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42 条记录 (耗时 0.033 秒)

    Dynamic optical amplifier
    1.
    发明授权
    Dynamic optical amplifier 失效
    动态光放大器

    公开(公告)号：US6151157A

    公开(公告)日：2000-11-21

    申请号：US884747

    申请日：1997-06-30

    申请人： Gary A. Ball ,  Paul Sanders

    发明人： Gary A. Ball ,  Paul Sanders

    IPC分类号： H01S3/10 ,  H04B10/17 ,  H01S3/00

    CPC分类号： H04B10/2941 ,  H01S3/10023 ,  H01S3/1003

    摘要： An optical amplifier for amplifying a plurality of signal components of a multi-wavelength optical beam passing through an optical fiber includes a portion of the optical fiber doped with a rare earth ion to amplify the optical signal wherein the gain spectrum as a function of the wavelength is nonuniform. The optical amplifier further includes a gain flattening module to compensate for the nonuniform gain spectrum of the doped fiber by attenuating each of the channels of the amplified signal to equalize the gain. A gain equalization module compensates for varying gain fluctuations due to the adding and subtracting of signal components. The gain equalization module adjusts dynamically each signal component of the optical beam such that the amplitudes of the signal components are substantially equal, in response to a plurality of control signals. Each control signal is representative of the degree of attenuation required to equalize the signal components. The respective control signals are generated by a loop status monitor that includes a waveguide for demultiplexing the optical beam, and a detector array that determines the amplitude of each signal component. A controller generates the control signals in dependence of the amplitude of the signal components.

    摘要翻译： 用于放大通过光纤的多波长光束的多个信号分量的光放大器包括掺杂有稀土离子的光纤的一部分以放大光信号，其中增益光谱作为波长的函数 是不均匀的。 光放大器还包括增益平坦化模块，通过衰减放大信号的每个通道以补偿增益来补偿掺杂光纤的不均匀增益谱。 增益均衡模块补偿由于信号分量的相加和减去引起的变化的增益波动。 增益均衡模块动态地调整光束的每个信号分量，使得响应于多个控制信号，信号分量的振幅基本相等。 每个控制信号代表均衡信号分量所需的衰减程度。 相应的控制信号由包括用于解复用光束的波导的环路状态监视器以及确定每个信号分量的振幅的检测器阵列产生。 控制器根据信号分量的振幅产生控制信号。

    High power three level fiber laser and method of making same
    2.
    发明授权
    High power three level fiber laser and method of making same 失效
    大功率三级光纤激光器及其制作方法

    公开(公告)号：US06031849A

    公开(公告)日：2000-02-29

    申请号：US971472

    申请日：1997-11-14

    申请人： Gary A. Ball ,  Paul Sanders

    发明人： Gary A. Ball ,  Paul Sanders

    IPC分类号： C03B37/018 ,  H01S3/067 ,  H01S3/30 ,  C03B37/023 ,  G02B6/26 ,  H01S3/00

    CPC分类号： H01S3/06708 ,  C03B37/01838 ,  C03B37/01853 ,  C03B37/01861 ,  C03B2201/12 ,  C03B2201/28 ,  C03B2201/31 ,  C03B2201/34 ,  C03B2203/02 ,  C03B2203/10 ,  C03B2203/29 ,  G02B6/03622

    摘要： A rare earth doped fiber for use in a fiber laser is presented. The fiber laser uses a single stripe broad area pump diode permits Yb lasing in its 3-level transition at 980 nm preferentially over the 1010 nm 4-level transition. The present fiber laser is characterized by a dual cladding fiber geometry which includes an inner rare earth doped single mode core. There is an inner cladding designed to be a multimode pump core for the pump light. The pump core is followed by a final cladding to confine the pump radiation. The present laser matches the larger/outer mode field to that of a single stripe broad area diode in order to maximize the pump intensity.

    摘要翻译： 介绍了一种用于光纤激光器的稀土掺杂光纤。 光纤激光器使用单条宽广域泵浦二极管，允许Yb激光器在980nm处的3级转换优先于1010nm的4级转换。 本发明的光纤激光器的特征在于包括内部稀土掺杂单模核心的双包层光纤几何形状。 有一个内包层，被设计为泵浦光的多模泵芯。 泵芯后面是最后的包层以限制泵浦辐射。 目前的激光器将较大/外部模式的场与单个条形宽区域二极管匹配，以使泵浦强度最大化。

    Multiple biopsy apparatus and related method of use
    3.
    发明授权
    Multiple biopsy apparatus and related method of use 有权
    多次活检装置及相关使用方法

    公开(公告)号：US08262587B2

    公开(公告)日：2012-09-11

    申请号：US12896627

    申请日：2010-10-01

    申请人： Gary McAlister ,  Paul Sanders

    发明人： Gary McAlister ,  Paul Sanders

    IPC分类号： A61B10/02

    CPC分类号： A61B10/0266 ,  A61B10/0275 ,  A61B10/0283 ,  A61B10/04 ,  A61B2010/0225

    摘要： An endoluminal biopsy device is provided with a proximal actuation mechanism attached to a distal sampler by at least one elongate member. The distal sampler includes a distal inner portion defining a plurality of chambers, each configured to receive a tissue sample, and a distal outer portion defining a cutting mechanism opening having a cutting edge adjacent the cutting mechanism opening. The distal outer portion is configured so that, when the cutting mechanism opening aligns with one of the plurality of chambers, the distal outer portion covers the remaining chambers. A related method for the use of such an endoluminal biopsy device also is provided.

    摘要翻译： 腔内活检装置设置有通过至少一个细长构件附接到远端取样器的近侧致动机构。 远端采样器包括限定多个室的远侧内部部分，每个室被构造成容纳组织样本，远侧外部部分限定切割机构开口，该切割机构开口具有与切割机构开口相邻的切割边缘。 远端外部部分构造成使得当切割机构开口与多个腔室中的一个对准时，远侧外部部分覆盖剩余的腔室。 还提供了使用这种腔内活检装置的相关方法。

    IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOF
    6.
    发明申请
    IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
    免疫组化及其使用方法

    公开(公告)号：US20080107656A1

    公开(公告)日：2008-05-08

    申请号：US11756487

    申请日：2007-05-31

    申请人： Brendan Crabb ,  Paul Sanders

    发明人： Brendan Crabb ,  Paul Sanders

    IPC分类号： A61K39/395 ,  A61K31/7088 ,  A61P33/02 ,  C07H21/00 ,  C07K16/00 ,  C12N15/63 ,  C40B40/08 ,  C12N1/00 ,  C07K14/00 ,  A61P33/06 ,  A61K38/16

    CPC分类号： C07K16/205 ,  A61K38/00 ,  C07K14/445 ,  Y02A50/412

    摘要： The present invention relates generally to a method of eliciting or otherwise inducing an immune response to a Plasmodium microorganism and compositions for use therein. More particularly, the present invention relates to a method of eliciting or otherwise inducing an immune response to a Plasmodium microorganism by administering an immunogenic composition comprising one or more of Pf38, Pf12, Pf41, Pf92 or Pf113 or immunogenic fragment or homologue thereof. The present invention is useful, inter alia, as a prophylactic and/or therapeutic treatment for Plasmodium infections of mammals such as, for example, Plasmodium falciparum infection.

    摘要翻译： 本发明一般涉及引发或以其它方式诱导对疟原虫微生物的免疫应答的方法及其中使用的组合物。 更具体地，本发明涉及通过施用包含Pf38，Pf12，Pf41，Pf92或Pf113中的一种或多种的免疫原性组合物或其免疫原性片段或同源物来引发或以其它方式诱导对疟原虫微生物的免疫应答的方法。 本发明尤其可用作哺乳动物（例如恶性疟原虫感染）的疟原虫感染的预防和/或治疗性治疗。

    Large diameter D-shaped optical waveguide and coupler
    7.
    发明授权
    Large diameter D-shaped optical waveguide and coupler 有权
    大直径D型光波导和耦合器

    公开(公告)号：US06996316B2

    公开(公告)日：2006-02-07

    申请号：US10098891

    申请日：2002-03-18

    申请人： Timothy J. Bailey ,  Robert N. Brucato ,  Alan D. Kersey ,  Martin A. Putnam ,  Paul Sanders ,  James Sullivan

    发明人： Timothy J. Bailey ,  Robert N. Brucato ,  Alan D. Kersey ,  Martin A. Putnam ,  Paul Sanders ,  James Sullivan

    IPC分类号： G02B6/02 ,  G02B6/34 ,  G02B6/22 ,  H01S3/067

    CPC分类号： G01L1/242 ,  G02B6/02057 ,  G02B6/274 ,  G02B6/2817 ,  G02B6/2821 ,  G02B6/2826 ,  G02B6/29334 ,  G02B6/4214 ,  H01S3/06708 ,  H01S3/0675 ,  H01S3/094003 ,  H01S3/094007 ,  H01S3/094019

    摘要： A large diameter D-shaped optical waveguide device 9, includes an optional circular waveguide portion 11 and a D-shaped waveguide portion 10 having at least one core 12 surrounded by a cladding 14. A portion of the waveguide device 9 has a generally D-shaped cross-section and has transverse waveguide dimension d2 greater than about 0.3 mm. At least one Bragg grating 16 may be impressed in the waveguide 10 and/or more than one grating or pair of gratings may be used and more than one core may be used. The device 9 provides a sturdy waveguide platform for coupling light into and out of waveguides and for attachment and alignment to other waveguides, for single and multi-core applications. The core and/or cladding 12,14 may be doped with a rare-earth dopant and/or may be photosensitive. At least a portion of the core 12 may be doped between a pair of gratings 50,52 to form a fiber laser or the grating 16 or may be constructed as a tunable DFB fiber laser or an interactive fiber laser within the waveguide 10. The waveguide may resemble a short “block” or a longer “cane” type, depending on the application and dimensions used.

    摘要翻译： 大直径D形光波导器件9包括可选的圆形波导部分11和D形波导部分10，其具有被包层14包围的至少一个核心12。 波导器件9的一部分具有大致D形的横截面并且横向波导尺寸d 2大于约0.3mm。 可以在波导10中施加至少一个布拉格光栅16，和/或可以使用多于一个的光栅或一对光栅，并且可以使用多于一个的芯。 器件9提供了一个坚固的波导平台，用于将光耦合到和流出波导，并用于连接和对准其他波导，用于单核和多核应用。 芯和/或包层12,14可掺杂稀土掺杂剂和/或可以是光敏的。 芯12的至少一部分可以掺杂在一对光栅50,52之间以形成光纤激光器或光栅16，或者可以被构造为波导10内的可调DFB光纤激光器或交互光纤激光器。波导 可能类似于短的“块”或更长的“手杖”类型，具体取决于所使用的应用和尺寸。

    Multiple biopsy apparatus and related method of use
    9.
    发明授权
    Multiple biopsy apparatus and related method of use 有权
    多次活检装置及相关使用方法

    公开(公告)号：US07828745B2

    公开(公告)日：2010-11-09

    申请号：US11256683

    申请日：2005-10-24

    申请人： Gary McAlister ,  Paul Sanders

    发明人： Gary McAlister ,  Paul Sanders

    IPC分类号： A61B10/00

    CPC分类号： A61B10/0266 ,  A61B10/0275 ,  A61B10/0283 ,  A61B10/04 ,  A61B2010/0225

    摘要： An endoluminal biopsy device is provided with a proximal actuation mechanism attached to a distal sampler by at least one elongate member. The distal sampler includes a distal inner portion defining a plurality of chambers, each configured to receive a tissue sample, and a distal outer portion defining a cutting mechanism opening having a cutting edge adjacent the cutting mechanism opening. The distal outer portion is configured so that, when the cutting mechanism opening aligns with one of the plurality of chambers, the distal outer portion covers the remaining chambers. A related method for the use of such an endoluminal biopsy device also is provided.

    摘要翻译： 腔内活检装置设置有通过至少一个细长构件附接到远端取样器的近侧致动机构。 远端采样器包括限定多个室的远侧内部部分，每个室被构造成容纳组织样本，远侧外部部分限定切割机构开口，该切割机构开口具有与切割机构开口相邻的切割边缘。 远端外部部分构造成使得当切割机构开口与多个腔室中的一个对准时，远侧外部部分覆盖剩余的腔室。 还提供了使用这种腔内活检装置的相关方法。