公开(公告)号：US20050043396A1

公开(公告)日：2005-02-24

申请号：US10674148

申请日：2003-09-29

Applicant: Hayley Zen ,  Shiqi Peng ,  Lanrong Bi ,  Ming Zhao ,  Chao Wang

Inventor： Hayley Zen ,  Shiqi Peng ,  Lanrong Bi ,  Ming Zhao ,  Chao Wang

IPC: C07D273/06 ,  C07D319/06 ,  C07D321/12 ,  A61K31/335

CPC classification number: C07D319/06 ,  C07D273/06 ,  C07D321/12

Abstract: The present invention discloses a series of benzoylamino-1,3-dioxacyclane compounds, of which compounds 1-21 were prepared via transacetalisation reaction between N-benzoylaminoglycol and 1,1,3,3-tetramethoxypropane; while compounds 22-48 were prepared via stereospecific acetalisation reaction between N-benzoylamino glycol and aromatic aldehyde, and if necessary, the nitro groups were reduced and further be salified with propane diacid and L-Arg or L-Lys. These compounds possess the structural type of PKC inhibitor and positive anti-inflammatory effect, and can be applied in medical fields as PKC inhibitor for corresponding therapy.

Abstract translation: 本发明公开了一系列苯甲酰基氨基-1,3-二氧杂环烷化合物，其中化合物1-21是通过N-苯甲酰氨基甘氨酸与1,1,3,3-四甲氧基丙烷之间的转化反应制备的; 而化合物22-48通过N-苯甲酰氨基二醇和芳族醛之间的立体特异性缩醛化反应制备，并且如果需要，硝基还原，并进一步用丙烷二酸和L-Arg或L-Lys进行成盐。 这些化合物具有PKC抑制剂的结构型和阳性消炎作用，可作为PKC抑制剂用于医学领域，用于相应的治疗。

公开(公告)号：US07138491B2

公开(公告)日：2006-11-21

申请号：US10680293

申请日：2003-10-08

Applicant: Shiqi Peng ,  Ming Zhao ,  Chao Wang ,  Yangfen Wu

Inventor： Shiqi Peng ,  Ming Zhao ,  Chao Wang ,  Yangfen Wu

IPC: A61K38/00

CPC classification number: C07K14/75 ,  A61K38/00

Abstract: The present invention relates to the protected intermediates and the deprotected products of P6A, related to the protected pseudopeptides introducing the protected intermediateds of P6A to 3S-(2-Boc)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid and the deprotected pseudopeptides, related to the protected pseudopeptides introducing the protected intermediateds of P6A to 3S-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester, related to the methods for their preparation, and related to their use as the thrombolytic agents.

Abstract translation: 本发明涉及受保护的中间体和P6A的去保护产物，其与被保护的假肽相关，引入受保护的中间体P6A至3S-（2-Boc）-1,2,3,4-四氢-β-咔啉-3 羧酸和去保护的假肽，与保护的假肽相关，引入受保护的中间体P6A至3S-1,2,3,4-四氢-β-咔啉-3-羧酸苄酯，涉及其制备方法 ，并且与它们作为溶栓剂的用途有关。

公开(公告)号：US20050080015A1

公开(公告)日：2005-04-14

申请号：US10680293

申请日：2003-10-08

Applicant: Shiqi Peng ,  Ming Zhao ,  Chao Wang ,  Yangfen Wu

Inventor： Shiqi Peng ,  Ming Zhao ,  Chao Wang ,  Yangfen Wu

IPC: A61K38/00 ,  C07K14/75 ,  A61K38/08 ,  C07K7/06

CPC classification number: C07K14/75 ,  A61K38/00

Abstract: The present invention relates to the protected intermediates and the deprotected products of P6A, related to the protected pseudopeptides introducing the protected intermediateds of P6A to 3S-(2-Boc)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid and the deprotected pseudopeptides, related to the protected pseudopeptides introducing the protected intermediateds of P6A to 3S-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester, related to the methods for their preparation, and related to their use as the thrombolytic agents.

Abstract translation: 本发明涉及受保护的中间体和P6A的去保护产物，其与被保护的假肽相关，引入受保护的中间体P6A至3S-（2-Boc）-1,2,3,4-四氢-β-咔啉-3 羧酸和去保护的假肽，与保护的假肽相关，引入受保护的中间体P6A至3S-1,2,3,4-四氢-β-咔啉-3-羧酸苄酯，涉及其制备方法 ，并且与它们作为溶栓剂的用途有关。

公开(公告)号：US06306837B1

公开(公告)日：2001-10-23

申请号：US09473737

申请日：1999-12-28

Applicant: Shiqi Peng ,  Chao Wang ,  Ming Zhao ,  Xingwei Li ,  Yancheng Wu ,  Taigang Mo

Inventor： Shiqi Peng ,  Chao Wang ,  Ming Zhao ,  Xingwei Li ,  Yancheng Wu ,  Taigang Mo

IPC: A61K3170

CPC classification number: C07H15/12 ,  Y10S514/836

Abstract: The present invention relates to a new kind of heavy metal chelating agents and a preparation process and uses thereof. The said heavy metal chelating agents are expressed in &agr;-[D(+)glucose-1-yl-amino]-&bgr;3-mercapto-(S)-propanoic acid (abbreviated to NGP,I) and/or N,N′-di[D(+)glucose-1-yl]-L-cystine (abbreviated to NGCD,II). In the process of preparation, glucose and cysteine are reacted with a base, with a reducing agent, and the obtained products are acidified to give NGP,I, which can be used in and/or as drugs, health foods and food additives for accelerating the excretion of heavy metals including Pb, Cd, Hg, Al, Sb, As, etc. The structural feature of the compounds of the present invention is that they contain glucose and cysteirie in their molecules. Compared with the heavy metal-excreting drugs of prior art, the compounds of the present invention have four advantages, namely suitability for oral administration, high ability to accelerate the excretion of heavy metals, high selectivity and less toxicity.

Abstract translation: 本发明涉及一种新型的重金属螯合剂及其制备方法和用途。 所述重金属螯合剂在α-[D（+）葡萄糖-1-基 - 氨基]-β-巯基 - （S） - 丙酸（缩写为NGP，I）和/或N， 二[D（+）葡萄糖-1-基] -L-胱氨酸（缩写为NGCD，II）。 在制备过程中，葡萄糖和半胱氨酸与碱反应，还原剂，将所得产物酸化，得到NGP，I，可用于和/或作为药物的保健食品和食品添加剂加速 重金属的排泄，包括Pb，Cd，Hg，Al，Sb，As等。本发明化合物的结构特征是它们在其分子中含有葡萄糖和半胱氨酸。 与现有技术的重金属排泄物相比，本发明的化合物具有四个优点，即口服适用性，加速重金属排泄能力高，选择性低，毒性小。

公开(公告)号：US07053047B2

公开(公告)日：2006-05-30

申请号：US10404124

申请日：2003-04-02

Applicant: Shigi Peng ,  Ming Zhao ,  Chao Wang ,  Lin Na

Inventor： Shigi Peng ,  Ming Zhao ,  Chao Wang ,  Lin Na

IPC: A61K38/00 ,  A61K38/12

CPC classification number: C07K7/64 ,  A61K38/00

Abstract: This invention relates to cyclic peptides, with the following formula (I) (SEQ ID NO: 1), cyclo(Xaa-Arg-Pro-Ala-Lys)  (I) where Xaa is Ala, Gly, Glu, Gln, Asp, Asn, Arg or Lys. The cyclic peptides have thrombolytic effects. This invention also relates to cyclic peptide preparations.

Abstract translation: 本发明涉及具有下式（I）（SEQ ID NO：1），<？在线公式描述=“在线公式”中的环状肽end =“lead”→>环（Xaa-Arg- Pro-Ala-Lys）（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中Xaa是Ala，Gly，Glu，Gln，Asp，Asn，Arg或Lys。 环肽具有溶栓作用。 本发明还涉及环肽制剂。

公开(公告)号：US10653653B2

公开(公告)日：2020-05-19

申请号：US16071485

申请日：2017-01-24

Applicant: Ming Zhao ,  Li-Ming Zhou

Inventor： Ming Zhao ,  Li-Ming Zhou

IPC: A61K31/197 ,  A61K41/00 ,  A61K47/12 ,  A61K45/06 ,  C07C53/16 ,  C07C229/22 ,  A61K9/00 ,  A61K9/06 ,  A61K9/08 ,  A61P17/10 ,  A61P17/06 ,  A61P35/00

Abstract: The present disclosure provides new salts of 5-aminolevulinic acid (5-ALA) and new salts of 5-ALA esters, their preparation, formulation and use as photosensitizing agents in photodynamic therapy, diagnosis and cosmetic cares.

公开(公告)号：US10471042B2

公开(公告)日：2019-11-12

申请号：US16068365

申请日：2017-01-13

Applicant: Ming Zhao ,  Li-Ming Zhou

Inventor： Ming Zhao ,  Li-Ming Zhou

IPC: A61K31/357 ,  A61K47/18 ,  A61K47/22 ,  A61K9/00 ,  A61K45/06

Abstract: The present disclosure provides a composition of artesunate, a process of preparing the same, and a method of treatment.

公开(公告)号：US09514120B1

公开(公告)日：2016-12-06

申请号：US13532183

申请日：2012-06-25

Applicant: Hong Chen ,  Michael Patrick Bacus ,  Ming Zhao

Inventor： Hong Chen ,  Michael Patrick Bacus ,  Ming Zhao

IPC: G06F17/00 ,  G06F17/27

CPC classification number: G06F17/273 ,  G06F17/2735 ,  G06F17/274

Abstract: A computing device hosting a server identifies one or more potential typographical errors in a work using an initial reference. The computing device sends data indicative of the presence of the potential typographical errors to users. The computing device collects feedback for the work from the users. The feedback for the work indicates whether the potential typographical errors are author-intended strings. The computing device combines the user feedback for the work with user feedback for other works and sorts the combined user feedback based on one or more selected parameters. The computing device determines, based on the sorted user feedback, that one or more of the potential typographical errors includes an acceptable string and updates the initial reference to include the acceptable string.

Abstract translation: 托管服务器的计算设备使用初始参考来识别作品中的一个或多个潜在的排印错误。 计算设备向用户发送指示潜在印刷错误存在的数据。 计算设备从用户收集工作的反馈。 工作的反馈意味着潜在的印刷错误是否是作者意图的字符串。 计算设备将用于工作的用户反馈与其他作品的用户反馈相结合，并且基于一个或多个所选参数对组合的用户反馈进行排序。 计算设备基于排序的用户反馈确定一个或多个潜在的排印错误包括可接受的字符串，并更新初始参考以包括可接受的字符串。

公开(公告)号：US09079151B2

公开(公告)日：2015-07-14

申请号：US13464013

申请日：2012-05-04

Applicant: Shi Shu ,  Ming Zhao ,  Jianshe Xue ,  Xiaoxiong Tian ,  Wenwen Sun

Inventor： Shi Shu ,  Ming Zhao ,  Jianshe Xue ,  Xiaoxiong Tian ,  Wenwen Sun

IPC: B01J13/10 ,  C09D11/10 ,  B01J13/20

CPC classification number: B01J13/10 ,  B01J13/206 ,  C09D11/10

Abstract: Embodiments of the disclosed technology provide an electronic ink microcapsule and a method for producing the same, wherein the electronic ink microcapsule comprises gelatin, polyanion, and an electrophoretic suspension, and the polyanion comprises a hydrolyzate of styrene-maleic anhydride-hexafluorobutyl (meth)acrylate-vinyl triethoxysilane tetracopolymer.

Abstract translation: 所公开的技术的实施方案提供电子墨水微胶囊及其制备方法，其中电子墨水微胶囊包含明胶，聚阴离子和电泳悬浮液，聚阴离子包含苯乙烯 - 马来酸酐 - （甲基）丙烯酸六氟丁酯的水解产物 乙烯基三乙氧基硅烷四聚物。

公开(公告)号：US20140256354A1

公开(公告)日：2014-09-11

申请号：US14349950

申请日：2011-12-29

Applicant: Ming Zhao ,  Wentao Zhang

Inventor： Ming Zhao ,  Wentao Zhang

IPC: H04W4/02

CPC classification number: H04W4/029 ,  G01C21/28 ,  G01S19/05 ,  G01S19/06 ,  G01S19/25 ,  H04L67/18

Abstract: A mobile broadband device and an assisted positioning method therefore are disclosed. A host initiates a positioning request to the mobile broadband device; a firmware of the mobile broadband device determines whether an assisted positioning function is needed for the positioning request received from the host, and when the assisted positioning function is needed, the device software initiates a request for acquiring assisted positioning data to the host; after receiving the request for acquiring the assisted positioning data from a device side, the host initiates the request for acquiring the assisted positioning data to a Secure User Plane Location (SUPL) server; the SUPL server sends positioning data to the host; after receiving the assisted positioning data, the host sends the assisted positioning data to the mobile broadband device; and the firmware of the mobile broadband device calculates standard Global Positioning System (GPS) data using the received assisted positioning data, and then outputs the standard GPS data to a positioning application program of the hose side. The disclosure enhances user experience, saves traffic for a user, increases benefits for the user, greatly reduces the load of the device side, improves the performance index of the product, and expands the application scope for the assisted positioning function.

Abstract translation: 因此，公开了一种移动宽带设备和辅助定位方法。 主机向移动宽带设备发起定位请求; 移动宽带设备的固件确定是否需要从主机接收的定位请求的辅助定位功能，并且当需要辅助定位功能时，设备软件发起向主机获取辅助定位数据的请求; 在接收到从设备侧获得辅助定位数据的请求之后，主机向安全用户平面位置（SUPL）服务器发起获取辅助定位数据的请求; SUPL服务器向主机发送定位数据; 在接收到辅助定位数据之后，主机将辅助定位数据发送到移动宽带设备; 并且移动宽带设备的固件使用接收的辅助定位数据计算标准全球定位系统（GPS）数据，然后将标准GPS数据输出到软管侧的定位应用程序。 本发明增强了用户体验，为用户节省了流量，增加了用户的利益，大大降低了设备侧的负载，提高了产品的性能指标，扩大了辅助定位功能的应用范围。