公开(公告)号：US06866150B2

公开(公告)日：2005-03-15

申请号：US10288926

申请日：2002-11-06

申请人： Hugh Mason ,  Michael J Gruslin ,  Joseph Winn

发明人： Hugh Mason ,  Michael J Gruslin ,  Joseph Winn

IPC分类号： B65D25/10 ,  B65D81/107 ,  B65D81/127 ,  B65D85/48

CPC分类号： B65D81/107 ,  B65D25/107 ,  B65D81/127 ,  B65D85/48

摘要： A containment unit for protecting fragile objects (e.g., medical slides) during transit is provided, wherein the unit is light weight, yet secure, and such that the objects are securely held in place during transit (e.g., mailing, delivery) to ensure that they are not jostled, intermingled, rearranged, displaced, broken, or otherwise physically harmed/affected.

摘要翻译： 提供了一种用于在运输过程中保护脆弱物体（例如医疗用滑块）的容纳单元，其中该单元重量轻且安全，并且使得物体在运输期间被安全地固定（例如邮寄，运送）以确保 它们不会被推挤，混杂，重新排列，流离失所，破碎或其他身体伤害/受影响。

公开(公告)号：US20210330785A1

公开(公告)日：2021-10-28

申请号：US17367296

申请日：2021-07-02

申请人： Hugh Mason ,  Andrew Diamos ,  Mary Pardhe ,  Brandon Favre

发明人： Hugh Mason ,  Andrew Diamos ,  Mary Pardhe ,  Brandon Favre

IPC分类号： A61K39/29 ,  C12N7/00 ,  A61P31/20 ,  A61K39/145 ,  A61K39/12 ,  A61K39/00

摘要： The disclosure relates to vaccination compositions, for example, against human papillomavirus, Zika virus, and flu virus. The disclosure also relates to vectors for producing the virus-like particles and immune complex platforms of the vaccination compositions.

公开(公告)号：US10125373B2

公开(公告)日：2018-11-13

申请号：US14762128

申请日：2014-01-22

申请人： THE ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY ,  Hugh Mason ,  Charles Arntzen ,  Sun Hee Rosenthal ,  Sean Winkle ,  Andrew Diamos

发明人： Hugh Mason ,  Charles Arntzen ,  Sun Hee Rosenthal ,  Sean Winkle ,  Andrew Diamos

IPC分类号： C12N15/82 ,  C07K16/28 ,  C12N7/00

摘要： A single vector or multiple separate vectors that contain two or more non-competing replicons for transient expression of the heavy and light chains of Rituximab in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures to optimize the expression is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of the multi-replicon single vector system for producing Rituximab in plant cells.

公开(公告)号：US11865174B2

公开(公告)日：2024-01-09

申请号：US17367296

申请日：2021-07-02

申请人： Hugh Mason ,  Andrew Diamos ,  Mary Pardhe ,  Brandon Favre

发明人： Hugh Mason ,  Andrew Diamos ,  Mary Pardhe ,  Brandon Favre

IPC分类号： A61K39/12 ,  A61K39/29 ,  A61K39/00 ,  A61K39/295 ,  A61P31/20 ,  C12N7/00 ,  A61K39/145

CPC分类号： A61K39/292 ,  A61K39/12 ,  A61K39/145 ,  A61P31/20 ,  C12N7/00 ,  A61K2039/505 ,  A61K2039/5258 ,  A61K2039/575 ,  A61K2039/6056 ,  A61K2039/70 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2710/20071 ,  C12N2730/10123 ,  C12N2730/10134 ,  C12N2730/10171 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2770/24134 ,  C12N2770/24171

摘要： The disclosure relates to vaccination compositions, for example, against human papillomavirus, Zika virus, and flu virus. The disclosure also relates to vectors for producing the virus-like particles and immune complex platforms of the vaccination compositions.

公开(公告)号：US20220193233A1

公开(公告)日：2022-06-23

申请号：US17541273

申请日：2021-12-03

申请人： Thomas McFarland ,  Greggory May ,  Hugh Mason ,  Andrew Diamos

发明人： Thomas McFarland ,  Greggory May ,  Hugh Mason ,  Andrew Diamos

IPC分类号： A61K39/395 ,  C07K16/32

摘要： Breast cancer is a leading cancer diagnosed in women in the U.S. and globally. To combat this deadly disease, continued innovation in immunotherapy treatment methods as an alternative to chemotherapies is gaining traction with promising results. Immunotherapy is the use of medicines to stimulate a subject's own immune system to recognize and destroy cancer cells more effectively. The instant application discloses an immunotherapy treatment and treatment method for breast cancer tumors with Her-2/neu overexpression.

公开(公告)号：US20050048074A1

公开(公告)日：2005-03-03

申请号：US10838834

申请日：2004-05-04

申请人： Guy Cardineau ,  Hugh Mason ,  Joyce VanEck ,  Dwayne Kirk ,  Amanda Walmsley

发明人： Guy Cardineau ,  Hugh Mason ,  Joyce VanEck ,  Dwayne Kirk ,  Amanda Walmsley

IPC分类号： A01H1/00 ,  A61K20060101 ,  A61K39/12 ,  C12N5/04 ,  C12N5/10 ,  C12N15/29 ,  C12N15/82

CPC分类号： C12N15/8258

摘要： The inventions is drawn towards vectors and methods useful for preparing genetically transformed plant cells that express immunogens from pathogenic organisms which are used to produce immunoprotective particles useful in vaccine preparations. The invention includes plant optimized genes that encode the HN protein of Newcastle Disease Virus. The invention also relates to methods of producing an antigen in a transgenic plant.

摘要翻译： 本发明涉及用于制备基因转化的植物细胞的载体和方法，所述转基因植物细胞表达用于产生用于疫苗制剂的免疫保护性颗粒的病原微生物的免疫原。 本发明包括编码新城疫病毒的HN蛋白的植物优化的基因。 本发明还涉及在转基因植物中产生抗原的方法。

公开(公告)号：US20150368660A1

公开(公告)日：2015-12-24

申请号：US14762128

申请日：2014-01-22

申请人： Hugh MASON ,  Charles ARNTZEN ,  Sun Hee ROSENTHAL ,  Sean WINKLE ,  Andy DIAMOS ,  THE ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： Hugh Mason ,  Charles Arntzen ,  Sun Hee Rosenthal ,  Sean Winkle ,  Andy Diamos

IPC分类号： C12N15/82 ,  C12N7/00 ,  C07K16/28

CPC分类号： C12N15/8258 ,  C07K16/2887 ,  C07K2317/13 ,  C07K2317/14 ,  C12N7/00 ,  C12N15/8203 ,  C12N15/8218 ,  C12N2750/12043

摘要： A single vector or multiple separate vectors that contain two or more non-competing replicons for transient expression of the heavy and light chains of Rituximab in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures to optimize the expression is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of the multi-replicon single vector system for producing Rituximab in plant cells.

摘要翻译： 描述了含有两个或更多个非竞争性复制子的单个载体或多个单独的载体，用于在烟草本生叶中短暂表达利妥昔单抗的重链和轻链。 还描述了将这些亚基蛋白正确组装到功能性低聚结构中以优化表达。 该系统通过消除对非竞争病毒的需要，推进植物瞬时表达技术，从而增强了用于在植物细胞中生产利妥昔单抗的多复制子单载体系统的实际商业应用。

公开(公告)号：US20050155113A1

公开(公告)日：2005-07-14

申请号：US10895791

申请日：2004-07-21

申请人： William Hamilton ,  Koen Hellendoorn ,  Timothy Jones ,  Dwayne Kirk ,  Hugh Mason ,  Xiuren Zhang ,  Charles Arntzen

发明人： William Hamilton ,  Koen Hellendoorn ,  Timothy Jones ,  Dwayne Kirk ,  Hugh Mason ,  Xiuren Zhang ,  Charles Arntzen

IPC分类号： A01H1/00 ,  A61K20060101 ,  A61K39/12 ,  C12N7/00 ,  C12N15/82 ,  C12Q1/70

CPC分类号： C12N15/8258 ,  A61K2039/5258 ,  A61K2039/542 ,  C07K14/005 ,  C12N2770/16022

摘要： The present invention relates to a synthetic plant-optimized nucleic acid molecule having a Norwalk virus capsid protein coding nucleotide sequence, and nucleic acid constructs, host cells, expression systems, and plants having the plant-optimized Norwalk virus nucleic acid molecule. The present invention also relates to a method of producing Norwalk virus capsid protein virus-like particles in a transgenic plant or transgenic plant seed transformed with a plant-optimized nucleic acid molecule encoding Norwalk virus capsid protein. The plant or a component thereof can be administered to a subject under conditions effective to immunize the subject against disease resulting from infection by a Norovirus, including Norwalk virus. An oral vaccine for immunization of a subject against Norwalk virus infection is also disclosed.

摘要翻译： 本发明涉及具有Norwalk病毒衣壳蛋白编码核苷酸序列的合成植物优化核酸分子，以及具有植物优化诺瓦克病毒核酸分子的核酸构建体，宿主细胞，表达系统和植物。 本发明还涉及在用植物优化的编码诺瓦克病毒衣壳蛋白的核酸分子转化的转基因植物或转基因植物种子中产生诺瓦克病毒衣壳蛋白病毒样颗粒的方法。 植物或其组分可以在有效免疫受试者的病症下施用于受诺如病毒（包括诺瓦克病毒）感染引起的疾病的病症。 还公开了用于免疫Norwalk病毒感染的受试者的口服疫苗。