POLYPEPTIDE OR FUSED PROTEIN THEREOF INHIBITING THE EXTRAVASATION OF WHITE BLOOD CELLS OR THE GROWTH AND/OR METASTASIS OF CANCER CELLS
    1.
    发明申请
    POLYPEPTIDE OR FUSED PROTEIN THEREOF INHIBITING THE EXTRAVASATION OF WHITE BLOOD CELLS OR THE GROWTH AND/OR METASTASIS OF CANCER CELLS 有权
    多肽或融合蛋白抑制白血病细胞的增殖或癌细胞的生长和/或转移

    公开(公告)号:US20120245091A1

    公开(公告)日:2012-09-27

    申请号:US13503262

    申请日:2010-08-24

    CPC分类号: A61K38/16

    摘要: The present invention relates to a polypeptide derived from a highly conserved region (HCR) I-III of an extracellular region of a CD99 and CD99 family such as CD99L2 and PBDX (or XG), which are a kind of transmembrane protein, or a fused protein thereof. The polypeptide or the fused protein thereof has an activating function of inhibiting the extravasation of white blood cells, or inhibiting the growth and/or metastasis of cancer cells. The present invention also provides a polynucleotide coding the polypeptide, a vector including same, and a transformant transformed by the vector. In addition, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof for preventing or treating inflammatory diseases. Further, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof inhibiting the growth and/or metastasis of cancer cells, i.e., a pharmaceutical composition for preventing or treating cancer.

    摘要翻译: 本发明涉及一种衍生自CD99和CD99家族例如CD99L2和PBDX(或XG)的胞外区的高度保守区(HCR)I-III的多肽,其是一种跨膜蛋白,或融合 蛋白质。 多肽或其融合蛋白具有抑制白细胞外渗或抑制癌细胞生长和/或转移的活化功能。 本发明还提供了编码多肽的多核苷酸,包含其的载体和由载体转化的转化体。 此外,本发明提供了包含用于预防或治疗炎性疾病的多肽或其融合蛋白质的药物组合物。 此外,本发明提供了包含抑制癌细胞的生长和/或转移的多肽或其融合蛋白的药物组合物,即用于预防或治疗癌症的药物组合物。

    Isolated polypeptides used for treatment of inflammatory diseases and inhibiting cancer metastasis
    2.
    发明授权
    Isolated polypeptides used for treatment of inflammatory diseases and inhibiting cancer metastasis 有权
    用于治疗炎性疾病和抑制癌症转移的分离的多肽

    公开(公告)号:US08530421B2

    公开(公告)日:2013-09-10

    申请号:US13503262

    申请日:2010-08-24

    CPC分类号: A61K38/16

    摘要: The present invention relates to a polypeptide derived from a highly conserved region (HCR) I-III of an extracellular region of a CD99 and CD99 family such as CD99L2 and PBDX(or XG), which are a kind of transmembrane protein, or a fused protein thereof. The polypeptide or the fused protein thereof has an activating function of inhibiting the extravasation of white blood cells, or inhibiting the growth and/or metastasis of cancer cells. The present invention also provides a polynucleotide coding the polypeptide, a vector including same, and a transformant transformed by the vector. In addition, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof for preventing or treating inflammatory diseases. Further, the present invention provides a is pharmaceutical composition including the polypeptide or the fused protein thereof inhibiting the growth and/or metastasis of cancer cells, i.e., a pharmaceutical composition for preventing or treating cancer.

    摘要翻译: 本发明涉及一种衍生自CD99和CD99家族例如CD99L2和PBDX(或XG)的胞外区的高度保守区(HCR)I-III的多肽,其是一种跨膜蛋白,或融合 蛋白质。 多肽或其融合蛋白具有抑制白细胞外渗或抑制癌细胞生长和/或转移的活化功能。 本发明还提供了编码多肽的多核苷酸,包含其的载体和由载体转化的转化体。 此外,本发明提供了包含用于预防或治疗炎性疾病的多肽或其融合蛋白质的药物组合物。 此外,本发明提供了包含抑制癌细胞的生长和/或转移的多肽或其融合蛋白的药物组合物,即用于预防或治疗癌症的药物组合物。

    Hybrid charge pump and method for operating the same, power management IC comprising the pump
    5.
    发明授权
    Hybrid charge pump and method for operating the same, power management IC comprising the pump 有权
    混合电荷泵及其操作方法,包括泵的电源管理IC

    公开(公告)号:US08988136B2

    公开(公告)日:2015-03-24

    申请号:US14074025

    申请日:2013-11-07

    IPC分类号: H02M3/07

    CPC分类号: H02M3/07

    摘要: A hybrid charge pump including a hybrid circuit configured to snub an over shoot or under shoot present in an input pulse in a snubbing operation if a level of the pulse is a first level, store the pulse in a charging operation if the level of the pulse is a second level different from the first level, and generate a negative voltage from the stored pulse in a negative voltage generation operation.

    摘要翻译: 一种混合电荷泵,其包括混合电路,其被配置为如果脉冲的电平为第一电平,则在缓冲操作中的输入脉冲中存在过拍或下拍,如果所述脉冲的电平 是与第一电平不同的第二电平,并且在负电压产生操作中从存储的脉冲产生负电压。

    Method of fabricating extended drain MOS transistor
    6.
    发明授权
    Method of fabricating extended drain MOS transistor 有权
    制造扩展漏极MOS晶体管的方法

    公开(公告)号:US08143139B2

    公开(公告)日:2012-03-27

    申请号:US12197331

    申请日:2008-08-25

    申请人: Kyoung-Jin Lee

    发明人: Kyoung-Jin Lee

    IPC分类号: H01L21/762 H01L29/78

    摘要: A method of fabricating an extended drain MOS transistor which reduces a design rule and prevents the generation of leakage current. The method includes sequentially forming a diffusion film, a first conductive epitaxial layer, a gate oxide layer and a hard mask layer over a semiconductor substrate, forming a first hard mask pattern having a first thickness by performing a first etching process on the hard mask layer, forming a second hard mask pattern having a second thickness by performing a second etching process on the first hard mask layer, and then forming a thin gate oxide layer by performing a third etching process on the gate oxide layer using the second hard mask pattern as a mask.

    摘要翻译: 一种制造扩展漏极MOS晶体管的方法,其减小了设计规则并防止产生漏电流。 该方法包括在半导体衬底上依次形成扩散膜,第一导电外延层,栅极氧化物层和硬掩模层,通过对硬掩模层进行第一蚀刻工艺,形成具有第一厚度的第一硬掩模图案 通过对第一硬掩模层进行第二蚀刻工艺形成具有第二厚度的第二硬掩模图案,然后通过使用第二硬掩模图案在栅极氧化物层上进行第三蚀刻工艺来形成薄的栅氧化层,作为 一个面具

    Polarizer, method of fabricating the same and liquid crystal display having the same
    7.
    发明授权
    Polarizer, method of fabricating the same and liquid crystal display having the same 有权
    偏振器,其制造方法和具有该偏振器的液晶显示器

    公开(公告)号:US08045102B2

    公开(公告)日:2011-10-25

    申请号:US12871298

    申请日:2010-08-30

    IPC分类号: G02F1/1335

    摘要: Disclosed are a polarizer, a method for fabricating the same, and a liquid crystal display having the same. The liquid crystal display includes a liquid crystal panel and a polarizer attached to the liquid crystal panel. The polarizer includes a polarizing film, a first support film, and a second support film. The first support film has optical anisotropy and is attached to the polarizing film. The first support film has a first thickness. The second support film is attached to the polarizing film while facing the first support film and has a second thickness, which is greater than the first thickness. The polarizer is fabricated by evaporating a solvent from a solution including polymer resin to form an optical film and then elongating the optical film.

    摘要翻译: 公开了一种偏振器,其制造方法和具有该偏振器的液晶显示器。 液晶显示器包括液晶面板和安装在液晶面板上的偏振片。 偏振片包括偏光膜,第一支撑膜和第二支撑膜。 第一支撑膜具有光学各向异性并附着于偏振膜。 第一支撑膜具有第一厚度。 第二支撑膜在面对第一支撑膜的同时附着到偏振膜,并且具有大于第一厚度的第二厚度。 通过从包括聚合物树脂的溶液中蒸发溶剂来制造偏振器,以形成光学膜,然后延长光学膜。

    CLOCK-BASED SOFT-START CIRCUIT AND POWER MANAGEMENT INTEGRATED CIRCUIT DEVICE
    8.
    发明申请
    CLOCK-BASED SOFT-START CIRCUIT AND POWER MANAGEMENT INTEGRATED CIRCUIT DEVICE 有权
    基于时钟的软启动电路和电源管理集成电路设备

    公开(公告)号:US20130265807A1

    公开(公告)日:2013-10-10

    申请号:US13713615

    申请日:2012-12-13

    IPC分类号: G05F1/46

    摘要: In a clock-based soft-start circuit configured to generate a soft-start reference voltage that restrains an inrush current at an initialization of power supplied to a DC-DC converter, the clock-based soft-start circuit comprises a time setting unit configured to set a soft-start time period in response to a clock signal. A ramp circuit is configured to generate a soft-start reference voltage which is ramped upward or downward between a base level and a reference voltage level during the soft start time period set by the time setting unit. In this manner, the clock-based soft-start circuit is applicable for all DC-DC converters and the soft-start in a linear slope is possible.

    摘要翻译: 在基于时钟的软启动电路中,基于时钟的软启动电路被配置为产生在提供给DC-DC转换器的电源的初始化时抑制浪涌电流的软启动基准电压,所述基于时钟的软启动电路包括: 以响应于时钟信号设置软启动时间段。 斜坡电路被配置为产生在由时间设置单元设置的软启动时间段期间在基准电平和基准电压电平之间上升或下降的软启动基准电压。 以这种方式,基于时钟的软启动电路适用于所有DC-DC转换器,并且可以在线性斜率中进行软启动。

    METHOD OF FABRICATING EXTENDED DRAIN MOS TRANSISTOR
    9.
    发明申请
    METHOD OF FABRICATING EXTENDED DRAIN MOS TRANSISTOR 有权
    制造扩展漏磁MOS晶体管的方法

    公开(公告)号:US20090057785A1

    公开(公告)日:2009-03-05

    申请号:US12197331

    申请日:2008-08-25

    申请人: Kyoung-Jin Lee

    发明人: Kyoung-Jin Lee

    IPC分类号: H01L21/762 H01L29/78

    摘要: A method of fabricating an extended drain MOS transistor which reduces a design rule and prevents the generation of leakage current. The method includes sequentially forming a diffusion film, a first conductive epitaxial layer, a gate oxide layer and a hard mask layer over a semiconductor substrate, forming a first hard mask pattern having a first thickness by performing a first etching process on the hard mask layer, forming a second hard mask pattern having a second thickness by performing a second etching process on the first hard mask layer, and then forming a thin gate oxide layer by performing a third etching process on the gate oxide layer using the second hard mask pattern as a mask.

    摘要翻译: 一种制造扩展漏极MOS晶体管的方法,其减小了设计规则并防止产生漏电流。 该方法包括在半导体衬底上依次形成扩散膜,第一导电外延层,栅极氧化物层和硬掩模层,通过对硬掩模层进行第一蚀刻工艺,形成具有第一厚度的第一硬掩模图案 通过对第一硬掩模层进行第二蚀刻工艺形成具有第二厚度的第二硬掩模图案,然后通过使用第二硬掩模图案在栅极氧化物层上进行第三蚀刻工艺来形成薄的栅氧化层,作为 一个面具

    Wireless transmitting and receiving antenna
    10.
    发明授权
    Wireless transmitting and receiving antenna 失效
    无线发射和接收天线

    公开(公告)号:US06476768B2

    公开(公告)日:2002-11-05

    申请号:US09750979

    申请日:2000-12-28

    IPC分类号: H01Q124

    CPC分类号: H01Q1/244 H01Q1/362

    摘要: Disclosed is a wireless transmitting and receiving antenna which comprises a bobbin made of insulation material and having a first penetration cavity in the center of the bobbin in a lengthwise direction; a first antenna comprising a helical conductor spirally wound on the bobbin and having a resonance frequency, and a matching bar inserted into the cavity of the bobbin, made of a conductor and providing a second penetration cavity in the direction identical with that of the first penetration cavity; a feeder positioned at one part of the bobbin so as to supply signals to the helical conductor; and a second antenna comprising: a rod inserted into the penetration cavities of the bobbin and the matching bar, moving between the penetration cavities in a slipping manner, and wrapped with the insulation material; a conduction material combined to the outer part of the rod, and electrically connecting the feeder and the helical conductor when the rod is inserted into the penetration cavities; and a stopper which is made of a conductor, positioned at the lower part of the rod, and when the rod. is drawn Afro, the penetration cavity, the moving of the stopper is limited, and it is contacted to the feeder so as to supply signals to the rod.

    摘要翻译: 公开了一种无线发射和接收天线,其包括由绝缘材料制成的线轴,并且在长度方向上具有在线轴中心的第一穿透腔; 第一天线,包括螺旋形地缠绕在线轴上并具有共振频率的螺旋形导体,以及插入到线轴的空腔中的匹配杆,由导体制成并且沿与第一穿透方向相同的方向提供第二穿透腔 腔体 位于线轴的一部分的馈电器,以向螺旋导体提供信号; 以及第二天线,包括:插入到所述线轴和匹配杆的穿透腔中的杆,以滑动方式在所述穿透腔之间移动并且用所述绝缘材料包裹; 导电材料组合到杆的外部,并且当杆插入穿透腔时,将进料器和螺旋导体电连接; 以及由导体制成的止动件,其位于杆的下部以及杆处。 被拉伸的非洲,穿透腔,止动器的移动受到限制,并且与进料器接触,以向杆提供信号。