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公开(公告)号：US20160311826A1
公开(公告)日：2016-10-27
申请号：US15103178
申请日：2014-12-10
Applicant: IRONWOOD PHARMACEUTICALS, INC.
Inventor： Paul Allan RENHOWE , James Edward SHEPPECK , Takashi NAKAI , Karthik IYER , Nicholas Robert PERL , Glen Robert RENNIE , Mark G. CURRIE , Kimberly Kafadar LONG , George Todd MILNE , Rajesh R. IYENGAR
IPC: C07D487/04 , C07D403/14 , C07D413/14 , C07D403/04 , C07D401/14
Abstract: The present patent application discloses at least the compounds according to Formula I shown below, or pharmaceutically acceptable salts thereof, wherein ring JB, n, JD, J, o, X, X1, J, RC, and W are as defined herein. These compounds are useful as stimulators of soluble sGC.
Abstract translation: 其中环JB，n，JD，J，o，X，X1，J，RC和W如本文所定义。 这些化合物可用作可溶性sGC的刺激剂。
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公开(公告)号：US20160375022A1
公开(公告)日：2016-12-29
申请号：US15245697
申请日：2016-08-24
Applicant: Ironwood Pharmaceuticals, Inc.
Inventor： Takashi NAKAI , Joel MOORE , Nicholas Robert PERL , Rajesh R. IYENGAR , Ara MERMERIAN , G-Yoon Jamie IM , Thomas Wai-Ho LEE , Colleen HUDSON , Glen Robert RENNIE , James JIA , Paul Allan RENHOWE , Timothy Claude BARDEN , Xiang Y. YU , James Edward SHEPPECK , Karthik IYER , Joon JUNG , George Todd MILNE , Kimberly Kafadar LONG , Mark G. CURRIE
IPC: A61K31/506 , A61K45/06
CPC classification number: A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04 , Y02A50/423
Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
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Patent Agency Ranking
公开(公告)号：US20170137439A1
公开(公告)日：2017-05-18
申请号：US15406994
申请日：2017-01-16
Applicant: Ironwood Pharmaceuticals, Inc.
Inventor： Takashi NAKAI , Joel MOORE , Nicholas Robert PERL , Rajesh R. IYENGAR , Ara MERMERIAN , G-Yoon Jamie IM , Thomas Wai-Ho LEE , Colleen HUDSON , Glen Robert RENNIE , James JIA , Paul Allan RENHOWE , Timothy Claude BARDEN , Xiang Y. YU , James Edward SHEPPECK , Karthik IYER , Joon JUNG , George Todd MILNE , Kimberly Kafadar LONG , Mark G. CURRIE
IPC: C07D498/04 , A61K31/506 , A61K31/5377 , C07D487/04 , C07D491/107 , C07D471/10 , C07D487/10 , C07D417/14 , A61K31/541 , A61K31/55 , C07D451/02 , C07D471/04 , C07D401/14 , C07D403/04 , A61K31/517 , A61K31/519 , C07D413/14
CPC classification number: A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04 , Y02A50/423
Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
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公开(公告)号：US20160324856A1
公开(公告)日：2016-11-10
申请号：US15110883
申请日：2015-01-13
Applicant: IRONWOOD PHARMACEUTICALS, INC.
Inventor： Kimberly Kafadar LONG , George Todd MILNE , Mark G. CURRIE
IPC: A61K31/506 , A61B5/026 , A61B5/00 , A61K45/06 , A61K31/519
CPC classification number: A61K31/506 , A61B5/026 , A61B5/4848 , A61K31/4439 , A61K31/519 , A61K45/06
Abstract: The present disclosure relates to methods, uses, pharmaceutical compositions and kits comprising a sGC stimulator or a pharmaceutically acceptable salt thereof, alone or in combination with one or more additional therapeutic agents, for the treatment of a neuromuscular disorder associated with loss or alteration of function of nitric oxide synthase (NOS).
Abstract translation: 本公开涉及包含sGC刺激剂或其药学上可接受的盐的方法，用途，药物组合物和试剂盒，其单独或与一种或多种另外的治疗剂组合用于治疗与功能丧失或改变相关的神经肌肉疾病 的一氧化氮合酶（NOS）。
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公开(公告)号：US20170136019A1
公开(公告)日：2017-05-18
申请号：US15406959
申请日：2017-01-16
Applicant: Ironwood Pharmaceuticals, Inc.
Inventor： Takashi NAKAI , Joel MOORE , Nicholas Robert PERL , Rajesh R. IYENGAR , Ara MERMERIAN , G-Yoon Jamie IM , Thomas Wai-Ho LEE , Colleen HUDSON , Glen Robert RENNIE , James JIA , Paul Allan RENHOWE , Timothy Claude BARDEN , Xiang Y. YU , James Edward SHEPPECK , Karthik IYER , Joon JUNG , George Todd MILNE , Kimberly Kafadar LONG , Mark G. CURRIE
IPC: A61K31/506 , A61K45/06
Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
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公开(公告)号：US20160347738A1
公开(公告)日：2016-12-01
申请号：US15215628
申请日：2016-07-21
Applicant: Ironwood Pharmaceuticals, Inc.
Inventor： Takashi NAKAI , Joel MOORE , Nicholas Robert PERL , Rajesh R. IYENGAR , Ara MERMERIAN , G-Yoon Jamie IM , Thomas Wai-Ho LEE , Colleen HUDSON , Glen Robert RENNIE , James JIA , Paul Allan RENHOWE , Timothy Claude BARDEN , Xiang Y. YU , James Edward SHEPPECK , Karthik IYER , Joon JUNG , George Todd MILNE , Kimberly Kafadar LONG , Mark G. CURRIE
IPC: C07D403/04 , A61K31/506 , A61K31/5377 , C07D471/10 , C07D491/107 , C07D487/10 , A61K31/541 , A61K31/55 , C07D471/08 , C07D487/04 , C07D498/04 , C07D417/14 , C07D401/14 , A61K31/519 , A61K31/517 , C07D413/14
CPC classification number: A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04
Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述了式I'和I的化合物，其可用作sGC的刺激剂，特别是NO-不依赖性血红素依赖性刺激剂。 这些化合物也可用于治疗，预防或治疗本文公开的各种疾病。
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公开(公告)号：US20160031903A1
公开(公告)日：2016-02-04
申请号：US14775954
申请日：2014-03-14
Applicant: IRONWOOD PHARMACEUTICALS, INC.
Inventor： Takashi NAKAI , Joel MOORE , Nicholas Robert PERL , Rajesh R. IYENGAR , Ara MERMERIAN , G-Yoon Jamie IM , Thomas Wai-Ho LEE , Colleen HUDSON , Glen Robert RENNIE , James JIA , Paul Allan RENHOWE , Timothy Claude BARDEN , Xiang Y. YU , James Edward SHEPPECK , Karthik IYER , Joon JUNG , George Todd MILNE , Kimberly Kafadar LONG
IPC: C07D498/04 , C07D487/04 , C07D417/14 , C07D491/107 , C07D471/04 , C07D413/14 , C07D487/10
CPC classification number: A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04
Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
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