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    Apertureless near field optical microscope
    1.
    发明授权
    Apertureless near field optical microscope 失效
    无孔近场光学显微镜

    公开(公告)号：US4947034A

    公开(公告)日：1990-08-07

    申请号：US344621

    申请日：1989-04-28

    申请人： Hemantha K. Wickramasinghe ,  Clayton C. Williams

    发明人： Hemantha K. Wickramasinghe ,  Clayton C. Williams

    IPC分类号： G02B21/36 ,  G01B11/30 ,  G01N37/00 ,  G01Q20/02 ,  G01Q60/22 ,  G02B21/00

    CPC分类号： G01Q60/22 ,  B82Y20/00 ,  B82Y35/00 ,  G01Q20/02 ,  Y10S977/862

    摘要： A near field optical microscopy method and apparatus eliminates the necessity of an aperture for scanning a sample surface and greatly reduces the detected background signal. A small dimension tip, on the order of atomic dimension, is disposed in close proximity to the sample surface. A dither motion is applied to the tip at a first frequency in a direction substantially normal to the plane of the sample surface. Dither motion is simultaneously applied to the sample at a second frequency in a direction substantially parallel to the plane of the sample surface. The amplitude of the motions are chosen to be comparable to the desired measurement resolution. The end of the tip is illuminated by optical energy. The scattered light from the tip and surface is detected at the difference frequency for imaging the sample surface at sub-wavelength resolution without the use of an aperture. Alternatively, the tip is maintained stationary and the sample undergoes motion in the two directions.

    Sub-lithographic printing method
    3.
    发明授权
    Sub-lithographic printing method 失效
    亚平版印刷法

    公开(公告)号：US08421194B2

    公开(公告)日：2013-04-16

    申请号：US13006403

    申请日：2011-01-13

    申请人： Chung H. Lam ,  Hemantha K. Wickramasinghe

    发明人： Chung H. Lam ,  Hemantha K. Wickramasinghe

    IPC分类号： H01L29/06

    CPC分类号： H01L21/0337

    摘要： A trench structure and an integrated circuit comprising sub-lithographic trench structures in a substrate. In one embodiment the trench structure is created by forming sets of trenches with a lithographic mask and filling the sets of trenches with sets of step spacer blocks comprising two alternating spacer materials which are separately removable from each other. In one embodiment, the trench structures formed are one-nth the thickness of the lithographic mask's feature size. The size of the trench structures being dependent on the thickness and number of spacer material layers used to form the set of step spacer blocks. The number of spacer material layers being n/2 and the thickness of each spacer material layer being one-nth of the lithographic mask's feature size.

    摘要翻译： 沟槽结构和集成电路，其包括衬底中的次光刻沟槽结构。 在一个实施例中，沟槽结构是通过用光刻掩膜形成一组沟槽而形成的，并且用一组间隔块块填充该组沟槽，该组间隔块包括彼此分离地可拆卸的两个交替间隔物材料。 在一个实施例中，形成的沟槽结构是光刻掩模的特征尺寸的厚度的十分之一。 沟槽结构的尺寸取决于用于形成一组步进间隔块的间隔材料层的厚度和数量。 间隔材料层的数量为n / 2，每个间隔材料层的厚度为光刻掩模的特征尺寸的十分之一。

    SUB-LITHOGRAPHIC PRINTING METHOD
    4.
    发明申请
    SUB-LITHOGRAPHIC PRINTING METHOD 失效
    分层印刷方法

    公开(公告)号：US20110108960A1

    公开(公告)日：2011-05-12

    申请号：US13006403

    申请日：2011-01-13

    申请人： Chung H. Lam ,  Hemantha K. Wickramasinghe

    发明人： Chung H. Lam ,  Hemantha K. Wickramasinghe

    IPC分类号： H01L21/02 ,  H01L29/06

    CPC分类号： H01L21/0337

    摘要： A trench structure and an integrated circuit comprising sub-lithographic trench structures in a substrate. In one embodiment the trench structure is created by forming sets of trenches with a lithographic mask and filling the sets of trenches with sets of step spacer blocks comprising two alternating spacer materials which are separately removable from each other. In one embodiment, the trench structures formed are one-nth the thickness of the lithographic mask's feature size. The size of the trench structures being dependent on the thickness and number of spacer material layers used to form the set of step spacer blocks. The number of spacer material layers being n/2 and the thickness of each spacer material layer being one-nth of the lithographic mask's feature size.

    摘要翻译： 沟槽结构和集成电路，其包括衬底中的次光刻沟槽结构。 在一个实施例中，沟槽结构是通过用光刻掩膜形成一组沟槽而形成的，并且用一组间隔块块填充该组沟槽，该组间隔块包括彼此分离地可拆卸的两个交替间隔物材料。 在一个实施例中，形成的沟槽结构是光刻掩模的特征尺寸的厚度的十分之一。 沟槽结构的尺寸取决于用于形成一组步进间隔块的间隔材料层的厚度和数量。 间隔材料层的数量为n / 2，每个间隔材料层的厚度为光刻掩模的特征尺寸的十分之一。

    Assembly suitable for identifying a code sequence of a biomolecule in a gel embodiment
    7.
    发明授权
    Assembly suitable for identifying a code sequence of a biomolecule in a gel embodiment 失效
    适合于在凝胶实施例中识别生物分子的代码序列的装配

    公开(公告)号：US5609744A

    公开(公告)日：1997-03-11

    申请号：US405481

    申请日：1995-03-16

    申请人： Frederic Zenharusern ,  Hemantha K. Wickramasinghe

    发明人： Frederic Zenharusern ,  Hemantha K. Wickramasinghe

    IPC分类号： G01N27/447 ,  G01Q60/18 ,  B01D61/42 ,  C12M3/00

    CPC分类号： G01Q60/22 ,  B82Y20/00 ,  B82Y35/00 ,  Y10S977/853

    摘要： An assembly suitable for identifying a code sequence of at least a portion of a biomolecule in a gel embodiment. The assembly comprises first means for migrating and separating a portion of a biomolecule in a gel; second means comprising a near-field probe for generating a super-resolution chemical analysis of a portion of a biomolecule; and, third means for correlating the super-resolution chemical analysis of the portion of the biomolecule with a broad spectral content of a referent biomolecule, for generating a code sequencing of the portion of the biomolecule.

    摘要翻译： 一种适于识别凝胶实施方案中生物分子的至少一部分的编码序列的组合体。 组件包括用于迁移和分离凝胶中生物分子的一部分的第一装置; 第二装置包括用于产生生物分子的一部分的超分辨率化学分析的近场探针; 以及用于将生物分子部分的超分辨率化学分析与参照生物分子的宽光谱含量相关联的第三装置，用于产生该部分生物分子的编码测序。

    Method and apparatus to separate molecules according to their mobilities
    8.
    发明授权
    Method and apparatus to separate molecules according to their mobilities 失效
    根据其迁移率分离分子的方法和装置

    公开(公告)号：US07579149B2

    公开(公告)日：2009-08-25

    申请号：US11047250

    申请日：2005-01-31

    申请人： Jane E. Frommer ,  Kerem Unal ,  Hemantha K. Wickramasinghe

    发明人： Jane E. Frommer ,  Kerem Unal ,  Hemantha K. Wickramasinghe

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12M23/00 ,  B01D57/02

    CPC分类号： G01N27/44791 ,  B82Y15/00

    摘要： A method and apparatus for separating molecules comprises placing different kinds of molecular species onto a probe; and introducing an electric field between the probe and a surface in proximity with the probe so that the different kinds of molecular species may be separated, wherein the different kinds of molecular species have differing mobilities, and wherein the different kinds of molecular species may be separated according to their differing mobilities, such that molecular species that have different mobilities migrate along the probe at different speeds towards the surface. The molecular species may comprise molecules. Alternatively, the molecular species may comprise molecular assemblies, wherein the molecular assemblies may comprise at least one of cells, bacteria, and viruses.

    摘要翻译： 用于分离分子的方法和装置包括将不同种类的分子物质放置在探针上; 并且在所述探针与所述探针附近的表面之间引入电场，使得可以分离所述不同种类的分子种类，其中所述不同种类的分子种类具有不同的迁移率，并且其中所述不同种类的分子种类可能被分离 根据它们不同的迁移率，使得具有不同迁移率的分子物质沿着探针以不同的速度朝向表面迁移。 分子种类可以包含分子。 或者，分子种类可以包括分子组装，其中分子组装可以包含细胞，细菌和病毒中的至少一种。