公开(公告)号：US20180223233A1

公开(公告)日：2018-08-09

申请号：US15749609

申请日：2016-07-01

申请人： HITACHI, LTD. ,  FUJIMORI KOGYO CO., LTD.

发明人： Masaru NANBA ,  Takashi ANDOU ,  Yui SUGITA ,  Sei MURAKAMI ,  Hiroyuki MATSUDA

IPC分类号： C12M1/06 ,  C12M1/02 ,  C12M3/00 ,  C12M1/00

CPC分类号： C12M1/06 ,  C12M1/007 ,  C12M1/02 ,  C12M3/00 ,  C12M23/14 ,  C12M23/26 ,  C12M23/48 ,  C12M27/20

摘要： A single-use cell culturing apparatus and a culturing bag are provided, each of which can improve efficiency of stirring a culture solution and further reduce a possibility of leakage of the culture solution. The single-use cell culturing apparatus of the present invention includes a housing that accommodates the culturing bag which is flexible and can seal the culture solution inside thereof. The housing has, on an inner surface thereof, a curved convex-shaped protrusion provided at a portion of a contact face at which the housing is in contact with the culturing bag. The culturing bag of the present invention is accommodated in the housing of the single-use cell culturing apparatus; is flexible; and can seal the culture solution inside thereof. The culturing bag includes a concave portion having a shape corresponding to the curved convex protrusion disposed on a part of the housing.

公开(公告)号：US20160186123A1

公开(公告)日：2016-06-30

申请号：US14909277

申请日：2014-08-01

申请人： HITACHI, LTD.

发明人： Masaru NANBA ,  Ryouichi HAGA ,  Sei MURAKAMI ,  Haruo SUZUKI

IPC分类号： C12M1/34 ,  C12M1/12 ,  C12M1/00

CPC分类号： C12M41/30 ,  C12M23/14 ,  C12M23/22 ,  C12M23/26 ,  C12M37/00 ,  C12M41/36

摘要： A cell culture apparatus is provided which can continuously and accurately measure turbidity of a cell culture solution and culture a cell, without inserting a turbidity sensor from outside into a sterile bag. The cell culture apparatus includes: a flexible and transparent sterile bag that is installed at a prescribed position in the cell culture apparatus and in which a cell contained in a cell culture solution is cultured; and a turbidity sensor that includes a light emitter which emits light to the cell culture solution in the sterile bag via a portion of the sterile bag, a light receiver which receives the light transmitted through the cell culture solution via another portion of the sterile bag, and that is configured to place the light emitter, the portion of the sterile bag, another portion of the sterile bag, and the light receiver, optically on a same straight line.

摘要翻译： 提供一种细胞培养装置，其可以连续且准确地测量细胞培养液的浊度并培养细胞，而不将浊度传感器从外部插入无菌袋中。 细胞培养装置包括：柔性透明的无菌袋，其安装在细胞培养装置的规定位置，培养细胞培养液中所含的细胞; 以及浊度传感器，其包括经由所述无菌袋的一部分向所述无菌袋中的细胞培养溶液发光的发光体，所述光接收器经由所述无菌袋的另一部分接收透过所述细胞培养溶液的光， 并且被配置为将光发射器，无菌袋的一部分，无菌袋的另一部分和光接收器光学地放置在相同的直线上。

公开(公告)号：US20160144294A1

公开(公告)日：2016-05-26

申请号：US14787428

申请日：2014-05-07

申请人： HITACHI, LTD.

发明人： Keisuke SHIBUYA ,  Yui SUGITA ,  Ryouichi HAGA ,  Masaru NANBA

IPC分类号： B01D15/38 ,  B01J20/286 ,  B01J20/24

CPC分类号： B01D15/3809 ,  B01D15/3876 ,  B01J20/24 ,  B01J20/286 ,  B01J20/3272 ,  B01J20/3425 ,  B01J20/3475 ,  B01J20/3483 ,  B01J2220/58 ,  C07K1/22

摘要： Provided is a purification device for purifying a useful substance (i.e., target substance) without using an acidic eluent. The purification device purifying the target substance comprises a column and a filler packed in the column. The filler contains a carrier, a temperature responsive polyamino acid bonded to the carrier, and a binding substance bonded to the temperature responsive polyamino acid and specifically bonding to the target substance.

摘要翻译： 提供一种不使用酸性洗脱液来纯化有用物质（即目标物质）的净化装置。 纯化目标物质的净化装置包括柱和填充在柱中的填料。 填料含有载体，与载体结合的温度响应性聚氨基酸，以及与温度响应性聚氨基酸键合并特异性结合目标物质的结合物质。