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1.发明授权Method for inducing deposition and maturation of bone comprising a co-therapeutic regimen of LMP-1 and BMP-2 有权诱导骨沉积和成熟的方法，包括LMP-1和BMP-2的共同治疗方案公开(公告)号：US07504374B2
公开(公告)日：2009-03-17
申请号：US11385612
申请日：2006-03-21
Applicant: Jeffrey C. Marx , William F. McKay , Scott D. Boden
Inventor： Jeffrey C. Marx , William F. McKay , Scott D. Boden
CPC classification number: A61K38/1709 , A61K38/1875 , A61K2300/00
Abstract: The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic strategies including small molecules and peptide mimics of LIM mineralization proteins, particularly LMP-1, to overcome the dose-related translational barriers for BMP-2 therapeutics.
Abstract translation: 本发明涉及用于治疗受损骨患者的方法和组合物。 具体地，本发明涉及包括LIM矿化蛋白（特别是LMP-1）的小分子和肽模拟物的组合治疗策略，以克服BMP-2治疗剂的剂量相关翻译屏障。
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公开(公告)号：US07892532B2
公开(公告)日：2011-02-22
申请号：US10806915
申请日：2004-03-23
Applicant: Frances Louisa Titus , Jeffrey C. Marx , Scott D. Boden , Sangwook T. (Tim) Yoon , Susan Drapeau
Inventor： Frances Louisa Titus , Jeffrey C. Marx , Scott D. Boden , Sangwook T. (Tim) Yoon , Susan Drapeau
CPC classification number: C07K14/005 , A61K38/00 , C07K14/43581 , C07K14/4702 , C07K14/475 , C07K14/495 , C07K14/51 , C07K2319/00 , C12N2740/16322
Abstract: The invention provides fusion polypeptides comprising protein transduction domains and osteoinductive polypeptides, as well as methods of using such polypeptides to induce osteogenesis and to promote proteoglycan synthesis. The invention also provides osteoinductive peptides which have demonstrated the ability to induce bone formation in vivo.
Abstract translation: 本发明提供了包含蛋白转导结构域和骨诱导多肽的融合多肽，以及使用这些多肽诱导成骨和促进蛋白多糖合成的方法。 本发明还提供已经证明在体内诱导骨形成的能力的骨诱导肽。
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公开(公告)号：US20120310366A1
公开(公告)日：2012-12-06
申请号：US13489173
申请日：2012-06-05
Applicant: Ping Li , Jeffrey C. Marx , William F. McKay
Inventor： Ping Li , Jeffrey C. Marx , William F. McKay
IPC: A61F2/28
CPC classification number: A61K31/366 , A61F2002/2839 , A61F2002/30677 , A61K31/22 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K33/42 , A61K47/22
Abstract: Implantable medical devices and methods are provided that have one or more statins disposed therein. The medical devices may be implanted at near or in a bone defect to enhance bone growth. In some embodiments, the medical device provided allows for sustain release of the statin and facilitates bone formation and repair of the fracture site.
Abstract translation: 提供了植入式医疗装置和方法，其中设置有一个或多个他汀类药物。 医疗装置可以植入在骨缺损附近或骨缺损处以增强骨生长。 在一些实施方案中，所提供的医疗装置允许持续释放他汀类并促进骨形成部位的骨形成和修复。
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4.发明申请COMPOSITIONS AND METHODS FOR DELIVERING CLONIDINE AND BUPIVACAINE TO A TARGET TISSUE SITE 有权将CLONIDINE和BUPIVACAINE递送至目标组织网站的组合物和方法公开(公告)号：US20120142649A1
公开(公告)日：2012-06-07
申请号：US13310240
申请日：2011-12-02
Applicant: Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
Inventor： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
IPC: A61K31/56 , A61P29/00 , A61K31/445
CPC classification number: A61K9/0024 , A61K31/167 , A61K31/4168 , A61K31/445 , A61K47/34 , A61K2300/00
Abstract: Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.
Abstract translation: 提供长时间有效的疼痛治疗。 通过施用有效量的即时释放布比卡因或利多卡因和持续释放的可乐定，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄 ，造成背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。
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公开(公告)号：US09308190B2
公开(公告)日：2016-04-12
申请号：US13489173
申请日：2012-06-05
Applicant: Ping Li , Jeffrey C. Marx , William F. McKay
Inventor： Ping Li , Jeffrey C. Marx , William F. McKay
IPC: A61F2/28 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K33/42 , A61F2/30
CPC classification number: A61K31/366 , A61F2002/2839 , A61F2002/30677 , A61K31/22 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K33/42 , A61K47/22
Abstract: Implantable medical devices and methods are provided that have one or more statins disposed therein. The medical devices may be implanted at near or in a bone defect to enhance bone growth. In some embodiments, the medical device provided allows for sustain release of the statin and facilitates bone formation and repair of the fracture site.
Abstract translation: 提供了植入式医疗装置和方法，其中设置有一个或多个他汀类药物。 医疗装置可以植入在骨缺损附近或骨缺损处以增强骨生长。 在一些实施方案中，所提供的医疗装置允许持续释放他汀类并促进骨形成部位的骨形成和修复。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20120142747A1
公开(公告)日：2012-06-07
申请号：US13309759
申请日：2011-12-02
Applicant: Jared T. Wilsey , Danielle L. Biggs , Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
Inventor： Jared T. Wilsey , Danielle L. Biggs , Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
IPC: A61K31/4168 , A61P29/00
CPC classification number: A61K31/4168 , A61K9/00 , A61K9/0024
Abstract: Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release clonidine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.
Abstract translation: 提供长时间有效的疼痛治疗。 通过在目标部位或其附近施用有效量的立即释放可乐定和持续释放的可乐定，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱狭窄，狭窄，椎间盘突出 背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。
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7.发明授权Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use 有权包含用于治疗神经元损伤的生物膜密封剂的组合物和使用方法公开(公告)号：US08945623B2
公开(公告)日：2015-02-03
申请号：US11418152
申请日：2006-05-03
Applicant: Josee Roy , William F. McKay , Jeffrey C. Marx
Inventor： Josee Roy , William F. McKay , Jeffrey C. Marx
IPC: A61K38/20 , A61K38/18 , A61K38/11 , A61K38/05 , A61K31/65 , A61K31/56 , A61K9/14 , A61K9/00 , A61K33/06 , A61K47/10
CPC classification number: A61K33/06 , A61K9/0019 , A61K31/56 , A61K31/65 , A61K31/765 , A61K47/10
Abstract: The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.
Abstract translation: 本发明提供用于治疗神经元损伤的组合物，试剂盒和方法。 在一个实施方案中，组合物包含生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。 静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，胃肠外给药，直接施用于病理状况的部位或其附近的生物膜密封剂和/或生物活性剂，以及任何 其组合。 或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。
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8.发明授权Compositions and methods for delivering clonidine and bupivacaine to a target tissue site 有权将可乐定和布比卡因递送至目标组织部位的组合物和方法公开(公告)号：US08623396B2
公开(公告)日：2014-01-07
申请号：US13310240
申请日：2011-12-02
Applicant: Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
Inventor： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
CPC classification number: A61K9/0024 , A61K31/167 , A61K31/4168 , A61K31/445 , A61K47/34 , A61K2300/00
Abstract: Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.
Abstract translation: 提供长时间有效的疼痛治疗。 通过施用有效量的即时释放布比卡因或利多卡因和持续释放的可乐定，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄 ，造成背痛和关节疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。
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公开(公告)号：US08252738B2
公开(公告)日：2012-08-28
申请号：US11875267
申请日：2007-10-19
Applicant: Jeffrey C. Marx , William F. McKay , Susan J. Drapeau
Inventor： Jeffrey C. Marx , William F. McKay , Susan J. Drapeau
CPC classification number: A61L27/54 , A61F2002/2817 , A61F2002/4445 , A61F2002/445 , A61K9/0024 , A61K38/1875 , A61L2300/252 , A61L2300/258 , A61L2300/414 , C12N5/0602 , C12N2501/105 , C12N2501/155 , C12N2501/165 , C12N2501/60 , C12N2501/998 , C12N2510/00 , A61K2300/00
Abstract: Methods of changing a phenotype of a cell are provided. The methods comprise increasing an amount of an amino acid sequence which is at least 70% identical to an amino acid sequence encoding an LMP protein or a fragment thereof in a cell. The cells may be contacted by either a composition comprising a nucleic acid sequence encoding the amino acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or by a composition comprising acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or any combination thereof. The cells may be contacted either in vivo or ex-vivo.
Abstract translation: 提供改变细胞表型的方法。 所述方法包括增加与细胞中编码LMP蛋白或其片段的氨基酸序列至少70％相同的氨基酸序列的量。 细胞可以由包含编码与编码LMP或其片段的氨基酸序列至少70％相同的氨基酸序列的核酸序列或包含至少70％的酸序列的组合物的组合物接触， 与编码LMP或其片段的氨基酸序列或其任何组合相同。 细胞可以在体内或体外接触。
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公开(公告)号：US20120142643A1
公开(公告)日：2012-06-07
申请号：US13309766
申请日：2011-12-02
Applicant: Jared T. Wilsey , Danielle L. Biggs , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
Inventor： Jared T. Wilsey , Danielle L. Biggs , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
IPC: A61K31/662 , A61P29/00 , A61K31/4168
CPC classification number: A61K31/195 , A61K9/0024 , A61K31/4168 , A61K31/662 , A61K45/06 , A61K47/34
Abstract: Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
Abstract translation: 提供长时间有效的疼痛治疗。 通过在目标部位或其附近施用有效量的可乐定和γ-氨基丁酸化合物，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘突出 背痛和关节疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。
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