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公开(公告)号：US20130149243A1
公开(公告)日：2013-06-13
申请号：US13510365
申请日：2010-11-06
申请人： Mathias Berndt , Heribert Schmitt-Willich , Matthias Friebe , Keith Graham , Thomas Brumby , Christina Hultsch , Hans-Jürgen Wester , Franziska Wagner
发明人： Mathias Berndt , Heribert Schmitt-Willich , Matthias Friebe , Keith Graham , Thomas Brumby , Christina Hultsch , Hans-Jürgen Wester , Franziska Wagner
IPC分类号： C07C227/20 , A61K51/04 , C07C309/73 , C07C309/66 , C07C271/22
CPC分类号： C07C227/20 , A61K51/0402 , A61K51/0406 , C07B59/001 , C07B2200/05 , C07C229/24 , C07C271/22 , C07C309/66 , C07C309/73
摘要： This invention relates to methods, which provide access to F-18 labeled glutamic acid derivatives.
摘要翻译： 本发明涉及提供进入F-18标记的谷氨酸衍生物的方法。
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2.发明申请Perfluoroalkyl-containing complexes, process for their production as well as their use 审中-公开含全氟烷基的络合物，其制备方法及其用途公开(公告)号：US20070020183A1
公开(公告)日：2007-01-25
申请号：US11486396
申请日：2006-07-14
申请人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
发明人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
IPC分类号： A61K49/10 , C07F5/00 , C07D257/02
CPC分类号： A61K49/0002 , A61K49/10 , A61K49/103 , A61K49/106 , A61K51/0482 , A61K51/0497 , C07D257/02 , C07D405/06
摘要： The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with an N-alkyl group of general formula 1, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography.
摘要翻译： 本发明涉及权利要求中特征的受试者，即具有通式1的N-烷基的全氟烷基金属络合物，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的应用， 以及MRT淋巴瘤。
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3.发明申请Conjugates of hydroxypyridinone derivative metal complexes with biomolecules and their use for MRI diagnosis 审中-公开羟基吡啶酮衍生物金属配合物与生物分子的结合及其在MRI诊断中的应用公开(公告)号：US20060292079A1
公开(公告)日：2006-12-28
申请号：US11313263
申请日：2005-12-20
申请人： Heribert Schmitt-Willich , Heiko Schirmer , Johannes Platzek , Stephane Dumas , Vincent Jacques , Thomas Brumby , Detlev Suelzle , Bernd Misselwitz
发明人： Heribert Schmitt-Willich , Heiko Schirmer , Johannes Platzek , Stephane Dumas , Vincent Jacques , Thomas Brumby , Detlev Suelzle , Bernd Misselwitz
CPC分类号： C07D401/12 , A61K49/085 , A61K49/103 , A61K49/14 , A61K49/143 , C07D213/69 , C07D213/82 , C07D401/14 , C07D403/14
摘要： The invention relates to conjugates of hydroxypyridinone derivative metal complexes and to their preparation. The conjugates are suitable as contrast agents in NMR diagnosis. A high relaxivity is achieved and the NMRD maximum is raised through a specific design of the ligands.
摘要翻译： 本发明涉及羟基吡啶酮衍生物金属络合物的缀合物及其制备方法。 缀合物在NMR诊断中适合作为造影剂。 实现了高的弛豫度，并通过配体的特定设计提高了NMRD最大值。
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4.发明授权Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system or of tumors 有权用于成像，诊断和/或治疗中枢神经系统或肿瘤疾病的化合物公开(公告)号：US08784775B2
公开(公告)日：2014-07-22
申请号：US12256957
申请日：2008-10-23
申请人： Lutz Lehmann , Andrea Thiele , Tobias Heinrich , Thomas Brumby , Christer Halldin , Balazs Gulyas , Sangram Nag
发明人： Lutz Lehmann , Andrea Thiele , Tobias Heinrich , Thomas Brumby , Christer Halldin , Balazs Gulyas , Sangram Nag
CPC分类号： C07D291/08 , A61K51/00 , A61K51/04 , C07B59/00 , C07C211/42 , C07C309/66 , C07C2602/08 , C07C2602/10 , C07D307/52
摘要： This invention relates to novel compounds suitable for labeling or already labeled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).
摘要翻译： 本发明涉及适用于标记或已经通过18F标记的新化合物，制备这种化合物的方法，包含这些化合物的组合物，包含这些化合物或组合物的试剂盒及其用途，通过正电子发射断层扫描法诊断成像的组合物或试剂盒 宠物）。
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5.发明申请COMPOUNDS FOR USE IN IMAGING, DIAGNOSING AND/OR TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM OR OF TUMORS 审中-公开用于成像，诊断和/或治疗中枢神经系统或肿瘤的疾病的化合物公开(公告)号：US20100233086A1
公开(公告)日：2010-09-16
申请号：US12739479
申请日：2008-10-14
申请人： Lutz Lehmann , Andrea Thiele , Tobias Heinrich , Thomas Brumby , Christer Halldin , Balazs Gulyas , Sangram Nag
发明人： Lutz Lehmann , Andrea Thiele , Tobias Heinrich , Thomas Brumby , Christer Halldin , Balazs Gulyas , Sangram Nag
IPC分类号： A61K49/00 , C07C211/29 , C07D307/52 , C07C309/73 , A61K31/137 , A61K31/34 , A61K31/255 , A61P25/00
CPC分类号： C07D291/08 , A61K49/0433 , A61K51/00 , A61K51/04 , C07B59/00 , C07C211/42 , C07C309/66 , C07C2602/08 , C07C2602/10 , C07D307/52
摘要： This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).
摘要翻译： 本发明涉及适用于标记或已经通过18F标记的新化合物，制备这种化合物的方法，包含这些化合物的组合物，包含这些化合物或组合物的试剂盒及其用途，通过正电子发射断层扫描法诊断成像的组合物或试剂盒 宠物）。
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6.发明授权Perfluoroalkyl-containing complexes, process for their production as well as their use 失效含全氟烷基的络合物，其制备方法及其用途公开(公告)号：US07618957B2
公开(公告)日：2009-11-17
申请号：US11487604
申请日：2006-07-17
申请人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
发明人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
IPC分类号： A01N43/00 , A61K31/33 , C07D245/00
CPC分类号： C07D257/02 , A61K49/0002 , A61K49/04 , A61K49/103 , A61K49/106 , A61K51/0478 , A61K51/0482
摘要： The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
摘要翻译： 本发明涉及权利要求所述的受试者，即具有通式I的含氮基团的全氟烷基金属络合物，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的用途，如 如在MRT淋巴瘤和血液池成像中。
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公开(公告)号：US20080292548A1
公开(公告)日：2008-11-27
申请号：US11851910
申请日：2007-09-07
申请人： Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Karramkam , Simon Ametamey
发明人： Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Karramkam , Simon Ametamey
IPC分类号： A61K51/08 , C07K5/117 , A61K38/07 , C07K7/06 , A61K38/08 , C07H19/073 , A61K31/7072
CPC分类号： C07K14/6555 , A61K51/088 , C07K14/57545
摘要： The present invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characterized by Formula II, wherein the substituents G, Q, L, Y and U have the meaning as defined in the specification and claims.
摘要翻译： 本发明涉及适用于或已经用18F放射性标记的新化合物，制备这种化合物的方法和用于诊断成像的这些化合物的用途。 这些标记的化合物由式II表征，其中取代基G，Q，L，Y和U具有如说明书和权利要求书中所定义的含义。
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公开(公告)号：US08557776B2
公开(公告)日：2013-10-15
申请号：US11851910
申请日：2007-09-07
申请人： Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Tania Karramkam , Simon Ametamey
发明人： Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Tania Karramkam , Simon Ametamey
CPC分类号： C07K14/6555 , A61K51/088 , C07K14/57545
摘要： The present invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characterized by Formula II, wherein the substituents G, Q, L, Y and U have the meaning as defined in the specification and claims.
摘要翻译： 本发明涉及适用于或已经用18F放射性标记的新化合物，制备这种化合物的方法和用于诊断成像的这些化合物的用途。 这些标记的化合物由式II表征，其中取代基G，Q，L，Y和U具有如说明书和权利要求书中所定义的含义。
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9.发明申请Perfluoroalkyl-Containing Complexes, Process For Their Production As Well As Their Use 审中-公开含全氟烷基的络合物，其制备方法及其用途公开(公告)号：US20090297454A1
公开(公告)日：2009-12-03
申请号：US12469234
申请日：2009-05-20
申请人： Heiko SCHIRMER , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
发明人： Heiko SCHIRMER , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
IPC分类号： A61K49/06 , C07D225/00 , A61K49/04 , A61K31/555
CPC分类号： C07D257/02 , A61K49/0002 , A61K49/04 , A61K49/103 , A61K49/106 , A61K51/0478 , A61K51/0482
摘要： The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
摘要翻译： 本发明涉及权利要求中特征的受试者，即具有通式I的含氮基团的全氟烷基金属络合物，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的用途，如 如在MRT淋巴瘤和血液池成像中。
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公开(公告)号：US07235561B2
公开(公告)日：2007-06-26
申请号：US10156759
申请日：2002-05-29
申请人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
发明人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
IPC分类号： A61K31/505 , C07D239/02 , A61P35/00
CPC分类号： C07D239/42 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/48 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/14 , C07D417/12 , C07D495/10 , C07F9/6512
摘要： This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
摘要翻译： 本发明涉及通式I的嘧啶衍生物，其中R 1，R 2，X，A和B具有说明书中所含的含义，作为 细胞周期蛋白依赖性激酶，其生产以及用作治疗各种疾病的药物。
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