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公开(公告)号：US20170362234A1
公开(公告)日：2017-12-21
申请号：US15527581
申请日：2015-11-19
发明人： James Lamond ELLIS , Karen Anderson EVANS , Ryan Michael FOX , William Henry MILLER , Mark Andrew SEEFELD
IPC分类号： C07D471/18 , C07D519/00 , A61K31/5517
CPC分类号： C07D471/18 , A61K31/551 , A61K31/5517 , C07D487/18 , C07D519/00
摘要： The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as Sirtuin Modulators useful for increasing lifespan of a cell, and in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
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公开(公告)号：US20160340328A1
公开(公告)日：2016-11-24
申请号：US15110776
申请日：2015-01-09
发明人： Sarah E. DOWDELL , Hilary Schenck EIDAM , Mark ELBAN , Ryan Michael FOX , Marlys HAMMOND , Mark A. HILFIKER , Tram H. HOANG , Lara KALLANDER , Brian Griffin LAWHORN , Sharada MANNS , Joanne PHILP , David G. WASHBURN , Guosen YE
IPC分类号： C07D307/68 , C07D405/04 , A61K31/443 , A61K31/416 , A61K31/428 , A61K31/4025 , C07F9/655 , A61K31/665 , A61K31/341 , C07D417/04
CPC分类号： C07D307/68 , A61K31/341 , A61K31/4025 , A61K31/416 , A61K31/428 , A61K31/443 , A61K31/665 , C07D307/12 , C07D307/24 , C07D307/38 , C07D405/04 , C07D407/04 , C07D417/04 , C07F9/65515
摘要： Disclosed are compounds having the formula: wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.
摘要翻译： 其中R1，R2和R3如本文所定义，以及制备和使用它们的方法，包括用作BMP1，TLL1和/或TLL2的抑制剂，以及用于治疗与BMP1，TLL1和/或TLL2活性相关的疾病。
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公开(公告)号：US20190048016A1
公开(公告)日：2019-02-14
申请号：US15527851
申请日：2015-11-19
发明人： James Lamond ELLIS , Karen Anderson EVANS , Ryan Michael FOX , William Henry MILLER , Mark Andrew SEEFELD
IPC分类号： C07D487/18 , C07D519/00 , A61P25/28 , A61P3/10 , A61P9/00
摘要： The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as Sirtuin Modulators useful for increasing lifespan of a cell, and in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
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公开(公告)号：US20170355705A1
公开(公告)日：2017-12-14
申请号：US15527440
申请日：2015-11-19
发明人： James Lamond ELLIS , Karen Anderson EVANS , Ryan Michael FOX , William Henry MILLER , Mark Andrew SEEFELD
IPC分类号： C07D487/18 , C07D471/18 , A61K31/551
CPC分类号： C07D487/18 , A61K31/4995 , A61K31/551 , A61K31/5517 , A61P3/10 , A61P9/00 , A61P25/28 , C07D471/18 , C07D519/00
摘要： The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as Sirtuin Modulators useful for increasing lifespan of a cell, and for use in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
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公开(公告)号：US20200095217A1
公开(公告)日：2020-03-26
申请号：US16655784
申请日：2019-10-17
发明人： Sarah E. DOWDELL , Hilary Schenck EIDAM , Mark ELBAN , Ryan Michael FOX , Marlys HAMMOND , Mark A. HILFIKER , Tram H. HOANG , Lara KALLANDER , Brian Griffin LAWHORN , Sharada MANNS , Joanne PHILP , David G. WASHBURN , Guosen YE
IPC分类号： C07D307/68 , C07D307/12 , C07D307/38 , C07D407/04 , C07D307/24 , A61K31/341 , A61K31/4025 , A61K31/416 , A61K31/428 , A61K31/443 , A61K31/665 , C07D405/04 , C07D417/04 , C07F9/655
摘要： Disclosed are compounds having the formula: wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.
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