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    Disc shunt delivery with stepped needle
    1.
    发明申请
    Disc shunt delivery with stepped needle 有权
    光纤分路输送带阶梯针

    公开(公告)号：US20120065570A1

    公开(公告)日：2012-03-15

    申请号：US13199906

    申请日：2011-09-12

    申请人： Jeffrey E. Yeung ,  Teresa T. Yeung ,  Andrew Yeung

    发明人： Jeffrey E. Yeung ,  Teresa T. Yeung ,  Andrew Yeung

    IPC分类号： A61M1/00

    CPC分类号： A61B17/3468 ,  A61B17/7061

    摘要： A solid stepped needle delivers a disc shunt bridging between muscle and a degenerated disc, drawing blood plasma from muscle into the degenerated disc to alleviate back pain and regenerate the disc. The device further includes pull lines attached to the ends of the disc shunt for withdrawing and repositioning the stepped needle during shunt delivery.

    摘要翻译： 固定的步进式针头在肌肉和退化椎间盘之间提供桥接分离器，将血浆从肌肉吸入退化椎间盘以减轻背部疼痛并再生椎间盘。 该装置还包括附接到盘分路的端部的拉线，用于在分流输送期间抽出和重新定位阶梯式针。

    Method of tissue repair with spiral of filament
    2.
    发明申请
    Method of tissue repair with spiral of filament 审中-公开
    长丝螺旋组织修复方法

    公开(公告)号：US20160193054A1

    公开(公告)日：2016-07-07

    申请号：US14998933

    申请日：2016-03-07

    申请人： Jeffrey E. Yeung ,  Teresa T. Yeung

    发明人： Jeffrey E. Yeung ,  Teresa T. Yeung

    IPC分类号： A61F2/44 ,  A61F2/00

    CPC分类号： A61F2/442 ,  A61B17/3468 ,  A61F2/0036 ,  A61F2/4611 ,  A61F2002/30289 ,  A61F2002/30294 ,  A61F2002/30677 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/4495 ,  A61F2002/4635 ,  A61F2210/0061 ,  A61F2230/0091 ,  A61F2310/00598 ,  A61F2310/0061 ,  A61F2310/0097 ,  A61F2310/00976 ,  A61F2310/00982

    摘要： A distal portion of a filament is extended beyond the distal end of a needle containing a gripper. A flexible one-way filament retainer with a snagging point is positioned adjacent to the extended filament. The needle with the extended filament and the one-way filament retainer are inserted into a cannula. During partial withdrawal of the needle, the snagging point of the one-way filament retainer hooks or retains the distal portion of the filament, depositing a section of the filament between the snagging point of the one-way filament retainer and the needle. When the needle is re-advanced, the needle pushes open the flexible one-way filament retainer, and the section of the filament is expelled or deposited in tissue. The needle can be rotated; the gripper engages and spirals the expelled filament to burrow into tissue. The method of needle partial withdrawal, re-advancement, rotation and pushing is repeated to pack and fill the tissue with interconnecting spirals of filament.

    摘要翻译： 细丝的远端部分延伸超过包含夹持器的针的远端。 具有阻塞点的柔性单向灯丝保持器定位成与延长的灯丝相邻。 具有延长丝和单向细丝保持器的针插入插管中。 在针的部分抽出期间，单向细丝保持器的阻塞点钩住或保持细丝的远端部分，将细丝的一部分沉积在单向细丝保持器的阻止点和针之间。 当针被重新推进时，针推开柔性单向细丝保持器，并且细丝的部分被排出或沉积在组织中。 针可旋转; 夹持器将排出的细丝接合并螺旋，以进入组织。 重复针头部分拔出，重新推进，旋转和推动的方法，用纤维互连螺旋包装和填充组织。

    Back pain relief and immuno protection of donor cells
    3.
    发明授权
    Back pain relief and immuno protection of donor cells 有权
    背部疼痛缓解和供体细胞的免疫保护

    公开(公告)号：US08540684B2

    公开(公告)日：2013-09-24

    申请号：US12930632

    申请日：2011-01-11

    申请人： Jeffrey E. Yeung ,  Teresa T. Yeung

    发明人： Jeffrey E. Yeung ,  Teresa T. Yeung

    IPC分类号： A61M5/00 ,  A61M5/31 ,  A61M5/178

    CPC分类号： A61L27/3658 ,  A61B17/00 ,  A61B17/7061 ,  A61F2/94 ,  A61F2002/444 ,  A61L27/3604 ,  A61L27/3804 ,  A61L27/3856 ,  A61L2430/38

    摘要： The intervertebral disc is avascular. With aging, endplates become occluded by calcified layers, and diffusion of nutrients and oxygen into the disc diminishes. The disc degenerates, and pain ensues. Conduits are delivered and deployed into the intervertebral disc to re-establish the exchange of nutrients and waste between the disc and bodily circulation to stop or reverse disc degeneration and relieve pain. The intervertebral disc installed with semi-permeable conduits may be used as an immuno-isolated capsule to encapsulate donor cells capable of biosynthesizing therapeutic molecules. The semi-permeable conduits establish the exchange of nutrients and therapeutic molecules between disc and bodily circulation to treat a disease without using immuno-suppressive drugs.

    摘要翻译： 椎间盘无血管。 随着老化，终板由钙化层堵塞，营养物质和氧气扩散到椎间盘中减少。 椎间盘退化，发生疼痛。 将管道输送并部署到椎间盘中，以重新建立椎间盘和身体循环之间的营养物和废物的交换，以停止或逆转椎间盘退变并减轻疼痛。 安装有半渗透管道的椎间盘可以用作免疫分离的囊以封装能够生物合成治疗分子的供体细胞。 半透性管道建立了盘与体循环之间的营养物质和治疗分子的交换，以治疗疾病而不使用免疫抑制药物。

    INTERNAL AND EXTERNAL DISC SHUNT ALLEVIATE BACK PAIN
    4.
    发明申请
    INTERNAL AND EXTERNAL DISC SHUNT ALLEVIATE BACK PAIN 审中-公开
    内部和外部光盘镜头背部疼痛

    公开(公告)号：US20120029412A1

    公开(公告)日：2012-02-02

    申请号：US13138071

    申请日：2011-01-03

    申请人： Jeffrey E. Yeung ,  Teresa T. Yeung

    发明人： Jeffrey E. Yeung ,  Teresa T. Yeung

    IPC分类号： A61M5/00

    CPC分类号： A61B17/7061

    摘要： The intervertebral disc is avascular. Nutrients and waste are diffused through adjacent vertebral bodies into the disc. As we age, calcified layers form between the disc and vertebral bodies, blocking diffusion of nutrients, oxygen and pH buffer in blood. Under anaerobic conditions, lactic acid is produced, irritating nerve endings and causing nonspecific pain. In addition, the disc begins to starve and flatten. The weight shifts abnormally from disc to the facet joints causing strain and back pain. Shunt coils are formed and spiraled over the distal shaft of a twistable needle, then deployed into the nucleus of a degenerated disc by a sliding sleeve. The coils serve as an internal shunt, drawing nutrients, oxygen and buffering solute from the superior and inferior diffusion zones to neutralize lactic acid in the mid layer of the degenerated disc. The coils also serve as a bulking agent within the repaired disc to sustain compression and reduce facet loading and segmental instability. The end strands of the shunt coils can also extend from the disc to draw blood plasma from muscle or bodily circulation to expedite neutralization of lactic acid and rebuild disc matrix for pain relief and disc regeneration.

    摘要翻译： 椎间盘无血管。 营养物和废物通过相邻的椎体扩散到椎间盘中。 随着年龄的增长，椎间盘和椎体之间形成钙化层，阻止血液中营养物质，氧气和pH缓冲液的扩散。 在厌氧条件下，产生乳酸，刺激性神经末梢并引起非特异性疼痛。 此外，光盘开始饿死并变平。 重量从椎间盘异常移动到小关节，引起应变和背部疼痛。 分流线圈形成并螺旋在可扭转针的远端轴上，然后通过滑动套管部署到退化的盘​​的核中。 线圈用作内部分流器，从上下扩散区吸取营养物质，氧气和缓冲溶质，以中和退化盘中间层的乳酸。 线圈还用作修复的盘中的填充剂，以维持压缩并减小面负荷和节段不稳定性。 分流线圈的末端线也可以从盘延伸以从肌肉或身体循环中吸取血浆，以加速乳酸的中和，并重建椎间盘基质以减轻疼痛和椎间盘再生。

    U-shaped disc shunt and delivery device
    5.
    发明授权
    U-shaped disc shunt and delivery device 有权
    U形盘分流和输送装置

    公开(公告)号：US08361007B2

    公开(公告)日：2013-01-29

    申请号：US12223370

    申请日：2007-02-05

    申请人： Jeffrey E. Yeung ,  Teresa T. Yeung

    发明人： Jeffrey E. Yeung ,  Teresa T. Yeung

    IPC分类号： A61M5/00 ,  A61M25/00

    CPC分类号： A61B17/06066 ,  A61B17/062 ,  A61B17/1615 ,  A61B17/1671 ,  A61B17/7061 ,  A61B2017/061 ,  A61B2017/90 ,  A61F2002/444 ,  A61L27/28 ,  A61L2430/38

    摘要： The intervertebral disc contains no blood vessels. Nutrients and waste are diffused mainly through adjacent vertebral bodies. As we age, calcified layers form between the disc and vertebral bodies, blocking diffusion. The disc begins to starve and flatten. The weight shifts abnormally from disc to the facet joints causing strain and back pain. Under anaerobic conditions, lactic acid is produced causing acidic irritation and unspecific pain. A U-shaped disc shunt (126) is delivered into and sealed within the degenerated disc simply by needle puncturing and withdrawal, to draw nutrients from bodily circulation into the avascular disc. A continual supply of nutrients increases biosynthesis of the water-retaining sulfated glycosaminoglycans, hence swelling pressure within the disc. The weight is re-shifted from the facet joints to the regenerated disc, alleviating back pain. With oxygen transported through the shunt, anaerobic production of lactic acid is minimized. In addition, the residual lactic acid is expelled through the U-shaped shunt during disc compression into bodily circulation to alleviate unspecific pain.

    摘要翻译： 椎间盘不含血管。 营养物和废物主要通过相邻的椎体扩散。 随着年龄的增长，钙化层形成在椎间盘和椎体之间，阻止扩散。 光盘开始变得饿死了。 重量从椎间盘异常移动到小关节，引起应变和背部疼痛。 在厌氧条件下，产生乳酸，引起酸性刺激和非特异性疼痛。 U型盘分流器（126）通过针穿刺和抽出而被简单地输送并且在退化的盘中被密封，从而将营养物质从身体循环中吸收到无血管盘中。 持续供应营养物质可增加保水性硫酸糖胺聚糖的生物合成，从而增加盘内的压力。 重量从小关节重新转移到再生椎间盘，减轻背痛。 通过分流运送的氧气，乳酸的厌氧生产被最小化。 另外，残留的乳酸通过U形分流在椎间盘压迫期间被排出到身体循环中以减轻非特异性疼痛。

    Device for disc shunt implantation and peri-shunt injection
    6.
    发明授权
    Device for disc shunt implantation and peri-shunt injection 有权
    光盘并联注入和分流注入装置

    公开(公告)号：US08088150B2

    公开(公告)日：2012-01-03

    申请号：US12322570

    申请日：2009-02-04

    申请人： Jeffrey E. Yeung ,  Teresa T. Yeung

    发明人： Jeffrey E. Yeung ,  Teresa T. Yeung

    IPC分类号： A61B17/88

    CPC分类号： A61B17/3468 ,  A61B17/3472 ,  A61B17/7061

    摘要： A Quincke tipped introducer needle contains two shafts with lumens, one recessed, both connected by a slit for housing a U- or V-shaped disc shunt. The recessed shaft minimizes the penetration size of the introducer needle for insertion into a narrow and nerve laden space adjacent to a degenerated intervertebral disc. The longitudinal slit connecting the two lumens allows passage of the distal portion of the U-shaped disc shunt through the introducer needle, to be delivered into the intervertebral disc.Pain emitting from the avascular disc is extremely difficult to treat due to lack of penetration or permeability of drug. The lumens of the introducer needle are also used to retain a peri-shunt injectable into the disc shunt for delivery into the painful disc. The peri-shunt injectable can be an analgesic, narcotic, anti-inflammatory drug, antibiotic, anticonvulsant, antidepressant, buffer agent or alkaline agent to alleviate pain. The peri-shunt injectable can also be a nerve toxin retained within the lumens to be loaded within the shunt for terminating transmission of pain signal emitting from the disc.

    摘要翻译： 一个Quincke尖头的导引针包含两个带腔的轴，一个凹进，一个凹进，两个通过用于容纳U形或V形盘分流的狭缝连接。 凹入的轴使导引针的穿透尺寸最小化，用于插入到与退化的椎间盘相邻的狭窄和神经负载的空间中。 连接两个流明的纵向狭缝允许U形盘分流的远端部分通过导引针通过，以被输送到椎间盘中。 从无血管盘发射的疼痛由于缺乏药物渗透或渗透性而难以治疗。 导引针的腔也用于将可分注的分流器保持在盘分流器中，以便输送到疼痛盘中。 分注注射剂可以是镇痛药，麻醉药，抗炎药，抗生素，抗惊厥药，抗抑郁药，缓冲剂或碱剂以缓解疼痛。 分注注射剂也可以是保留在腔内的神经毒素，以装载在分流器内，用于终止从盘发射的疼痛信号的传播。

    Internal and external disc shunts alleviate back pain
    9.
    发明申请
    Internal and external disc shunts alleviate back pain 审中-公开
    内部和外部光盘分流可减轻背部疼痛

    公开(公告)号：US20110098628A1

    公开(公告)日：2011-04-28

    申请号：US12930355

    申请日：2011-01-03

    申请人： Jeffrey E. Yeung ,  Teresa T. Yeung

    发明人： Jeffrey E. Yeung ,  Teresa T. Yeung

    IPC分类号： A61M5/00

    CPC分类号： A61B17/3468 ,  A61B2017/00261 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/30289 ,  A61F2002/30677 ,  A61F2002/444 ,  A61F2002/4495 ,  A61F2002/4635 ,  A61F2310/00598 ,  A61F2310/0097

    摘要： The intervertebral disc is avascular. Nutrients and waste are diffused through adjacent vertebral bodies into the disc. As we age, calcified layers form between the disc and vertebral bodies, blocking diffusion of nutrients, oxygen and pH buffer in blood. Under anaerobic conditions, lactic acid is produced, irritating nerve endings and causing nonspecific pain. In addition, the disc begins to starve and flatten. The weight shifts abnormally from disc to the facet joints causing strain and back pain.Shunt coils are formed and spiraled over the distal shaft of a twistable needle, then deployed into the nucleus of a degenerated disc by a sliding sleeve. The coils serve as an internal shunt, drawing nutrients, oxygen and buffering solute from the superior and inferior diffusion zones to neutralize lactic acid in the mid layer of the degenerated disc. The coils also serve as a bulking agent within the repaired disc to sustain compression and reduce facet loading and segmental instability. The end strands of the shunt coils can also extend from the disc to draw blood plasma from muscle or bodily circulation to expedite neutralization of lactic acid and rebuild disc matrix for pain relief and disc regeneration.

    摘要翻译： 椎间盘无血管。 营养物和废物通过相邻的椎体扩散到椎间盘中。 随着年龄的增长，椎间盘和椎体之间形成钙化层，阻止血液中营养物质，氧气和pH缓冲液的扩散。 在厌氧条件下，产生乳酸，刺激性神经末梢并引起非特异性疼痛。 此外，光盘开始饿死并变平。 重量从椎间盘异常移动到小关节，引起应变和背部疼痛。 分流线圈形成并螺旋在可扭转针的远端轴上，然后通过滑动套管部署到退化的盘​​的核中。 线圈用作内部分流器，从上下扩散区吸取营养物质，氧气和缓冲溶质，以中和退化盘中间层的乳酸。 线圈还用作修复的盘中的填充剂，以维持压缩并减小面负荷和节段不稳定性。 分流线圈的末端线也可以从盘延伸以从肌肉或身体循环中吸取血浆，以加速乳酸的中和，并重建椎间盘基质以减轻疼痛和椎间盘再生。

    U-Shaped Disc Shunt and Delivery Device
    10.
    发明申请
    U-Shaped Disc Shunt and Delivery Device 有权
    U形光盘分流和传送装置

    公开(公告)号：US20090024071A1

    公开(公告)日：2009-01-22

    申请号：US12223370

    申请日：2007-02-05

    申请人： Jeffrey E. Yeung ,  Teresa T. Yeung

    发明人： Jeffrey E. Yeung ,  Teresa T. Yeung

    IPC分类号： A61M5/00

    CPC分类号： A61B17/06066 ,  A61B17/062 ,  A61B17/1615 ,  A61B17/1671 ,  A61B17/7061 ,  A61B2017/061 ,  A61B2017/90 ,  A61F2002/444 ,  A61L27/28 ,  A61L2430/38

    摘要： The intervertebral disc contains no blood vessels. Nutrients and waste are diffused mainly through adjacent vertebral bodies. As we age, calcified layers form between the disc and vertebral bodies, blocking diffusion. The disc begins to starve and flatten. The weight shifts abnormally from disc to the facet joints causing strain and back pain. Under anaerobic conditions, lactic acid is produced causing acidic irritation and unspecific pain. A U-shaped disc shunt (126) is delivered into and sealed within the degenerated disc simply by needle puncturing and withdrawal, to draw nutrients from bodily circulation into the avascular disc. A continual supply of nutrients increases biosynthesis of the water-retaining sulfated glycosaminoglycans, hence swelling pressure within the disc. The weight is re-shifted from the facet joints to the regenerated disc, alleviating back pain. With oxygen transported through the shunt, anaerobic production of lactic acid is minimized. In addition, the residual lactic acid is expelled through the U-shaped shunt during disc compression into bodily circulation to alleviate unspecific pain.

    摘要翻译： 椎间盘不含血管。 营养物和废物主要通过相邻的椎体扩散。 随着年龄的增长，钙化层形成在椎间盘和椎体之间，阻止扩散。 光盘开始变得饿死了。 重量从椎间盘异常移动到小关节，引起应变和背部疼痛。 在厌氧条件下，产生乳酸，引起酸性刺激和非特异性疼痛。 U型盘分流器（126）通过针穿刺和抽出而被简单地输送并且在退化的盘中被密封，从而将营养物质从身体循环中吸收到无血管盘中。 持续供应营养物质可增加保水性硫酸糖胺聚糖的生物合成，从而增加盘内的压力。 重量从小关节重新转移到再生椎间盘，减轻背痛。 通过分流运送的氧气，乳酸的厌氧生产被最小化。 另外，残留的乳酸通过U形分流在椎间盘压迫期间被排出到身体循环中以减轻非特异性疼痛。