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公开(公告)号：US20150284713A1
公开(公告)日：2015-10-08
申请号：US14441157
申请日：2013-11-08
CPC分类号： C12N15/1065 , A61K47/6889 , A61K47/6898 , B82Y5/00 , C07K2317/22 , C07K2317/569 , C07K2317/622 , C07K2318/00 , C07K2318/20 , C07K2319/41 , C07K2319/70 , C07K2319/90 , C12N15/1037 , C40B40/10
摘要： The present application relates to methods for the functionalization of antibodies using transglutaminase, in particular antibodies lacking Fc regions. Also disclosed herein are peptide tags for transglutaminase, linking reagents, functionalized antibodies, multi-specific antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
摘要翻译： 本申请涉及使用转谷氨酰胺酶特异性抗体功能化的方法，特别是缺乏Fc区的抗体。 本文还公开了用于转谷氨酰胺酶，连接试剂，官能化抗体，多特异性抗体，药物组合物和治疗疾病和/或病症的方法的肽标签。
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公开(公告)号：US10434180B2
公开(公告)日：2019-10-08
申请号：US15214331
申请日：2016-07-19
发明人： Delphine Bregeon , Patrick Dennler , Christian Belmant , Laurent Gauthier , François Romagne , Eliane Fischer , Roger Schibli
IPC分类号： A61K31/5517 , C07K16/00 , C07K16/30 , C07K19/00 , C07C217/08 , C07C223/02 , C07C229/26 , C07C233/62 , C07C247/04 , C07D225/08 , C07D257/08 , C07D277/06 , C07F9/50 , C12N9/10 , C12P21/00 , G01N33/68 , A61K47/48 , A61K47/68
摘要： The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
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公开(公告)号：US10132799B2
公开(公告)日：2018-11-20
申请号：US14414432
申请日：2013-07-10
发明人： Christian Belmant , Delphine Bregeon , Patrick Dennler , Eliane Fischer , François Romagne , Roger Schibli , Laurent Gauthier
IPC分类号： A61K47/48 , C07K16/00 , C07K16/30 , C07K19/00 , A61K31/5517 , C07C217/08 , C07C223/02 , C07C229/26 , C07C233/62 , C07C247/04 , C07C323/12 , C07C323/60 , C07D225/08 , C07D257/08 , C07D277/06 , C07F9/50 , C12N9/10 , C12P21/00 , G01N33/68 , G01N33/532 , G01N33/50 , A61K47/68
摘要： Provided is a method for the functionalization of immunoglobulins through the use of transglutaminase, including methods for screening functionalized antibodies for characteristics of interest, antibody compositions comprising a plurality of functionalized antibodies, and functionalized antibodies with rodent constant regions.
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公开(公告)号：US20160331842A1
公开(公告)日：2016-11-17
申请号：US15214331
申请日：2016-07-19
发明人： Delphine Bregeon , Patrick Dennler , Christian Belmant , Laurent Gauthier , François Romagne , Eliane Fischer , Roger Schibli
IPC分类号： A61K47/48 , C07K16/30 , A61K31/5517
CPC分类号： A61K47/48569 , A61K31/5517 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/24 , C07K2317/40
摘要： The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
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公开(公告)号：US20150346195A1
公开(公告)日：2015-12-03
申请号：US14414432
申请日：2013-07-10
发明人： Christian Belmant , Delphine Bregeon , Patrick Dennler , Eliane Fischer , François Romagne , Roger Schibli
IPC分类号： G01N33/532 , C07K16/00 , A61K47/48 , G01N33/50
CPC分类号： G01N33/532 , A61K47/68 , C07K16/00 , C07K2317/24 , G01N33/5014 , G01N33/6854
摘要： Provided is a method for the functionalization of immunoglobulins through the use of transglutaminase, including methods for screening functionalized antibodies for characteristics of interest, antibody compositions comprising a plurality of functionalized antibodies, and functionalized antibodies with rodent constant regions.
摘要翻译： 提供了通过使用转谷氨酰胺酶来功能化免疫球蛋白的方法，包括筛选用于感兴趣特征的功能化抗体的方法，包含多个官能化抗体的抗体组合物和具有啮齿动物恒定区的功能化抗体。
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公开(公告)号：US10036010B2
公开(公告)日：2018-07-31
申请号：US14441157
申请日：2013-11-08
CPC分类号： C12N15/1065 , A61K47/6889 , A61K47/6898 , B82Y5/00 , C07K2317/22 , C07K2317/569 , C07K2317/622 , C07K2318/00 , C07K2318/20 , C07K2319/41 , C07K2319/70 , C07K2319/90 , C12N15/1037 , C40B40/10
摘要： The present application relates to methods for the functionalization of antibodies using transglutaminase, in particular antibodies lacking Fc regions. Also disclosed herein are peptide tags for transglutaminase, linking reagents, functionalized antibodies, multi-specific antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
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公开(公告)号：US09427478B2
公开(公告)日：2016-08-30
申请号：US14582040
申请日：2014-12-23
发明人： Delphine Bregeon , Patrick Dennler , Christian Belmant , Laurent Gauthier , François Romagne , Eliane Fischer , Roger Schibli
IPC分类号： A61K47/48 , C07K16/00 , C07K16/30 , C07K19/00 , A61K31/5517
CPC分类号： A61K47/48569 , A61K31/5517 , A61K47/48384 , A61K47/48715 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/24 , C07K2317/40
摘要： The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
摘要翻译： 本申请涉及免疫球蛋白的酶官能化方法，特别是与药物的方法。 本文还公开了连接试剂，官能化抗体，药物组合物和治疗疾病和/或病症的方法。
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公开(公告)号：US20150165064A1
公开(公告)日：2015-06-18
申请号：US14582040
申请日：2014-12-23
发明人： Delphine Bregeon , Patrick Dennler , Christian Belmant , Laurent Gauthier , François Romagne , Eliane Fischer , Roger Schibli
IPC分类号： A61K47/48 , A61K31/5517
CPC分类号： A61K47/48569 , A61K31/5517 , A61K47/48384 , A61K47/48715 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/24 , C07K2317/40
摘要： The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
摘要翻译： 本申请涉及免疫球蛋白的酶官能化方法，特别是与药物的方法。 本文还公开了连接试剂，官能化抗体，药物组合物和治疗疾病和/或病症的方法。
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