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1.发明授权公开(公告)号：US09958465B2
公开(公告)日：2018-05-01
申请号：US15403896
申请日：2017-01-11
Applicant: Illumina, Inc. , Illumina Singapore Pte Ltd
Inventor： Beng Keong Ang , Heng Kuang Cheng , John M. Beierle , Bradley Kent Drews , David Kaplan
CPC classification number: G01N35/00029 , B01L3/502715 , B01L9/527 , G01N21/6428 , G01N21/645 , G01N21/6456 , G01N21/6486 , G01N35/0099 , G01N35/021 , G01N35/04 , G01N35/1002 , G01N35/1095 , G01N2021/6482 , G01N2035/00158 , G01N2035/00237 , G01N2035/00326 , G01N2035/00356 , G01N2035/0465
Abstract: Detection apparatus includes a microfluorometer having an objective, an excitation radiation source, and a detector. The detection apparatus also includes a fluidic system for delivering reagents from a reagent cartridge to a flow cell. The fluidic system includes a manifold body having a plurality of fluidic channels configured for fluid communication between the reagent cartridge and the flow cell. The fluidic system also includes a plurality of reagent sippers. The fluidic system also includes a valve configured to mediate fluid between reagent reservoirs and the flow cell. The detection apparatus also includes a flow cell latch clamp module having a clamp cover for holding the flow cell. The objective is configured to direct excitation radiation from the radiation source to the flow cell and to direct emission from the flow cell to the detector. The microfluorometer is movable to acquire wide-field images of different areas of the flow cell.
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2.发明申请公开(公告)号：US20180217170A1
公开(公告)日：2018-08-02
申请号：US15936365
申请日：2018-03-26
Applicant: Illumina, Inc. , Illumina Singapore Pte Ltd
Inventor： Beng Keong Ang , Heng Kuang Cheng , John M. Beierle , Bradley Kent Drews , David Kaplan
Abstract: Detection apparatus includes a microfluorometer having an objective, an excitation radiation source, and a detector. The detection apparatus also includes a fluidic system for delivering reagents from a reagent cartridge to a flow cell. The fluidic system includes a manifold body having a plurality of fluidic channels configured for fluid communication between the reagent cartridge and the flow cell. The fluidic system also includes a plurality of reagent sippers. The fluidic system also includes a valve configured to mediate fluid between reagent reservoirs and the flow cell. The detection apparatus also includes a flow cell latch clamp module having a clamp cover for holding the flow cell. The objective is configured to direct excitation radiation from the radiation source to the flow cell and to direct emission from the flow cell to the detector. The microfluorometer is movable to acquire wide-field images of different areas of the flow cell.
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3.发明授权公开(公告)号：US10830781B2
公开(公告)日：2020-11-10
申请号：US15936365
申请日：2018-03-26
Applicant: Illumina, Inc. , Illumina Singapore Pte Ltd
Inventor： Beng Keong Ang , Heng Kuang Cheng , John M. Beierle , Bradley Kent Drews , David Kaplan
IPC: G01N35/00 , B01L3/00 , G01N1/28 , G01N1/00 , G01N21/64 , G01N35/04 , G01N35/10 , B01L9/00 , G01N1/31 , G01N21/17 , G01N35/02
Abstract: Detection apparatus includes a microfluorometer having an objective, an excitation radiation source, and a detector. The detection apparatus also includes a fluidic system for delivering reagents from a reagent cartridge to a flow cell. The fluidic system includes a manifold body having a plurality of fluidic channels configured for fluid communication between the reagent cartridge and the flow cell. The fluidic system also includes a plurality of reagent sippers. The fluidic system also includes a valve configured to mediate fluid between reagent reservoirs and the flow cell. The detection apparatus also includes a flow cell latch clamp module having a clamp cover for holding the flow cell. The objective is configured to direct excitation radiation from the radiation source to the flow cell and to direct emission from the flow cell to the detector. The microfluorometer is movable to acquire wide-field images of different areas of the flow cell.
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公开(公告)号：US12000854B2
公开(公告)日：2024-06-04
申请号：US17831222
申请日：2022-06-02
Applicant: Illumina, Inc.
Inventor： Wesley A. Cox-Muranami , James Osmus , Paul Crivelli , Bradley Kent Drews
IPC: G01N35/10
CPC classification number: G01N35/1097
Abstract: An apparatus includes a fluidic circuit, a bypass fluidic circuit, a first set of fluid wells, a second set of fluid wells, a first valve, and a second valve. The first valve operatively associated with the first set of fluid wells such that the first selectively fluidly connects any one of the first set of fluid wells to a first valve outlet. The second valve operatively associated with the fluidic circuit, the bypass fluidic circuit, the first valve outlet, and the second set of fluid wells such that the second valve selectively fluidly connects any one of the second set of fluid wells and the first valve outlet to the fluidic circuit or the first valve outlet to the bypass fluidic circuit.
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公开(公告)号：US11192105B2
公开(公告)日：2021-12-07
申请号：US16827391
申请日：2020-03-23
Applicant: Illumina, Inc.
Inventor： Bradley Kent Drews , Michael Dai Wang , Umberto Ulmanella , Stephen Wayne Clark , Johanna Lynn Whitacre , Steven Scott Phelps , Michelle L. Alvarez , Michael Adalbert Niziolek , Debra Sue Bryan , Joshua Augustin Darland
Abstract: An analysis system may perform operations on an analyte that may be combined with multiple regents prior to being introduced into a flow cell. The instrument may include a volume into which the reagents to be combined with the analyte are aspirated one-by-one. The volume may be formed as a serpentine channel in a valve manifold associated with sippers for aspirating the reagents. The reagents may then be mixed by cycling a pump to move the reagents within the mixing volume or channel. For this, the reagents may be aspirated from a recipient into the volume or channel, ejected back into the recipient, and this process may be performed repeatedly to enhance mixing.
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Patent Agency Ranking
公开(公告)号：US20180188278A1
公开(公告)日：2018-07-05
申请号：US15841085
申请日：2017-12-13
Applicant: Illumina, Inc.
Inventor： Bradley Kent Drews , Kevin James Cappa
CPC classification number: G01N35/1016 , B01L3/0293 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/143 , B01L2200/16 , B01L2300/024 , B01L2300/0877 , B01L2400/0478 , B01L2400/0622 , G01N35/1002 , G01N35/1009 , G01N35/1097 , G01N2035/1025
Abstract: A system includes a reagent selector valve controllable to select a reagent flow path from a plurality of reagent flow paths, and a pump coupled to the reagent flow path to draw a liquid through the reagent flow path in accordance with a prescribed test protocol. The system includes a discharge flow path to expel the drawn liquid, and a flow meter to measure liquid displaced by the pump and that outputs data representative of the measured flow. The system also includes a processor to access the data and to determine a volume of the liquid displaced by the pump.
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公开(公告)号：US20180188141A1
公开(公告)日：2018-07-05
申请号：US15841098
申请日：2017-12-13
Applicant: Illumina, Inc.
Inventor： Bradley Kent Drews , Michael Dai Wang , Umberto Ulmanella , James Michael Osmus , Stephen Wayne Clark , Johanna Lynn Whitacre , Steven Scott Phelps , Michelle L. Alvarez , Michael Adalbert Niziolek , Debra Sue Bryan , Joshua Augustin Darland
IPC: G01N1/38 , G01N1/14 , B01L3/00 , G01N35/10 , C12Q1/6874 , B01F13/10 , B01F15/02 , B01F5/00 , B01F5/06 , B01F3/08
CPC classification number: G01N1/38 , B01F3/0861 , B01F3/088 , B01F5/0065 , B01F5/0647 , B01F11/0074 , B01F13/1055 , B01F15/00876 , B01F15/0243 , B01F15/0283 , B01F2215/0037 , B01L3/502 , B01L3/502715 , B01L3/502738 , B01L3/52 , B01L3/527 , B01L2200/027 , B01L2200/16 , B01L2300/0832 , B01L2300/0877 , B01L2300/0883 , B01L2400/0644 , C12Q1/6874 , G01N1/14 , G01N35/1002 , G01N35/1016 , G01N35/1095 , G01N35/1097 , G01N2001/1418 , G01N2001/1436 , G01N2001/386 , G01N2035/1058
Abstract: An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.
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公开(公告)号：US20180188131A1
公开(公告)日：2018-07-05
申请号：US15841089
申请日：2017-12-13
Applicant: Illumina, Inc.
Inventor： Bradley Kent Drews , Kevin James Cappa
CPC classification number: G01M3/26 , G05B15/02 , G05D7/0676 , G05D16/2066
Abstract: An analysis system includes a fluidic system includes a number of components that are interconnected to form a fluidic system having a plurality of flow paths. An example method of pressure testing the fluidic system includes (a) selecting a flow path from the plurality of flow paths through a flow cell in accordance with a prescribed test protocol; (b) actuating a pump to pressurize a fluid in the selected flow path; (c) generating pressure data representative of the pressure in the selected flow path; and (d) processing the pressure data to determine whether the selected flow path maintains pressure in a desired manner.
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公开(公告)号：US12011713B2
公开(公告)日：2024-06-18
申请号：US17817204
申请日：2022-08-03
Applicant: Illumina, Inc.
Inventor： Wesley A. Cox-Muranami , Kay Klausing , Bradley Kent Drews , Nicholas Watson , Jennifer Olivia Foley , Murphy Hitchcock , Paul Sangiorgio , Sz-Chin Steven Lin
IPC: B01L3/00
CPC classification number: B01L3/502 , B01L2200/141 , B01L2200/16 , B01L2300/047 , B01L2300/06 , B01L2400/0487 , B01L2400/0644
Abstract: A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device.
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公开(公告)号：US11975328B2
公开(公告)日：2024-05-07
申请号：US17507254
申请日：2021-10-21
Applicant: Illumina, Inc. , Illumina Cambridge Limited
Inventor： Bradley Kent Drews , Gudrun Stengel , James Christopher Blake , Mohammed Kafeel Ahamed , Michael Steven Becker , Michael Dangelo , Mark J. Nibbe , Daniel L. Fuller , Oliver Jon Miller
CPC classification number: B01L3/50853 , B01L3/502715 , B01L9/523 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0684 , B01L2200/0689 , B01L2300/041 , B01L2300/047 , B01L2300/048 , B01L2300/0681 , B01L2300/0819 , B01L2300/0829
Abstract: The assembly includes a docking console and a manifold. The docking console includes a cartridge support surface having a first end and a second end. The manifold has one or more wells defined therein. The docking console further includes a manifold retention bracket to releasably hold the manifold against a fluid cartridge supported on the cartridge support surface at an interface position such that the one or more wells are in fluid communication with the fluid cartridge and a biased seal bar to press the fluid cartridge against the manifold held by the manifold retention bracket. A hydrophilic porous frit disposed within at least one of the wells and is to permit liquid to flow through the outlet aperture but prevent gas from passing through the outlet aperture.
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