公开(公告)号：US20190185584A1

公开(公告)日：2019-06-20

申请号：US16045539

申请日：2018-07-25

Applicant: Genentech, Inc.

Inventor： Justin SCHEER ,  Christoph SPIESS ,  Daniel G. YANSURA

IPC: C07K16/46 ,  C07K16/30 ,  C07K16/24 ,  C07K16/28

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/244 ,  C07K16/247 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  Y02A50/41

Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.

公开(公告)号：US20190270814A1

公开(公告)日：2019-09-05

申请号：US16271410

申请日：2019-02-08

Applicant: Genentech, Inc.

Inventor： Diego ELLERMAN ,  Teemu T. JUNTTILA ,  Twyla Noelle LOMBANA ,  Dionysos SLAGA ,  Christoph SPIESS

IPC: C07K16/28 ,  C07K16/32 ,  A61K9/00 ,  A61P35/00 ,  A61K47/65

Abstract: The present invention provides bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen (e.g., a T cell antigen, such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen, such as HER2). Bispecific antigen-binding molecules are useful in the treatment of disorders, such as cancer (e.g., HER2-positive cancer). The invention also features methods of producing bispecific antigen-binding molecules, methods of treating disorders using bispecific antigen-binding molecules, and compositions including bispecific antigen-binding molecules.

公开(公告)号：US20160368985A1

公开(公告)日：2016-12-22

申请号：US15184690

申请日：2016-06-16

Applicant: Genentech, Inc.

Inventor： Isidro HOTZEL ,  Teemu T. JUNTTILA ,  Ji LI ,  Justin SCHEER ,  Danielle DICARA ,  Diego ELLERMAN ,  Christoph SPIESS ,  Paul J. CARTER

IPC: C07K16/28 ,  G01N33/574 ,  A61K45/06 ,  A61K47/48 ,  C07K16/30 ,  A61K39/395

CPC classification number: C07K16/283 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2809 ,  C07K16/2827 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/62 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/57492 ,  G01N2333/70535

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

Abstract translation: 本发明涉及抗FcRH5抗体，包括抗FcRH5抗体，其包含FcRH5结合结构域和CD3结合结构域（例如，FcRH5T细胞依赖性双特异性（TDB）抗体）及其使用方法。

公开(公告)号：US20210171662A1

公开(公告)日：2021-06-10

申请号：US17025980

申请日：2020-09-18

Applicant: Genentech, Inc.

Inventor： Justin SCHEER ,  Christoph SPIESS ,  Daniel G. YANSURA

IPC: C07K16/46 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30

Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.

公开(公告)号：US20190315860A1

公开(公告)日：2019-10-17

申请号：US16395009

申请日：2019-04-25

Applicant: Genentech, Inc.

Inventor： Isidro HOTZEL ,  Teemu T. JUNTTILA ,  Ji LI ,  Justin SCHEER ,  Danielle DICARA ,  Diego ELLERMAN ,  Christoph SPIESS ,  Paul J. CARTER

IPC: C07K16/28 ,  A61K47/68 ,  C07K16/30 ,  A61K45/06 ,  A61K39/395 ,  G01N33/574

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US20180282431A1

公开(公告)日：2018-10-04

申请号：US15796530

申请日：2017-10-27

Applicant: Genentech, Inc.

Inventor： Justin SCHEER ,  Christoph SPIESS ,  Daniel G. YANSURA

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/24

Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.

公开(公告)号：US20250032610A1

公开(公告)日：2025-01-30

申请号：US18752672

申请日：2024-06-24

Applicant: Genentech, Inc.

Inventor： Paul CARTER ,  Christoph SPIESS ,  Yiyuan YIN ,  Jianhui ZHOU ,  Wendy SANDOVAL ,  Jacob CORN ,  Michael DILLON

IPC: A61K39/44 ,  A61K39/00 ,  A61K39/395 ,  C07K16/46 ,  G01N33/68 ,  G16B5/00 ,  G16B20/00 ,  G16B20/30 ,  G16B20/50

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

公开(公告)号：US20240360229A1

公开(公告)日：2024-10-31

申请号：US18416525

申请日：2024-01-18

Applicant: Genentech, Inc.

Inventor： Christoph SPIESS ,  Baomei WANG ,  Ambrose Jon WILLIAMS ,  Cecilia Pui Chi CHIU ,  Michael Andrew DILLON ,  Teemu Tapani JUNTTILA ,  James Thomas KOERBER

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/2866 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73

Abstract: The present invention provides anti-C-C motif chemokine receptor 8 (CCR8) antigen-binding molecules (e.g., bispecific antigen-binding molecules) and compositions thereof. The invention also features polynucleotides, vectors, host cells, methods of production, pharmaceutical compositions, methods of treating a disease or disorder, such as cancer, methods of depleting regulatory T cells, related uses and compositions for use, and kits for use with the one or more methods.

公开(公告)号：US20240190966A1

公开(公告)日：2024-06-13

申请号：US18504041

申请日：2023-11-07

Applicant: Genentech, Inc.

Inventor： WeiYu LIN ,  Christoph SPIESS ,  Liping SUN ,  Yan WU ,  Cecilia P.C. CHIU ,  Walter Christian DARBONNE ,  Michael Andrew DILLON

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2824 ,  C07K16/2809 ,  A61K2039/507 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92

Abstract: Provided herein are anti-Ly6G6D (lymphocyte antigen 6 complex, locus G61) antibodies and methods of using the same.

公开(公告)号：US20200055939A1

公开(公告)日：2020-02-20

申请号：US16345619

申请日：2017-10-27

Applicant: Genentech, Inc.

Inventor： Twyla Noelle LOMBANA ,  Christoph SPIESS ,  Jeong KIM ,  Evangeline TOY ,  Jill SCHARTNER ,  Zhengmao YE ,  Jack BEVERS, III ,  Ryan COOK ,  Marissa MATSUMOTO ,  Amy BERKLEY

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00

Abstract: The invention provides anti-MIC antibodies and methods of using the same.