公开(公告)号：US20160291046A1

公开(公告)日：2016-10-06

申请号：US14777550

申请日：2014-03-19

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Chie YABUTANI ,  Akihisa MAKINO ,  Sakuichiro ADACHI

IPC: G01N35/00 ,  G01N33/86

CPC classification number: G01N35/00693 ,  G01N21/272 ,  G01N21/82 ,  G01N33/86 ,  G01N35/0092 ,  G01N2035/00702 ,  G01N2035/0097

Abstract: A detection unit 113 measures scattered light intensity E as a coagulation index. A first curve fitting function 120B-a c calculates, at a predetermined time interval, a parameter for an approximate curve of a coagulation curve by curve fitting, based on the measured scattered light intensity E. An early reaction checking function 120B-b determines whether there is a lag phase as an early coagulation index change, based on the parameter for the approximate curve. The parameter has been calculated at the predetermined time interval by the first curve fitting function 120B-a. A clotting time calculation function 120B-f calculates clotting time, based on whether there is the lag phase.

Abstract translation: 检测单元113测量作为凝结指数的散射光强度E. 第一曲线拟合函数120B-ac基于所测量的散射光强度E，以预定的时间间隔计算用于曲线拟合的凝固曲线的近似曲线的参数。早期反应检查功能120B-b确定是否存在 作为早期凝血指数变化的滞后期，基于近似曲线的参数。 已经通过第一曲线拟合函数120B-a以预定时间间隔计算了参数。 凝血时间计算功能120B-f基于是否存在滞后期来计算凝血时间。

公开(公告)号：US20190316963A1

公开(公告)日：2019-10-17

申请号：US16472129

申请日：2017-10-24

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Takeshi ISHIDA ,  Isao YAMAZAKI ,  Sakuichiro ADACHI ,  Shin IMAMURA

IPC: G01J3/10 ,  G01J3/04 ,  G01J3/02 ,  G01N21/27 ,  G01N21/64

Abstract: An automatic analysis apparatus comprises: a light source generating light having a center wavelength equal to or shorter than 340 nm; a fluorescent substance excited by the light source light, and generates light together with transmitted light from the light source, having a wavelength of 340 nm to 800 nm; a condenser lens; at least one slit; a reaction cell holding a reaction solution where a specimen and reagent are mixed, and that the light source light and the light from the fluorescent substance enter; and a detector that detects light transmitted through the reaction cell. The light source, fluorescent substance, condenser lens, and slit are provided along a straight light corresponding to the optical axis. The width of the slit's opening is equal to or narrower than the width of a ray forming an image of the light source at the position of the slit.

公开(公告)号：US20190310275A1

公开(公告)日：2019-10-10

申请号：US16307787

申请日：2017-04-24

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION ,  ROCHE DIAGNOSTICS OPERATIONS INC.

Inventor： Takeshi ISHIDA ,  Sakuichiro ADACHI ,  Yoshihiro YAMASHITA ,  Shunichirou NOBUKI ,  Hisashi YABUTANI ,  Isao YAMAZAKI ,  Michaela WINDFUHR ,  Bernhard HAUPTMANN ,  Simon KUESTER

IPC: G01N35/00 ,  G01N35/10 ,  A61L2/10 ,  A61L2/24

Abstract: An automatic analyzer is equipped with a sterilization mechanism removably attached to an opening of a container that holds a reagent and having an ultraviolet light generation section that radiates ultraviolet light; a suction nozzle removably attached, together with the sterilization mechanism, to the opening of the container; an analysis section adding the reagent drawn in by suction from the container via the suction nozzle to the reagent, and executing an analysis operation; and a control section exercising variable control over an irradiation light intensity of the ultraviolet light generated by the ultraviolet light generation section.

公开(公告)号：US20170131306A1

公开(公告)日：2017-05-11

申请号：US15126789

申请日：2015-03-09

Applicant: Hitachi High-Technologies Corporation

Inventor： Shinji TARUMI ,  Sakuichiro ADACHI ,  Chie YABUTANI ,  Akihisa MAKINO

IPC: G01N35/00 ,  G01N33/86 ,  G01N21/27 ,  G01N21/51 ,  G01N21/59

CPC classification number: G01N35/00871 ,  G01N21/272 ,  G01N21/51 ,  G01N21/59 ,  G01N33/4905 ,  G01N33/86 ,  G01N2021/135 ,  G01N2021/513 ,  G01N2021/825 ,  G01N2201/12753 ,  G01N2201/12792 ,  G16H10/40 ,  G16H50/20

Abstract: An automatic analytical apparatus includes a reaction container for mixing a sample with a reagent to react the sample to the reagent, a measurement unit that irradiates a reaction solution in the reaction container with light and measures the intensity of transmitted light or scattered light, a control unit that processes time-series light intensity data obtained through the measurement in the measurement unit, a storage unit that stores one or more approximation functions each approximating to a time-series change in the light intensity data, and an output unit that outputs a processing result of the control unit. The control unit selects any one of the approximation functions stored in the storage unit, calculates an approximate curve indicating a time-series change in the light intensity data using the selected approximation function, calculates deviation feature information based on deviation information between the light intensity data and the approximate curve, and detects and classifies an abnormality included in the light intensity data using the deviation feature information.

公开(公告)号：US20180231537A1

公开(公告)日：2018-08-16

申请号：US15749197

申请日：2016-06-28

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Toshiyuki INABE ,  Akihisa MAKINO ,  Sakuichiro ADACHI ,  Chie YABUTANI

IPC: G01N33/542 ,  G01N35/00 ,  G01N33/86 ,  G01N33/52 ,  G01N21/82

Abstract: The automatic analysis device is provided with (1) a measurement mechanism having a light measuring unit having a reaction container in which the sample is dispensed, a light source which emits light to the reaction container, and a detection unit that detects scattered light from the sample in the reaction container, (2) an amplifier circuit unit having an adder-subtractor that adds or subtracts a correction signal to or from a first measurement signal from the detection unit, and an amplifier circuit which amplifies the output signal by the adder-subtractor at a fixed amplification rate to output a second measurement signal, and (3) an arithmetic operation unit which calculates the correction signal on the basis of a difference between the signal level of the second measurement signal and a target value, and which executes an analysis action based on the second measurement signal after correction by means of the correction signal.

公开(公告)号：US20160077119A1

公开(公告)日：2016-03-17

申请号：US14786234

申请日：2014-06-05

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Sakuichiro ADACHI ,  Hajime YAMAZAKI ,  Masahiko IIJIMA ,  Shigeki MATSUBARA

IPC: G01N35/00 ,  G01N21/59 ,  G01N21/51

CPC classification number: G01N35/00584 ,  G01N21/272 ,  G01N21/51 ,  G01N21/532 ,  G01N21/59 ,  G01N21/82 ,  G01N35/00 ,  G01N2021/825 ,  G01N2035/00891

Abstract: The automatic analysis device includes an analysis unit that corrects, based on a measured value at the time of a first light amount measurement with water dispensed in the reaction cell before the sample is dispensed therein; a measured value at the time of a second light amount measurement after the sample and a preprocessing reagent are dispensed into the reaction cell; a liquid amount in the reaction cell at the time of the second light amount measurement; and a liquid amount in the reaction cell at the time of a third light amount measurement after the reaction reagent has been dispensed into the reaction cell and before the reaction reagent and the substance to be measured react with each other.

Abstract translation: 自动分析装置包括分析单元，其基于在将样品分配在其中之前，在反应池中分配的水进行第一光量测量时的测量值; 在将样品和预处理试剂分配到反应池中之后的第二光量测量时的测量值; 在第二光量测量时反应池中的液体量; 并且在反应试剂已经分配到反应池中之前并且在反应试剂和被测量物质彼此反应之前，在第三光量测量时在反应池中的液体量。

公开(公告)号：US20190162744A1

公开(公告)日：2019-05-30

申请号：US16308516

申请日：2017-06-16

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Yuto KAZAMA ,  Masahiko IIJIMA ,  Sakuichiro ADACHI

IPC: G01N35/04 ,  G01N35/10

Abstract: An automatic analysis device has a plurality of types of photometers having different quantitative ranges, and an analysis control unit for quantifying the desired component in specimens based on measurement values of one or more photometers selected from among the plurality of types of photometers. The analysis control unit: sets a switching region in an overlap region of respective quantitative ranges of the plurality of types of photometers, said switching region having a greater width than does the variation in quantitative values of the desired component based on the measurement values of photometers having the same specimen; compares the quantitative value of a quantitative range portion that corresponds to the switching region and the quantitative values of the desired component based on the measurement values of the photometers; and selects a photometer to be used in quantitative output of the desired component from among the plurality of types of photometers.

公开(公告)号：US20190212262A1

公开(公告)日：2019-07-11

申请号：US16328818

申请日：2017-08-04

Applicant: Hitachi High-Technologies Corporation

Inventor： Yuya MATSUOKA ,  Sakuichiro ADACHI ,  Akihisa MAKINO

IPC: G01N21/51 ,  G01N33/49

Abstract: This automatic analysis apparatus is provided with: an analysis port comprising a reaction container holding part that holds a reaction container storing the liquid mixture of a sample and a reagent, a light source that emits light to the liquid mixture stored in the reaction container held by the reaction container holding part, and a detector that detects light generated when the light from the light source is emitted to the liquid mixture; and a control unit that controls the analysis port, and analyzes the sample on the basis of information about the detected light. The automatic analysis apparatus is characterized in that: the surface of an inner wall of the reaction container holding part is configured to reflect at least a portion of the light emitted from the light source; and the control unit executes control so as to emit the light from the light source in a state where the reaction container is not held by the reaction container holding part, to detect the light reflected on the surface of the inner wall of the reaction container holding part by the detector, and to not use the analysis port for analysis when the result of the detection shows that the detected light is less than a first value determined in advance.

公开(公告)号：US20190025192A1

公开(公告)日：2019-01-24

申请号：US16070306

申请日：2016-11-28

Applicant: Hitachi High-Technologies Corporation

Inventor： Sakuichiro ADACHI ,  Masahiko IIJIMA ,  Yuto KAZAMA

IPC: G01N21/03 ,  G01N21/27 ,  G01N21/49 ,  G01N35/00 ,  B01L3/00

Abstract: As a standard solution for evaluating a scattered light measuring optical system mounted on an automated analyzer, a standard solution containing an insoluble carrier at a concentration, at which transmittance is in a range of 10% to 50%, is used, and a light quantity of a light source is adjusted such that a scattered light detector outputs a predetermined value.

公开(公告)号：US20160025758A1

公开(公告)日：2016-01-28

申请号：US14775544

申请日：2014-03-31

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Takeshi YOGI ,  Sakuichiro ADACHI ,  Hajime YAMAZAKI

IPC: G01N35/02 ,  G01N21/49 ,  G01N35/10

CPC classification number: G01N35/025 ,  G01N21/253 ,  G01N21/49 ,  G01N21/51 ,  G01N21/82 ,  G01N35/1002 ,  G01N2021/825 ,  G01N2035/0439 ,  G01N2201/061 ,  G01N2201/12

Abstract: To reduce the influence of air bubbles and dust in measuring scattered light beams on an automatic analyzer. A light source emits a light beam with a first wavelength 18a on a shorter wavelength side and a light beam with a second wavelength 18b on a longer wavelength side, and then, transmitted light beams 19a and 19b and scattered light beams 21a and 21b are received. Noise is estimated from the ratio between the intensities of the transmitted light beams with the first wavelength and the second wavelength and a change in the amount of the scattered light beam with the second wavelength. Then, the estimated noise is subtracted from a change in the amount of the scattered light beam with the first wavelength, so that noise due to air bubbles and dust is reduced.

Abstract translation: 减少自动分析仪测量散射光束中气泡和灰尘的影响。 光源在较短波长侧发射具有第一波长18a的光束和在较长波长侧具有第二波长18b的光束，然后接收透射光束19a和19b以及散射光束21a和21b 。 根据第一波长和第二波长的透射光束的强度与第二波长的散射光束的量的变化率来估计噪声。 然后，从具有第一波长的散射光束的量的变化中减去估计噪声，从而降低由于气泡和灰尘引起的噪声。