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    IMPROVED MASS CYTOMETRY
    4.
    发明申请
    IMPROVED MASS CYTOMETRY 有权

    公开(公告)号：US20220310373A1

    公开(公告)日：2022-09-29

    申请号：US17620049

    申请日：2020-06-17

    Applicant: Fluidigm Canada Inc.

    Inventor： Paul Corkum ,  Alexander Loboda ,  David M. Rayner

    IPC: H01J49/00 ,  H01J49/16 ,  H01J49/04 ,  G01N15/14

    Abstract: Embodiments of the present invention relate to replacement of the previous ICP-based ionisation system with a new laser ionisation system, providing improved mass spectrometer-based apparatus and methods for using them to analyse samples, in particular the use of mass spectrometry mass cytometry, imaging mass spectrometry and imaging mass cytometry, for the analysis of biological samples. Accordingly, embodiments of the present invention provide an apparatus, for example a mass cytometer, comprising: 1) a sampler; 2) a laser ionisation system to receive material removed from the sample by the sampler, wherein the laser ionisation system comprises an ionisation system conduit and a pulsed laser adapted to ionise sample material passing through or exiting the ionisation system conduit; and 3) a mass spectrometer to receive elemental ions from said ionisation system and to analyse said elemental ions.

    HIGH RESOLUTION IMAGING APPARATUS AND METHOD
    5.
    发明申请
    HIGH RESOLUTION IMAGING APPARATUS AND METHOD 有权

    公开(公告)号：US20210118661A1

    公开(公告)日：2021-04-22

    申请号：US17253538

    申请日：2019-06-18

    Applicant: Paul Corkum ,  Fluidigm Canada Inc.

    Inventor： Paul Corkum ,  Alexander V. Loboda

    IPC: H01J49/04 ,  H01J49/00 ,  H01J49/10 ,  H01J49/06 ,  H01J49/40 ,  H01J49/02 ,  G02B21/33 ,  H01J37/28 ,  H01J37/20 ,  G01N33/68

    Abstract: The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMCTM) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.

    APPARATUS AND METHOD FOR TUNABLE GENERATION OF COHERENT RADIATION
    6.
    发明申请
    APPARATUS AND METHOD FOR TUNABLE GENERATION OF COHERENT RADIATION 有权
    用于可产生相干辐射的装置和方法

    公开(公告)号：US20160149371A1

    公开(公告)日：2016-05-26

    申请号：US14936756

    申请日：2015-11-10

    Applicant: University of Ottawa

    Inventor： Giulio Vampa ,  Paul Corkum ,  Thomas Brabec

    IPC: H01S3/109 ,  H01S5/04 ,  H01S5/042 ,  H01S3/16 ,  H01S5/06

    CPC classification number: H01S5/0428 ,  G02F1/35 ,  G02F1/37 ,  G02F2001/354 ,  H01S3/108 ,  H01S3/109 ,  H01S3/16 ,  H01S3/1628 ,  H01S5/041 ,  H01S5/042 ,  H01S5/0425 ,  H01S5/0427 ,  H01S5/0604

    Abstract: A method and apparatus is disclosed for generating tunable attosecond-scale radiation pulses, with a frequency in range of ultraviolet to soft-X-ray, from a solid-state medium. The invention utilizes an intense laser pulse to drive a high harmonic generation (HHG) process in a solid state medium and a weak secondary field to control the HHG process. The weak secondary field has a frequency equal to the second harmonic of the intense laser pulse. The spatial, temporal and spectral properties of the HHG process and the emitted harmonic beam are tuned by adjusting the relative delay between the two fields and the intensity of the weak secondary field.

    Abstract translation: 公开了一种用于从固态介质产生具有紫外至软X射线范围的可调谐阿秒秒级辐射脉冲的方法和装置。 本发明利用强激光脉冲驱动固态介质和弱二次场中的高次谐波发生（HHG）过程，以控制HHG过程。 弱次级场的频率等于强激光脉冲的二次谐波。 通过调整两个场之间的相对延迟和弱二次场的强度来调整HHG过程和发射谐波束的空间，时间和光谱特性。

    Apparatus and method for tunable generation of coherent radiation
    7.
    发明授权
    Apparatus and method for tunable generation of coherent radiation 有权
    用于可调谐产生相干辐射的装置和方法

    公开(公告)号：US09496681B2

    公开(公告)日：2016-11-15

    申请号：US14936756

    申请日：2015-11-10

    Applicant: University of Ottawa

    Inventor： Giulio Vampa ,  Paul Corkum ,  Thomas Brabec

    IPC: H01S3/10 ,  H01S5/042 ,  H01S5/04 ,  H01S5/06 ,  H01S3/109 ,  H01S3/108 ,  H01S3/16 ,  G02F1/35

    CPC classification number: H01S5/0428 ,  G02F1/35 ,  G02F1/37 ,  G02F2001/354 ,  H01S3/108 ,  H01S3/109 ,  H01S3/16 ,  H01S3/1628 ,  H01S5/041 ,  H01S5/042 ,  H01S5/0425 ,  H01S5/0427 ,  H01S5/0604

    Abstract: A method and apparatus is disclosed for generating tunable attosecond-scale radiation pulses, with a frequency in range of ultraviolet to soft-X-ray, from a solid-state medium. The invention utilizes an intense laser pulse to drive a high harmonic generation (HHG) process in a solid state medium and a weak secondary field to control the HHG process. The weak secondary field has a frequency equal to the second harmonic of the intense laser pulse. The spatial, temporal and spectral properties of the HHG process and the emitted harmonic beam are tuned by adjusting the relative delay between the two fields and the intensity of the weak secondary field.

    Abstract translation: 公开了一种用于从固态介质产生具有紫外至软X射线范围的可调谐阿秒秒级辐射脉冲的方法和装置。 本发明利用强激光脉冲驱动固态介质和弱二次场中的高次谐波发生（HHG）过程，以控制HHG过程。 弱次级场的频率等于强激光脉冲的二次谐波。 通过调整两个场之间的相对延迟和弱二次场的强度来调整HHG过程和发射谐波束的空间，时间和光谱特性。

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