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公开(公告)号：US20190315860A1
公开(公告)日：2019-10-17
申请号：US16395009
申请日：2019-04-25
Applicant: Genentech, Inc.
Inventor： Isidro HOTZEL , Teemu T. JUNTTILA , Ji LI , Justin SCHEER , Danielle DICARA , Diego ELLERMAN , Christoph SPIESS , Paul J. CARTER
IPC: C07K16/28 , A61K47/68 , C07K16/30 , A61K45/06 , A61K39/395 , G01N33/574
Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
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公开(公告)号：US20150166661A1
公开(公告)日：2015-06-18
申请号：US14574132
申请日：2014-12-17
Applicant: Genentech, Inc.
Inventor： Xiaocheng CHEN , Mark S. DENNIS , Allen J. EBENS, JR. , Teemu T. JUNTTILA , Robert F. KELLEY , Mary A. MATHIEU , Liping L. SUN
IPC: C07K16/28 , A61K31/573 , A61K47/48 , A61K45/06 , A61K39/395 , C07K16/30
CPC classification number: C07K16/32 , A61K31/573 , A61K39/39558 , A61K45/06 , A61K47/6881 , A61K2039/505 , C07K16/2809 , C07K16/2827 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/71 , C07K2317/73 , C07K2317/92
Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
Abstract translation: 本发明提供分化3（CD3）抗体的抗簇及其使用方法。
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公开(公告)号：US20200299409A1
公开(公告)日：2020-09-24
申请号：US16790656
申请日：2020-02-13
Applicant: Genentech, Inc.
Inventor： Xiaocheng CHEN , Mark S. DENNIS , Allen J. EBENS, Jr. , Teemu T. JUNTTILA , Robert F. KELLEY , Mary A. MATHIEU
IPC: C07K16/32 , C07K16/28 , A61K39/395 , C07K16/30 , A61K45/06 , A61K31/573 , A61K47/68
Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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公开(公告)号：US20170204194A1
公开(公告)日：2017-07-20
申请号：US15473242
申请日：2017-03-29
Applicant: Genentech, Inc.
Inventor： Xiaocheng CHEN , Mark S. DENNIS , Allen J. EBENS, Jr. , Teemu T. JUNTTILA , Robert F. KELLEY , Mary A. MATHIEU
CPC classification number: C07K16/32 , A61K31/573 , A61K39/39558 , A61K45/06 , A61K47/6881 , A61K2039/505 , C07K16/2809 , C07K16/2827 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/71 , C07K2317/73 , C07K2317/92
Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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5.发明申请公开(公告)号：US20220098325A1
公开(公告)日：2022-03-31
申请号：US17473401
申请日：2021-09-13
Applicant: Genentech, Inc.
Inventor： Teemu T. JUNTTILA , Stuart LUTZKER
IPC: C07K16/32 , A61P35/00 , C07K16/28 , A61K45/06 , A61K39/395
Abstract: The present invention provides methods of treating of HER2-positive cancers (such as HER2-positive breast cancer and HER2-positive gastric cancers) using HER2 antibodies, such as a combination of a HER2 T cell-dependent bispecific antibody (TDB) with an additional HER2 antibody (e.g., trastuzumab).
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Patent Agency Ranking
公开(公告)号：US20200299408A1
公开(公告)日：2020-09-24
申请号：US16790616
申请日：2020-02-13
Applicant: Genentech, Inc.
Inventor： Xiaocheng CHEN , Mark S. DENNIS , Allen J. EBENS, JR. , Teemu T. JUNTTILA , Robert F. KELLEY , Mary A. MATHIEU
IPC: C07K16/32 , C07K16/28 , A61K39/395 , C07K16/30 , A61K45/06 , A61K31/573 , A61K47/68
Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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公开(公告)号：US20190270814A1
公开(公告)日：2019-09-05
申请号：US16271410
申请日：2019-02-08
Applicant: Genentech, Inc.
Inventor： Diego ELLERMAN , Teemu T. JUNTTILA , Twyla Noelle LOMBANA , Dionysos SLAGA , Christoph SPIESS
Abstract: The present invention provides bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen (e.g., a T cell antigen, such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen, such as HER2). Bispecific antigen-binding molecules are useful in the treatment of disorders, such as cancer (e.g., HER2-positive cancer). The invention also features methods of producing bispecific antigen-binding molecules, methods of treating disorders using bispecific antigen-binding molecules, and compositions including bispecific antigen-binding molecules.
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8.发明申请公开(公告)号：US20160368985A1
公开(公告)日：2016-12-22
申请号：US15184690
申请日：2016-06-16
Applicant: Genentech, Inc.
Inventor： Isidro HOTZEL , Teemu T. JUNTTILA , Ji LI , Justin SCHEER , Danielle DICARA , Diego ELLERMAN , Christoph SPIESS , Paul J. CARTER
IPC: C07K16/28 , G01N33/574 , A61K45/06 , A61K47/48 , C07K16/30 , A61K39/395
CPC classification number: C07K16/283 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/507 , C07K16/2809 , C07K16/2827 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/62 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/57492 , G01N2333/70535
Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
Abstract translation: 本发明涉及抗FcRH5抗体，包括抗FcRH5抗体，其包含FcRH5结合结构域和CD3结合结构域（例如，FcRH5T细胞依赖性双特异性（TDB）抗体）及其使用方法。
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公开(公告)号：US20230096941A1
公开(公告)日：2023-03-30
申请号：US17734239
申请日：2022-05-02
Applicant: Genentech, Inc.
Inventor： Allen J. EBENS , Meredith C. HAZEN , Jo-Anne HONGO , Jennifer W. JOHNSTON , Teemu T. JUNTTILA , Ji LI , Andrew G. POLSON
IPC: C07K16/28 , A61K47/68 , A61K39/395 , A61K51/10
Abstract: The invention provides anti-FcRH5 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20190112389A1
公开(公告)日：2019-04-18
申请号：US16144452
申请日：2018-09-27
Applicant: Genentech, Inc.
Inventor： Xiaocheng CHEN , Mark S. DENNIS , Allen J. EBENS, JR. , Teemu T. JUNTTILA , Robert F. KELLEY , Mary A. MATHIEU , Liping L. SUN
IPC: C07K16/32 , A61K39/395 , A61K45/06 , A61K47/68 , C07K16/28 , A61K31/573 , C07K16/30
Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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