公开(公告)号：US20140369981A1

公开(公告)日：2014-12-18

申请号：US14118867

申请日：2012-07-18

申请人： Jiangnan University

发明人： Fengwei Tian ,  Wei Chen ,  Qixiao Zhai ,  Hao Zhang ,  Jianxin Zhao ,  Gang Wang ,  Yuanda Song ,  Qiuxiang Zhang ,  Xiaoming Liu ,  Min Guo ,  Daming Fan

IPC分类号： A61K35/74 ,  A23L1/30

CPC分类号： A61K35/747 ,  A23C9/1234 ,  A23C11/106 ,  A23C13/16 ,  A23C19/032 ,  A23L2/382 ,  A23L19/00 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/67 ,  C12N1/20 ,  C12R1/25

摘要： The Lactobacillus plantarum CCFM8661 is tolerant to acid and lead ions in vitro which can tolerate lead ions solution with the initial concentration of 150 mg/L, and has a strong capability of binding lead ions, which can reduce the lead level in mice blood, liver, kidney and stomach, significantly improve antioxidant indicators and alleviate pathological symptoms of lead exposed mice.

摘要翻译： 植物乳杆菌CCFM8661在体外耐受酸和铅离子，可以耐受初始浓度为150 mg / L的铅离子溶液，并具有较强的结合铅离子的能力，可以降低小鼠血液，肝脏的铅水平 ，肾，胃，显着改善抗氧化指标，减轻铅暴露小鼠的病理症状。

公开(公告)号：US09649347B2

公开(公告)日：2017-05-16

申请号：US14980606

申请日：2015-12-28

申请人： Jiangnan University

发明人： Wei Chen ,  Fengwei Tian ,  Wenli Huang ,  Jianxin Zhao ,  Hao Zhang ,  Gang Wang ,  Qiuxiang Zhang ,  Xiaoming Liu ,  Daming Fan ,  Feifei Chi

IPC分类号： A01N63/02 ,  A61K35/747 ,  C12R1/225 ,  A23C9/123 ,  C12N1/20 ,  A23L33/135

CPC分类号： A61K35/747 ,  A23C9/1234 ,  A23L33/135 ,  A23Y2220/73 ,  C12N1/20 ,  C12R1/225

摘要： An anti-oxidative Lactobacillus rhamnosus CCFM1107 can relieve chronic alcoholic liver injury, and L. rhamnosus CCFM1107 can be used in preparing dairy products as starter culture. The dairy products of this invention include milk, milk powder, milk capsules or fermented milk containing L. rhamnosus CCFM1107. It has strong abilities of anti-oxidation, scavenging diphenyl picrylhydrazyl (DPPH) radical and hydroxyl radical, inhibiting lipid peroxidation, tolerating cholate, chlorine sodium and pH, and can improve liver function and antioxidative index, lower serum endotoxin level and regulate intestinal flora distribution, thus effectively relieving alcoholic liver injury of mice.

公开(公告)号：US20140363501A1

公开(公告)日：2014-12-11

申请号：US14117833

申请日：2012-07-19

申请人： Jiangnan University

发明人： Wei Chen ,  Fengwei Tian ,  Wenli Huang ,  Jianxi n Zhao ,  Hao Zhang ,  Gang Wang ,  Qiuxiang Zhang ,  Xiaoming Liu ,  Daming Fan ,  Feifei Chi

IPC分类号： A61K35/74 ,  A23C9/123 ,  A61K9/48 ,  C12N1/20 ,  C12R1/225 ,  A61K47/46

CPC分类号： A61K35/747 ,  A23C9/1232 ,  A23C9/1234 ,  A23C9/18 ,  A23Y2220/15 ,  A23Y2220/73 ,  A23Y2240/75 ,  A61K9/48 ,  A61K47/46 ,  A61K2035/11 ,  C12N1/20 ,  C12R1/225

摘要： An anti-oxidative Lactobacillus rhamnosus CCFM1107 can relieve chronic alcoholic liver injury, and L. rhamnosus CCFM1107 can be used in preparing dairy products as starter culture. The dairy products of this invention include milk, milk powder, milk capsules or fermented milk containing L. rhamnosus CCFM1107. It has strong abilities of anti-oxidation, scavenging diphenyl picrylhydrazyl (DPPH) radical and hydroxyl radical, inhibiting lipid peroxidation, tolerating cholate, chlorine sodium and pH, and can improve liver function and antioxidative index, lower serum endotoxin level and regulate intestinal flora distribution, thus effectively relieving alcoholic liver injury of mice.

摘要翻译： 抗氧化型鼠李糖乳杆菌CCFM1107可缓解慢性酒精性肝损伤，鼠李糖杆菌CCFM1107可用于制备乳制品作为起始培养物。 本发明的乳制品包括牛奶，奶粉，​​乳胶囊或含有鼠李糖乳杆菌CCFM1107的发酵乳。 抗氧化能力强，二苯基苦基肼基（DPPH）自由基和羟基自由基清除，抑制脂质过氧化，耐胆汁酸，氯钠和pH值高，能改善肝功能和抗氧化指标，降低血清内毒素水平，调节肠道菌群分布 ，从而有效缓解小鼠的酒精性肝损伤。

公开(公告)号：US09451781B2

公开(公告)日：2016-09-27

申请号：US14241082

申请日：2012-12-07

申请人： Jiangnan University

发明人： Wei Chen ,  Fengwei Tian ,  Qixiao Zhai ,  Gang Wang ,  Xiaoming Liu ,  Qiuxiang Zhang ,  Daming Fan ,  Jianxin Zhao ,  Hao Zhang

IPC分类号： C12N1/20 ,  A23C9/123 ,  C12R1/25 ,  A23C13/16 ,  A23L1/212 ,  A61K35/742 ,  A23C11/10 ,  A23C19/032 ,  A23L1/30 ,  A23L2/02 ,  A23L2/38 ,  A61K35/747 ,  A23L1/015 ,  A61K35/00

CPC分类号： A23C9/1234 ,  A23C11/106 ,  A23C13/16 ,  A23C19/0323 ,  A23L2/02 ,  A23L2/382 ,  A23L5/28 ,  A23L19/00 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/67 ,  A61K35/742 ,  A61K35/747 ,  A61K2035/11 ,  C12N1/20 ,  C12R1/25

摘要： The invention provides a novel strain of cadmium-removing Lactobacillus plantarum bacterium, CCFM8610, which has a good tolerance to acidic environments. Lactobacillus plantarum CCFM8610 has a good tolerance to cadmium-containing medium and can effectively bind cadmium in vitro. Animal studies have shown that it can effectively reduce tissue cadmium accumulation and facilitate fecal cadmium excretion. Lactobacillus plantarum CCFM8610 has a great potential to be used as an active ingredient in cadmium-removing pharmaceutical drugs and fermented foods.

摘要翻译： 本发明提供了一种新的镉去除植物乳杆菌菌株CCFM8610，其对酸性环境具有良好的耐受性。 植物乳杆菌CCFM8610对镉培养基具有良好的耐受性，可以有效地结合体外镉。 动物研究表明，它可以有效减少组织镉的积累，促进粪便镉排泄。 植物乳杆菌CCFM8610具有很大的潜力用作镉去除药物和发酵食品中的活性成分。

公开(公告)号：US20160113975A1

公开(公告)日：2016-04-28

申请号：US14980606

申请日：2015-12-28

申请人： Jiangnan University

发明人： Wei Chen ,  Fengwei Tian ,  Wenli Huang ,  Jianxi n Zhao ,  Hao Zhang ,  Gang Wang ,  Qiuxiang Zhang ,  Xiaoming Liu ,  Daming Fan ,  Feifei Chi

IPC分类号： A61K35/747 ,  A23C9/123 ,  C12R1/225

CPC分类号： A61K35/747 ,  A23C9/1234 ,  A23L33/135 ,  A23Y2220/73 ,  C12N1/20 ,  C12R1/225

摘要： An anti-oxidative Lactobacillus rhamnosus CCFM1107 can relieve chronic alcoholic liver injury, and L. rhamnosus CCFM1107 can be used in preparing dairy products as starter culture. The dairy products of this invention include milk, milk powder, milk capsules or fermented milk containing L. rhamnosus CCFM1107. It has strong abilities of anti-oxidation, scavenging diphenyl picrylhydrazyl (DPPH) radical and hydroxyl radical, inhibiting lipid peroxidation, tolerating cholate, chlorine sodium and pH, and can improve liver function and antioxidative index, lower serum endotoxin level and regulate intestinal flora distribution, thus effectively relieving alcoholic liver injury of mice.

摘要翻译： 抗氧化型鼠李糖乳杆菌CCFM1107可缓解慢性酒精性肝损伤，鼠李糖杆菌CCFM1107可用于制备乳制品作为起始培养物。 本发明的乳制品包括牛奶，奶粉，​​乳胶囊或含有鼠李糖乳杆菌CCFM1107的发酵乳。 抗氧化能力强，二苯基苦基肼基（DPPH）自由基和羟基自由基清除，抑制脂质过氧化，耐胆汁酸，氯钠和pH值高，能改善肝功能和抗氧化指标，降低血清内毒素水平，调节肠道菌群分布 ，从而有效缓解小鼠的酒精性肝损伤。