Abstract:
A shifting device for a transmission of a motor vehicle has an actuation lever (1) which can be selectively transferred into (a) a first selector gate, more particularly an automatic selector gate, in which the lever is mechanically coupled to a transmitting component (2) for actuating a gearshift cable or a gearshift linkage, or (b) a second selector gate, more particularly a sequential selector gate, in which the lever is decoupled from the transmitting component, the transmitting component being movably mounted, more particularly pivotably mounted. A locking means (11) can immobilize the transmitting component such that no force is exerted on the gearshift cable or the gearshift linkage as long as the actuation lever has been transferred into the second selector gate. The transmitting component may be released by a transfer of the actuation lever into the first selector gate.
Abstract:
A shifting device for a transmission of a motor vehicle has an actuation lever (1) which can be selectively transferred into (a) a first selector gate, more particularly an automatic selector gate, in which the lever is mechanically coupled to a transmitting component (2) for actuating a gearshift cable or a gearshift linkage, or (b) a second selector gate, more particularly a sequential selector gate, in which the lever is decoupled from the transmitting component, the transmitting component being movably mounted, more particularly pivotably mounted. A locking means (11) can immobilize the transmitting component such that no force is exerted on the gearshift cable or the gearshift linkage as long as the actuation lever has been transferred into the second selector gate. The transmitting component may be released by a transfer of the actuation lever into the first selector gate.
Abstract:
The invention relates to novel cascade polymer complexes, to compositions comprising these compounds, to the use of the complexes in NMR diagnosis, and to processes for preparing these compounds and compositions. The complex-forming cascade polymer complexes according to the invention can be described by general formula I: R-L-A-{X—[Y-(Z-{W—Kw}z)y]x}a−1 (I) where R=is an HSA-binding unit, L=is a linker or a bond, A=is a nitrogen-containing cascade core of base multiplicity a, X and Y are independently of one another a direct linkage or a cascade reproduction unit of reproduction multiplicity x and y, respectively, Z and W=are independently of one another a direct linkage or a cascade reproduction unit of reproduction multiplicity z and w, respectively, K is the residue of a complexing agent, a=is numbers 2 to 12, and x, y, z and w are independently of one another the numbers 1 to 4, with the proviso that exactly one multiplicity of the base multiplicity a of the cascade core A represents exactly one point of linkage to L, and with the proviso that the cascade polymer complexes comprise in the complexing agent residue K in total at least 4 ions of an element of atomic number 20 to 29, 39, 42 to 44 or 57 to 83 and comprise where appropriate cations of inorganic and/or organic bases, amino acids or amino amides.
Abstract:
A new process for the production of triiodotrimesic acid that is used as an intermediate product for the synthesis of x-ray contrast media is described.
Abstract:
The invention relates to hydroxypyridinone derivatives, their metal complexes, their preparation and their use for preparing conjugates with biomolecules. The conjugates are suitable as contrast agents in NMR diagnosis. A high relaxivity is achieved and the NMRD maximum is raised through a specific design of the ligands.
Abstract:
The invention relates to pharmaceutical agents that contain at least one fluoroalkyl-containing metal complex that has a critical micelle-formation concentration of 1 nm, and at least one natural or synthetic epothilone or epothilone derivative, optionally with the additives that are commonly used in galenicals.
Abstract:
The metal complexes of general formula I in which Hal stands for bromine or iodine, and A1 and A2 have different meanings, are suitable as contrast media.
Abstract:
The invention relates to the subjects characterized in the patent claims, namely metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use, processes for their preparation and their use in NMR and X-ray diagnosis, radiodiagnosis and radiotherapy, and in MRT lymphography.
Abstract:
The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
Abstract:
The invention relates to conjugates that consist of macrocyclic metal complexes with biomolecules and their production. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as as agents for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.