公告)号：US09451781B2

公开(公告)日：2016-09-27

申请号：US14241082

申请日：2012-12-07

Applicant: Jiangnan University

Inventor： Wei Chen ,  Fengwei Tian ,  Qixiao Zhai ,  Gang Wang ,  Xiaoming Liu ,  Qiuxiang Zhang ,  Daming Fan ,  Jianxin Zhao ,  Hao Zhang

IPC: C12N1/20 ,  A23C9/123 ,  C12R1/25 ,  A23C13/16 ,  A23L1/212 ,  A61K35/742 ,  A23C11/10 ,  A23C19/032 ,  A23L1/30 ,  A23L2/02 ,  A23L2/38 ,  A61K35/747 ,  A23L1/015 ,  A61K35/00

CPC classification number: A23C9/1234 ,  A23C11/106 ,  A23C13/16 ,  A23C19/0323 ,  A23L2/02 ,  A23L2/382 ,  A23L5/28 ,  A23L19/00 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/67 ,  A61K35/742 ,  A61K35/747 ,  A61K2035/11 ,  C12N1/20 ,  C12R1/25

Abstract: The invention provides a novel strain of cadmium-removing Lactobacillus plantarum bacterium, CCFM8610, which has a good tolerance to acidic environments. Lactobacillus plantarum CCFM8610 has a good tolerance to cadmium-containing medium and can effectively bind cadmium in vitro. Animal studies have shown that it can effectively reduce tissue cadmium accumulation and facilitate fecal cadmium excretion. Lactobacillus plantarum CCFM8610 has a great potential to be used as an active ingredient in cadmium-removing pharmaceutical drugs and fermented foods.

Abstract translation: 本发明提供了一种新的镉去除植物乳杆菌菌株CCFM8610，其对酸性环境具有良好的耐受性。 植物乳杆菌CCFM8610对镉培养基具有良好的耐受性，可以有效地结合体外镉。 动物研究表明，它可以有效减少组织镉的积累，促进粪便镉排泄。 植物乳杆菌CCFM8610具有很大的潜力用作镉去除药物和发酵食品中的活性成分。