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    Dental releasing materials
    2.
    发明授权
    Dental releasing materials 有权
    牙齿释放材料

    公开(公告)号：US07632878B2

    公开(公告)日：2009-12-15

    申请号：US12288183

    申请日：2008-10-17

    申请人： Huakun Xu ,  Limin Sun ,  Shozo Takagi ,  Laurence C. Chow

    发明人： Huakun Xu ,  Limin Sun ,  Shozo Takagi ,  Laurence C. Chow

    IPC分类号： A61K6/083 ,  C08K3/32 ,  C08K3/34 ,  A61C5/00

    CPC分类号： A61L27/54 ,  A61L27/44 ,  A61L2300/112 ,  A61L2300/624 ,  A61L2400/12

    摘要： Combining nanosized particles of a source of desired dental restorative, repair or therapeutic materials with strengthening agents in various generally nanosized form such as whiskers, fibers, particles and the like in a resin matrix provides a highly strain resistant composite which more effectively releases the therapeutic agents. The utilization of nano sized particles of the therapeutic agent in the combination enables observation of significantly improved therapeutic results.

    摘要翻译： 将所需牙科修复剂，修复或治疗材料源的纳米尺寸颗粒与各种通常纳米尺寸形式的增强剂（例如晶须，纤维，颗粒等）在树脂基质中组合提供了高度耐应变的复合材料，其更有效地释放治疗剂 。 联合使用治疗剂的纳米级颗粒可以观察到显着改善的治疗结果。

    Dental and endodontic filling materials and methods
    5.
    发明授权
    Dental and endodontic filling materials and methods 有权
    牙科和牙髓填充材料及方法

    公开(公告)号：US09101436B2

    公开(公告)日：2015-08-11

    申请号：US11550543

    申请日：2006-10-18

    申请人： Laurence C. Chow ,  Shozo Takagi

    发明人： Laurence C. Chow ,  Shozo Takagi

    IPC分类号： A61K6/08 ,  A61C5/04 ,  A61K6/00

    CPC分类号： A61C5/50 ,  A61K6/0038

    摘要： Disclosed are endodontic filling materials and methods. A method for filling a dental root canal may include providing a hydrosetting filling material and inserting the hydrosetting filling material into the dental root canal, the material setting in the root canal to form a biocompatible filling. The hydrosetting filling material comprises a hydrogel former and a filler. The hydrogel former is at least one of a reactive organic hydrogel formers, an inorganic hydrogel formers, and a non-reactive organic hydrogel formers, and the filler is at least one of a self-hardening and a non-hardening filler. Plural filling material precursor compositions that collectively contain hydrogel formers and fillers may be provided.

    摘要翻译： 公示的是根管填充材料和方法。 用于填充牙根管的方法可以包括提供水合物填充材料，并将水合物填充材料插入牙根管，根管中设置的材料以形成生物相容的填充物。 水凝胶填充材料包括水凝胶形成剂和填料。 水凝胶形成剂是反应性有机水凝胶形成剂，无机水凝胶形成剂和非反应性有机水凝胶形成剂中的至少一种，填料是自硬化和非硬化填料中的至少一种。 可以提供集体含有水凝胶形成剂和填料的多种填充材料前体组合物。

    Fluoride-calcium compositions, dental products, and methods for providing dental fluoride
    6.
    发明授权
    Fluoride-calcium compositions, dental products, and methods for providing dental fluoride 有权
    氟化钙组合物，牙科产品和提供氟化氟的方法

    公开(公告)号：US08956594B2

    公开(公告)日：2015-02-17

    申请号：US11552414

    申请日：2006-10-24

    申请人： Laurence C. Chow ,  Shozo Takagi

    发明人： Laurence C. Chow ,  Shozo Takagi

    IPC分类号： A61K8/21 ,  A61K8/24 ,  A61K33/06 ,  A61Q11/00 ,  A61K8/19

    CPC分类号： A61Q11/00 ,  A61K8/19 ,  A61K8/21 ,  A61K8/24

    摘要： Disclosed are dental compositions and methods. In accordance with one embodiment, a dental composition includes calcium, fluorine, which is generally present in the form of fluoride, and phosphate or another stabilizing anion. The composition is stable as against precipitation of calcium fluoride during transport and storage, but is unstable against the precipitation of calcium fluoride in the oral cavity of a human. In many embodiments, the amount of fluoride may be less than the amount of fluoride used in a comparable composition intended for a similar purpose. A dental method comprises applying the composition to the oral cavity of a patient, whereupon calcium fluoride precipitates from the composition.

    摘要翻译： 公开了牙科用组合物和方法。 根据一个实施方案，牙科用组合物包括通常以氟化物形式存在的钙，氟，磷酸盐或其它稳定阴离子。 该组合物在运输和储存期间对于氟化钙的沉淀是稳定的，但是对于人体口腔中氟化钙的沉淀是不稳定的。 在许多实施方案中，氟化物的量可以小于用于类似目的的类似组合物中使用的氟化物的量。 牙科方法包括将组合物施用于患者的口腔，于是氟化钙从组合物中沉淀出来。

    Anti-carious chewing gums, candies, gels, toothpastes and dentifrices
    8.
    发明授权
    Anti-carious chewing gums, candies, gels, toothpastes and dentifrices 失效
    抗龋齿的口香糖，糖果，凝胶，牙膏和牙粉

    公开(公告)号：US5993786A

    公开(公告)日：1999-11-30

    申请号：US88869

    申请日：1998-06-02

    申请人： Laurence C. Chow ,  Shozo Takagi ,  Gerald L. Vogel

    发明人： Laurence C. Chow ,  Shozo Takagi ,  Gerald L. Vogel

    IPC分类号： A23G3/00 ,  A23G3/34 ,  A23G3/36 ,  A23G4/00 ,  A23G4/06 ,  A61K8/00 ,  A61K8/19 ,  A61K8/20 ,  A61K8/24 ,  A61K8/36 ,  A61K8/362 ,  A61K8/365 ,  A61K9/68 ,  A61K33/42 ,  A61P19/00 ,  A61Q11/00 ,  A61K7/16

    CPC分类号： A61Q11/00 ,  A23G3/362 ,  A23G4/064 ,  A61K8/19 ,  A61K8/24 ,  A61K9/0058

    摘要： The invention relates to anticarious delivery vehicles, specifically chewing gums, candies, confectioneries, toothpastes, dentifrices and gels. The invention specifically provides chewing gums, candies, confectioneries, toothpastes, dentifrices and gels containing non-toxic sparingly soluble calcium and phosphate compounds as additives, causing the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than 5 minutes. The invention provides released calcium phosphate ions that diffuse into partially demineralized tooth enamel or dentin, leading to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. The invention thus provides agents and methods for remineralization of teeth and for reducing or eradicating cariogenic challenge in plaque following sucrose intake. The formulations of the invention can thereby produce effective anticaries actions without the use of fluoride. In addition, the formulations of the invention can be used to desensitize hypersensitive teeth.

    摘要翻译： 本发明涉及抗转运载体，特别是口香糖，糖果，糖果，牙膏，洁齿剂和凝胶。 本发明专门提供口香糖，糖果，糖果，牙膏，洁牙剂和含有无毒性微溶钙和磷酸盐化合物作为添加剂的凝胶，导致钙和磷酸根离子逐渐持续持续一段时间不间断 5分钟。 本发明提供了释放的磷酸钙离子，其扩散到部分去矿物质的牙釉质或牙本质中，导致龋齿病变，牙斑，开口牙质小管和暴露牙本质的再矿化和修复。 因此，本发明提供了用于牙齿再矿化的药剂和方法，并且用于在蔗糖摄入之后减少或消除斑块中的致龋性攻击。 因此，本发明的制剂可以在不使用氟化物的情况下产生有效的防龋作用。 此外，本发明的制剂可用于使过敏性牙齿脱敏。

    Control of calcium fluoride formation in mouth rinses, dentifrices and gels
    9.
    发明授权
    Control of calcium fluoride formation in mouth rinses, dentifrices and gels 失效
    口腔冲洗，洁齿剂和凝胶中氟化钙形成的控制

    公开(公告)号：US5891448A

    公开(公告)日：1999-04-06

    申请号：US741333

    申请日：1996-10-29

    申请人： Laurence C. Chow ,  Shozo Takagi

    发明人： Laurence C. Chow ,  Shozo Takagi

    IPC分类号： A61K8/20 ,  A61K8/21 ,  A61K8/24 ,  A61K8/36 ,  A61K8/362 ,  A61K8/365 ,  A61K8/41 ,  A61K8/44 ,  A61K8/55 ,  A61K9/00 ,  A61Q11/00

    CPC分类号： A61Q11/00 ,  A61K8/21 ,  A61K8/24 ,  A61K8/365 ,  A61K8/44 ,  A61K8/55 ,  A61K2800/88

    摘要： Specific compositions and methods are disclosed employing calcium fluoride inhibitors in two-component fluoride delivery systems to produce an initial delay in calcium fluoride formation and to control the rate of reactions that precipitate calcium fluoride in order to achieve enhanced fluoride deposition in the oral environment. In the two-component fluoride delivery system, one component contains a source of calcium ions and the other a source of fluoride ions. An inhibitor of calcium fluoride formation is present in one or both phases such that when one or both components are mixed the formation of calcium fluoride precipitate does not occur until at least about five seconds after mixing. The system may be employed in the form of mouth rinses, dentifrices, or chewable tablets.

    摘要翻译： 公开了在双组分氟化物递送系统中使用氟化钙抑制剂以产生氟化钙形成的初始延迟并控制沉淀氟化钙的反应速率以在口腔环境中实现增强的氟化物沉积的具体组合物和方法。 在双组分氟化物递送系统中，一个组分含有钙离子源，另一个组分含有氟离子源。 在一个或两个相中存在形成氟化钙的抑制剂，使得当将一种或两种组分混合时，在混合后至少约五秒钟之后，不会形成氟化钙沉淀物。 该系统可以以漱口剂，洁牙剂或咀嚼片的形式使用。