公开(公告)号：US20210138065A1

公开(公告)日：2021-05-13

申请号：US17127697

申请日：2020-12-18

Applicant: HOFFMANN-LA ROCHE INC. ,  GENENTECH, INC.

Inventor： Christian KLEIN ,  Sabine LANG ,  Pablo UMANA ,  Andrew G. POLSON

IPC: A61K39/395 ,  A61K47/68 ,  C07K16/28 ,  A61K31/40 ,  A61K31/5365 ,  A61K45/06

Abstract: The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with a CD79b antibody-drug conjugate for the treatment of cancer, especially to the combination therapy of CD20 expressing cancers with an afucosylated humanized B-Ly1 antibody and a CD79b antibody-drug conjugate.

公开(公告)号：US20230096941A1

公开(公告)日：2023-03-30

申请号：US17734239

申请日：2022-05-02

Applicant: Genentech, Inc.

Inventor： Allen J. EBENS ,  Meredith C. HAZEN ,  Jo-Anne HONGO ,  Jennifer W. JOHNSTON ,  Teemu T. JUNTTILA ,  Ji LI ,  Andrew G. POLSON

IPC: C07K16/28 ,  A61K47/68 ,  A61K39/395 ,  A61K51/10

Abstract: The invention provides anti-FcRH5 antibodies and immunoconjugates and methods of using the same.