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公开(公告)号：US20170137439A1
公开(公告)日：2017-05-18
申请号：US15406994
申请日：2017-01-16
Applicant: Ironwood Pharmaceuticals, Inc.
Inventor： Takashi NAKAI , Joel MOORE , Nicholas Robert PERL , Rajesh R. IYENGAR , Ara MERMERIAN , G-Yoon Jamie IM , Thomas Wai-Ho LEE , Colleen HUDSON , Glen Robert RENNIE , James JIA , Paul Allan RENHOWE , Timothy Claude BARDEN , Xiang Y. YU , James Edward SHEPPECK , Karthik IYER , Joon JUNG , George Todd MILNE , Kimberly Kafadar LONG , Mark G. CURRIE
IPC: C07D498/04 , A61K31/506 , A61K31/5377 , C07D487/04 , C07D491/107 , C07D471/10 , C07D487/10 , C07D417/14 , A61K31/541 , A61K31/55 , C07D451/02 , C07D471/04 , C07D401/14 , C07D403/04 , A61K31/517 , A61K31/519 , C07D413/14
CPC classification number: A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04 , Y02A50/423
Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
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公开(公告)号：US20160031903A1
公开(公告)日：2016-02-04
申请号：US14775954
申请日：2014-03-14
Applicant: IRONWOOD PHARMACEUTICALS, INC.
Inventor： Takashi NAKAI , Joel MOORE , Nicholas Robert PERL , Rajesh R. IYENGAR , Ara MERMERIAN , G-Yoon Jamie IM , Thomas Wai-Ho LEE , Colleen HUDSON , Glen Robert RENNIE , James JIA , Paul Allan RENHOWE , Timothy Claude BARDEN , Xiang Y. YU , James Edward SHEPPECK , Karthik IYER , Joon JUNG , George Todd MILNE , Kimberly Kafadar LONG
IPC: C07D498/04 , C07D487/04 , C07D417/14 , C07D491/107 , C07D471/04 , C07D413/14 , C07D487/10
CPC classification number: A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04
Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
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公开(公告)号：US20170136019A1
公开(公告)日：2017-05-18
申请号：US15406959
申请日：2017-01-16
Applicant: Ironwood Pharmaceuticals, Inc.
Inventor： Takashi NAKAI , Joel MOORE , Nicholas Robert PERL , Rajesh R. IYENGAR , Ara MERMERIAN , G-Yoon Jamie IM , Thomas Wai-Ho LEE , Colleen HUDSON , Glen Robert RENNIE , James JIA , Paul Allan RENHOWE , Timothy Claude BARDEN , Xiang Y. YU , James Edward SHEPPECK , Karthik IYER , Joon JUNG , George Todd MILNE , Kimberly Kafadar LONG , Mark G. CURRIE
IPC: A61K31/506 , A61K45/06
Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
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公开(公告)号：US20170065586A1
公开(公告)日：2017-03-09
申请号：US15266021
申请日：2016-09-15
Applicant: Ironwood Pharmaceuticals, Inc.
Inventor： Takashi NAKAI , Nicholas Robert PERL , Joel MOORE
IPC: A61K31/513 , A61K31/519 , A61K31/5377 , A61K45/06 , A61K31/506
CPC classification number: C07D413/14 , A61K31/4155 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D487/04 , Y02A50/423 , A61K2300/00
Abstract: The present patent application discloses at least the compounds according to Formula I or Formula Ib shown below, or pharmaceutically acceptable salts thereof, wherein ring B, JB, n, JD, J, o, X, RC and RA are as described herein.
Abstract translation: 其中环B，JB，n，JD，J，o，X，RC和RA如本文所述。
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公开(公告)号：US20160347738A1
公开(公告)日：2016-12-01
申请号：US15215628
申请日：2016-07-21
Applicant: Ironwood Pharmaceuticals, Inc.
Inventor： Takashi NAKAI , Joel MOORE , Nicholas Robert PERL , Rajesh R. IYENGAR , Ara MERMERIAN , G-Yoon Jamie IM , Thomas Wai-Ho LEE , Colleen HUDSON , Glen Robert RENNIE , James JIA , Paul Allan RENHOWE , Timothy Claude BARDEN , Xiang Y. YU , James Edward SHEPPECK , Karthik IYER , Joon JUNG , George Todd MILNE , Kimberly Kafadar LONG , Mark G. CURRIE
IPC: C07D403/04 , A61K31/506 , A61K31/5377 , C07D471/10 , C07D491/107 , C07D487/10 , A61K31/541 , A61K31/55 , C07D471/08 , C07D487/04 , C07D498/04 , C07D417/14 , C07D401/14 , A61K31/519 , A61K31/517 , C07D413/14
CPC classification number: A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04
Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述了式I'和I的化合物，其可用作sGC的刺激剂，特别是NO-不依赖性血红素依赖性刺激剂。 这些化合物也可用于治疗，预防或治疗本文公开的各种疾病。
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Patent Agency Ranking
公开(公告)号：US20170112845A1
公开(公告)日：2017-04-27
申请号：US15168937
申请日：2016-05-31
Applicant: Ironwood Pharmaceuticals, Inc.
Inventor： Charles KIM , Takashi NAKAI , Thomas Wai-Ho LEE , Joel MOORE , Nicholas Robert PERL , Jason ROHDE
IPC: A61K31/5377 , A61K45/06 , A61K31/497 , A61K31/444 , A61K31/427 , A61K31/506 , A61K31/4439
CPC classification number: A61K31/5377 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D417/14 , Y02A50/423
Abstract: Compounds of Formula IA and Formula IB are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
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公开(公告)号：US20160311826A1
公开(公告)日：2016-10-27
申请号：US15103178
申请日：2014-12-10
Applicant: IRONWOOD PHARMACEUTICALS, INC.
Inventor： Paul Allan RENHOWE , James Edward SHEPPECK , Takashi NAKAI , Karthik IYER , Nicholas Robert PERL , Glen Robert RENNIE , Mark G. CURRIE , Kimberly Kafadar LONG , George Todd MILNE , Rajesh R. IYENGAR
IPC: C07D487/04 , C07D403/14 , C07D413/14 , C07D403/04 , C07D401/14
Abstract: The present patent application discloses at least the compounds according to Formula I shown below, or pharmaceutically acceptable salts thereof, wherein ring JB, n, JD, J, o, X, X1, J, RC, and W are as defined herein. These compounds are useful as stimulators of soluble sGC.
Abstract translation: 其中环JB，n，JD，J，o，X，X1，J，RC和W如本文所定义。 这些化合物可用作可溶性sGC的刺激剂。
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公开(公告)号：US20140323448A1
公开(公告)日：2014-10-30
申请号：US14264200
申请日：2014-04-29
Applicant: Ironwood Pharmaceuticals Inc.
Inventor： Charles KIM , Takashi NAKAI , Thomas Wai-Ho LEE , Joel MOORE , Nicholas Robert PERL , Jason ROHDE , Rajesh R. IYENGAR , Ara MERMERIAN , Angelika FRETZEN
IPC: C07D401/04 , A61K31/444 , C07D403/04 , A61K31/506 , A61K31/4439 , C07D409/14 , C07D403/14 , C07D491/048 , A61K31/497 , C07D413/14 , C07D473/34 , A61K31/522 , C07D498/04 , A61K31/5365 , C07D401/14
CPC classification number: C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , Y02A50/423 , A61K2300/00
Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述式I化合物。 它们作为sGC的刺激剂是有用的，特别是NO不依赖于血红素依赖性刺激物。 这些化合物可用于治疗，预防或治疗本文公开的各种疾病。
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公开(公告)号：US20170305878A1
公开(公告)日：2017-10-26
申请号：US15435723
申请日：2017-02-17
Applicant: Ironwood Pharmaceuticals, Inc.
Inventor： Charles KIM , Takashi NAKAI , Thomas Wai-Ho LEE , Joel MOORE , Nicholas Robert PERL , Jason ROHDE , Rajesh R. IYENGAR , Ara MERMERIAN , Angelika FRETZEN
IPC: C07D401/04 , A61K31/4155 , C07D473/34 , C07D417/14 , C07D413/14 , C07D409/14 , C07D405/14 , C07D403/14 , C07D403/04 , C07D401/14 , A61K45/06 , A61K31/5365 , A61K31/522 , A61K31/506 , A61K31/497 , A61K31/444 , A61K31/4439 , C07D491/048 , C07D498/04
CPC classification number: C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , Y02A50/423 , A61K2300/00
Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
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公开(公告)号：US20160375022A1
公开(公告)日：2016-12-29
申请号：US15245697
申请日：2016-08-24
Applicant: Ironwood Pharmaceuticals, Inc.
Inventor： Takashi NAKAI , Joel MOORE , Nicholas Robert PERL , Rajesh R. IYENGAR , Ara MERMERIAN , G-Yoon Jamie IM , Thomas Wai-Ho LEE , Colleen HUDSON , Glen Robert RENNIE , James JIA , Paul Allan RENHOWE , Timothy Claude BARDEN , Xiang Y. YU , James Edward SHEPPECK , Karthik IYER , Joon JUNG , George Todd MILNE , Kimberly Kafadar LONG , Mark G. CURRIE
IPC: A61K31/506 , A61K45/06
CPC classification number: A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04 , Y02A50/423
Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
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