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公开(公告)号：US20240294630A1
公开(公告)日：2024-09-05
申请号：US18650566
申请日：2024-04-30
CPC分类号： C07K16/244 , A61P11/02 , A61P11/06 , C07K2317/24 , C07K2317/40 , C07K2317/90 , C07K2317/94
摘要： The present disclosure relates to compositions for treating interleukin 5 (IL-5) mediated diseases, and related methods.
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公开(公告)号：US20230414634A1
公开(公告)日：2023-12-28
申请号：US18031899
申请日：2021-10-18
IPC分类号： A61K31/554 , A61P17/04
CPC分类号： A61K31/554 , A61P17/04
摘要： Methods of treating pruritus, including cholestatic pruritus, particularly cholestatic pruritus in primary biliary cholangitis comprising administration of the compound or a pharmaceutically acceptable salt thereof, are disclosed.
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公开(公告)号：US11478478B2
公开(公告)日：2022-10-25
申请号：US16735956
申请日：2020-01-07
发明人： Dominique Amans , Stephen John Atkinson , Lee Andrew Harrison , David Jonathan Hirst , Robert Peter Law , Matthew Lindon , Alexander Preston , Jonathan Thomas Seal , Christopher Roland Wellaway
IPC分类号： A61K31/506 , C07D401/14 , C07D405/14 , C07D413/14 , C07D215/227 , C07D215/46 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/08 , C07D498/04 , A61P29/00 , A61P37/00 , A61P31/12 , A61P35/00 , C07D215/44 , A61K31/4375 , A61K31/4706 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/5386 , C07D498/08
摘要： The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.
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公开(公告)号：US11229623B2
公开(公告)日：2022-01-25
申请号：US16796989
申请日：2020-02-21
发明人： Edward J. Brnardic , Carl A. Brooks , Brian Griffin Lawhorn , Guosen Ye , Linda S. Barton , Brian W. Budzik , Jay M. Matthews , John Jeffrey McAtee , Jaclyn R. Patterson , Joseph E. Pero , Robert Sanchez , Matthew Robert Sender , Lamont Roscoe Terrell , David J. Behm , James V. Thomas
IPC分类号： A61K31/40 , A61K31/695 , A61K31/424 , A61K31/4155 , A61K31/4025 , A61K31/4439 , A61K31/429 , A61K31/4245 , A61K31/501 , A61K31/506 , A61K31/5386 , A61K31/427 , A61K31/407 , A61K45/06 , C07D207/48 , C07D513/04 , C07D401/12 , C07D409/12 , C07D498/10 , C07D403/12 , C07D413/12 , A61P7/10 , A61P29/00 , A61P19/00 , A61P15/00 , A61P1/16 , A61P1/10 , A61P31/04 , A61P17/00 , A61P17/04 , A61P37/06 , A61P27/02 , A61P27/06 , A61P1/00 , A61P43/00 , A61P37/04 , A61P13/12 , A61P13/10 , A61P25/06 , A61P25/28 , A61P11/06 , A61P11/14 , A61P11/02 , A61P1/04 , A61P1/18 , A61P3/04 , A61P3/00 , A61P9/00 , A61P3/10 , A61K9/00 , A61K9/20 , A61K9/48 , C07D417/12 , C07D491/107 , C07F7/08
摘要： The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
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公开(公告)号：US11214582B2
公开(公告)日：2022-01-04
申请号：US17018301
申请日：2020-09-11
发明人： Carlos Alemparte-Gallardo , Michael Richard Kevin (Dickon) Alley , David Barros-Aguirre , Ilaria Giordano , Vincent Hernandez , Xianfeng Li , Jacob J. Plattner
摘要： Substituted benzoxaboroles whose structure comprises Formula (III), wherein R3 is selected from —CH3, —CII2CII3, —CII2═CII2, —CII2CII2CII3, —CH(CH3)2, —CH2CH2═CH2, and cyclopropyl, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, and —CH(CH3)2; compositions containing such compounds, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US20210340246A1
公开(公告)日：2021-11-04
申请号：US17373223
申请日：2021-07-12
IPC分类号： C07K16/24
摘要： The present disclosure relates to compositions, for treating interleukin 5 (IL-5) mediated diseases, and related methods.
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公开(公告)号：US20210053999A1
公开(公告)日：2021-02-25
申请号：US17089058
申请日：2020-11-04
发明人： Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要： Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US10849897B2
公开(公告)日：2020-12-01
申请号：US16489876
申请日：2018-02-27
发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Etienne Levernier , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven
IPC分类号： A61K31/506 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/501 , C07D213/81 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12
摘要： The present invention is directed to pyridyl derivatives which are bromodomain inhibitors, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases or conditions.
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公开(公告)号：US20200325110A1
公开(公告)日：2020-10-15
申请号：US16305439
申请日：2017-06-27
IPC分类号： C07D281/10 , C07D303/04 , C12P17/02
摘要： Methods for the preparation of the following compound are disclosed. The compound can be incorporated into pharmaceutical formulations, including tablets and such tablets can be used for treating cholestatic liver diseases.
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公开(公告)号：US20200308160A1
公开(公告)日：2020-10-01
申请号：US16302118
申请日：2017-05-18
发明人： Patrick STOY , Carl A. BROOKS , Guosen YE
IPC分类号： C07D413/14 , A61K9/20 , A61K9/00
摘要： The present invention relates to a novel compound useful as a TRPV4 antagonist, specifically the compound 1-(((5S,7R)-3-(5-cyclopropylpyrazin-2-yl)-7-hydroxy-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compound.The compound of the invention can be useful in the treatment of a disease state selected from: atherosclerosis, disorders related to vasogenic edema, postsurgical abdominal edema, ocular edema, cerebral edema, local and systemic edema, fluid retention, sepsis, hypertension, inflammation, bone related dysfunctions and congestive heart failure, pulmonary disorders, chronic obstructive pulmonary disorder, ventilator induced lung injury, high altitude induced pulmonary edema, acute respiratory distress syndrome, acute lung injury, pulmonary fibrosis, sinusitis/rhinitis, asthma, cough; including acute cough, sub-acute cough and chronic cough, pulmonary hypertension, overactive bladder, cystitis, pain, motor neuron disorders, genetic gain of function disorders, cardiovascular disease, renal dysfunction, stroke, glaucoma, retinopathy, endometriosis, pre-term labor, dermatitis, pruritus, pruritus in liver disease, diabetes, metabolic disorder, obesity, migraine, pancreatitis, tumor suppression, immunosuppression, osteoarthritis, crohn's disease, colitis, diarrhea, intestinal irregularity (hyperreactivity/hyporeactivity), fecal incontinence, irritable bowel syndrome (IBS), constipation, intestinal pain and cramping, celiac disease, lactose intolerance, and flatulence.
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