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公开(公告)号:US20090022664A1
公开(公告)日:2009-01-22
申请号:US11851786
申请日:2007-09-07
申请人: Ananth Srinivasan , Thomas Brumby , Timo Stellfeld , Keith Graham , Ulrike Voigtmann , Jessica Becaud , Linjing Mu
发明人: Ananth Srinivasan , Thomas Brumby , Timo Stellfeld , Keith Graham , Ulrike Voigtmann , Jessica Becaud , Linjing Mu
IPC分类号: A61K51/08 , C07D203/08 , C07D403/12 , C07K7/06 , A61K51/04 , C07H19/073 , C07D487/04
CPC分类号: C07C311/19 , C07B59/001 , C07B2200/05 , C07D203/08 , C07D203/24 , C07D207/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D487/04 , C07D487/22 , C07D491/04 , C07K5/06191 , C07K7/02
摘要: The present invention relates to novel compounds suitable for or already radiolabelled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging.
摘要翻译: 本发明涉及适用于或已经用18F放射性标记的新化合物,制备这些化合物的方法和用于诊断成像的这些化合物的用途。
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公开(公告)号:US20080170993A1
公开(公告)日:2008-07-17
申请号:US11923219
申请日:2007-10-24
申请人: Ananth SRINIVASAN , Ulrike Voigtmann , Mathias Berndt , Keith Grahan , Sabine Zitzmann , Lutz Lehmann , Ansgar Fitzner
发明人: Ananth SRINIVASAN , Ulrike Voigtmann , Mathias Berndt , Keith Grahan , Sabine Zitzmann , Lutz Lehmann , Ansgar Fitzner
IPC分类号: A61K51/04 , A61K31/501 , C07D405/04 , A61P35/00
CPC分类号: C07H19/06 , A61K47/60 , A61K51/0491
摘要: The present invention relates to nucleoside analogues and more particularly to labeled nucleoside analogues. It has been found new thymidine analogues can be stably labeled with a detectable label moiety. Further the present invention relates to methods of making above compounds and use of such compounds for diagnostic imaging of tumor cells and/or treatment of proliferative diseases. In addition, the present invention relates to the preparation and use of positron emitting compounds for positron emission tomography (PET). A kit is also disclosed.
摘要翻译: 本发明涉及核苷类似物,更具体地涉及标记的核苷类似物。 已经发现新的胸苷类似物可以用可检测的标记部分稳定地标记。 此外,本发明涉及制备上述化合物的方法以及这些化合物用于肿瘤细胞诊断成像和/或治疗增殖性疾病的方法。 此外,本发明涉及用于正电子发射断层摄影(PET)的正电子发射化合物的制备和应用。 还披露了一个套件。
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公开(公告)号:US20070066516A1
公开(公告)日:2007-03-22
申请号:US11412099
申请日:2006-04-27
申请人: Ananth Srinivasan , Leonard Luyt
发明人: Ananth Srinivasan , Leonard Luyt
CPC分类号: C07K14/6555 , A61K38/00 , A61K51/08 , A61K51/083 , C07K7/64
摘要: The present invention concerns compounds comprising novel cyclized peptides with increased selectivity towards binding to the somatostatin receptor 5 (SSTR5) its production and use in the diagnosis and treatment of somatostatin-responsive diseases or diseases characterized by up-regulation of somatostatin receptors, in particular proliferative diseases.
摘要翻译: 本发明涉及包含与生长抑素受体5(SSTR 5)结合增加的选择性的新型环化肽的化合物,其用于诊断和治疗生长抑素反应性疾病或特征在于上调的疾病, 调节生长抑素受体,特别是增殖性疾病。
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公开(公告)号:US08557776B2
公开(公告)日:2013-10-15
申请号:US11851910
申请日:2007-09-07
申请人: Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Tania Karramkam , Simon Ametamey
发明人: Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Tania Karramkam , Simon Ametamey
CPC分类号: C07K14/6555 , A61K51/088 , C07K14/57545
摘要: The present invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characterized by Formula II, wherein the substituents G, Q, L, Y and U have the meaning as defined in the specification and claims.
摘要翻译: 本发明涉及适用于或已经用18F放射性标记的新化合物,制备这种化合物的方法和用于诊断成像的这些化合物的用途。 这些标记的化合物由式II表征,其中取代基G,Q,L,Y和U具有如说明书和权利要求书中所定义的含义。
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公开(公告)号:US20110112293A1
公开(公告)日:2011-05-12
申请号:US12937665
申请日:2009-04-09
申请人: John Cyr , Ananth Srinivasan , Mathias Berndt , Keith Graham , Dae Yoon Chi , Byoung Se Lee , So Young Chu , Song-Yi Lim , Sang Ju Lee , Jin-Sook Ryu , Seung Jun Oh
发明人: John Cyr , Ananth Srinivasan , Mathias Berndt , Keith Graham , Dae Yoon Chi , Byoung Se Lee , So Young Chu , Song-Yi Lim , Sang Ju Lee , Jin-Sook Ryu , Seung Jun Oh
IPC分类号: C07C17/361 , C07C67/307 , C07C41/22 , C07C17/38 , C07C67/48 , C07C41/34 , C07C41/38 , C07C67/58 , C07C309/76 , C07C229/60 , C07D233/60 , C07C309/68 , C07C309/75 , C07D405/12 , C07D405/04 , C07D249/04 , C07C211/23 , C07C309/72 , C09K3/00
CPC分类号: C07B63/02 , C07B59/00 , C07B59/001 , C07B2200/11
摘要: The present invention provides novel and advantageous processes for preparing and purifying chemical compounds such as pharmaceuticals. The processes comprise a nucleophilic substitution reaction with a moiety X wherein the leaving group L of a substrate S in the reaction is covalently attached to a purification moiety M. This concept offers a convenient and lime-saving way to purity the desired product S-X from non-reacted precursors S-L-M and by-products L-M.
摘要翻译: 本发明提供了制备和纯化化合物如药物的新颖且有利的方法。 该方法包括与部分X的亲核取代反应,其中反应中的底物S的离去基团L共价连接到纯化部分M.该概念提供了一种方便和节省石灰的方法,从非纯化中纯化所需产物SX - 前体SLM和副产物LM。
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公开(公告)号:US20090317326A1
公开(公告)日:2009-12-24
申请号:US11851940
申请日:2007-09-07
申请人: Ananth Srinivasan , Timo Stellfeld
发明人: Ananth Srinivasan , Timo Stellfeld
IPC分类号: A61K51/08 , C07K7/00 , A61K51/04 , A61K101/02
CPC分类号: C07D249/18 , A61K38/00 , A61K49/085 , A61K49/14 , A61K51/088 , C07D233/64 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04 , C07D471/04 , C07K1/13 , C07K5/0202 , C07K5/0205 , C07K7/086 , C07K14/655
摘要: The present invention relates to radiolabelled substitute benzene compounds for diagnostic imaging. The present invention provides methods for preparation of such compounds, in particular, preparation of novel compounds which serve as precursors for 18F-labeling, and the use of thus 18F-labeled compounds for diagnostic imaging.
摘要翻译: 本发明涉及用于诊断成像的放射性标记的替代苯化合物。 本发明提供了这种化合物的制备方法,特别是制备用作18F标记的前体的新化合物,以及使用18F标记的化合物进行诊断成像。
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公开(公告)号:US20070021349A1
公开(公告)日:2007-01-25
申请号:US11410283
申请日:2006-04-25
申请人: Ananth Srinivasan , Leonard Luyt
发明人: Ananth Srinivasan , Leonard Luyt
CPC分类号: C07C323/59 , A61K38/00 , C07K5/0202 , C07K5/1019 , C07K7/02 , C07K7/06 , C07K7/54 , C07K7/64
摘要: The present invention concerns novel orthogonally protected amino acids, there production and use for the synthesis of binding compounds usable in the diagnosis and treatment of proliferative diseases, in particular tumor diseases.
摘要翻译: 本发明涉及新型正交保护的氨基酸,其生产和用于合成可用于诊断和治疗增殖性疾病,特别是肿瘤疾病的结合化合物。
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公开(公告)号:US20120241171A1
公开(公告)日:2012-09-27
申请号:US13071267
申请日:2011-03-24
摘要: A hanger assembly provided for multiple hanging opportunities. If liner is being run and the primary hanger doesn't work then a backup hanger is available to set near the nonfunctional primary hanger. In drilling with casing applications when there is a steering equipment malfunction or an MWD breakdown or bit wear requiring the BHA to be pulled, the liner can be hung where it is and the BHA pulled. Upon running back in with the BHA on a running tool the initial hanger can be released and the running tool configured to only set a different hanger when the total depth is reached in drilling with the liner. The running tool is then retrieved and the completion can go on.
摘要翻译: 提供多个悬挂机会的衣架组合。 如果衬管正在运行,并且主衣架不起作用,则备用衣架可用于设置在非功能性主吊架附近。 在有套管应用的情况下,当有转向设备故障或MWD故障或钻头磨损要求BHA被拉动时,衬管可以挂在其上并且BHA拉。 在运行工具上返回BHA时,可以释放初始衣架,并且运行工具配置为仅在使用衬管钻孔时达到总深度时才设置不同的衣架。 然后检索运行的工具,完成可以继续。
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公开(公告)号:US20080292548A1
公开(公告)日:2008-11-27
申请号:US11851910
申请日:2007-09-07
申请人: Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Karramkam , Simon Ametamey
发明人: Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Karramkam , Simon Ametamey
IPC分类号: A61K51/08 , C07K5/117 , A61K38/07 , C07K7/06 , A61K38/08 , C07H19/073 , A61K31/7072
CPC分类号: C07K14/6555 , A61K51/088 , C07K14/57545
摘要: The present invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characterized by Formula II, wherein the substituents G, Q, L, Y and U have the meaning as defined in the specification and claims.
摘要翻译: 本发明涉及适用于或已经用18F放射性标记的新化合物,制备这种化合物的方法和用于诊断成像的这些化合物的用途。 这些标记的化合物由式II表征,其中取代基G,Q,L,Y和U具有如说明书和权利要求书中所定义的含义。
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公开(公告)号:US20110137063A1
公开(公告)日:2011-06-09
申请号:US13002123
申请日:2009-06-24
IPC分类号: C07C309/77 , C07C309/80 , C07C309/86 , C07C309/68 , C07C309/76 , C07C209/74 , C07C227/18 , C07C209/84 , C07C227/40
CPC分类号: C07B59/00 , C07B2200/05 , C07C309/65 , C07C309/73
摘要: The present invention relates to novel perfluorinated precursors for the production of F-18 labeled radiotracers for Positron Emission Tomography (PET) and processes for radiolabeling and purification using these precursors. The invention also comprises radiopharmaceutical kits using these precursors and processes.
摘要翻译: 本发明涉及用于生产用于正电子发射断层扫描(PET)的F-18标记放射性示踪剂的新型全氟化前体和使用这些前体的放射性标记和纯化的方法。 本发明还包括使用这些前体和方法的放射性药物试剂盒。
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