公开(公告)号：US20170112845A1

公开(公告)日：2017-04-27

申请号：US15168937

申请日：2016-05-31

Applicant: Ironwood Pharmaceuticals, Inc.

Inventor： Charles KIM ,  Takashi NAKAI ,  Thomas Wai-Ho LEE ,  Joel MOORE ,  Nicholas Robert PERL ,  Jason ROHDE

IPC: A61K31/5377 ,  A61K45/06 ,  A61K31/497 ,  A61K31/444 ,  A61K31/427 ,  A61K31/506 ,  A61K31/4439

CPC classification number: A61K31/5377 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/506 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  Y02A50/423

Abstract: Compounds of Formula IA and Formula IB are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.

公开(公告)号：US20140323448A1

公开(公告)日：2014-10-30

申请号：US14264200

申请日：2014-04-29

Applicant: Ironwood Pharmaceuticals Inc.

Inventor： Charles KIM ,  Takashi NAKAI ,  Thomas Wai-Ho LEE ,  Joel MOORE ,  Nicholas Robert PERL ,  Jason ROHDE ,  Rajesh R. IYENGAR ,  Ara MERMERIAN ,  Angelika FRETZEN

IPC: C07D401/04 ,  A61K31/444 ,  C07D403/04 ,  A61K31/506 ,  A61K31/4439 ,  C07D409/14 ,  C07D403/14 ,  C07D491/048 ,  A61K31/497 ,  C07D413/14 ,  C07D473/34 ,  A61K31/522 ,  C07D498/04 ,  A61K31/5365 ,  C07D401/14

CPC classification number: C07D401/04 ,  A61K31/4155 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/506 ,  A61K31/522 ,  A61K31/5365 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D473/34 ,  C07D491/048 ,  C07D498/04 ,  Y02A50/423 ,  A61K2300/00

Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract translation: 描述式I化合物。 它们作为sGC的刺激剂是有用的，特别是NO不依赖于血红素依赖性刺激物。 这些化合物可用于治疗，预防或治疗本文公开的各种疾病。

公开(公告)号：US20170305878A1

公开(公告)日：2017-10-26

申请号：US15435723

申请日：2017-02-17

Applicant: Ironwood Pharmaceuticals, Inc.

Inventor： Charles KIM ,  Takashi NAKAI ,  Thomas Wai-Ho LEE ,  Joel MOORE ,  Nicholas Robert PERL ,  Jason ROHDE ,  Rajesh R. IYENGAR ,  Ara MERMERIAN ,  Angelika FRETZEN

IPC: C07D401/04 ,  A61K31/4155 ,  C07D473/34 ,  C07D417/14 ,  C07D413/14 ,  C07D409/14 ,  C07D405/14 ,  C07D403/14 ,  C07D403/04 ,  C07D401/14 ,  A61K45/06 ,  A61K31/5365 ,  A61K31/522 ,  A61K31/506 ,  A61K31/497 ,  A61K31/444 ,  A61K31/4439 ,  C07D491/048 ,  C07D498/04

CPC classification number: C07D401/04 ,  A61K31/4155 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/506 ,  A61K31/522 ,  A61K31/5365 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D473/34 ,  C07D491/048 ,  C07D498/04 ,  Y02A50/423 ,  A61K2300/00

Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.

公开(公告)号：US20150342954A1

公开(公告)日：2015-12-03

申请号：US14824689

申请日：2015-08-12

Applicant: IRONWOOD PHARMACEUTICALS, INC.

Inventor： Charles KIM ,  Takashi NAKAI ,  Joel MOORE ,  Nicholas Robert PERL ,  G-Yoon Jamie IM ,  Timothy Claude BARDEN ,  Rajesh R. IYENGAR ,  Daniel P. ZIMMER ,  Angelika FRETZEN ,  Paul Allan RENHOWE

IPC: A61K31/52 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/519 ,  A61K31/506 ,  A61K31/513

CPC classification number: A61K31/52 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K45/06 ,  C07D403/04 ,  C07D413/14 ,  C07D417/14 ,  C07D473/00 ,  C07D487/04 ,  C07D513/22 ,  Y02A50/423

Abstract: Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.

公开(公告)号：US20150250795A1

公开(公告)日：2015-09-10

申请号：US14698244

申请日：2015-04-28

Applicant: Ironwood Pharmaceuticals, Inc.

Inventor： Charles KIM ,  Takashi NAKAI ,  Thomas Wai-Ho LEE ,  Joel MOORE ,  Nicholas Robert PERL ,  Jason ROHDE

IPC: A61K31/5377 ,  A61K31/506 ,  A61K31/497 ,  A61K31/444 ,  A61K31/427 ,  A61K45/06 ,  A61K31/4439

CPC classification number: A61K31/5377 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/506 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  Y02A50/423

Abstract: Compounds of Formula IA and Formula IB are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract translation: 描述了式IA和式IB的化合物。 它们作为sGC的刺激剂是有用的，特别是NO不依赖于血红素依赖性刺激物。 这些化合物可用于治疗，预防或治疗本文公开的各种疾病。