公开(公告)号：US20240210388A1

公开(公告)日：2024-06-27

申请号：US18392118

申请日：2023-12-21

申请人： IMEC VZW

发明人： Liesbet LAGAE ,  Olivier HENRY ,  Nick VAN HELLEPUTTE

IPC分类号： G01N33/543

CPC分类号： G01N33/5438 ,  G01N33/54306

摘要： According to an aspect there is provided a sensing device for detection of at least one characteristic of a substance. The sensing device comprises:



a plurality of cavities, each comprising an opening;
a plurality of sensors for detecting the at least one characteristic, the plurality of sensors being arranged into a plurality of sets of sensors, each set being arranged in a mutually unique cavity;
a plurality of protective membranes, each being arranged to cover the opening of the mutually unique cavity, preventing the substance from entering the cavity, thereby protecting the set of sensors from being exposed to the substance.




The sensing device is configured for providing a different activation timing for different protective membranes, whereby different sets of sensors are exposed to the substance at different points in time, for providing detection of the at least one characteristic at multiple time points.

公开(公告)号：US20180169653A1

公开(公告)日：2018-06-21

申请号：US15899982

申请日：2018-02-20

申请人： PANASONIC CORPORATION ,  IMEC VZW

发明人： Shuji SATO ,  Yasuaki OKUMURA ,  Yukari NISHIYAMA ,  Tatsurou KAWAMURA ,  Ben JONES ,  Liesbet LAGAE ,  Tim STAKENBORG

IPC分类号： B01L3/00 ,  G01N33/543

CPC分类号： B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2300/041 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/0861 ,  B01L2400/0406 ,  B01L2400/0688 ,  G01N21/03 ,  G01N27/416 ,  G01N33/54386

摘要： A micro analysis chip comprises an inlet and a fluid flow path communicating thereto. The fluid flow path comprises a first flow path, a second flow path, and a third flow path arranged continuously along a longitudinal direction of the fluid flow path. An antibody is bound on at least one peripheral surface selected from the group consisting of peripheral surfaces of the second and third flow paths. A cross-sectional area of the third flow path is constant or increased monotonically along a direction X from the second flow path toward the third flow path. A cross-sectional area of the second flow path is increased monotonically along the direction X from the one end to the other end of the second flow path. A cross-sectional area of the first flow path is larger than a cross-sectional area at the one end of the second flow path.

公开(公告)号：US20210191316A1

公开(公告)日：2021-06-24

申请号：US17128092

申请日：2020-12-19

申请人： IMEC VZW ,  Katholieke Universiteit Leuven

发明人： Zhenxiang LUO ,  Abdulkadir YURT ,  Dries BRAEKEN ,  Liesbet LAGAE ,  Richard STAHL

IPC分类号： G03H1/00 ,  G02B21/06 ,  G02B21/36 ,  G03H1/04 ,  H04N13/254

摘要： A method for three-dimensional imaging of a sample (302) comprises: receiving (102) interference patterns (208) acquired using light-detecting elements (212), wherein each interference pattern (208) is formed by scattered light from the sample (302) and non-scattered light from a light source (206; 306), wherein the interference patterns (208) are acquired using different angles between the sample (302) and the light source (206; 306); performing digital holographic reconstruction applying an iterative algorithm to change a three-dimensional scattering potential of the sample (302) to improve a difference between the received interference patterns (208) and predicted interference patterns based on the three-dimensional scattering potential; wherein the iterative algorithm reduces a sum of a data fidelity term and a non-differentiable regularization term and wherein the iterative algorithm includes a forward-backward splitting method alternating between forward gradient descent (108) on the data fidelity term and backward gradient descent (110) on the regularization term.

公开(公告)号：US20200348288A1

公开(公告)日：2020-11-05

申请号：US16957092

申请日：2018-12-19

申请人： IMEC VZW ,  Katholieke Universiteit Leuven

发明人： Dries BRAEKEN ,  Thomas PAUWELYN ,  Liesbet LAGAE

IPC分类号： G01N33/50 ,  G06K9/20 ,  G06K9/00 ,  G01N27/02 ,  G01N21/47

摘要： A method for analysis of cardiomyocyte function comprises: receiving (302) in a measurement position a substrate (110) carrying cardiomyocytes on a cell culturing surface; recording (304) electrical signals from the cardiomyocytes; simultaneously with said recording, acquiring (306) a sequence of images of the cardiomyocytes on the cell culturing surface based on detecting light wavefront information of reflected light; determining (308) an electrical representation relating to an intracellular and/or extracellular action potential, and/or an impedimetric electrical image of a cardiomyocyte based on the recorded electrical signals; and determining (310) a contractile representation relating to cellular deformation during contractility action of a group of cardiomyocytes based on the acquired sequence of images, wherein the electrical representation and the contractile representation apply to a common period of time.