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公开(公告)号：US20150013490A1
公开(公告)日：2015-01-15
申请号：US14241249
申请日：2012-08-29
申请人： Heiko Schirmer , Wei Yang
发明人： Heiko Schirmer , Wei Yang
CPC分类号： F16H59/0278 , F16H59/0204 , F16H59/04 , F16H2059/026 , Y10T74/20159
摘要： A shifting device for a transmission of a motor vehicle has an actuation lever (1) which can be selectively transferred into (a) a first selector gate, more particularly an automatic selector gate, in which the lever is mechanically coupled to a transmitting component (2) for actuating a gearshift cable or a gearshift linkage, or (b) a second selector gate, more particularly a sequential selector gate, in which the lever is decoupled from the transmitting component, the transmitting component being movably mounted, more particularly pivotably mounted. A locking means (11) can immobilize the transmitting component such that no force is exerted on the gearshift cable or the gearshift linkage as long as the actuation lever has been transferred into the second selector gate. The transmitting component may be released by a transfer of the actuation lever into the first selector gate.
摘要翻译： 用于机动车辆的变速器的变速装置具有致动杠杆（1），该致动杠杆可以选择性地转移到（a）第一选择器门，更具体地是自动选择器门，其中杠杆机械地联接到发送部件 2）用于致动变速电缆或变速联动装置，或（b）第二选择器门，更具体地是顺序选择器门，其中杆与传动部件分离，传动部件可移动地安装，更具体地可枢转地安装 。 锁定装置（11）可以固定传动部件，使得只要致动杆已经被传送到第二选择器门中，就不会对换档电缆或换档连杆施加力。 可以通过将致动杠杆传送到第一选择器门来释放发送部件。
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2.发明申请METAL CHELATES HAVING A PERFLUORINATED PEG RADICAL, PROCESSES FOR THEIR PREPARATION, AND THEIR USE 失效具有全氟代PEG辐射的金属螯合物，其制备方法及其使用公开(公告)号：US20080159954A1
公开(公告)日：2008-07-03
申请号：US11873986
申请日：2007-10-17
IPC分类号： A61K49/00 , C07C229/00 , C07H15/00
CPC分类号： C07D257/02 , A61K49/0433 , A61K49/085 , A61K49/126 , A61K51/0474 , C07D213/81
摘要： The invention relates to the subjects characterized in the patent claims, namely metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use, processes for their preparation and their use in NMR and X-ray diagnosis, radiodiagnosis and radiotherapy, and in MRT lymphography.
摘要翻译： 本发明涉及专利权利要求所述的受试者，即具有全氟化PEG基团的金属螯合物，其制备方法及其用途，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的用途，以及 在MRT淋巴瘤中。
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3.发明申请Perfluoroalkyl-containing complexes, process for their production as well as their use 失效含全氟烷基的络合物，其制备方法及其用途公开(公告)号：US20070189969A1
公开(公告)日：2007-08-16
申请号：US11487604
申请日：2006-07-17
申请人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
发明人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
IPC分类号： A61B5/055 , A61K49/04 , C07D257/02
CPC分类号： C07D257/02 , A61K49/0002 , A61K49/04 , A61K49/103 , A61K49/106 , A61K51/0478 , A61K51/0482
摘要： The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
摘要翻译： 本发明涉及权利要求中特征的受试者，即具有通式I的含氮基团的全氟烷基金属络合物，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的用途，如 如在MRT淋巴瘤和血液池成像中。
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公开(公告)号：US20070093674A1
公开(公告)日：2007-04-26
申请号：US11607016
申请日：2006-12-01
申请人： Heiko Schirmer , Ulrich Niedballa , Hannelore Niedballa , Johannes Platzek , Jose Martin , Juan Harto , Jose Carretero
发明人： Heiko Schirmer , Ulrich Niedballa , Hannelore Niedballa , Johannes Platzek , Jose Martin , Juan Harto , Jose Carretero
IPC分类号： C07C51/255 , C07C69/035
CPC分类号： C07C69/007 , C07C51/16 , C07C51/285 , C07C67/00 , C07C67/035 , C07C63/72 , C07C63/68 , C07C69/63
摘要： A new process for the production of triiodotrimesic acid that is used as an intermediate product for the synthesis of x-ray contrast media is described.
摘要翻译： 描述了用作生产用于合成X射线造影剂的中间产物的三碘三次风酸的新方法。
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公开(公告)号：US07208140B2
公开(公告)日：2007-04-24
申请号：US10780887
申请日：2004-02-19
申请人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Jose Luis Martin , Juan R. Harto , Bjoern Riefke
发明人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Jose Luis Martin , Juan R. Harto , Bjoern Riefke
IPC分类号： A61B5/055 , C07F5/00 , C07D225/00 , C07D243/14
CPC分类号： A61K49/10 , A61K49/0002 , A61K49/0438 , A61K49/085 , A61K49/106 , C07D257/02
摘要： The metal complexes of general formula I in which Hal stands for bromine or iodine and A1 and A2 have different meanings, are suitable as contrast media.
摘要翻译： 其中Hal代表溴或碘的通式I的金属络合物和具有不同含义的适合作为造影剂。
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公开(公告)号：US07355067B2
公开(公告)日：2008-04-08
申请号：US11607016
申请日：2006-12-01
申请人： Heiko Schirmer , Hannelore Niedballa, legal representative , Johannes Platzek , Jose Luis Martin , Juan R. Harto , Jose Carretero
发明人： Ulrich Niedballa
CPC分类号： C07C69/007 , C07C51/16 , C07C51/285 , C07C67/00 , C07C67/035 , C07C63/72 , C07C63/68 , C07C69/63
摘要： A new process for the production of triiodotrimesic acid that is used as an intermediate product for the synthesis of x-ray contrast media is described.
摘要翻译： 描述了用作生产用于合成X射线造影剂的中间产物的三碘三次风酸的新方法。
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7.发明申请Perfluoroalkyl-containing complexes, process for their production as well as their use 审中-公开含全氟烷基的络合物，其制备方法及其用途公开(公告)号：US20070020183A1
公开(公告)日：2007-01-25
申请号：US11486396
申请日：2006-07-14
申请人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
发明人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
IPC分类号： A61K49/10 , C07F5/00 , C07D257/02
CPC分类号： A61K49/0002 , A61K49/10 , A61K49/103 , A61K49/106 , A61K51/0482 , A61K51/0497 , C07D257/02 , C07D405/06
摘要： The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with an N-alkyl group of general formula 1, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography.
摘要翻译： 本发明涉及权利要求中特征的受试者，即具有通式1的N-烷基的全氟烷基金属络合物，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的应用， 以及MRT淋巴瘤。
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8.发明授权Macrocyclic metal complexes and their use for the production of conjugates with biomolecules 失效大环金属络合物及其与生物分子生产缀合物的用途公开(公告)号：US07164016B2
公开(公告)日：2007-01-16
申请号：US10198046
申请日：2002-07-19
申请人： Johannes Platzek , Heribert Schmitt-Willich , Günther Michl , Thomas Frenzel , Detlev Sülzle , Hans Bauer , Bernd Radüchel , Hanns-Joachim Weinmann , Heiko Schirmer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Günther Michl , Thomas Frenzel , Detlev Sülzle , Hans Bauer , Bernd Radüchel , Hanns-Joachim Weinmann , Heiko Schirmer
IPC分类号： C07D257/02
CPC分类号： A61K49/10 , A61K47/54 , A61K47/547 , A61K49/0002 , A61K49/085 , A61K49/14 , A61K49/143 , C07D257/02
摘要： The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
摘要翻译： 本发明涉及大环金属络合物及其生产和用于与生物分子生产缀合物的用途。 缀合物适用于NMR诊断和放射诊断以及放射治疗中的造影剂。 通过大环化合物的特殊结合实现高的放松性，并且可以进行微调的松弛度。
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9.发明申请Conjugates of hydroxypyridinone derivative metal complexes with biomolecules and their use for MRI diagnosis 审中-公开羟基吡啶酮衍生物金属配合物与生物分子的结合及其在MRI诊断中的应用公开(公告)号：US20060292079A1
公开(公告)日：2006-12-28
申请号：US11313263
申请日：2005-12-20
申请人： Heribert Schmitt-Willich , Heiko Schirmer , Johannes Platzek , Stephane Dumas , Vincent Jacques , Thomas Brumby , Detlev Suelzle , Bernd Misselwitz
发明人： Heribert Schmitt-Willich , Heiko Schirmer , Johannes Platzek , Stephane Dumas , Vincent Jacques , Thomas Brumby , Detlev Suelzle , Bernd Misselwitz
CPC分类号： C07D401/12 , A61K49/085 , A61K49/103 , A61K49/14 , A61K49/143 , C07D213/69 , C07D213/82 , C07D401/14 , C07D403/14
摘要： The invention relates to conjugates of hydroxypyridinone derivative metal complexes and to their preparation. The conjugates are suitable as contrast agents in NMR diagnosis. A high relaxivity is achieved and the NMRD maximum is raised through a specific design of the ligands.
摘要翻译： 本发明涉及羟基吡啶酮衍生物金属络合物的缀合物及其制备方法。 缀合物在NMR诊断中适合作为造影剂。 实现了高的弛豫度，并通过配体的特定设计提高了NMRD最大值。
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公开(公告)号：US09383001B2
公开(公告)日：2016-07-05
申请号：US14241249
申请日：2012-08-29
申请人： Heiko Schirmer , Wei Yang
发明人： Heiko Schirmer , Wei Yang
CPC分类号： F16H59/0278 , F16H59/0204 , F16H59/04 , F16H2059/026 , Y10T74/20159
摘要： A shifting device for a transmission of a motor vehicle has an actuation lever (1) which can be selectively transferred into (a) a first selector gate, more particularly an automatic selector gate, in which the lever is mechanically coupled to a transmitting component (2) for actuating a gearshift cable or a gearshift linkage, or (b) a second selector gate, more particularly a sequential selector gate, in which the lever is decoupled from the transmitting component, the transmitting component being movably mounted, more particularly pivotably mounted. A locking means (11) can immobilize the transmitting component such that no force is exerted on the gearshift cable or the gearshift linkage as long as the actuation lever has been transferred into the second selector gate. The transmitting component may be released by a transfer of the actuation lever into the first selector gate.
摘要翻译： 用于机动车辆的变速器的变速装置具有致动杠杆（1），该致动杠杆可以选择性地转移到（a）第一选择器门，更具体地是自动选择器门，其中杠杆机械地联接到发送部件 2）用于致动变速电缆或变速联动装置，或（b）第二选择器门，更具体地是顺序选择器门，其中杆与传动部件分离，传动部件可移动地安装，更具体地可枢转地安装 。 锁定装置（11）可以固定传动部件，使得只要致动杆已经被传送到第二选择器门中，就不会对换档电缆或换档连杆施加力。 可以通过将致动杠杆传送到第一选择器门来释放发送部件。
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