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公开(公告)号：US20210299113A1
公开(公告)日：2021-09-30
申请号：US16334400
申请日：2017-09-20
发明人： Edward J. BRNARDIC , Carl A. BROOKS , Brian Griffin LAWHORN , Peng LI , Jay M. MATTHEWS , John Jeffrey McATEE , Joseph E. PERO , Matthew Robert SENDER , Lamont Roscoe TERRELL , David J. BEHM
IPC分类号： A61K31/4439 , A61K45/06 , C07D401/12 , C07D207/48 , A61K31/40 , C07D417/12 , A61K31/427 , C07D403/12 , A61K31/506 , C07D498/10 , A61K31/5386
摘要： The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
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公开(公告)号：US20190202784A1
公开(公告)日：2019-07-04
申请号：US16334410
申请日：2017-09-20
发明人： Edward J. BRNARDIC , Carl A. BROOKS , Brian W. BUDZIK , Brian Griffin LAWHORN , Jay M. MATTHEWS , John Jeffrey McATEE , Joseh E. PERO , David J. BEHM
IPC分类号： C07D207/48 , C07D401/12 , A61K31/4439 , A61K31/40 , A61K45/06 , A61P9/04 , A61P11/14
摘要： The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
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公开(公告)号：US20160340328A1
公开(公告)日：2016-11-24
申请号：US15110776
申请日：2015-01-09
发明人： Sarah E. DOWDELL , Hilary Schenck EIDAM , Mark ELBAN , Ryan Michael FOX , Marlys HAMMOND , Mark A. HILFIKER , Tram H. HOANG , Lara KALLANDER , Brian Griffin LAWHORN , Sharada MANNS , Joanne PHILP , David G. WASHBURN , Guosen YE
IPC分类号： C07D307/68 , C07D405/04 , A61K31/443 , A61K31/416 , A61K31/428 , A61K31/4025 , C07F9/655 , A61K31/665 , A61K31/341 , C07D417/04
CPC分类号： C07D307/68 , A61K31/341 , A61K31/4025 , A61K31/416 , A61K31/428 , A61K31/443 , A61K31/665 , C07D307/12 , C07D307/24 , C07D307/38 , C07D405/04 , C07D407/04 , C07D417/04 , C07F9/65515
摘要： Disclosed are compounds having the formula: wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.
摘要翻译： 其中R1，R2和R3如本文所定义，以及制备和使用它们的方法，包括用作BMP1，TLL1和/或TLL2的抑制剂，以及用于治疗与BMP1，TLL1和/或TLL2活性相关的疾病。
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公开(公告)号：US20200261411A1
公开(公告)日：2020-08-20
申请号：US16796989
申请日：2020-02-21
发明人： Edward J. BRNARDIC , Carl A. BROOKS , Brian Griffin LAWHORN , Guosen YE , Linda S. BARTON , Brian W. BUDZIK , Jay M. MATTHEWS , John Jeffrey McATEE , Jaclyn R. PATTERSON , Joseph E. PERO , Robert SANCHEZ , Matthew Robert SENDER , Lamont Roscoe TERRELL , David J. BEHM , James V. THOMAS
IPC分类号： A61K31/40 , C07F7/08 , C07D513/04 , C07D491/107 , C07D417/12 , C07D409/12 , A61K45/06 , A61K31/695 , A61K31/5386 , A61K31/506 , A61K31/501 , A61K31/4439 , A61K31/429 , A61K31/427 , A61K31/4245 , A61K31/424 , A61K31/4155 , A61K31/407 , A61K31/4025 , A61K9/48 , A61K9/20 , A61K9/00 , C07D498/10 , C07D207/48 , C07D413/12 , C07D401/12 , C07D403/12
摘要： The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
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公开(公告)号：US20200095217A1
公开(公告)日：2020-03-26
申请号：US16655784
申请日：2019-10-17
发明人： Sarah E. DOWDELL , Hilary Schenck EIDAM , Mark ELBAN , Ryan Michael FOX , Marlys HAMMOND , Mark A. HILFIKER , Tram H. HOANG , Lara KALLANDER , Brian Griffin LAWHORN , Sharada MANNS , Joanne PHILP , David G. WASHBURN , Guosen YE
IPC分类号： C07D307/68 , C07D307/12 , C07D307/38 , C07D407/04 , C07D307/24 , A61K31/341 , A61K31/4025 , A61K31/416 , A61K31/428 , A61K31/443 , A61K31/665 , C07D405/04 , C07D417/04 , C07F9/655
摘要： Disclosed are compounds having the formula: wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.
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公开(公告)号：US20190216774A1
公开(公告)日：2019-07-18
申请号：US16334391
申请日：2017-09-20
发明人： Edward J. BRNARDIC , Carl A. BROOKS , Brian Griffin LAWHORN , Guosen YE , Lisa S. BARTON , Brian W. BUDZIK , Jay M. MATTHEWS , John Jeffrey McATEE , Jacyln R. PATTERSON , Joseph E. PERO , Robert SANCHEZ , Matthew Robert SENDER , Lamont Roscoe TERRELL , David J. BEHM , James V. THOMAS
IPC分类号： A61K31/40 , A61K9/00 , A61K45/06 , C07D207/48 , C07D413/12 , A61K31/4245 , A61K31/506 , C07D403/12 , C07D409/12 , C07D417/12 , A61K31/4025 , A61K31/427 , A61K31/4155 , A61K31/429 , C07D513/04 , C07D401/12 , A61K31/4439 , A61K31/501 , A61K31/407 , C07D491/107 , C07F7/08 , A61K31/695 , A61K31/5386 , C07D498/10 , A61K31/424 , A61K9/48 , A61K9/20
摘要： The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
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