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公开(公告)号：US20210347994A1
公开(公告)日：2021-11-11
申请号：US17300459
申请日：2021-07-06
发明人： Luke LAVIS , Jonathan B. Grimm
摘要： The present invention is generally directed to the synthesis and use of fluorophores. It is more specifically directed to the synthesis and use of deuterated fluorophores. In one case, the present invention provides a compound of the structure shown in FIG. 44.
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2.发明公开公开(公告)号：US20240239818A1
公开(公告)日：2024-07-18
申请号：US18390289
申请日：2023-12-20
发明人： Luke D. LAVIS , Pratik Kumar , Carla Nicolini , Jonathan B. Grimm
IPC分类号： C07F7/08 , C07D495/04 , C07K1/22 , G01N21/64
CPC分类号： C07F7/0812 , C07D495/04 , C07K1/22 , G01N21/6486
摘要： The application discloses a compound having a moiety that is either an affinity tag-containing moiety or a protein-manipulation moiety, a self-labeling protein (SLP) ligand, and a rhodamine dye linking the affinity tag-containing moiety or a protein-manipulation moiety to the SLP ligand. Also disclosed is a complex, which includes the compound and a SLP. Also disclosed is a method that involves contacting the compound and a SLP with a cell, and visualizing fluorescence in the cell or purifying the SLP and associated biological components from the cell.
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公开(公告)号：US10018624B1
公开(公告)日：2018-07-10
申请号：US15897571
申请日：2018-02-15
发明人： Luke D. Lavis , Jonathan B. Grimm , Jiji Chen , Timothee Lionnet , Zhengjian Zhang , Andrey Revyakin , Joel Slaughter
IPC分类号： C07D205/06 , C07D401/14 , C07D405/04 , C07D413/14 , C07D473/18 , C07F7/08 , C09B1/16 , C09B11/02 , C09B11/28 , G01N33/52 , C09B15/00 , C09B19/00 , C09B69/00 , C09K11/06 , G01N33/58 , C09B57/02 , C07D519/00 , C07D493/10 , C07D403/14 , C07D405/14
摘要： The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.
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公开(公告)号：US09933417B2
公开(公告)日：2018-04-03
申请号：US15301270
申请日：2015-04-01
发明人： Luke D. Lavis , Jonathan B. Grimm , Jiji Chen , Timothee Lionnet , Zhengjian Zhang , Andrey Revyakin , Joel Slaughter
IPC分类号： G01N33/52 , C07D205/06 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D473/18 , C07F7/08 , C09B1/16 , C09B11/02 , C09B11/28 , C09B15/00 , C09B19/00 , C09B57/02 , C09B69/00 , C09K11/06 , G01N33/58 , C07D493/10 , C07D519/00
CPC分类号： G01N33/52 , C07D205/06 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D473/18 , C07D493/10 , C07D519/00 , C07F7/0812 , C09B1/16 , C09B11/02 , C09B11/24 , C09B11/28 , C09B15/00 , C09B19/00 , C09B21/00 , C09B57/02 , C09B69/008 , C09K11/06 , C09K2211/1029 , C09K2211/1044 , C09K2211/1096 , G01N33/582
摘要： The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.
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公开(公告)号：US11787946B2
公开(公告)日：2023-10-17
申请号：US17300459
申请日：2021-07-06
发明人： Luke Lavis , Jonathan B. Grimm
CPC分类号： C09B11/24 , C07B59/002 , C09B1/00 , C09B3/14 , C09B6/00 , C09B47/04 , C09B57/001
摘要： The present invention is generally directed to the synthesis and use of fluorophores. It is more specifically directed to the synthesis and use of deuterated fluorophores. In one case, the present invention provides a compound of the structure shown in FIG. 44.
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公开(公告)号：US10407399B2
公开(公告)日：2019-09-10
申请号：US15756788
申请日：2016-09-01
IPC分类号： C07D311/16 , C07D307/94 , C07D311/82 , C07D405/12 , A61N5/06 , A61K41/00 , C09K11/06 , G01N21/64 , G01N33/58 , G01N33/84
摘要： The presently-disclosed subject matter relates to analyte-activated photolabile compounds. The compounds include the formula: wherein Z includes a maskable molecule; L is selected from a bond, C, C(O), O, alkyl, (O)alkyl, and alkoxy; R1 is selected from H, halogen, alkyl, and acyl; each R2 is independently selected from H, alkyl, aryl, and acyl, and is optionally substituted with one or more heteroatoms independently selected from COOH and COO(alkyl); and R3 is selected from H, alkyl, aryl, halogen, CN, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, CHO, COOH, COO(alkyl), COO(aryl), PO3H2, and SO3H, and is optionally substituted with one or more heteroatoms independently selected from N, O, and S, halogen, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, NO2, CHO, COO, COOH, COO(alkyl), COO(aryl), C(O)NR2, PO3H2, and/or SO3H. Also provided are methods of detecting calcium and treating a subject with the analyte-activated photolabile compounds.
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公开(公告)号：US11958976B2
公开(公告)日：2024-04-16
申请号：US17975310
申请日：2022-10-27
发明人： Luke D. Lavis , Jonathan B. Grimm
IPC分类号： C07D405/12 , C07D311/80 , C07D313/14 , C07D473/32 , C07D493/10 , C07F7/08 , C09B11/24 , C09B11/28 , G01N21/64
CPC分类号： C09B11/24 , C07D311/80 , C07D313/14 , C07D405/12 , C07D473/32 , C07D493/10 , C07F7/0816 , C09B11/28 , G01N21/6458 , G01N2021/6439
摘要： Provided are a photoactive fluorophore, a photoactive ligand, and a photoactive complex. The photoactive fluorophore includes a photoactivatable derivative of an azetidine-containing Janelia-Fluor dye. The photoactive ligand includes a photoactive fluorophore and a protein tag. The photoactive complex includes a photoactive ligand conjugated to a protein. Also provided are methods of in vivo labeling with and photoactivation of the photoactive fluorophore, ligand, and complex.
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公开(公告)号：US20240052169A1
公开(公告)日：2024-02-15
申请号：US18445510
申请日：2023-09-11
发明人： Luke Lavis , Jonathan B. Grimm
CPC分类号： C09B11/24 , C07B59/002 , C09B1/00 , C09B57/001 , C09B6/00 , C09B47/04 , C09B3/14
摘要： The present invention is generally directed to the synthesis and use of fluorophores. It is more specifically directed to the synthesis and use of deuterated fluorophores. In one case, the present invention provides a compound of the structure shown in FIG. 44.
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公开(公告)号：US20230095090A1
公开(公告)日：2023-03-30
申请号：US17975310
申请日：2022-10-27
发明人： Luke D. Lavis , Jonathan B. Grimm
IPC分类号： C09B11/24 , G01N21/64 , C07D311/80 , C07F7/08 , C07D493/10 , C07D313/14 , C09B11/28 , C07D405/12 , C07D473/32
摘要： Provided are a photoactive fluorophore, a photoactive ligand, and a photoactive complex. The photoactive fluorophore includes a photoactivatable derivative of an azetidine-containing Janelia-Fluor dye. The photoactive ligand includes a photoactive fluorophore and a protein tag. The photoactive complex includes a photoactive ligand conjugated to a protein. Also provided are methods of in vivo labeling with and photoactivation of the photoactive fluorophore, ligand, and complex.
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公开(公告)号：US11091643B2
公开(公告)日：2021-08-17
申请号：US16501722
申请日：2019-05-28
发明人： Luke Lavis , Jonathan B. Grimm
摘要： The present invention is generally directed to the synthesis and use of fluorophores. It is more specifically directed to the synthesis and use of deuterated fluorophores. In one case, the present invention provides a compound of the structure shown in FIG. 44.
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