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    HYDROPHILIC NANOPARTICLES SURFACE-MODIFIED WITH MONOSACCHARIDE PHOSPHATE OR MONOSACCHARIDE PHOSPHATE DERIVATIVES, ITS COLLOIDAL SOLUTION AND USE THEREOF
    2.
    发明申请
    HYDROPHILIC NANOPARTICLES SURFACE-MODIFIED WITH MONOSACCHARIDE PHOSPHATE OR MONOSACCHARIDE PHOSPHATE DERIVATIVES, ITS COLLOIDAL SOLUTION AND USE THEREOF 有权
    用单磷酸盐或单磷酸盐磷酸盐衍生物修饰的亲水性纳米颗粒，其胶体溶液及其用途

    公开(公告)号：US20140161734A1

    公开(公告)日：2014-06-12

    申请号：US14236502

    申请日：2012-08-03

    申请人： HANWHA CHEMICAL CORPORATION

    发明人： Eung Gyu Kim ,  Bong-Sik Jeon ,  Eun Byul Kwon ,  Ju Young Park ,  Wan Jae Myeong

    IPC分类号： A61K49/18

    CPC分类号： A61K49/1824 ,  A61B5/055 ,  A61K9/5036 ,  A61K9/5115 ,  A61K47/26 ,  A61K49/1845

    摘要： Disclosed are a composition including hydrophilic nanoparticles that have a monosaccharide-phosphate or a derivative thereof adhered to the surface thereof, a colloidal solution of the composition dispersed in water, and a magnetic resonance imaging contrast agent including the colloidal solution. According to the present invention, nanoparticles having biocompatibility and excellent water-dispersibility can be prepared by modifying the surface of inorganic nanoparticles. The prepared nanoparticles may be effectively used in a variety of applications including, for example, in vivo imaging applications such as an MRI contrast agent, nano-electronic convergence technologies such as a quantum dot light emitting device, biomedical applications such as hyperthermia, or the like. Moreover, compared to existing nanoparticles dispersed by a dispersion stabilizer known in the art, excellent dispersion stability and a relatively small hydrodynamic diameter may be attained.

    摘要翻译： 公开了包含粘附在其表面上的单糖 - 磷酸酯或其衍生物的亲水性纳米颗粒，分散在水中的组合物的胶体溶液和包含胶体溶液的磁共振成像造影剂的组合物。 根据本发明，通过改变无机纳米粒子的表面，可以制备具有生物相容性和优异的水分散性的纳米粒子。 所制备的纳米颗粒可以有效地用于各种应用，包括例如体内成像应用如MRI造影剂，纳米电子收敛技术如量子点发光器件，生物医学应用如热疗，或 喜欢。 此外，与通过本领域已知的分散稳定剂分散的现有纳米颗粒相比，可以获得优异的分散稳定性和相对较小的流体动力学直径。