公开(公告)号：US20190270814A1

公开(公告)日：2019-09-05

申请号：US16271410

申请日：2019-02-08

Applicant: Genentech, Inc.

Inventor： Diego ELLERMAN ,  Teemu T. JUNTTILA ,  Twyla Noelle LOMBANA ,  Dionysos SLAGA ,  Christoph SPIESS

IPC: C07K16/28 ,  C07K16/32 ,  A61K9/00 ,  A61P35/00 ,  A61K47/65

Abstract: The present invention provides bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen (e.g., a T cell antigen, such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen, such as HER2). Bispecific antigen-binding molecules are useful in the treatment of disorders, such as cancer (e.g., HER2-positive cancer). The invention also features methods of producing bispecific antigen-binding molecules, methods of treating disorders using bispecific antigen-binding molecules, and compositions including bispecific antigen-binding molecules.